WO2017109250A1 - Lentille ophtalmique et ensemble de lentilles ophtalmiques pour corriger la presbytie - Google Patents

Lentille ophtalmique et ensemble de lentilles ophtalmiques pour corriger la presbytie Download PDF

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Publication number
WO2017109250A1
WO2017109250A1 PCT/ES2016/070897 ES2016070897W WO2017109250A1 WO 2017109250 A1 WO2017109250 A1 WO 2017109250A1 ES 2016070897 W ES2016070897 W ES 2016070897W WO 2017109250 A1 WO2017109250 A1 WO 2017109250A1
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WO
WIPO (PCT)
Prior art keywords
holes
ophthalmic lens
lens according
ophthalmic
lens
Prior art date
Application number
PCT/ES2016/070897
Other languages
English (en)
Spanish (es)
Inventor
Walter Daniel FURLÁN
Juan Antonio MONSORIU SERRA
Fernando GIMÉNEZ PALOMARES
Laura REMÓN MARTÍN
Salvador GARCÍA DELPECH
Patricia Udaondo Mirete
Original Assignee
Universitat De València
Universitat Politècnica De València
Ajl Ophtalmic, S.A.
Tecnologia Ocular Preventiva, S.L.
Fundación Para La Investigación Del Hospital Universitario La Fe De Valencia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitat De València, Universitat Politècnica De València, Ajl Ophtalmic, S.A., Tecnologia Ocular Preventiva, S.L., Fundación Para La Investigación Del Hospital Universitario La Fe De Valencia filed Critical Universitat De València
Publication of WO2017109250A1 publication Critical patent/WO2017109250A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1654—Diffractive lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1601—Lens body having features to facilitate aqueous fluid flow across the intraocular lens, e.g. for pressure equalization or nutrient delivery
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes

Definitions

  • the present invention concerns, in general, in a first aspect, an ophthalmic lens for the correction of presbyopia comprising a central through hole to increase the depth of a focus from a distance and through holes distributed around it, and more particularly to an ophthalmic lens whose through holes are distributed by concentric annular regions so that the light diffracted by them generates a near focus.
  • a second aspect of the invention concerns a set of ophthalmic lenses, comprising two ophthalmic lenses, according to the first aspect, intended for simultaneous use by a patient to provide binocular vision.
  • presbyopia or "tired eyesight” has historically been approached from different perspectives, from bifocal and progressive contact lenses and lenses, to multifocal intraocular lenses, all of them to ensure that the patient can see clearly at close distances and intermediate.
  • KAMRA® Acufocus, Irving, CA, USA
  • Kamra consists of an opaque ring of polyvinylidene fluoride (PVDF) of 3, 8 mm in diameter with a central opening of 1.6 mm (smaller than the pupil diameter) and a thickness of 6 ⁇ .
  • the Kamra ophthalmic lens meets the characteristics of the preamble of claim 1 of the present invention, since it constitutes the closest antecedent to the invention.
  • micro-holes are arranged irregularly on the surface in order to minimize the generation of visible artifacts due to the transmission of light through them, that is to say, the diffracted light, leaving an inner and outer perimeter region substantially free of micro holes.
  • an ophthalmic lens for the correction of presbyopia which comprises, in a known manner, a lens body provided with:
  • the said through holes are provided to fulfill an additional function to that related to allowing the passage of nutrients, said additional function being that of generating a near focus for said eye, for which the through holes are distributed by at least one annular region so that the light diffracted by them generates said near focus.
  • the effects of diffraction of the Light through the through holes is not only not combated but also used and optimized, especially its distribution, to create the aforementioned focus, in order to correct presbyopia.
  • the lens proposed by the first aspect of the present invention is a diffractive lens:
  • - of amplitude consisting of an opaque material with through holes
  • - phase consisting of a transparent material with through holes
  • - amplitude and phase hybrid consisting of a partially transparent material with through holes.
  • the through holes are distributed by two or more concentric annular regions.
  • the through holes are configured, sized and arranged so that part of the light diffracted by them also converges on the aforementioned focus from afar, thus collaborating with the central hole to increase the intensity of light directed to the focus from far.
  • a multifocal lens designed for at least such near and far foci is constituted, where, by constructive interference, the light diffracted by the lens converges on said foci.
  • the through holes are configured, sized and arranged so that part of the light diffracted by them converges into one or more additional spotlights, preferably including two or more spotlights, thus forming a multifocal lens of more than two spotlights.
  • Both the central through hole contour and that of the through holes may have any shape, depending on the exemplary embodiment, such as circular, elliptical or irregular.
  • the lens of the first aspect of the invention comprises, distributed by said annular regions, other diffractive elements, advantageously porous, which are constituted by at least one of the following optical elements:
  • - element of transparent optical material for at least part of the visible radiation, of optical properties different from those of the interstitial material between through holes, and - protruding or indented topology element by at least one of the ophthalmic lens faces.
  • the through holes are configured, sized and distributed for the additional purpose of compensating, at least partially, the aberrations of the eye, in particular those of high order (especially spherical aberration and chromatic aberration).
  • each of the annular regions where the through holes are located radially follows a periodic or aperiodic distribution.
  • the through holes in each of the annular regions are angularly spaced or follow an aperiodic or irregular distribution.
  • the through holes are arranged in concentric annular regions elliptically, such that the axes of the ellipses coincide with the main meridians of an astigmatism eye.
  • the semi-axes of the ellipses are obtained with the previous equation.
  • each of the annular regions are distributed with a certain density, which can be different in each annular region, to provide an effect equivalent to an amplitude filter that allows obtaining any desired relative intensity between the different foci generated by the lens and / or to correct residual eye aberrations, especially spherical aberration.
  • said annular regions are divided into different adjacent angular sectors, each with a different radial distribution of zones to achieve a greater depth of focus. This aspect is studied in a general way, but only for refractive lenses, in the following reference: de Gracia, Pablo, Carlos Dorronsoro, and Susana Marcos. "Multiple zone multifocal phase designs" Optics letters 38.18 (2013): 3526-3529.
  • the ophthalmic lens of the invention is a contact lens, an intraocular lens (phakic or pseudophakic) or, preferably, an intracorneal lens.
  • the largest transverse dimension of the contour of each of the through holes has a value that is between 4 ⁇ and 300 ⁇ .
  • said larger transverse dimension refers to their diameter.
  • the largest transverse dimension of its contour ie its diameter, when the hole is circular
  • the total diameter of the lens is between 3.0 and 26 mm.
  • the ophthalmic lens proposed by the first aspect of the invention comprises only said lens body, which is constituted by a single substrate.
  • the anterior part of the ophthalmic lens proposed by the invention is convex and the concave rear face, with the In order to adapt to the shape of the eye.
  • the lens is flat, being of a soft material that allows its adaptation to the shape of the cornea .
  • the material from which the substrate that forms the lens of the invention is made is biocompatible, and, for one embodiment, is colored to resemble the color of the patient's iris or to selectively absorb part of the visible radiation by acting as a filter. color.
  • the lens object of the first aspect of the invention may be rigid or flexible, be flat or have a certain degree of curvature to adapt to the structure of the attached eye (eg for a contact lens or an implant intracorneal the internal face would be concave and the external face convex), and its profile may have a constant thickness or decrease from the center to the periphery.
  • the thicknesses can vary between 3 ⁇ and 30 ⁇ .
  • the multifocal nature of the lens proposed by the present invention is preferably adapted to presbyte patients of any age, by creating at least one near focus; however, for some embodiments, the lens has some refractive power to compensate for other visual and / or refractive defects. Also, the lens is compatible with other eye surgeries that use femtosecond or excimer lasers, such as LASIK, to correct refractive defects.
  • the lens is transparent to electromagnetic radiation outside the visible range so as not to interfere with diagnostic or therapeutic tests that require observation or treatment of internal structures of the eye.
  • the lens is composed of a polarizing polymer that absorbs electromagnetic radiation in a particular direction (depending on the orientation) and transmits light in the perpendicular direction. to the previous one (linearly polarized light) to absorb reflections on bright surfaces and reduce glare.
  • the lens of the present invention creates a close focus, so the need for reading glasses is less than with the Kamra.
  • the invention enhances the focus from far away and reduces the intensity of the focus closely so that night vision problems also disappear.
  • the lens of the first aspect of the invention can be implanted (or arranged superficially, if it is a contact lens) in both eyes, so that these problems do not exist. If implanted in a single eye, the amount of light it receives is greater than with the Kamra and the potential Pulfrich effect would be much less obvious.
  • a second aspect of the invention concerns a set of ophthalmic lenses for the correction of presbyopia, comprising two ophthalmic lenses according to the first aspect of the invention, one configured for the dominant eye of a patient and the other for the non-eye. dominant, the aforementioned two ophthalmic lenses being provided for simultaneous use by said patient to provide binocular vision, unlike the Kamra implant, which only includes a lens that must be disposed unilaterally in the non-dominant eye of the patient.
  • Figure 1 shows the ophthalmic lens of the first aspect of the present invention, for two embodiments, illustrated in view a) schematically and in view b) in a more realistic manner;
  • Figure 2a shows another embodiment of the lens proposed by the first aspect of the present invention, where the through holes are arcs constituting ring segments, in this case both the central opening and the through holes have been illustrated in white and the rest of the regions in black, although the latter are not necessarily opaque (neither in this nor in the rest of the attached figures), and may even be made of a transparent material depending on the embodiment;
  • Figure 2b illustrates an exemplary embodiment of the lens of the first aspect of the invention, for which the lens body is made of a material transparent to visible radiation, and the through holes are configured, sized and distributed with a certain density , which is different in each annular region, to provide an effect equivalent to an amplitude filter that allows obtaining any desired relative intensity between the different foci generated by the lens and / or to correct residual ocular aberrations, especially spherical aberration, the spherical aberrations being annular regions divided into different adjacent angular sectors, in particular in four sectors (delimited by the dashed lines shown in the figure) in which the radial distribution of the zones is different to provide an increased depth of focus closely.
  • Figures 3a and 3b respectively illustrate, in their left views, the lens object of the first aspect of the present invention for an exemplary embodiment for which it is a diffractive lens of amplitude and the Kamra lens, and, in its right views, respective graphs of PSF (English “Point Spread Function", or impulse response) normalized axial vs. blur showing the intensities of the foci, for different wavelengths, inside the eye, obtained for the corresponding lenses.
  • PSF Terms “Point Spread Function", or impulse response
  • FIGS 1, 2 and 3a five examples of embodiment of the ophthalmic lens for the correction of presbyopia proposed by the first aspect of the invention are illustrated, which comprises, as can be seen in the figures, a lens body 1 equipped with:
  • the diffraction of the light generated by the central hole 2 and the holes 3 distributed in the annular zones creates at least two foci, so that the lens as a whole behaves like a multifocal diffractive lens (preferably) of amplitude.
  • the through holes 3 are circular and are distributed over several annular regions, in a much larger number in view b) (both of holes 3 and of annular regions), which corresponds to a case more realistic application than that of sight a).
  • the through holes 3 are arc portions into which each annular region is divided.
  • Figure 2b illustrates another embodiment of the lens of the first aspect of the invention, for which the annular regions divided into different adjacent angular sectors, in particular in four sectors (delimited by the dashed lines shown in the figure) in which the radial distribution of the zones is different to provide an increased depth of focus closely.
  • the through holes in each of the annular regions are distributed with a variable density in each annular region, to provide an effect equivalent to an amplitude filter.
  • the present inventors have performed a series of simulations with both the lens of the present invention and the Kamra lens, according to the configurations illustrated in the left views of said figures. , whose results are illustrated by the graphs of the right views of such figures.
  • Figures 3a and 3b they respectively illustrate, in their left views, the lens object of the first aspect of the present invention for an exemplary embodiment for which this is a diffractive lens of amplitude with a diameter of the central hole of 1, 2 mm and an external diameter of 3.3 mm, and the Kamra lens with a diameter of the central hole of 1.6 mm and an external diameter of 3.8 mm and, in its right views, respective graphics of normalized axial PSF versus blur showing the intensities of the foci, for different wavelengths (450 nm, 550 nm and 650 nm), inside the eye with a pupil of 3.8 mm diameter, obtained for the corresponding lenses.
  • this is a diffractive lens of amplitude with a diameter of the central hole of 1, 2 mm and an external diameter of 3.3 mm
  • the Kamra lens with a diameter of the central hole of 1.6 mm and an external diameter of 3.8 mm and, in its right views, respective graphics of normalized axial PSF versus blur showing the
  • the "inlay” Kamra has no near spotlights.
  • the longitudinal chromatic aberration of the eye is approximately the same value but of the opposite sign (see: Vinas, M., Dorronsoro, C, Cortes, D., Pascual, D., & Marcos, S. (2015). "Longitudinal chromatic aberration of the human eye in the visible and near infrared from wavefront sensing, double-pass and psychophysics.” Biomedical optics express, 6 (3), 948-962), so, for focus closely with polychromatic illumination, the chromatic aberration would be partially compensated.
  • the far focus generated by the lens of the invention for the design wavelength (550 nm) is a 92% more intense than for the Kamra inlay, which is an additional advantage, since in addition to improving near vision, the lens of the invention provides far better vision than that provided with the Kamra inlay .
  • the lens proposed by the present invention clearly improves the performance offered by the Kamra lens, optimizing the vision of nearby objects and ensuring a wide range of clear vision between near and far objects (greater than that achieved with known lenses).
  • the aforementioned benefits are even better for the set of lenses of the second aspect of the present invention, since, unlike the Kamra lens, the proposed set allows the application of lenses in both eyes of a patient without creating binocular vision problems.
  • a person skilled in the art could introduce changes and modifications in the described embodiments without departing from the scope of the invention as defined in the appended claims.

Abstract

Lentille ophtalmique et ensemble de lentilles ophtalmiques pour corriger la presbytie. La lentille comprend un corps de lentille (1) équipé: - d'un trou traversant central (2) dimensionné pour augmenter la profondeur de focalisation de loin de l'œil dans lequel est placée la lentille ophtalmique; et - d'orifices traversants (3) répartis autour du trou traversant central (2), pour permettre le passage de nutriments et générer la focalisation de près pour l'œil, c'est pourquoi les orifices traversants (3) sont répartis sur une ou plusieurs régions annulaires pour que la lumière diffractée par ceux-ci génère ladite focalisation de près. L'ensemble de lentilles comprend deux lentilles ophtalmiques selon l'invention, une pour chaque œil d'un patient, prévues pour une utilisation simultanée par le patient pour offrir une vision binoculaire.
PCT/ES2016/070897 2015-12-24 2016-12-15 Lentille ophtalmique et ensemble de lentilles ophtalmiques pour corriger la presbytie WO2017109250A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201531911A ES2619577B2 (es) 2015-12-24 2015-12-24 Lente oftálmica y conjunto de lentes oftálmicas para la corrección de la presbicia
ESP201531911 2015-12-24

Publications (1)

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WO2017109250A1 true WO2017109250A1 (fr) 2017-06-29

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PCT/ES2016/070897 WO2017109250A1 (fr) 2015-12-24 2016-12-15 Lentille ophtalmique et ensemble de lentilles ophtalmiques pour corriger la presbytie

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WO (1) WO2017109250A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0335731A2 (fr) * 1988-04-01 1989-10-04 Minnesota Mining And Manufacturing Company Lentilles ophtalmiques multifocales diffractives
US5108169A (en) * 1991-02-22 1992-04-28 Mandell Robert B Contact lens bifocal with switch
US5628794A (en) * 1996-03-08 1997-05-13 Lindstrom; Richard L. Multifocal corneal implant lens having a hydrogelo coating
WO2000052516A2 (fr) * 1999-03-01 2000-09-08 Boston Innovative Optics, Inc. Systeme et procede destines a l'augmentation de la profondeur focale de l'oeil humain
US20060235514A1 (en) * 2005-04-14 2006-10-19 Silvestrini Thomas A Corneal optic formed of degradation resistant polymer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0335731A2 (fr) * 1988-04-01 1989-10-04 Minnesota Mining And Manufacturing Company Lentilles ophtalmiques multifocales diffractives
US5108169A (en) * 1991-02-22 1992-04-28 Mandell Robert B Contact lens bifocal with switch
US5628794A (en) * 1996-03-08 1997-05-13 Lindstrom; Richard L. Multifocal corneal implant lens having a hydrogelo coating
WO2000052516A2 (fr) * 1999-03-01 2000-09-08 Boston Innovative Optics, Inc. Systeme et procede destines a l'augmentation de la profondeur focale de l'oeil humain
US20060235514A1 (en) * 2005-04-14 2006-10-19 Silvestrini Thomas A Corneal optic formed of degradation resistant polymer

Also Published As

Publication number Publication date
ES2619577A1 (es) 2017-06-26
ES2619577B2 (es) 2018-04-02

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