WO2017107955A1 - Titanium nickel-based shape memory alloy tissue closing clip, release device, and clip accommodating device - Google Patents

Titanium nickel-based shape memory alloy tissue closing clip, release device, and clip accommodating device Download PDF

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Publication number
WO2017107955A1
WO2017107955A1 PCT/CN2016/111526 CN2016111526W WO2017107955A1 WO 2017107955 A1 WO2017107955 A1 WO 2017107955A1 CN 2016111526 W CN2016111526 W CN 2016111526W WO 2017107955 A1 WO2017107955 A1 WO 2017107955A1
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WO
WIPO (PCT)
Prior art keywords
clip
clamping
seat
closure clip
end
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PCT/CN2016/111526
Other languages
French (fr)
Chinese (zh)
Inventor
杨西群
杨潇
Original Assignee
杨西群
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Publication date
Priority to CN201510970910 priority Critical
Priority to CN201510970910.7 priority
Priority to CN201610407973.6 priority
Priority to CN201610409039.8 priority
Priority to CN201610407973.6A priority patent/CN105902290B/en
Priority to CN201610409039.8A priority patent/CN105997184B/en
Application filed by 杨西群 filed Critical 杨西群
Publication of WO2017107955A1 publication Critical patent/WO2017107955A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound

Abstract

A titanium nickel-based shape memory alloy tissue closing clip (90), a release device (80), and a clip accommodating device. The closing clip (90) is a closed strip made of a hyperelastic titanium nickel-based shape memory alloy material, and the closed strip is formed by means of end-to-end connection of at least three outer segmental arcs (91) and the same quantity of inner segmental arcs (92) in a stagger manner, and is formed in a dish shape or a bowl shape. The closing clip (90) also comprises tooth-shaped protrusions (93) disposed on the tops of the inner segmental arcs (92) and pointing to the center of the closing clip (90), and comprises parallel clips that are same in quantity and are in a one-to-one correspondence with the outer segmental arcs (91). The tissue closing clip (90) is used for closing for treating tissue perforation, anal fistula endostoma and alimentary tract hemorrhage as well as excision of polypus tissue. By means of the shape memory property and hyperelasticity of titanium nickel-based shape memory alloy, the closing clip is opened when a temperature is lower than a set temperature or under external force and is automatically closed when the temperature is higher than the set temperature or external force is withdrawn, and treatment is carried out by performing continuous automatic pressurization on a focus. The closing clip is quite simple in structure, machining technology and operation process, and finally, no foreign matter is left in the body.

Description

Ti-Ni based shape memory alloy closure clip delivery, a clamping device FIELD

The present invention relates to a tissue closure clip and the corresponding delivery, a clamping device, in particular, relates to an organization made of Ti-Ni based shape memory alloy material closure clip and the corresponding delivery, a clamping device. Tissue closure clip according to the present invention, for perforating tissue, anal fistula inside the mouth, gastrointestinal bleeding and removal of polyps is closed.

Background technique

Currently used in clinical tissue closure, it is the use of digestive closer disposable as auxiliary equipment, such as making use of stainless steel staple Mouth closed anal fistula incision anastomosis, or the use of purse-string suture on the anal fistula be closed. The device is invasive surgical instruments, patients have to endure great pain, and stainless steel nails will long stay in the human body, causing the operation to fail.

To this end, Applicants have invented a method for Ti-Ni based shape memory alloys tissue closure clip, see FIG. 1 to FIG. 46, which uses a shape-memory and superelastic nickel titanium based shape memory alloy is at a temperature below the set temperature or opened by an external force, is automatically closed after unloading or force above the set temperature, the lesion continuous automatic pressing of therapeutic purposes. However, the Ti-Ni based shape memory alloy closure clip memory, superelastic and sterile surgical procedures required, which leads to difficult to be opened and serving temporarily fixed closure clip's seat, so that accurate force and unloading close to the lesions is also very easy. Thus, with the closure clip is also a need for a serving and supporting the use of clamping.

SUMMARY

One object of the present invention to provide a nickel titanium based shape memory alloy closure clip, which utilizes a shape memory and superelastic properties of nickel titanium memory alloy based, or open at below the set temperature by an external force, the high at a set temperature or force closed automatically after unloading, for continuously and automatically pressurized to lesions for therapeutic purposes.

Another object of the present invention is to provide two delivery devices for use in a surgical procedure for the new Ti-Ni based shape memory alloy closure clip, which may be the shape of an open closure clip is temporarily fixed, and then the operation according to the doctor's, fast and accurate the closure clip release.

Another object of the present invention is to provide a clamping device for use in a surgical procedure for the new Ti-Ni based shape memory alloy closure clip, which can be easily opened and closed temporarily fixed clip's serving base closure clip.

Technical solutions of the present invention are: Ti-Ni based shape memory alloys tissue closure clip is made of a nickel-titanium based shape memory alloy, which is special in that: the closure comprising a body having a closed clip strip; the closed strip connected to the same number of interleaved inner arc segment 92 at least three end-rounded outer arc sequentially arranged sections 91; the closure clip body planar layout, the layout bowl or dish-shaped layout.

Said outer arc segment 91 is the number 3,4, 5,6 or 8.

Further comprising a closure clip disposed above the top of each inner arc segment 92 and the center point of the toothed projections 93 closure clip.

Said outer arc segment 91 is the number 3,4, 5,6 or 8.

All the outer diameter of the top 91 of the arc segment where the circle is 10-20mm, all within the top or arc segment 92 of the top toothed projections 93 located diameter circle is 1-4mm; cone angle of the closure clip body is 120- 180 °.

All the outer diameter of the top 91 of the arc segment where the circle is 12-16mm, all within the top or arc segment 92 of the top toothed projections 93 to the diameter of a circle located 1-3mm; cone angle of the closure strip 160 °.

Further comprising a closure clip above the same and correspond to the number of parallel outer arc segment 91 interposed; the clip comprises two parallel clip 94 disposed in parallel; the two ends of clip 94 are respectively fixed to the outer arcs 91 the inner ends secured, non-secured end is positioned outside the arc region 91 surrounded.

It said two opposite sides of the clip body 94 are respectively provided with engagement means; said engaging means comprises a convex 941 and at least one tine and the tine tip tooth position shifted relative to the clip body, or convex comprises at least a tine 941 and a groove 942 and the concave shape of the groove and the number of tines relative to the clip body to match, or comprising at least one smooth convex rounded projection 943 and the groove 944 and the concave rounded groove and opposing collet smoothly matches the shape of the number of projections.

All the outer diameter of the top 91 of the arc segment where the circle is 10-20mm, all within the top or arc segment 92 of the top toothed projections 93 to the diameter of a circle located 1-4mm; cone angle of the closure strip 120 -180 °; distance of the two clip body 94 is 0.5-2mm.

All the outer diameter of the top 91 of the arc segment where the circle is 12-16mm, all within the top or arc segment 92 of the top toothed projections 93) where the diameter of the circle is 1-3mm; cone angle of the strip is closed 160 °.

A nickel titanium based shape memory alloy serving clip is closed, comprising a housing; the housing is provided with a handle and a housing for the engaging of the cavity structure, which is special in that:

Further comprising a push rod disposed in the housing unit, the housing provided at the front end of push ring unit;

The push means comprises a trigger lever, a push rod, a return spring stopper; the push rod may be moved forward under the action of the trigger and the stopper means, and in situ under the action of return of the return spring and the stopper ;

The push means comprises a ring on the pressure seat, the seat under pressure, wire holder, two wires, push ring;

The upper and lower press-pressure seat seating engagement of the upper and lower L-shaped hollow tubular structure, which is connected to the rear end of the front end of the housing, its front end turned downward to form a closed clamp seat 80 to 100 degrees, the seat is provided with a closure clip a through hole penetrating vertically; wire fixing base provided at the rear of the L-shaped hollow tubular structure and is connected to the front end of the push rod; rear end of the two wires are fixed to the wire holder, wherein the parallel portion provided on the pressure seat between the seat and the lower pressure, push sleeve front end respectively on the outer ring closure clip is hinged seat.

The stopper means includes a stopper and a rear stopper base front seat in the housing, the front portion of the push rod is disposed forward of the front stopper base, the push rod arranged in the middle of the front and rear limit stopper base between the bit holder, which is provided with a spring seat, in the middle of the return spring push rod sleeve and located between the front seat and a stopper spring seat, the rear of the push rod disposed behind the rear seat stopper which a trigger is provided below the groove; the trigger is disposed inside handle, the handle extending to the outer end thereof, the other end of the trigger into the card slot.

Between the wire holder connected with the push rod by the rotation mechanism, one end of the wire holder connected with the rotating mechanism, the push rod and the other end connected to the rotation mechanism, the wire holder is rotatable about the central axis of the push rod rotation.

The rotation mechanism includes a fixed shaft and a movable shaft, the end portion of the shaft is provided with a boss, the boss and the wire diameter of the neck by a fixing base secured, the neck diameter is larger than the boss; the fixed shaft provided with a boss and a slot adapted to the neck portion adapted to the rotation limiting groove, and said projection can be rotated from the side where the groove Ka Ruka given axis, from the neck side locking shaft into the rotation limiting groove and rotated therein.

The above-described pushing lever unit further comprises safety catch; the securing bolt disposed at the rear of the housing, the outer surface of the housing which button, which is provided inside the housing a hook, the hook can be driven away from the button or snap pushers safety catch above the rear slot.

Further comprising a push lever unit above safety mechanism; the securing means is a fuse holder, which is hinged at one end in the middle of the inside of the trigger, and the other end can be locked to the inside handle to secure the trigger with respect to the handle angle.

And said handle engaging around the housing of a pistol shape cavity structure.

Clamping device for Ti-Ni based shape memory alloys tissue closure clip, which is special because: a clamping cone assembly 40; clamping the clamping cone assembly 40 comprises a cylinder 41 connected sequentially, clamping cone 43, prisms 42; the clamping cylinder 41 has a plurality of uniformly distributed circumferential side second guide grooves 411; said holding tapered surface 43 on the cone with a plurality of uniformly distributed grooves clamping cone 431; the said prism 42 includes a plurality of circumferentially equispaced prism 421; 421 number of the prisms 90 within the arc with the closure clip and the number of segments 92 of the same cross-sectional shape between the prism 42 and the closure clip 92 of the inner arc void match; position of the prism 421 and the second guiding groove 411 corresponding to; an intermediate position of the two prisms 421 clamping tapered end of each of the grooves 431 adjacent the other end of the adjacent two second guide primer of the middle groove; the outer diameter of the clamping cylinder 41 is closed clip serving the outer diameter 80 matches seat 22; the second guide groove 411 and the first guide on the closure clip 22 correspondence of the position of the groove 221.

The above-mentioned clamping cone assembly 40 further includes a positioning post 41 provided on the outer end surface of the clamping cylinder 44; 44 and the positioning post 80 of the clip serving closes the through hole 22 of the base 21 matches.

The positioning ribs 441 provided with a positioning column; the positioning ribs 441 and the clamp 80 is closed to serve positioning groove 21 on the seat 22 of the through-holes match.

The above-described clamping assembly further comprises a clamping seat 30; clamping the seat assembly 30 includes a housing, a plurality of pallets 31 from one post hole and a clamping portion sequentially disposed inwardly of the housing 32, clamping cone 34, a prismatic hole 33; 43 form the clamping cone and the clamping cone 34 matches; the prism 33 and the aperture 42 to match the shape of a prism; 31 circumferentially uniformly distributed plurality of pallets 32 to a clamping post holes inner surface; the inner edge of each pallet is provided with an outer end portion of the latch 311; the same number of pallets 31 and the second guide groove 411, the position of one correspondence; and the latch 311 can be caught closure clip 90 corresponding to the outer arc segment 91, so as to drive the planar layout, the layout of the bowl or dish-shaped layout closure clip through the prism 42, the clamping cone 41 is moved to the clamping cylinder, the cylinder expands to shaped layout.

The number of the prism 421 is 3,4,5,6,8.

The above-described clamping assembly further comprises a seat 50 backward; backward the seat assembly 50 includes a column 52 and stepped backward backward pins 52 on the sleeve of sleeve 51 backward; the backward side of column 52 is provided with a circumferential 411 equal to the number of the plurality of the second guide groove, one-third position of the guide groove 521; 5244 the backward outer diameter and the positioning columns are the same; the external force may be set backward Backward movement along the column and reset under the action of an internal spring.

Backward above the seat assembly 50 further includes a pin 52 disposed at the outer end face of the backward backward positioning post 53; an outer end face of the clamping cylinder 41 is provided with a swing post holes 45, backward of the post hole 45 and down matched to the positioning post 53.

The number of the prism 421 is 3,4,5,6,8.

Advantageous effects of the invention are:

1, the present invention is a closed closure clip strip, by a plurality of alternately arranged outer and inner arcs formed by arcs connected end to end, the structure is very simple.

2, the present invention is a closed closure clip is cut into strips with a Ti-Ni based shape memory alloy plate or pipe, it can be used by memory processing, simple process.

3, in order to enhance the effect of the closure, the closure clip of the present invention uses four off preventing means: the first stage is closed clip body, which employs a superelastic nickel titanium based shape memory alloy material temperature above the memory, setting memory material below body temperature, when the folder is closed into the body, the material exhibits superelasticity, shrink inward, continued pressure on the tissue; second level is provided at the top of each segment and the arc center point closure clip the serrations which may be an internal tissue puncture, preventing closure clip off; the third stage is arranged parallel to clips, full-clamped tissue, to improve the closing effect; the fourth stage is arranged in parallel on the clamp engagement means, by the parallel engagement means disposed on the opposite clamp can clamp the tissue further, can maximize the closure clip to prevent accidental detachment.

4, the present invention is simple surgical procedure. The present invention is a tissue closure when the clip is closed within the tissue piercing extraoral peripheral tissue, or toothed on the inner arc segment arc closure clip projections extraoral peripheral tissues to treat tissue within the stapling action automatically at body temperature pressing extraoral peripheral tissue trauma does not form a new organization, to maintain good blood circulation in the tissue tension while overcoming, prompting the closing of the mouth tissue perforation, good surgical results.

5, the present invention is at one end clamped tissue closure clip maintain good blood circulation, at the same time promote the healing of tissue perforation, the other end of the clamped tissue due to ischemic necrosis of the tissue caused by the closure clip off automatically, to do the final into the body without leaving any foreign body.

6, the closure clip of the present invention in special circumstances may also be tissue closure clip removal tool may also be long term implantation in vivo.

7, the present invention is the dual function organized tissue resection and anastomosis.

8, the present invention uses a closed heart-shaped pattern, can achieve full closure, closing effect is better than the conventional parallel closed mode.

9, the present invention is non-invasive surgical instruments.

10, the present invention serve Memory Alloys anastomosis clip released special equipment, primarily for gastrointestinal bleeding vessel sealing, tissue gastrointestinal perforation, local tissue proliferation resection, removal of hemorrhoids, anal fistula closing the mouth and the like.

11, the present invention is simple delivery structure, convenient operation, can achieve the purpose of tissue ablation or anastomosis, reducing the burden on the doctor's surgery.

12, using the coupling structure and the rotary joints between the push rods and push ring unit serving cell according to the invention, so that the handle does not move in the case, the unit may push ring rotatable about its own axis, so as to accommodate different angles of lesions.

13, clamping of the present invention may be nickel-titanium based shape memory alloy by a tissue closure clip planar layout, dished or bowl-shaped layout layout layout easily expanded into a tubular shape, thereby realizing the opening and closing and temporarily fixed clip's serving cylindrical closure clip seat.

14, clamping of the present invention may be implemented in a suit or anti-loaded closure clip for use in a variety of lesions.

15, clamping structure of the present invention is simple and easy to use.

BRIEF DESCRIPTION

1 to FIG. 4 is a schematic view of an outer arc three tissue closure clip comprises; wherein:

FIG. 1 is a front view of the front of the memory of the deformation;

2 is a perspective view of the front of the memory effect of the deformation, the strip can be seen in the same plane;

FIG 3 is a bottom view of the memory effect of the deformation can be seen that the arc is shifted to one side;

FIG 4 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

5 to FIG. 8 is a schematic view of an outer arc 3 and the upper strap serrations arc segment of tissue closure clip comprising; wherein:

FIG 5 is a front view of the front of the memory of the deformation;

FIG 6 is a perspective view of the front of the memory effect of the deformation, the strip can be seen in the same plane;

FIG. 7 is a bottom view of the memory effect of the deformation can be seen that the arc is shifted to one side;

8 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

9 to FIG. 12 is a schematic view of an outer arc segment comprises four tissue closure clip; wherein:

FIG 9 is a front view of the front of the memory of the deformation;

FIG 10 is a perspective view of the front of the memory effect of the deformation, the strip can be seen in the same plane;

FIG 11 is a bottom view of the memory effect of the deformation can be seen that the arc is shifted to one side;

FIG 12 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

13 to FIG. 16 is a schematic diagram includes four outer and inner arc segment arc upper strap serrations tissue closure clip; wherein:

FIG 13 is a front view of the front of the memory of the deformation;

FIG 14 is a perspective view of the front of the memory effect of the deformation, the strip can be seen in the same plane;

FIG 15 is a bottom view of the memory effect of the deformation can be seen that the arc is shifted to one side;

FIG 16 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

17 to FIG. 20 is a schematic view of an outer arc 5 comprises a tissue closure clip; wherein:

FIG 17 is a front view of the front of the memory of the deformation;

FIG 18 is a perspective view of the front of the memory effect of the deformation, the strip can be seen in the same plane;

FIG 19 is a bottom view of the memory effect of the deformation can be seen that the arc is shifted to one side;

FIG 20 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

21 to FIG. 24 is a schematic view of an outer arc 5 and the top of the arc segment with serrations tissue closure clip comprising; wherein:

FIG 21 is a front view of the front of the memory of the deformation;

FIG 22 is a perspective view of the front of the memory effect of the deformation, the strip can be seen in the same plane;

FIG 23 is a bottom view of the memory effect of the deformation can be seen that the arc is shifted to one side;

FIG 24 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

25 to FIG. 28 is a schematic view of the organization of the six outer arc closure clip comprises; wherein:

FIG 25 is a front view of the front of the memory of the deformation;

FIG 26 is a perspective view of the front of the memory effect of the deformation, the strip can be seen in the same plane;

FIG 27 is a bottom view of the memory effect of the deformation can be seen that the arc is shifted to one side;

FIG 28 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

29 to FIG. 32 is a schematic view of an outer arc segment 6 and the top of the arc segment with serrations tissue closure clip comprising; wherein:

FIG 29 is a front view of the front of the memory of the deformation;

FIG 30 is a perspective view of the front of the memory effect of the deformation, the strip can be seen in the same plane;

FIG 31 is a bottom view of the memory effect of the deformation can be seen that the arc is shifted to one side;

FIG 32 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

33 to 36 are schematic eight arcs outer tissue closure clip comprises; wherein:

FIG 33 is a front view of the front of the memory of the deformation;

FIG 34 is a perspective view of the front of the memory effect of the deformation, the strip can be seen in the same plane;

FIG 35 is a bottom view of the memory effect of the deformation can be seen that the arc is shifted to one side;

FIG 36 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

37 to FIG. 38 is a schematic view of an outer arc segments 8 and the upper strap serrations arc segment of tissue closure clip comprising; wherein:

FIG 37 is a front view of the front of the memory of the deformation;

FIG 38 is a perspective view of the memory effect of the deformation can be seen that the arc is shifted to one side;

FIG 39 is a four outer arc, arc with the top serrations, with four parallel and parallel to the clamp clip serrations schematic tissue closure clip is provided with;

FIG 40 is a four outer arc, arc with the top serrations, with four parallel and parallel to the clamp clip is provided with a toothed projections and recesses schematic tissue closure clip;

FIG 41 is a four outer arc, arc with the top serrations, with four parallel and interposed schematic rounded projection provided on the inner rounded grooves and perforations tissue closure clip parallel port folder;

FIG 42 is a three outer arc, arc with the top serrations, with three parallel and parallel to the clamp clip is provided on the open port showing a state of the tissue closure clip perforated smoothly rounded grooves and protrusions;

FIG 43 is a three outer arc, the arc 3 with the top of the tooth projections 3 parallel with the upper folder and a schematic view of the projection and is provided with a smooth rounded grooves tissue closure clip is parallel to the perforated opening folders;

FIG 44 is a perspective schematic view of the effect of the perforations 43 in FIG tissue closure clip opening;

FIG 45 is a four outer arc, arc with the top serrations, with four parallel and parallel to the clamp clip is provided with serrations schematic view of another tissue closure clip;

FIG 46 is a four outer arc, arc with the top serrations, with four parallel projections interposed and smoothly rounded grooves and a schematic view of another tissue closure clip is provided on the parallel clamp;

FIG 47 is a cross-sectional view of the delivery device;

FIG 48 is a schematic view of a push ring unit on the pressure seat removed;

FIG 49 is a schematic structural diagram of a push ring unit;

FIG 50 is an overall view of the delivery device;

FIG 51 is an exploded view of the delivery device;

52 and FIG. 53 is a schematic view of clamping assembly of the present invention, the cone;

FIG 54 is a schematic view of clamping assembly of the seat of the present invention;

FIG 55 is a cross-sectional view of FIG 54;

Positive closure clip 56 is mounted on the clamping cone and a clamping assembly of the present invention has not been put on the seat assembly in an initial state in FIG;

FIG 57 is a clamping seat assembly, clamping cone assembly, the closure clip, a schematic view of the initial position of the delivery device;

FIG 58 is a clamping seat assembly into the closing nip schematic assembly clamping cone assembly position;

FIG 59 is a schematic view of the position of the seat assembly and a clamping device serving fully bonded;

FIG 60 is a schematic view of a closed position when the clamping clip mount assembly is about to run out;

FIG 61 is a schematic view of the position when the clamping device serving base assembly is about to run out;

Positive closure clip 62 is mounted on the clamping cone and a clamping assembly of the present invention has not been put on the seat assembly in an initial state in FIG;

FIG 63 is a closure clip being installed on the backward position of the seat assembly of the present invention, a schematic diagram;

FIG 64 is a schematic view of the closure clip the reversed position of the closure clip serving base according to the present invention;

Reference numerals: 1 - a handle, a trigger 2-, 3- trigger torsion 4- safety catch, the stopper base 5-, 6- trigger grooves, pushers 7-, 8- safety catch grooves, the front limit 9- seat position, the return spring 10-, 11- clasp, 12 housing, 13 rotary joint, 14 coupling, the wire holder 15, a fixing bolt 16-, 17- wire, on the pressure seat 18, 19 - under pressure seat, a push ring 20, through holes 21, 22 closed clip mount, a first guide groove 221-, 23- spring seat, 24 guide post, a guide cone 25, the neck clamping 26- , fuse holder 27-, 30- clamping hub assembly, card board 31-, 311- latch, clamping the post hole 32-, 33- prism clamping hole, clamping cone 34-, 40- clamping cone assembly , 41- clamping cylinder, a second guide groove 411-, 42- prism, prism 421-, 43- clamping cone, a clamping cone groove 431-, 44- positioning post, 441- positioning groove 45 - Backward positioning hole, the positioning hole slots 451- backward, backward seat assembly 50, sleeve 51 backward, backward column 52-, 521- third guide groove, 53- backward positioning post 80 delivery, a closure clip 90-, 91- outer arc, the arc 92-, 93- serrations, collet 94-, 941- tines, 942-V-shaped groove, rounded projections 943-, 944- sleek Slot.

detailed description

Referring to FIGS. 1 to 46, Ti-Ni based shape memory alloy closure clip, comprising a closure clip body, the body is closed closure clip strip made of nickel titanium based shape memory alloy material, the strip of at least three staggered inner and outer arcs of the same number of arc segments being sequentially connected end to end planar layout, the layout dish or bowl-shaped layout; closed cone angle range of the plate-like strip layout or layouts of the bowl 120-180 °, most preferably 160 °. Ti-Ni based shape memory alloy materials processing closure tape having a superelastic memory above the desired temperature of the clinical memory trait. When an external force or a temperature lower than the memory may change its shape, the external memory is restored again unloaded to or higher than the temperature of shape memory. The optimal number of external arc segment is 3 or 4, when special needs, can be a 5, 6 or 8.

Nickel base strip titanium shape memory alloy, at which temperature superelastic memory, an external force can change its shape after the external force disappears resume its memorized shape.

For best results of operations, set at a temperature memorized shape memory, all of the inner diameter of the top circle of the arcs is located 1-4mm, the outer diameter of the top of all the circular arcs is located 10-20mm; below under the temperature conditions and the memory by the external diameter of the top circle arcs where changes occur, with the same size as the outer arc. After temperature is reached or exceeded and the external memory unloaded, the top of all the arcs move closer to the center of the strip where the diameter of the circle restore 1-4mm.

To prevent accidental removal of the closure clip, while closing to achieve better results, the serrations may also be provided on top of each inner arc segment, both serrations center toward the closed clip.

Two clamping bodies arranged in parallel to each clip comprises parallel;; two collet ends are fixed to both ends of the outer arc segment to further enhance the closing effect solid, consistent closure clip may include a number of arc segments parallel to the outer clip even, non-fixed end positioned within the outer arc segment enclosed by area.

To prevent accidental removal of the closure process, the engagement means may be respectively provided in opposite sides of the two clamping bodies. Engaging means may have various structural forms, structures are three main types:

1, the male engagement means comprises at least one tine and tine tips and tooth position shifted relative to the collet; in FIG. 41, each clip comprises two tines, the tines 4 of each closure clip interlace arrangement.

2, and at least one concave groove tine engaging means comprises a convex, and the shape of the groove and the number of tines relative to the clip body to match, for example, grooves may be rounded groove may be V-shaped groove; in FIG 42, each clamp includes two tines and two rounded slots, rounded grooves and tines of the collet relative to the corresponding set.

3, the engagement means comprises a groove smoothly rounded convex projection and at least one concave groove and the rounded opposite collet smoothly number matching the shape of the protrusions; FIG. 43, each clip comprising a body and a rounded protrusion smooth groove.

Within the tissue closure clip extraoral perforated peripheral tissues, having an inner arc segment superelastic closure clip or the arc segment and the serrations fit together to treat tissue within the mouth automatically pressurized at the same pressure, blood circulation scar tissue side of the well, the inner healing, to the non-invasive in vivo without leaving a foreign object and purpose.

Referring to FIGS. 47 to 51, is used to deliver the Ti-Ni based shape memory alloys tissue closure clip, comprising a housing, disposed within the housing push rod unit, provided at the front end of the housing push ring unit; housing is provided with a handle, and pistol shape cavity structure engaging the housing about the push lever unit comprising a trigger, a push rod, a return spring stopper; push lever is movable forwardly under the action of the trigger, and the return spring returns to its original role ; stop means disposed within the housing comprising a front seat and a rear stop limiting the seat, the front portion of the push rod stopper provided in front of the front seat, between the front pushers arranged in the middle seats and rear stopper stopper base , which is provided with a spring seat, in the middle of the return spring push rod sleeve and located between the front stopper base and the spring seat, the rear pushers stopper is provided behind the rear seat, which is arranged below a trigger groove; trigger provided in the inside handle, the handle extending to the outer end thereof, the other end of the trigger into the card slot; push lever unit further comprises a fuse plug; safety device may be a safety catch or a fuse holder. Safety catch provided in the rear housing, the outer surface of the housing which button, which is provided inside the housing a hook, the hook can be snapped into the button in the drive or out of the safety catch tank above the rear pushers; end of the hinge bracket Insurance in the middle of the inside of the trigger, and the other end can be locked to the inside handle to secure the trigger with respect to the handle angle. Pushing means comprises a ring on the pressure seat, the seat under pressure, wire holder, a wire, a push ring; depression on the pressure seat and the seat engaging the upper and lower L-shaped hollow tubular structure, and its rear end is connected to the front end of the housing, the front end turned down to form a closed clamp seat 80 to 100 degrees, the closure clip is provided with a through hole vertically penetrating the housing; wire holder is provided at the rear end of the tubular cavity of an L-shaped structure and is connected to the front end of the push rod; fixed central wire in the wire holder, both ends thereof extending in parallel between the pressure seat forwardly downwardly depressed and bent to a closed clip mount seat at the two ends of the wire respectively in the outer sleeve to push the outer ring closure clip seat hinge ; wire fixing base and the front end of the push rod is connected via a coupling; L-shaped front end rear end of the housing cavity of the tubular structure are connected by rotary joints.

Closure clip works: Ti-Ni based shape memory alloy closure clip, comprising a body formed of a closed closure clip strip; at least three outer arc segment of the closed strip staggered arrangement and the same number of arc segments end to end within the sequence connection; closed strip forming a planar layout, the layout dish or bowl-shaped layout; closure strip having a superelastic nickel titanium based shape memory alloy material is made higher than the temperature of the memory, when the external force is less than or memory its shape may change temperature, unloading or higher than the external memory again when the temperature returns to the memory shape.

Works nickel titanium based shape memory alloys tissue closure clip is the use of temperature effects and superelastic nickel titanium based shape memory function alloys opened at a low temperature and external force, at a high temperature close to restore the memorized shape, with the body tissue, necrosis combined physiological mechanism, as well as Ti-Ni based shape memory alloys tissue closure clip rational structure design, to achieve the object of the organization anastomosis.

The functional properties of shape memory Ti-Ni based shape memory alloy material produced in the lesions closure clip is released, so that the temperature may vary or change of an external force closure clip, can play a leading role in the clinical surgery.

Tissue anastomosis: the memory alloy anal fistula closure clip semi-closed state memory, closed gap of about 1-2mm. The closed closure clip opened after closing sleeve serving base clip of the present invention, the trigger is pulled, the push rod moves forward, the forward movement of drive wire, push wire drive ring moves downward into the closure clip needs at the closed tissue. If necessary, thin lines with good tissue binding, from the through hole piercing the wire, tension, pulling tissue into a closed folder, and then pull the trigger, the release clip is closed, sandwiching the center of the annular tissue to be closed, continuous automatic compression, the organization firmly pressed and stapling. Pressurized organization for good blood circulation, pressurized hyperplasia formation of scar tissue provides tissue regeneration, the purpose of the organization consistent.

Excision: the shape memory alloy within the fistula closure clip port memory is fully closed state, the remaining steps match the same with the tissue. Within a pressurized ring resulting in tissue ischemia and tissue necrosis, and necrosis of tissue at the side of the ring, outside the ring tissue proliferation other side of the tissue match. Since the inner ring tissue necrosis, forming an incision, necrotic tissue, nickel-titanium shape memory alloys also come off the closure clip, after falling excreted under the action of peristalsis, so that the body without leaving any foreign material.

Reliability of the closure clip: a Ti-Ni based shape memory alloys produced by different thickness of sheet closure clip, which determines the constant pressure and can compensate for different characteristics of the tissue thickness, and to produce a stable organization lasting pressure to ensure uniform and may control of compression anastomosis procedure. Tissue anastomosis different time portion in tissue regeneration, necrotic tissue, to ensure the reliability of the tissue stapling.

Off time of the closure clip: the Ti-Ni based shape memory alloys anal fistula closure works clip is the use of the temperature effector function nickel titanium based shape memory alloy is opened at a low temperature, high temperature closure restore the memorized shape, with human tissue hyperplasia, necrosis physiological mechanism combined tissue healing time of ten days, ten days after closure clip falling out of the body. Design principle and structure as well as clinical use and operation of Ti-Ni based shape memory alloys tissue closure clip than the current clinical stapling means staples all of the metal is more scientific, more convenient, is an ideal tissue closure clip instrument.

Referring to FIGS. 52 to 61, Ti-Ni based shape memory alloy being installed with the embodiment of the closure clip clamping device comprising clamping cone assembly 40 and the clamping block assembly 30; cone clamping assembly 40 comprises a positioning post 44 are connected in turn, means clamp cylinder 41, the clamping cone 43, prisms 42; the clamping cylinder 41 has four circumferentially equispaced side second guide grooves 411 axially; tapered surface 43 on the clamping cone 4 are uniformly distributed clamping taper grooves 431; prism 42 includes four circumferentially equispaced prism 421; cross-sectional shape of the prism and the closure clip between the arc gap 92 matches; the number of the prism 421 and the closure clip 90 within arc 92 the same number; position of the prism 421 and the second guiding groove 411 corresponding to; each clamping taper grooves 431 at the intermediate position of two neighboring prisms 421; the outer diameter of the closed clamping cylinder 41 serving 80 clip matches the outer diameter of seat 22; a second guide groove 411 correspond with the position of the closure clip on the first guide groove 221, 22; clamping seat assembly 30 includes a housing 4 arranged axially card and a clamping plate 31 from an end portion of the post hole are sequentially disposed inwardly of the housing 32, clamping tapered hole 34, hole 33 prism; clamping tapered hole 34 and clamping cone 43 matches the shape of the body; prism 42 and holes 33 matches the shape of a prism; four pallets 31 are circumferentially distributed in the inner surface 32 of the clamping post hole; inner side of each outer end portion of the card is provided with a plate overhanging the latch 311; uniform pallets number 31 and the second guide groove 411, the position of correspondence; latch 311 can be caught on the closure clip 90 corresponding to the outer arc segment 91, so as to drive the prism on a planar layout, layout dish or bowl-shaped closure clip layout through a prism, a cone motion clamping to the clamping cylinder 41, the expansion into the cylindrical layout of the closure clip. Positioning post 44 is closed with a clip serving inner bore 80 matches seat 22; locating pillar 441 is provided with a detent edge; positioning rib 441 is closed and the clamp 80 serving seat positioning slot bore 22 matches.

Suits clamping process: see FIGS. 56 and 57, the closure sleeve 90 into the clip clamping cone assembly of prisms 40 on the body 42, the card 44 and then clamping the cone assembly positioning post 40 is delivered into the housing through the closure clip hole, then the closure clip on the four outer arc tooth jammed card holder assembly clamping plate 30 of the four cards, and then clamping the seat assembly 30 closer to the clamping cone assembly 40 (see FIG. 58), driven by closure clip 90 passes through a prism, a clamping cone 43, after 41, the final expansion of the clamping cylinder into a cylindrical shape and is set in the serving base closure clip (see FIG. 59), followed by removing the clamping seat assembly 30 (see FIGS. 60 and 61) and clamping cone assembly, the final alignment of the closure clip for closing tissue holder, the trigger is pulled, the release clip is closed, the closure clip is released outward conical angle (i.e., the state of being installed) .

Referring to FIGS. 62 and 63, Ti-Ni based shape memory alloy anti-loaded embodiment of the closure clip with a clamping device, comprising a backward seat assembly 50, clamping assembly 40 and the cone clamping block assembly 30; cone clamping assembly 40 comprises successively clamping cylinder 41 connected clamping cone 43, prisms 42; the clamping cylinder 41 has four circumferentially equispaced side second guide grooves 411 axially; tapered surface 43 on the clamping cone uniform there are four clamping taper grooves 431; prism 42 includes four circumferentially equispaced prism 421; cross-sectional shape of the prism and the closure clip between the arc gap 92 matches; prism 421 and the number of the closure clip 90 consistent with the number of arcs 92 of; the second position of the prism 421 and the corresponding guide groove 411; 431 each clamping taper grooves 421 at the intermediate position of two neighboring prisms; clamping the outer diameter of the cylinder 41 serving the closure clip 80 matches the outer diameter of the seat 22; a second guide groove 411 correspond with the position of the closure clip on the first guide groove 221, 22; clamping seat assembly 30 includes a housing, four axially card board set 31 and the clamping post holes sequentially from the one end portion disposed inwardly of the housing 32, clamping tapered hole 34, hole 33 prism; clamping cone 34 and mounted 43 matches the shape of a cone clamp; prism 33 and the aperture 42 to match the shape of a prism; four pallets 31 are circumferentially distributed in the inner surface 32 of the clamping post hole; portion of the inner side of the outer end of each plate is provided with a card outer teeth 311 extending card; card plate 31 coincides with the number of the second guide groove 411, the position of correspondence; latch 311 can be caught on the closure clip 90 corresponding to the outer arc segments 91, thereby driving the prisms a planar layout, the layout of the bowl or dish-shaped layout closure clip through a prism, a cone motion clamping to the clamping cylinder 41, the expansion into the cylindrical layout of the closure clip. Positioning post 44 is closed with a clip serving inner bore 80 matches seat 22;

Backward seat assembly 50 includes a column 52 and stepped backward in the sleeve 52 of the Backward backward sleeve 51 column; column 52 is provided with a circumferential side backward equal to the number 411 and the second guide groove 4, the position of eleven corresponding to the third guide groove 521; outer diameter equal to 5244 and backward positioning post column; column backward movement backward along the sleeve and reset under the action of the internal spring by an external force.

Anti-loaded clamping process: Referring to Figure 62, the seat assembly backward backward backward positioning post card 53 into the pin hole 40 of the clamping cone assembly 50, 45, 90 and then set into the closure clip clamping cone assembly 40 42, four outer arc then stuck clamping seat latch assembly of four pallets 30 on the closure clip, and then clamping the seat assembly 30 to close the clamping cone prism assembly 40, to drive closure clip 90 passes through a prism, a clamping cone 43, after 41, the final expansion of the clamping cylinder into a cylindrical shape and fitted over the pin 52 backward, and the seat assembly 50 and the backward cone clamping assembly 40 separated. Referring to Figure 63, the seat assembly backward backward positioning post card 53 into the through hole serving's seat 50 of the closure clip,

Sequentially removing the clamping block assembly 30 (see FIGS. 60 and 61) and clamping cone assembly, the final alignment of the closure clip for closing tissue holder, the trigger is pulled, the release clip is closed, the closure clip is released toward the cone angle the outer (i.e., the state of being installed).

The present invention simply by changing the number of prisms 421, to apply to the number of outer arc is a Ti-Ni shape memory alloy 3,5,6,8 tissue closure clip.

Claims (25)

  1. Ti-Ni based shape memory alloy closure clip is made of a nickel-titanium based shape memory alloy material, characterized by: a closure body having a closed clip strip; said closure strip arranged in at least three interleaved an outer arc segment (91) and the same number of arc (92) smoothly connected end to end in sequence; the closure clip body planar layout, the layout bowl or dish-shaped layout.
  2. The Ti-Ni shape memory alloy of the tissue closure clip of claim 1, wherein: the number of said outer arc segment (91) is 3,4,5,6 or 8.
  3. The Ti-Ni shape memory alloy of the tissue closure clip of claim 1, wherein: said clip further comprises a closure disposed within each toothed arc segment (92) and the top of the center point of the closure clip projections (93 ).
  4. Ti-Ni based shape memory alloy according tissue closure clip according to claim 3, characterized in that: the number of said outer arc segment (91) is 3,4,5,6 or 8.
  5. According to claim 1 or 2 or 3 or 4, wherein the Ti-Ni based shape memory alloy closure clip, characterized in that: the outer diameter of the top of all arcs (91) where the circle is 10-20mm, all the arcs ( 92) the top or top serrations (93) where the diameter of the circle is 1-4mm; cone angle of the closure clip body is 120-180 °.
  6. The Ti-Ni based shape memory alloy as claimed in claim 5, wherein the tissue closure clip, characterized in that: the outer diameter of the top of all arcs (91) where the circle is 12-16mm, all the arcs (92) or top of the top serrations (93) where the diameter of the circle is 1-3mm; cone angle of the closure strip is 160 °.
  7. The titanium-nickel 1 or 2 or 3 or as claimed in claim 4, wherein the shape memory alloy-based tissue closure clip, characterized in that: said clip further comprises closing the same outer arc (91) and the number of parallel correspondence of the folder; the clip comprises two parallel clip body (94) disposed in parallel; two fixed end of the clip body (94), respectively, and an outer arc segment (91) is secured at both ends, non-fixed end located outside the arc segment region (91) is surrounded.
  8. Ti-Ni shape memory alloy of the tissue closure clip according to claim 7, wherein: (94) two opposite sides of the clip body are provided with engagement means; said engaging means comprises at least one convex tines (941) and the position of the tines with the tooth tip offset relative to the clip body, or convex comprises at least one tine (941) and concave recess (942) and said recess opposite collet shaped tines number matches, or at least comprises a convex rounded protrusion (943) and a rounded concave recess (944) and said rounded groove and opposing collet smoothly matches the shape of the number of projections.
  9. The Ti-Ni shape memory alloy of the tissue closure clip of claim 8, wherein: an outer diameter of the top of all arcs (91) where the circle is 10-20mm, all the arcs (92) or top of the top serrations (93) where the diameter of the circle is 1-4mm; cone angle of the closure strip is 120-180 °; distance of the two clip body (94) is 0.5-2mm.
  10. The Ti-Ni shape memory alloy of the tissue closure clip of claim 9, wherein: the outer diameter of the top of all arcs (91) where the circle is 12-16mm, all the arcs (92) or top of the top serrations (93) where the diameter of the circle is 1-3mm; cone angle of the closure strip is 160 °.
  11. A nickel titanium based shape memory alloy serving clip is closed, comprising a housing; the housing is provided with a handle and a housing for the engaging of the cavity structure, wherein:
    Further comprising a push rod disposed in the housing unit, the housing provided at the front end of push ring unit;
    The push means comprises a trigger lever, a push rod, a return spring stopper; the push rod may be moved forward under the action of the trigger and the stopper means, and in situ under the action of return of the return spring and the stopper ;
    The push means comprises a ring on the pressure seat, the seat under pressure, wire holder, two wires, push ring;
    The upper and lower press-pressure seat seating engagement of the upper and lower L-shaped hollow tubular structure, which is connected to the rear end of the front end of the housing, its front end turned downward to form a closed clamp seat 80 to 100 degrees, the seat is provided with a closure clip a through hole penetrating vertically; wire fixing base provided at the rear of the L-shaped hollow tubular structure and is connected to the front end of the push rod; rear end of the two wires are fixed to the wire holder, wherein the parallel portion provided on the pressure seat between the seat and the lower pressure, push sleeve front end respectively on the outer ring closure clip is hinged seat.
  12. The delivery device of claim 11, wherein: said stop means includes a housing disposed in a front seat and a rear stop limiting the seat, the front portion of the push rod disposed in front of the front stopper base, the said pushers arranged in the middle between the stopper and the rear stopper base front seat, which is provided with a spring seat, in the middle of the return spring push rod sleeve and located between the front seat and the spring seat stopper, the a push rod disposed in the rear portion behind the rear seat stopper, provided with a groove which is below the trigger; trigger disposed outside of the inside handle, the handle extending to one end thereof, the other end of the card into the slot of the trigger.
  13. The delivery device 11 or claim 12, wherein: the wire between the fixing base and connected to the push rod by the rotation mechanism, one end of the wire holder connected to the rotating mechanism, rotating the push rod mechanism the other end of the wire holder is rotatable about a central axis of the push rod.
  14. The delivery device according to claim 13, wherein: the rotation mechanism includes a fixed shaft and the end portion of the movable shaft, the shaft is provided with a boss, the boss and the wire fixing base by a neck secured, the greater than the diameter of said boss neck diameter; the fixed shaft is provided with a boss and a slot adapted to limit rotation of the neck adapted to the groove, the boss may be given axis from the edge of the card and wherein the slot is rotated, the neck portion may be from the side of the rotation limiting groove of the locking shaft and rotates therein.
  15. The delivery device of claim 14, wherein: said push rod unit further comprises a safety catch; the securing bolt disposed at the rear of the housing, the outer surface of the housing which button is located, which hooks disposed within the housing, the hook snaps on the button at the driving safety catch groove or away from the rear of the upper pushers.
  16. The delivery device of claim 14, wherein: said push rod unit includes a further safety mechanism; the securing means is a fuse holder, which is hinged at one end in the middle of the inside of the trigger, and the other end is fixed so as to be snapped inside handle trigger relative to the handle angle.
  17. The delivery device of claim 14, wherein: said handle housing and engaging the pistol about the shape of the cavity structure.
  18. Clamping device for Ti-Ni based shape memory alloys tissue closure clip, characterized by: a clamping cone assembly (40); said clamping cone assembly (40) comprises a clamping cylinder (41) sequentially connected, clamping cone (43), prism (42); said clamping cylinder (41) are uniformly distributed on the circumferential side a plurality of second guide grooves (411); the clamping cone (43) cone a plurality of uniformly distributed clamping surface tapered grooves (431); said prism (42) comprises a prism (421) a plurality of circumferentially equispaced; said prism (421) to the number of closure clip (90) within the arc consistent with the number of segments (92) and said prism (42) with a closed cross-sectional shape of the clip between the arc gap (92) match; said prism (421) and the second guiding groove (411) corresponding to the position; two prisms (421) in an intermediate position of each end of the clamping cone grooves (431) located adjacent to the other end at the intermediate position of the adjacent two second guide grooves; said clamping cylinder an outer diameter (41) of the outer diameter of the delivery device (80) of the closure clip holder (22) is matched; a first guide groove on said second guide groove (411) and a closed clamp seat (22) ( 221) positions one by one.
  19. The clamping device according to claim 18, wherein: said clamping cone assembly (40) further includes a clamping cylinder (41) is positioned outside the end face of the column (44); said positioning post (44 match) the delivery device (80) of the closure clip holder (22) through hole (21).
  20. Through the positioning ribs (441) and delivery (80) of the closure clip seat (22); positioning said pillar is provided with a positioning rib (441): The clamping device according to claim 19, characterized in that matched positioning groove (21) hole.
  21. The clamping device 18 or 19 or claim 20, wherein claim: further comprising a clamping seat assembly (30); said clamping seat assembly (30) comprises a housing, a plurality of pallets (31) and clamping the post hole (32), clamping cone (34), a prismatic hole (33) housing an end portion inwardly disposed sequentially; the clamping cone (34) and the clamping cone (43) form matches; said prism hole (33) and the prism (42) matches the shape; a plurality of pallets (31) are distributed in the circumferential inner surface of the clamping post hole (32); the inner edge of each pallet an outer end portion provided with a latch (311); equal to the number of said card plate (31) and the second guide groove (411), the position of one correspondence; said latch (311) to be clamped closure clip (90 a) corresponding to the outer arc segment (91), so as to drive the planar layout, the layout of the bowl or dish-shaped layout through prism closure clip (42), the clamping cone is moved to the clamping cylinder (41) , expanded into a cylindrical shape layout.
  22. The clamping device according to claim 21, wherein: the number of said prism (421) is 3,4,5,6,8.
  23. The clamping device according to claim 21, wherein: said clamping assembly further comprises a backward seat (50); said backward seat assembly (50) comprises a stepped backward column (52) and sleeve Backward in column (52) Backward sleeve (51); (52) a circumferential side surface of the column is provided with a same number of backward and a second plurality of guide grooves (411), a position one-third guide grooves (521); Backward said column (52) and the outer diameter of the positioning posts (44) consistent with the outer diameter; the backward movement of the column jacket backward along the external force and internal reset spring.
  24. The clamping device according to claim 23, wherein: said backward seat assembly (50) further comprises a backward column disposed outer end surface (52) of the backward positioning post (53); said holding column an outer end surface (41) is provided with a swing post hole (45), the backward post hole (45) and the positioning post 53 Backward match.
  25. According to claim 18,19,20,23 or clamping device of claim 24, wherein: the number of said prism (421) is 3,4,5,6,8.
PCT/CN2016/111526 2015-12-22 2016-12-22 Titanium nickel-based shape memory alloy tissue closing clip, release device, and clip accommodating device WO2017107955A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201510970910 2015-12-22
CN201510970910.7 2015-12-22
CN201610409039.8 2016-06-12
CN201610407973.6A CN105902290B (en) 2015-12-22 2016-06-12 Ti-Ni based shape memory alloys tissue closure clip
CN201610409039.8A CN105997184B (en) 2016-06-12 2016-06-12 Served within a nickel titanium based shape memory alloys anal fistula closure clip
CN201610407973.6 2016-06-12

Publications (1)

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WO2017107955A1 true WO2017107955A1 (en) 2017-06-29

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CN105997184A (en) * 2016-06-12 2016-10-12 杨西群 Release device for titanium-nickel-based shape memory alloy anal fistula internal opening closing clamp
CN205831852U (en) * 2015-12-22 2016-12-28 杨西群 Ni -based shape memory alloy of titanium organizes closed clamp
CN205831861U (en) * 2016-06-12 2016-12-28 杨西群 A broadcast ware that is used for ni -based shape memory alloy anal fistula internal orifice closed clamp of titanium

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5582615A (en) * 1995-10-30 1996-12-10 Pilling Weck, Incorporated Handle for surgical clip applicator systems
US20020188318A1 (en) * 2000-12-07 2002-12-12 Carley Michael T. Closure device and methods for making and using them
US20110144661A1 (en) * 2001-04-24 2011-06-16 Houser Russell A Tissue closure devices, device and systems for delivery, kits and methods therefor
US20030036755A1 (en) * 2001-08-15 2003-02-20 Integrated Vascular Systems, Inc. Apparatus and methods for reducing lung volume
US20030158577A1 (en) * 2002-02-21 2003-08-21 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US20100125164A1 (en) * 2008-11-18 2010-05-20 Labombard Denis Adapter for attaching devices to endoscopes
US20110152888A1 (en) * 2009-10-30 2011-06-23 Ovesco Endoscopy Ag Medical Instrument for Setting Tissue Clips
CN105902290A (en) * 2015-12-22 2016-08-31 杨西群 Titanium nickel-based shape memory alloy tissue closing clip
CN205831852U (en) * 2015-12-22 2016-12-28 杨西群 Ni -based shape memory alloy of titanium organizes closed clamp
CN105997184A (en) * 2016-06-12 2016-10-12 杨西群 Release device for titanium-nickel-based shape memory alloy anal fistula internal opening closing clamp
CN205831861U (en) * 2016-06-12 2016-12-28 杨西群 A broadcast ware that is used for ni -based shape memory alloy anal fistula internal orifice closed clamp of titanium

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