WO2017095918A3 - Procédés de traitement du cancer au moyen d'antagonistes de rspo3 - Google Patents

Procédés de traitement du cancer au moyen d'antagonistes de rspo3 Download PDF

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Publication number
WO2017095918A3
WO2017095918A3 PCT/US2016/064207 US2016064207W WO2017095918A3 WO 2017095918 A3 WO2017095918 A3 WO 2017095918A3 US 2016064207 W US2016064207 W US 2016064207W WO 2017095918 A3 WO2017095918 A3 WO 2017095918A3
Authority
WO
WIPO (PCT)
Prior art keywords
rspo3
methods
antagonists
treating cancer
antagonist
Prior art date
Application number
PCT/US2016/064207
Other languages
English (en)
Other versions
WO2017095918A4 (fr
WO2017095918A2 (fr
Inventor
Ann M. Kapoun
Chun Zhang
Min Wang
Yu-Wang Liu
Gilbert O'YOUNG
Fiore CATTARUZZA
Original Assignee
Oncomed Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharmaceuticals, Inc. filed Critical Oncomed Pharmaceuticals, Inc.
Publication of WO2017095918A2 publication Critical patent/WO2017095918A2/fr
Publication of WO2017095918A3 publication Critical patent/WO2017095918A3/fr
Publication of WO2017095918A4 publication Critical patent/WO2017095918A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

La présente invention concerne des compositions permettant d'identifier des tumeurs susceptibles de répondre à un traitement avec un antagoniste de RSPO3 (par exemple un anticorps anti-RSPO3). L'invention concerne également des procédés d'identification de tumeurs et/ou de patients qui sont susceptibles de répondre ou de ne pas répondre au traitement avec un antagoniste de RSPO3 (par exemple un anticorps anti-RSPO3). L'invention concerne en outre des procédés de traitement d'un patient atteint d'un cancer, lorsqu'il est prévu que le cancer réponde à un antagoniste de RSPO3 (par exemple un anticorps anti-RSPO3).
PCT/US2016/064207 2015-12-01 2016-11-30 Procédés de traitement du cancer au moyen d'antagonistes de rspo3 WO2017095918A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562261618P 2015-12-01 2015-12-01
US62/261,618 2015-12-01
US201662308577P 2016-03-15 2016-03-15
US62/308,577 2016-03-15

Publications (3)

Publication Number Publication Date
WO2017095918A2 WO2017095918A2 (fr) 2017-06-08
WO2017095918A3 true WO2017095918A3 (fr) 2017-07-13
WO2017095918A4 WO2017095918A4 (fr) 2017-08-31

Family

ID=58797679

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/064207 WO2017095918A2 (fr) 2015-12-01 2016-11-30 Procédés de traitement du cancer au moyen d'antagonistes de rspo3

Country Status (1)

Country Link
WO (1) WO2017095918A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110339364B (zh) * 2018-04-02 2021-02-12 上海邦耀生物科技有限公司 Lgr4/rspo阻断剂与抗免疫检查点抑制剂联合用于肿瘤的免疫治疗
KR102531265B1 (ko) * 2019-10-24 2023-05-12 가톨릭대학교 산학협력단 Rspo3 억제제를 포함하는 심장 판막 질환의 예방 또는 치료용 조성물

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007100357A2 (fr) * 2005-10-07 2007-09-07 Nuvelo, Inc. Scfa1, protéine du type facteur des cellules souches et utilisations de celle-ci
US20070244061A1 (en) * 2003-10-10 2007-10-18 Deutsches Krebsforschungszentrum Compositions for Diagnosis and Therapy of Diseases Associated with Aberrant Expression of Futrins (R-Spondisn) and/or Wnt
WO2012178058A1 (fr) * 2011-06-22 2012-12-27 Indiana University Research And Technology Corporation Compositions et méthodes de détection, de diagnostic et de pronostic du cancer du thymus
WO2013120056A1 (fr) * 2012-02-11 2013-08-15 Genentech, Inc. Translocations de r-spondine et leurs procédés d'utilisation
WO2014165232A1 (fr) * 2013-03-12 2014-10-09 Curegenix, Inc. Composés pour le traitement du cancer
WO2015058132A2 (fr) * 2013-10-18 2015-04-23 Genentech, Inc. Anticorps anti-rspo et leurs méthodes d'utilisation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070244061A1 (en) * 2003-10-10 2007-10-18 Deutsches Krebsforschungszentrum Compositions for Diagnosis and Therapy of Diseases Associated with Aberrant Expression of Futrins (R-Spondisn) and/or Wnt
WO2007100357A2 (fr) * 2005-10-07 2007-09-07 Nuvelo, Inc. Scfa1, protéine du type facteur des cellules souches et utilisations de celle-ci
WO2012178058A1 (fr) * 2011-06-22 2012-12-27 Indiana University Research And Technology Corporation Compositions et méthodes de détection, de diagnostic et de pronostic du cancer du thymus
WO2013120056A1 (fr) * 2012-02-11 2013-08-15 Genentech, Inc. Translocations de r-spondine et leurs procédés d'utilisation
WO2014165232A1 (fr) * 2013-03-12 2014-10-09 Curegenix, Inc. Composés pour le traitement du cancer
WO2015058132A2 (fr) * 2013-10-18 2015-04-23 Genentech, Inc. Anticorps anti-rspo et leurs méthodes d'utilisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SESHAGIRI, S ET AL.: "Recurrent R-spondin fusions in colon cancer", NATURE LETTER., vol. 488, no. 7413, 30 August 2012 (2012-08-30), pages 660 - 664, XP055060432 *

Also Published As

Publication number Publication date
WO2017095918A4 (fr) 2017-08-31
WO2017095918A2 (fr) 2017-06-08

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