WO2017094031A3 - Novel process for preparation of apremilast - Google Patents

Novel process for preparation of apremilast Download PDF

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Publication number
WO2017094031A3
WO2017094031A3 PCT/IN2016/050434 IN2016050434W WO2017094031A3 WO 2017094031 A3 WO2017094031 A3 WO 2017094031A3 IN 2016050434 W IN2016050434 W IN 2016050434W WO 2017094031 A3 WO2017094031 A3 WO 2017094031A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
apremilast
novel process
formula
compound
Prior art date
Application number
PCT/IN2016/050434
Other languages
French (fr)
Other versions
WO2017094031A2 (en
Inventor
Rajamannar Thennati
Shriprakash Dhar DWIVEDI
Kanaksinh Jesingbhai Jadav
Sudhakar Kambhampati
Rajesh Lalmani GIRI
Mehulkumar Maheshbhai Patel
Vishal Diliprao MOHITE
Original Assignee
Sun Pharmaceutical Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Limited filed Critical Sun Pharmaceutical Industries Limited
Publication of WO2017094031A2 publication Critical patent/WO2017094031A2/en
Publication of WO2017094031A3 publication Critical patent/WO2017094031A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton

Abstract

The present invention related to a novel compound of Formula II, its enantiomers or acid addition salts thereof and process for its preparation. The compound of Formula II can be used for preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2- (methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide also known as apremilast.
PCT/IN2016/050434 2015-12-04 2016-12-05 Novel process for preparation of apremilast WO2017094031A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN4599MU2015 2015-12-04
IN4599/MUM/2015 2015-12-04
IN201621007579 2016-03-03
IN201621007579 2016-03-03

Publications (2)

Publication Number Publication Date
WO2017094031A2 WO2017094031A2 (en) 2017-06-08
WO2017094031A3 true WO2017094031A3 (en) 2017-06-29

Family

ID=58796483

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2016/050434 WO2017094031A2 (en) 2015-12-04 2016-12-05 Novel process for preparation of apremilast

Country Status (1)

Country Link
WO (1) WO2017094031A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016174685A1 (en) * 2015-04-27 2016-11-03 Mylan Laboratories Limited Process for the enantiomeric resolution of apremilast intermediates
CN109384704A (en) * 2017-08-03 2019-02-26 重庆医药工业研究院有限责任公司 A kind of preparation method of Apremilast
CN109293631B (en) * 2018-11-30 2020-05-08 常州制药厂有限公司 Preparation method of 3-amino-N- (2, 6-dioxo-3-piperidyl) -phthalimide compound

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130217918A1 (en) * 2012-02-21 2013-08-22 Celgene Corporation Processes for the preparation of (s)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
CN104447445A (en) * 2014-12-05 2015-03-25 新发药业有限公司 Preparation method for synthesizing apremilast intermediate
CN104744323A (en) * 2015-03-11 2015-07-01 中山奕安泰医药科技有限公司 Process for synthesizing apremilast chiral amine intermediate
CN104761474A (en) * 2015-03-11 2015-07-08 中山奕安泰医药科技有限公司 Synthetic method of apremilast chiral amine intermediate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130217918A1 (en) * 2012-02-21 2013-08-22 Celgene Corporation Processes for the preparation of (s)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
CN104447445A (en) * 2014-12-05 2015-03-25 新发药业有限公司 Preparation method for synthesizing apremilast intermediate
CN104744323A (en) * 2015-03-11 2015-07-01 中山奕安泰医药科技有限公司 Process for synthesizing apremilast chiral amine intermediate
CN104761474A (en) * 2015-03-11 2015-07-08 中山奕安泰医药科技有限公司 Synthetic method of apremilast chiral amine intermediate

Also Published As

Publication number Publication date
WO2017094031A2 (en) 2017-06-08

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