WO2017085613A4 - Weighing and characterizing materials by acoustic levitation - Google Patents

Weighing and characterizing materials by acoustic levitation Download PDF

Info

Publication number
WO2017085613A4
WO2017085613A4 PCT/IB2016/056846 IB2016056846W WO2017085613A4 WO 2017085613 A4 WO2017085613 A4 WO 2017085613A4 IB 2016056846 W IB2016056846 W IB 2016056846W WO 2017085613 A4 WO2017085613 A4 WO 2017085613A4
Authority
WO
WIPO (PCT)
Prior art keywords
particles
acoustic
levitation
weight
column
Prior art date
Application number
PCT/IB2016/056846
Other languages
French (fr)
Other versions
WO2017085613A1 (en
Inventor
Manuel Sanchez-Felix
Xiang KOU
Mark HOBAUGH
Steven WERELEY
Ahmed Amin
Original Assignee
Novartis Ag
Microfluidic Innovations, Llc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Microfluidic Innovations, Llc. filed Critical Novartis Ag
Publication of WO2017085613A1 publication Critical patent/WO2017085613A1/en
Publication of WO2017085613A4 publication Critical patent/WO2017085613A4/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/04—Analysing solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/032—Analysing fluids by measuring attenuation of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/04—Analysing solids
    • G01N29/11—Analysing solids by measuring attenuation of acoustic waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0626—Fluid handling related problems using levitated droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01G—WEIGHING
    • G01G9/00—Methods of, or apparatus for, the determination of weight, not provided for in groups G01G1/00 - G01G7/00
    • G01N2015/1021—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/023—Solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/024—Mixtures
    • G01N2291/02416—Solids in liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/024—Mixtures
    • G01N2291/02458—Solids in solids, e.g. granules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/024—Mixtures
    • G01N2291/02466—Biological material, e.g. blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/028—Material parameters
    • G01N2291/02818—Density, viscosity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/028—Material parameters
    • G01N2291/02854—Length, thickness

Abstract

The invention relates to a method of determining the weight of a material which is in the form of a solid particle or a liquid droplet, comprising introducing said material into an acoustic levitation field, so that it is positioned and kept in position by an acoustic node of a standing wave in the acoustic levitation field, determining the position of the material and using the position information to determine the weight of the material; to a method of dispensing a material in the form of a solid particle or a liquid droplet or mixture, comprising introducing said material into an acoustic levitation field, so that it is positioned and kept in position by an acoustic node of a standing wave in the acoustic levitation field, determining information on any one or more features selected from the position, the shape, the weight and the orientation of the material and using the obtained feature to dispense the material into a final destination; and to apparatus for use in the methods mentioned, as well as to related invention aspects.

Claims

AMENDED CLAIMS received by the International Bureau on 02 June 2017 (02.06.2017)
1. A method of determining at least one characteristic of at least one of a plurality of particles comprising: providing at least one vertical levitation column comprising at least one standing acoustic wave having at least one capture node; introducing said plurality of particles sequentially into said at least one vertical levitation column; allowing each of said plurality of particles in said at least one vertical levitation column to be positioned at a capture node of the at least one standing acoustic wave; determining at least one characteristic of each of said plurality of particles using at least one instrument external to said at least one vertical levitation column; and manipulating acoustic pressure, thereby re-positioning said at least one of a plurality of particles to other capture nodes.
2. The method of claim 1 wherein the plurality of particles comprises solids or liquid droplets.
3. The method of claim 2 wherein at least one of the plurality of particles is subjected to an electric charge.
4. The method of claim 1 wherein the at least one characteristic is selected from
position, orientation, shape, form, size, and property.
5. The method of claim 4 wherein property is selected from weight and density.
6. The method of claim 5 wherein weight is determined by a position of at least one of the plurality of particles relative to a datum.
7. The method of claim 5 wherein weight is determined relative to calibration data of particles having known weight.
8. The method of claim 1 wherein the plurality of particles is subjected to one or more of at least one transverse acoustic wave, at least one superimposed acoustic wave, at least one electrical field, at least one gas stream, at least one fluid stream, and combinations thereof.
1
9. The method of claim 1 wherein the plurality of particles exists as a solution, dispersion, suspension of solid materials in a solvent or solvent mixture, or an emulsion of immiscible liquid materials in a solvent or solvent mixture.
10. The method of claim 1 wherein the plurality of particles comprises pulverous,
crystalline, amorphous, granular, agglomerate, solid state mixture, micellar, liposomal, viral, cellular, or entrapment material, or combinations thereof.
1 1 . The method of claim 1 wherein the plurality of particles is selected from at least one drug, at least one excipient, at least one synthetic drug intermediate, at least one cell component, at least one cell, at least one food product, at least one nutraceutical, at least one radioactive material, at least one placebo, or combinations thereof.
12. The method of claim 1 wherein the at least one characteristic is determined using an optical system, an audio system, or a combination thereof.
13. The method of claim 1 wherein the plurality of particles is introduced sequentially into the at least one levitation column in batches.
14. The method of claim 1 wherein each of the plurality of particles is positioned
individually at a capture node.
15. The method of claim 1 wherein at least two of the plurality of particles is positioned at a capture node.
16. The method of claim 1 wherein a plurality of vertical levitation columns is formed by placing in a levitation column an acoustic mask having a plurality of acoustic apertures.
17. The method of claim 16 wherein the plurality of levitation columns are moved in
parallel by rotation of the acoustic mask.
2
18. The method of claim 1 wherein the plurality of particles is dispensed from the at least one levitation column by gravitational force.
19. The method of claim 1 wherein each of the plurality of particles is dispensed to at least one predetermined destination.
20. The method of claim 1 wherein more than one of the plurality of particles is
dispensed to the same predetermined destination.
21 . The method of claim 20 wherein a sum weight of the plurality of particles dispensed to at least one predetermined destination is ascertained.
22. The method of claim 18 wherein the position of at least one of the plurality of
particles is shifted relative to the at least one predetermined destination prior to being dispensed.
23. The method of claim 1 wherein the plurality of particles is sequentially introduced to the at least one vertical levitation column using a singulation device.
24. A system for assessing characteristics of at least one particle, the system comprising at least one pair of acoustic transducers or transducer/reflector pair, at least one variable power supply, at least one analytical instrument, and at least one computer processor.
25. The system of claim 24 further comprising at least one rotational acoustic mask having at least one aperture.
26. The system of claim 24 further comprising at least one singulation device.
3

STATEMENT UNDER ARTICLE 19 (1 )

The Written Opinion contends that the subject matter of original claims 1 -6 and 8-10 lack novelty over references D1 (Kavouras et al.) and D2 (Leiterer et al.). It was further contended that based upon D1 and D2, the subject matter of original claims 1-6 and 8-10 does not involve an inventive step under PCT article 33(3).

D1 does not teach or suggest the claimed method and apparatus (as amended) for high- throughput, continuous, and concurrent determination of characteristics of multiple particles in a single acoustic column using variable acoustic pressure, simultaneous employment of multiple parallel acoustic columns, use of individual particle characteristics information to establish a corresponding dispensing destination, or use of a rotational acoustic mask or other means to shift particles relative to the predetermined dispensing destinations.

D1 is limited to the use of acoustic levitation as a means to suspend a particle which can then be subjected to various reaction conditions and the reaction observed. This is evidenced by the teaching in Part IV which discusses a proposed method of determining a weight change in a particle undergoing a reaction.

Observing a weight change does not teach determining an absolute weight, i.e. , a characteristic or property. Finally because D1 is limited to examining levitated particles, it teaches or suggests nothing with respect to high-throughput analysis and dispensation of particles to destinations predetermined by their individual characteristics.

Similarly, D2 also is limited to teaching acoustically levitating a particle for purposes of examining the particle. As with D1 , it is completely devoid of any teaching with respect to high-throughput, continuous, and concurrent analysis of individual particle characteristics using variable acoustic pressure, employment of multiple parallel columns, use of individual particle characteristics to establish a dispensing destination, or use of a rotational acoustic mask or other means to shift particles relative to predetermined dispensing destinations.

PCT/IB2016/056846 2015-11-16 2016-11-14 Weighing and characterizing materials by acoustic levitation WO2017085613A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/094697 2015-11-16
PCT/CN2015/094697 WO2017084012A1 (en) 2015-11-16 2015-11-16 Acoustic material weighing and manipulation

Publications (2)

Publication Number Publication Date
WO2017085613A1 WO2017085613A1 (en) 2017-05-26
WO2017085613A4 true WO2017085613A4 (en) 2017-07-20

Family

ID=57392014

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/CN2015/094697 WO2017084012A1 (en) 2015-11-16 2015-11-16 Acoustic material weighing and manipulation
PCT/IB2016/056846 WO2017085613A1 (en) 2015-11-16 2016-11-14 Weighing and characterizing materials by acoustic levitation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/094697 WO2017084012A1 (en) 2015-11-16 2015-11-16 Acoustic material weighing and manipulation

Country Status (1)

Country Link
WO (2) WO2017084012A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107591066A (en) * 2017-10-24 2018-01-16 西北工业大学 A kind of controllable acoustic levitation experimental provision of more physical environments
DE102017129763A1 (en) * 2017-12-13 2019-06-13 Universität Hamburg Method and device for coating a single particle
EP3823758A4 (en) 2018-07-20 2022-04-06 Brighton Technologies LLC Method and apparatus for determining a mass of a droplet from sample data collected from a liquid droplet dispensation system
CN109269630B (en) * 2018-08-30 2021-07-02 哈尔滨工业大学（威海） Underwater ultrasonic suspension field measuring device and using method
CN109695437B (en) * 2018-12-27 2021-05-21 西南石油大学 Gas well ultrasonic suspension liquid drainage gas production system and implementation method
WO2020232348A1 (en) * 2019-05-15 2020-11-19 The Regents Of The University Of California Omnidirectional spiral surface acoustic wave generation
JP6839227B2 (en) * 2019-05-31 2021-03-03 Ｄｇｓｈａｐｅ株式会社 Droplet attachment device
CA3165491A1 (en) * 2020-01-27 2021-08-05 Damir KHISMATULLIN Apparatus, systems and methods for in vitro screening of complex biological fluids

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420977A (en) * 1982-03-15 1983-12-20 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic rotation control
US5036944A (en) * 1986-03-24 1991-08-06 Intersonics Incorporated Method and apparatus for acoustic levitation
US5890580A (en) * 1993-07-12 1999-04-06 Kaijo Corporation Object levitating apparatus, object transporting apparatus, and object levitating bearing along with an object levitating process and object transporting process
US6109098A (en) 1998-06-30 2000-08-29 Doukhin Dispersion Technology, Inc. Particle size distribution and zeta potential using acoustic and electroacoustic spectroscopy
US6216091B1 (en) 1998-09-25 2001-04-10 Panametrics, Inc. Ultrasonic measurement system with molecular weight determination
US7080556B2 (en) 2002-06-14 2006-07-25 National Research Council Of Canada Ultrasonic apparatus and methods for the monitoring of melting, mixing and chemical reaction processes
JP2005239391A (en) * 2004-02-27 2005-09-08 Toyota Industries Corp Object levitation device and object levitation carrying device
US9327264B2 (en) * 2011-01-31 2016-05-03 Uchicago Argonne, Llc Containerless synthesis of amorphous and nanophase organic materials
CN202935948U (en) * 2012-08-15 2013-05-15 吉林大学 Ultrasonic wave and air floatation mixed non-contact automatic conveying device
KR101473532B1 (en) 2012-11-20 2014-12-16 지에스칼텍스 주식회사 Recombinant microorganism having enhanced butanol producing ability and method for producing butanol using the same
CN104085691A (en) * 2014-07-30 2014-10-08 华东理工大学 Ultrasonic suspension conveying device

Also Published As

Publication number Publication date
WO2017084012A1 (en) 2017-05-26
WO2017085613A1 (en) 2017-05-26

Similar Documents

Publication Publication Date Title
WO2017085613A4 (en) Weighing and characterizing materials by acoustic levitation
Zaragoza et al. Molecular dynamics study of nanoconfined TIP4P/2005 water: how confinement and temperature affect diffusion and viscosity
Dressler et al. Chemical and biological dynamics using droplet-based microfluidics
Barnoud et al. Hydrophobic compounds reshape membrane domains
Daniels et al. Hysteresis and competition between disorder and crystallization in sheared and vibrated granular flow
Sandler et al. Effect of moisture on powder flow properties of theophylline
Stewart et al. Development of a biorelevant, material-sparing membrane flux test for rapid screening of bioavailability-enhancing drug product formulations
Dasgupta et al. Capillary assembly of microscale ellipsoidal, cuboidal, and spherical particles at interfaces
Schroen et al. Droplet microfluidics for food and nutrition applications
Tewari et al. Signatures of incipient jamming in collisional hopper flows
Eslami et al. Mechanisms of nucleation and solid–solid-phase transitions in Triblock Janus Assemblies
Ermakova et al. Effect of ergosterol on the fungal membrane properties. All-atom and coarse-grained molecular dynamics study
Vizserálek et al. PAMPA study of the temperature effect on permeability
Rezvantalab et al. Role of geometry and amphiphilicity on capillary-induced interactions between anisotropic Janus particles
WO2019208115A1 (en) Gas diffusion simulation method and device
Yang et al. Effect of interparticle interactions on agglomeration and sedimentation rates of colloidal silica microspheres
Hilder et al. Silicon carbide nanotube as a chloride-selective channel
Sicard et al. Numerical analysis of Pickering emulsion stability: insights from ABMD simulations
Coetzee et al. The calibration of dem parameters for the bulk modelling of cohesive materials
Kato et al. Phase separation and protein partitioning in compartmentalized cell-free expression reactions
Kamranian Marnani et al. The effect of the presence of very cohesive geldart C ultra-fine particles on the fluidization of geldart a fine particle beds
Rozynek et al. Assembly and rearrangement of particles confined at a surface of a droplet, and intruder motion in electro-shaken particle films
Kang et al. Characterization and detection of acceleration-induced cavitation in soft materials using a drop-tower-based integrated system
Yu et al. Effect of polymer granules on the electrostatic behavior in gas− solid fluidized beds
Kesselheim et al. Effects of dielectric mismatch and chain flexibility on the translocation barriers of charged macromolecules through solid state nanopores

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16801052

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16801052

Country of ref document: EP

Kind code of ref document: A1