WO2017084855A1 - Procédé permettant d'améliorer l'hygiène personnelle - Google Patents

Procédé permettant d'améliorer l'hygiène personnelle Download PDF

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Publication number
WO2017084855A1
WO2017084855A1 PCT/EP2016/075995 EP2016075995W WO2017084855A1 WO 2017084855 A1 WO2017084855 A1 WO 2017084855A1 EP 2016075995 W EP2016075995 W EP 2016075995W WO 2017084855 A1 WO2017084855 A1 WO 2017084855A1
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Prior art keywords
composition
silver
cleansing
weight
surfactant
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PCT/EP2016/075995
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English (en)
Inventor
Ajit Manohar AGARKHED
Nikita TOMAR
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Unilever N.V.
Unilever Plc
Conopco, Inc., D/B/A Unilever
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Publication of WO2017084855A1 publication Critical patent/WO2017084855A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/12—Water-insoluble compounds
    • C11D3/1206—Water-insoluble compounds free metals, e.g. aluminium grit or flakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/12—Water-insoluble compounds
    • C11D3/1213—Oxides or hydroxides, e.g. Al2O3, TiO2, CaO or Ca(OH)2
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3947—Liquid compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

  • the present invention relates to an antimicrobial cleansing composition. It particularly relates to liquid cleansing compositions containing oligodynamic metal based antimicrobial agent. Such cleansing compositions are particularly prone to discoloration owing to the inherent instability of the metal.
  • Antimicrobial soap bars and compositions for cleaning hands and body are increasingly preferred by consumers.
  • Antimicrobial cleansing compositions containing oligodynamic metal like silver, copper or zinc are very effective against a variety of bacteria. Silver is most widely used. However some metals, especially silver, are particularly prone to destabilization when exposed to high pH, heat and strong sunlight which cause darkening or agglomeration or under extreme conditions, even phase separation.
  • ppm or ppb parts per million/parts per billion
  • silver-based agents provide excellent antimicrobial properties, but aesthetic problems due to discoloration is a major concern. This is believed to be due to causes, like inherent thermal and photo-instability of silver ions, along with other mechanisms.
  • a wide range of silver salts are known to be thermally and photolytically unstable, discolouring to form brown, grey or black products.
  • Silver ions may be formally reduced to its metallic state, assuming various physical forms and shapes (particles and filaments), often appearing brown, grey or black in colour. Reduced forms of silver that form particles of sizes of the order of the wavelength of visible light may also appear pink, orange, yellow or beige due to light scattering effects.
  • Silver based antimicrobial agents act quickly against some of the Gram negative bacteria. However, such silver compounds generally tend to destabilize and darken over a period. In view of this phenomenon, the compositions tend to darken or discolor. This presents a technical problem which manifests itself after production and usually at the time of storage.
  • US 2003 235623 A discloses wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid and halogen salts (Br, I) and/or salts of heavy metals (for example, silver halides) with surfactant agents, either cationic, like chlorhexidine and/or quaternary ammonium salts, like didecyl- methyl-polyoxy-ethyl-ammonium propionate, chlorides of ammonium or compounds of ammonium propylamide or anionic, like lauryl sulphate, dodecyl sulphate or alkyl succinic salts, with suitable excipients, some of which may be ethyl or isopropyl alcohol, chlorhexidine, non-chlorinated quaternary ammonium salts, like didecyl- methyl-polyoxy-ethyl-ammonium
  • DE 102007003693 A discloses silver and hydrogen peroxide containing disinfectant, characterized by the following composition per litre: 5 to100 g solution mediator, 5 to 70 g hydrogen peroxide, 5 to 70 g surfactant, 0.1 to 20 mg colloidal silver, and water as the rest.
  • W0151 13785 A1 discloses a cleansing composition having pH of at least 9, said composition comprising: (i) 20 to 85 wt % anionic surfactant; and, (ii) a silver(l) compound having silver ion solubility (in water at 25 degrees C) of at least 1 x 10 "4 mol/L, at a level equivalent to silver content of 0.01 to 100 ppm, wherein the free alkali content of said composition is less than 0.01 percent.
  • the composition is a robust and improved cleansing composition with a stable color.
  • W0151 13782 A1 discloses a cleansing composition comprising a surfactant, an oligodynamic metal or ions thereof, a chelating agent and a polymer having a group comprising a site having one or more lone pair of electrons wherein the surfactant is soap.
  • the polymer having a group comprising a site having one or more lone pair of electrons enhances antimicrobial efficacy of the oligodynamic metal.
  • W0151 13785 A1 discloses a cleansing composition having pH of at least 9.
  • the compositions comprise 20 to 85 % by wt anionic surfactant and a silver (I) compound having silver ion solubility (in water at 25 °C) of at least 1 x 10 "4 mol/L at a level equivalent to silver content of 0.01 to 100 ppm.
  • the free alkali content of said composition is less than 0.01 %.
  • the composition is a robust improved cleansing composition with stable colour.
  • US2012003326 A discloses antibacterially active detergent, cleaning agent, after-treatment agent or washing aid that contains elementary silver and/or a silver compound as an antibacterial component, an aldehyde component, and hydrogen peroxide to stabilize the aldehydes against oxidation by silver.
  • US2012003289 A discloses an auxiliary washing aid comprising a textile substrate coated or otherwise impregnated with a composition comprising elementary silver and/or a silver compound, non-neutralized fatty acid, and hydrogen peroxide.
  • EP2829179 A discloses a silver and hydrogen peroxide- containing disinfectant which comprises intermediate solution (5-100 g), hydrogen peroxide (5 to 70 g), surfactant (5 to70 g), colloidal silver (0.1 to 20 mg), and water (balance).
  • An independent claim is included for production of the disinfectant comprising mixing intermediate solution, essential oil, hydrogen peroxide and surfactant with water and adding colloidal silver.
  • US4414127A (Syntex Inc, 1983) discloses aqueous solutions for cleaning contact lenses comprising a water-soluble peroxide, transition metal salts, an amphoteric or anionic surfactant, and, optionally, tonicity salts. There still remains an unmet need for faster acting and efficacious antimicrobial compositions.
  • a method of improving personal hygiene comprising a step of applying to the body a cleansing composition comprising surfactant from 1 % to 45% by weight of the composition; oligodynamic metal from 0.00001 % to 0.01 % by weight of the composition; and peroxide from 0.001 % to 2% by weight of the composition.
  • a method of inhibiting microbial growth on a surface comprising the steps of: applying a composition of the first aspect of the invention to the surface; and rinsing the surface with a suitable solvent.
  • composition of first aspect for improving personal hygiene.
  • the cleansing composition used in the method of the present invention comprises surfactant, oligodynamic metal, and peroxide.
  • the compositions of the present invention are preferred for non-therapeutic use, and more particularly preferred for use in cleaning surfaces of human body including skin, hair or oral cavity or for hard surface cleaning applications in a cosmetic manner.
  • Oligodynamic metal based antimicrobial agents have very good antimicrobial effect. However such metals often tend to discolor under alkaline conditions. It often leads to discoloration of the product itself. This effect, though undesirable, is more prominent in the case of personal washes that are lighter in color and more so with white colored personal washes. Discoloration tends to intensify over a period and with increase in temperature, and often it is found that the change is irreversible.
  • the discoloration is believed to be caused by susceptibility of oligodynamic metal ions to heat and light.
  • a wide range of oligodynamic metal salts is thermally and photo- chemically unstable, discoloring to form brown, gray or black particles.
  • compositions comprising selected ingredients, namely oligodynamic metal and peroxide and surfactant, in selective amounts result in antimicrobial compositions with high color stability even when pH of the composition is very high.
  • the present invention provides a method of improving personal hygiene, comprising a step of applying to the body an antimicrobial cleansing composition comprising surfactant ranging from 1 to 45 wt%, oligodynamic metal ranging from 0.00005 wt% to 0.01 wt% and peroxide ranging from 0.001 wt% to 2 wt% based on the weight of the composition.
  • an antimicrobial cleansing composition comprising surfactant ranging from 1 to 45 wt%, oligodynamic metal ranging from 0.00005 wt% to 0.01 wt% and peroxide ranging from 0.001 wt% to 2 wt% based on the weight of the composition.
  • the cleansing composition includes a cleansing composition, a cleansing composition, and a cleansing composition.
  • the cleansing composition is preferably in a liquid or gel type format. These include handwash liquids, bodywash liquids, hand-sanitizers, shower gels, shampoo, floor cleansers and hard surface cleaning compositions.
  • the cleansing composition contains a base of one or more surfactants to provide the basic cleansing action.
  • the surfactant may be of any class such as anionic, cationic, non-ionic, amphoteric, zwitterionic or a mixture thereof and it can be chosen according to the end use.
  • Anionic surfactants are the most preferred as they provide good cleansing action and they are often used in variety of cleansing compositions.
  • the anionic surfactants may be soap-based ones which are sodium/potassium salts of long chain fatty acids.
  • the cleansing composition comprises 1 to 45 wt% surfactant, more preferably 5 to 25 wt%, still more preferably 10 to 20 wt% based on the weight of the composition.
  • the type and total surfactant content will depend on the intended purpose of the composition, for example, where the composition is soap based then it will predominately contain fatty acid soaps.
  • a shampoo will contain a major portion of sodium alkyl sulphate, or sodium alkyl ether sulphate.
  • a shower gel usually contains sodium lauryl ether sulphate and a betaine.
  • the composition will contain a mixture of different types of surfactants.
  • the anionic surfactant may be, for example, an aliphatic sulfonate, such as a primary alkane (e.g. C8 to C22) sulfonate, primary alkane (e.g., C8 to C22) disulfonate, C8 to C22 alkene sulfonate, C8 to C22 hydroxyalkane sulfonate or alkyl glyceryl ether sulfonate (AGS); or an aromatic sulfonate such as alkyl benzene sulfonate.
  • Alpha olefin sulfonates are also suitable as anionic surfactants.
  • the anionic may also be an alkyl sulfate (e.g., C12 to C18 alkyl sulfate), especially a primary alcohol sulfate or an alkyl ether sulfate (including alkyl glyceryl ether sulfates).
  • the anionic surfactant can also be a sulfonated fatty acid such as alpha sulfonated tallow fatty acid, a sulfonated fatty acid ester such as alpha sulfonated methyl tallowate or mixtures thereof.
  • the anionic surfactant may also be alkyl sulfosuccinates (including mono- and dialkyl, e.g., C6 to C22 sulfosuccinates); alkyl and acyl taurates, alkyl and acyl sarcosinates,
  • sulfoacetates C8 to C22 alkyl phosphates and phosphates, alkyl phosphate esters and alkoxyl alkyl phosphate esters, acyl lactates or lactylates, C8 to C2, monoalkyl succinates and maleates, sulphoacetates, and acyl isethionates.
  • anionic surfactants is C8 to C20 alkyl ethoxy (1 to 20 EO) carboxylates.
  • Yet another suitable class of anionic surfactant is C8-C18 acyl isethionates.
  • esters are prepared by reacting alkali metal isethionates with mixed aliphatic fatty acids having from 6 to 18 carbon atoms and an iodine value of less than 20. At least 75% of the mixed fatty acids have from 12 to 18 carbon atoms and up to 25% have from 6 to 10 carbon atoms.
  • the acyl isethionate may also be alkoxylated isethionates.
  • the alkyl ether sulphates, alkyl ether sulphosuccinates, alkyl ether phosphates and alkyl ether carboxylic acids and salts thereof may contain from 1 to 20 ethylene oxide or propylene oxide units per molecule
  • Typical anionic cleansing surfactants for use in the compositions of the invention include sodium oleyl succinate, ammonium lauryl sulphosuccinate, sodium lauryl sulphate, sodium lauryl ether sulphate, sodium lauryl ether sulphosuccinate, ammonium lauryl sulphate, ammonium lauryl ether sulphate, sodium dodecylbenzene sulphonate, triethanolamine dodecylbenzene sulphonate, sodium cocoyl isethionate, sodium lauryl isethionate, lauryl ether carboxylic acid and sodium N-lauryl sarcosinate.
  • anionic cleansing surfactants are sodium lauryl sulphate, sodium lauryl ether sulphate (n)EO, (where n is from 1 to 3), sodium lauryl ether sulphosuccinate(n)EO, (where n is from 1 to 3), ammonium lauryl sulphate, ammonium lauryl ether sulphate(n)EO, (where n is from 1 to 3), sodium cocoyl isethionate and lauryl ether carboxylic acid (n) EO (where n is from 10 to 20).
  • anionic cleansing surfactants may also be suitable.
  • the surfactant is selected from the group comprising an anionic surfactants. These include alkyl sulphate, fatty acid amides and linear alkyl benzene sulphonate or combinations thereof. It is further preferred that the surfactant comprises soap.
  • a particularly preferred format for compositions are liquid cleansing compositions which can be used for bodywash as well as handwash. These formats contain a major proportion of fatty acid soap as the anionic surfactant.
  • fatty acid soap or, more simply, “soap” is used here in its popular sense, i.e., salts of aliphatic alkane- or alkene monocarboxylic fatty acids preferably having 6 to 22 carbon atoms, and preferably 8 to 18 carbon atoms.
  • Liquid cleansing formulations comprises fatty acid soap from 5 to 65% by weight, preferably from 10 to 55% by weight.
  • the referenced fatty acid levels are for formulations in the form typically provided to consumers, without taking into account dilution in use.
  • formulations containing fatty acid soap at higher levels within such range are typically diluted with water such that the diluted composition that is applied to the skin typically contains 25 wt% or less, more particularly from 0.2 to 25 wt% or less of fatty acid soap.
  • Typical of the soap salts are alkali metal or alkanol ammonium salts of such fatty acids, although other metal salts thereof, e.g., magnesium salts, may also be employed.
  • Sodium, potassium, magnesium, mono-, di- and tri-ethanol ammonium salts of such acids are among the more common soaps suitable for use herein.
  • potassium soaps are used in the formulations of this invention, but up to about 25 wt% of the soap may be sodium or magnesium soaps.
  • the fatty acids from which the soap salts are derived may contain unsaturation.
  • the level of unsaturation should be in accordance with commercially acceptable standards. Excessive unsaturation is normally avoided to minimize color and odor issues.
  • not more than to 40 wt% of the fatty acids from which the soap salts are formed are unsaturated. It is preferred that from 10 to 40 wt%, more particularly from 20 to 40 wt% of the fatty acids from which the soap salts are formed are unsaturated.
  • the combination of C12, C14, C16, and C18 fatty acids accounts for from 90 to 100wt%, more particularly from 95 to 100 wt% of the total fatty acids from which the soap salts are formed and, preferably, that the combination of C16 and C18 fatty acids accounts for from 10 to 35wt%, more particularly from 12 to 30 wt%, even more particularly from 14 to 28 wt%, of the total fatty acids from which the soap salts are formed.
  • the total amount of Cs and C10 fatty acids is less than 5 wt%, and preferably is less than 3 wt% of the fatty acids from which the soap salts are formed.
  • the total amount of soap in the cleansing compositions generally ranges from 1 to 45 wt%, preferably from preferably 5 to 25 wt%, still more preferably 10 to 20 wt% based on the total weight of the composition.
  • amphoteric surfactants include at least one acid group. This may be a carboxylic or a sulphonic acid group. They include quaternary nitrogen and therefore are quaternary amido acids. They should generally include an alkyl or alkenyl group of 7 to 18 carbon atoms. Suitable amphoteric surfactants include amphoacetates, alkyl and alkyl amido betaines, and alkyl and alkyl amido sulphobetaines. Amphoacetates and diamphoacetates are also intended to be covered in possible zwitterionic and/or amphoteric compounds which may be used.
  • Zwitterionic surfactants may also be present in some compositions of this invention.
  • Zwitterionic surfactants suitable for use herein include, but are not limited to derivatives of aliphatic quaternary ammonium, phosphonium, and sulfonium compounds, in which the aliphatic radicals can be straight or branched chain, and wherein one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one substituent contains an anionic group, e.g., carboxy, sulfonate, sulfate, phosphate, or phosphonate.
  • Illustrative zwitterionics are coco dimethyl carboxymethyl betaine, cocoamidopropyl betaine, cocobetaine, oleyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl bis-(2-hydroxyethyl) carboxymethyl betaine, stearyl bis-(2- hydroxypropyl) carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, lauryl bis-(2-hydroxpropyl)alpha-carboxyethyl betaine, and mixtures thereof.
  • the sulfobetaines may include stearyl dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, lauryl bis-(2-hydroxyethyl) sulfopropyl betaine and mixtures thereof.
  • Suitable nonionic surfactants include the reaction products of compounds having a hydrophobic group and a reactive hydrogen atom, for example aliphatic alcohols or fatty acids, with alkylene oxides, especially ethylene oxide either alone or with propylene oxide.
  • alkylene oxides especially ethylene oxide either alone or with propylene oxide.
  • Examples include the condensation products of aliphatic (C8-C18) primary or secondary linear or branched alcohols with ethylene oxide, and products made by condensation of ethylene oxide with the reaction products of propylene oxide and ethylenediamine.
  • nonionic detergent compounds include long chain tertiary amine oxides, long chain tertiary phosphine oxides and dialkyl sulphoxides.
  • the nonionic may also be a sugar amide, such as alkyl polysaccharides and alkyl polysaccharide amides.
  • examples of some cationic surfactants which may be used are the quaternary ammonium compounds such as alkyldimethylammonium halides.
  • Peroxide compounds are a class of chemical compounds in which two oxygen atoms are linked together by a single covalent bond.
  • organic and inorganic peroxides are useful as bleaching agents, as initiators of polymerization reactions, and in the preparation of hydrogen peroxide and other oxygen compounds.
  • the negatively charged peroxide ion (O2 2" ) is present in inorganic compounds that may be regarded as salts of the very weak acid hydrogen peroxide; examples are sodium peroxide (Na2C>2), a bleaching agent, and barium peroxide (BaC>2), formerly used as a source of hydrogen peroxide.
  • peroxides Two categories of peroxides exist in which one or both of the oxygen atoms are covalently linked to atoms other than hydrogen.
  • One category is represented by cumene hydroperoxide, an organic compound used as a polymerization initiator and as a source of phenol and acetone, and peroxysulfuric acid, an inorganic compound used as an oxidizing agent.
  • the other category includes di-fe/t-butyl peroxide and
  • ammonium peroxydisulfate both used as initiators.
  • the peroxides in the composition range from 0.001 % to 2 % by weight of the composition, more preferably from 0.01 to 1 wt% and more preferably from 0.03 to 0.5 wt%.
  • the peroxides for use in the present invention preferably include but are not limited to hydroperoxide, superoxides, dioxygenyls, ozones, ozonides or mixtures thereof, more preferably the peroxides comprise hydroperoxides and most preferably hydrogen peroxide.
  • Inorganic peroxides can be ionic and covalent peroxide.
  • the first class mostly contains the peroxides of the alkali and alkaline earth metals whereas the covalent peroxides are represented by such compounds as hydrogen peroxide and peroxymonosulfuric acid (H2SO5).
  • H2SO5 peroxymonosulfuric acid
  • peroxides of transition metals have a more covalent character. It should be noted that in some older literature some high-valence metal oxides are incorrectly named peroxides (e.g. PbC>2, Mn02, Ag404) even though they do not contain the peroxide ion.
  • Organic peroxides can be divided into two major classes, peroxy acids and organic hydroperoxides
  • Hydroperoxides are a particularly preferred class of peroxides for the present invention. Hydroperoxides contain the 0-O-H " unit. Hydrogen peroxide is therefore also an example of a hydroperoxide. One of the most commonly used hydroperoxides is called i-butyl hydroperoxide (or fe/t-butyl hydroperoxide). In a highly preferred aspect of the present invention the peroxide is a hydrogen peroxide, shown below with a peroxo unit.
  • PV peroxide value
  • the Oligodynamic metal contains a metal having oligodynamic activity. It (also called as oligodynamic action) is the effect of inhibiting, or killing micro-organisms by the use of very small amounts of a chemical substance. Several metals exhibit such an effect. Preferred metals are silver, copper, zinc or gold. Silver is particularly preferred. In the ionic form it may exist as a salt or any compound in any applicable oxidation state.
  • the cleansing composition of the present invention comprises 0.00001 to 0.01 wt% of oligodynamic metal. It is preferred that the metal is present in the form of a compound, more preferably to a compound of silver; then an appropriate amount of the compound is included so that the active metal content is within the broad and preferred ranges as already indicated. The compound is present more preferably from 0.0001 wt% to 0.005 wt% and most preferably from 0.0003 to 0.0015 wt%.
  • the weight ratio of peroxide to oligodynamic metal is in the range of 0.5:1 to 2000:1 , more preferably in the range of 10:1 to 500:1 and most preferably in the range of 25:1 to 100:1.
  • the cleansing composition of the present invention contains silver as the oligodynamic metal. It is further preferred that Silver is included in the form of Silver(l) compound but may also be in the form of particles, eg., nanoparticles.
  • Silver(l) compounds are one or more water-soluble silver(l) compounds having silver ion solubility at least 1 .0 x10 "4 mol/L (in water at 25°C).
  • Silver ion solubility is a value derived from a solubility product (Ksp) in water at 25°C, a well known parameter that is reported in numerous sources. More particularly, silver ion solubility [Ag+], a value given in mol/L may be calculated using the formula:
  • [Ag+] (Ksp ⁇ x) ⁇ 1/ ⁇ x +1 » , wherein Ksp is the solubility product of the compound of interest in water at 25°C, and x represents the number of moles of silver ion per mole of compound. It has been found that Silver(l) compounds having a silver ion solubility of at least 1 x 10 "4 mol/L in are suitable for use herein. Silver ion solubility values for a variety of silver compounds are given in Table 1 :
  • silver is present in the form of a compound selected from silver oxide, silver nitrate, silver acetate, silver sulfate, silver benzoate, silver salicylate, silver carbonate, silver citrate or silver phosphate.
  • silver(l) compound is silver oxide.
  • the compounds are added in amounts equivalent to the silver content. This can be easily determined by knowing the molecular formula and the relative molecular mass of the concerned silver-based compound. Water
  • the personal cleansing formulations of the subject invention preferably contains water in an amount of from 20 to 90%, by weight more particularly from 50 to 85% by weight, based on the total weight of the formulation.
  • water contents are representative of a relatively broad range of formulations, including both concentrated and non- concentrates products, with formulations having water contents of from 20 to less than 50% by weight of water being typical of concentrated products.
  • the formulations are commonly diluted with water.
  • the extent of dilution depends on the particular product form. Less commonly, but also contemplated for use herein are formulations that are foamed without dilution, typically through the use of pump dispensers in which product is passed through a screen in the pump.
  • pH of the compositions of the present invention ranges from 9 to 1 1.
  • Optional and preferred ingredients are preferred.
  • the formulations typically include one or more skin benefit agents.
  • skin benefit agent is defined as a substance which softens or improves the elasticity, appearance, and youthfulness of the skin (stratum corneum) by either increasing its water content, adding, or replacing lipids and other skin nutrients, or both, and keeps it soft by retarding the decrease of its water content.
  • emollients including, for example, hydrophobic emollients, hydrophilic emollients, or blends thereof.
  • Useful skin benefit agents include the following: (a) silicone oils and modifications thereof such as linear and cyclic polydimethylsiloxanes; amino, alkyl, alkylaryl, and aryl silicone oils; (b) fats and oils including natural fats and oils such as jojoba, soybean, sunflower, rice bran, avocado, almond, olive, sesame, persic, castor, coconut, and mink oils; cacao fat; beef tallow and lard; hardened oils obtained by hydrogenating the aforementioned oils; and synthetic mono, di and triglycerides such as myristic acid glyceride and 2-ethylhexanoic acid glyceride; (c) waxes such as carnauba, spermaceti, beeswax, lanolin, and derivatives thereof; (d) hydrophobic and hydrophilic plant extracts; (e) hydrocarbons such as liquid paraffin, petrolatum, microcrystalline wax, ceresin, squalene, pristan and
  • vitamins, minerals, and skin nutrients such as milk, vitamins A, E, and K; vitamin alkyi esters, including vitamin C alkyi esters; magnesium, calcium, copper, zinc and other metallic components;
  • sunscreens such as octyl methoxyl cinnamate (Parsol MCX) and butyl methoxy benzoylmethane (Parsol 1789);
  • phospholipids such as alpha-hydroxy acids and beta-hydroxy acids.
  • Skin benefit agents commonly account for up to 30wt.% of the liquid soap formulation, with levels of from 0 to 25wt.%, more particularly from 0 to 20wt%, being typical of the levels at which those skin benefit agents generally known as "emollients" are employed in many of the subject formulations.
  • Preferred skin benefit agents include fatty acids, hydrocarbons, polyhydric alcohols, polyols and mixtures thereof, with emollients that include at least one C12 to C18 fatty acid, petrolatum, glycerol, sorbitol and/or propylene glycol being of particular interest in one or more embodiments.
  • water soluble/dispersible polymers can be cationic, anionic, amphoteric or nonionic types with molecular weights higher than 100,000 Dalton. They are known to increase the viscosity and stability of liquid personal cleansing formulation, to enhance in-use and after-use skin sensory properties, and to enhance lather creaminess and lather stability. When present, the total amount of such polymers commonly ranges from 0.1 to 10% by weight of the personal cleansing formulation.
  • Preservatives/antimicrobials can desirably be incorporated into the personal cleansing formulations of this invention to protect against the growth of potentially harmful microorganisms. Suitable traditional preservatives for formulations of this invention are alkyl esters of para-hydroxybenzoic acid. Other preservatives/ antimicrobials which have more recently come into use include hydantoin derivatives, propionate salts, and a variety of quaternary ammonium compounds. Among the
  • preservatives/antimicrobials of particular interest are phenoxyethanol, methyl paraben, propyl paraben, imidazolidinyl urea, sodium dehydroacetate and benzyl alcohol.
  • Other preservatives of particular interest are dimethyloldimethylhydantoin (Glydant XL1000), parabens, sorbic acid, thymol and terpineol to name a few (with combinations of thymol and terpineol as described, for example, in U.S. Patent Application Publication No. 201 1/02231 14 incorporated herein by reference, being of particular interest in one or more embodiments).
  • the preservatives/antimicrobials should be selected having regard for the use of the formulation and possible incompatibilities between the preservatives and other ingredients.
  • Preservatives are preferably employed in amounts ranging from 0.01 to 2% by weight of the personal cleansing formulation.
  • Additional optional ingredients which may be present in the subject personal cleansing formulations are, for example: fragrances; sequestering and chelating agents such as tetrasodium ethylenediaminetetraacetate (EDTA), ethane hydroxyl diphosphonate (EHDP), and etidronic acid, aka 1-hydroxyethylidene diphosphonic acid (HEDP);
  • coloring agents such as zinc stearate, magnesium stearate, ⁇ 2, ethylene glycol monostearate (EGMS), ethylene glycol distearate (EGDS) or Lytron 621 (Styrene/Acrylate copolymer) and the like; pH adjusters; antioxidants, for example, butylated hydroxytoluene (BHT) and the like; stabilizers; suds boosters, such as for example, coconut acyl mono- or diethanol amides; ionizing salts, such as, for example, sodium chloride and sodium sulfate, and other ingredients such as are conventionally used in liquid soap formulations.
  • the total amount of such additional optional ingredients is typically from 0 to 10% by weight, more particularly from 0.1 to 5% by weight, based on the total weight of the personal cleansing formulation.
  • an alcohol is present in the range of 1 to 90 %wt, more preferably 15 to 80 %wt and most preferably 20 to 70 %wt.
  • the alcohols for use in the sanitizer composition are C2 to C 4 monohydric alcohols.
  • the personal cleansing formulations of this invention are of interest with respect to biocidal activity against Gram positive bacteria, including in particular S. aureus.
  • Gram positive bacteria including in particular S. aureus.
  • Other Gram, positive bacteria against which the soap formulations are of interest are S.
  • the formulations provides a log-io reduction in biocial activity against Staphylococcus aureus ATCC 6538 of at least 2.5, preferably of least 3, at a contact time of 30 seconds and even more preferably provides a Log-io Reduction against S. aureus ATCC 6538 of at least 1 .5 even more preferably at least 2 at a contact time of 10 seconds.
  • the personal cleansing formulations are diluted, as needed, to form aqueous cleansing compositions that are applied to the skin for contact times less than 1 minute, more particularly 30 seconds or less (with contact times of 10 to 30 seconds being of interest with respect to contact times of a moderate to a relatively long duration and contact times of 10 seconds or less being of interest with respect to contact times of short to moderate duration) and thereafter is removed from the skin, typically by rinsing with water.
  • the personal cleansing formulation can be diluted before, after or simultaneous with its being placed on the skin, with dilution typically occurring by the formulation being worked into a lather in the hands or on an applicator, such as a facecloth, sponge or pouf.
  • samples were stored at 27°C, 37°C, 45°C and monitored over a period of a period of 12 weeks and at 50°C for a period of 4 weeks.
  • the samples are intermittently observed by trained analysts for any change in colour or general appearance. Usually the test lasts for a total period of twelve weeks. Samples are then graded and rated on a scale on the basis of appearance.
  • the present invention provides a method of inhibiting microbial growth on a surface comprising the steps of applying a composition of the present invention on to the surface; and rinsing the surface with a suitable solvent.
  • the present invention provides use of a composition comprising 25% to 85% by weight surfactant, 0.00005% to 0.01 % by weight oligodynamic metal, 0.001 % to 2% by weight of peroxide for improved personal hygiene.
  • the personal cleansing formulations herein described may be produced by preparative techniques as are conventional in the art. In one very general methodology, to a heated aqueous phase of water, is added melted fatty acid, followed by caustic (to neutralize the fatty acid and form soap), synthetic detergents and co-solvents; the remaining ingredients are added, as appropriate, as the product is cooled to room temperature.
  • the personal cleansing formulations may be provided in a variety of different product forms including, for example, hand, face and body washes, shower gels, and the like.
  • the formulations may be provided in bottles, pump dispensers, tubes, sachets, or other packaging suitable for the product form. Examples
  • the preferred liquid compositions (PLC) of the present invention were prepared indicated in Table 2.
  • Example 2 Color Stability White colored compositions according to Table 2 were made for this experiment.
  • samples were stored at 27 °C, 37 °C, 45 °C and monitored over a period of a period of 12 weeks and at 50 °C for a period of 4 weeks. Their colour was particularly observed at fixed intervals throughout the period.
  • compositions were said to have failed the test when they were discolored beyond acceptable level.
  • the data in the table 3 indicate that each comparative composition failed the test while each experimental (preferred) soap composition retained the initial colour to an appreciable extent.
  • Solution preparation depends, in part, on the particular form of the liquid soap formulation.
  • formulations that are not diluted in use e.g., self-foaming formulations, are employed as is.
  • a formulation that contains 30 wt.% or less of detersive surfactant and which is intended to be diluted in use is mixed with an equal amount, by weight, of water to form a soap solution containing 50 wt% of the initial formulation.
  • a formulation that contains more than 30 wt% of detersive surfactant and which is intended to be diluted in use is mixed with water to form a soap solution containing 16 wt% of the initial formulation.
  • Staphylococcus aureus ATCC 6538 were used in this study to represent Gram positive bacteria, respectively.
  • the bacteria was stored at -80°C.
  • Fresh isolates were cultured twice on Tryptic Soy Agar plates for 24 hours at 37°C before each experiment.
  • Time-kill assays are performed according to the European Standard, EN 1040:2005 entitled "Chemical Disinfectants and Antiseptics - Quantitative Suspension Test for the Evaluation of Basic Bactericidal Activity of Chemical Disinfectants and Antiseptics - Test Method and Requirements (Phase 1 )" incorporated herein by reference Following this procedure Growth-phase bacterial cultures at 1.5X10 8 to 5 X10 8 colony forming units per ml (cfu/ml) are treated with the soap solutions (prepared as described above) at 25 °C. In forming the test sample 8 parts by weight of the soap solution, prepared as described above, is combined with 1 part by weight of culture and 1 part by weight of water.
  • test solutions are neutralized to arrest the antibacterial activity of the soap solutions. Then test solutions are serially diluted, plated on solid medium, incubated for 24 hours and surviving cells are enumerated. Bactericidal activity is defined as the log reduction in cfu/ml relative to the bacterial concentration at 0 seconds. Cultures not exposed to any soap solutions serve as no- treatment controls.
  • Logio Reduction logio (numbers control) - logio (test sample survivors)
  • Control II 1.4 2.4
  • Table 5 show that for an amount of 10 ppm (0.001 wt%) of silver in the composition, addition of hydrogen peroxide does not affect the antimicrobial efficacy of the composition. This data shows the method of improving personal hygiene in accordance with the invention.

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Abstract

La présente invention concerne un procédé d'amélioration de l'hygiène personnelle, comprenant une étape d'application, sur le corps, d'une composition nettoyante comprenant un tensioactif représentant de 1 % à 45 % en poids de la composition; un métal oligodynamique représentant de 0,00001 % à 0,01 % en poids de la composition; et du peroxyde représentant entre 0,001 % et 2 % en poids de la composition.
PCT/EP2016/075995 2015-11-18 2016-10-27 Procédé permettant d'améliorer l'hygiène personnelle WO2017084855A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021224114A1 (fr) * 2020-05-04 2021-11-11 Unilever Ip Holdings B.V. Composition antibactérienne

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414127A (en) * 1981-07-06 1983-11-08 Syntex (U.S.A.) Inc. Contact lens cleaning solutions
US20120003326A1 (en) * 2009-03-20 2012-01-05 Henkel Ag & Co. Kgaa Detergent, cleaning agent, aftertreatment agent, or washing aid containing aldehydes and having an antibacterial effect
US20120003289A1 (en) * 2009-03-20 2012-01-05 Henkel Ag & Co. Kgaa Washing aid having an antibacterial effect
EP2829179A1 (fr) * 2007-01-25 2015-01-28 Johann Landmann Produit de désinfection
WO2015113782A1 (fr) * 2014-01-29 2015-08-06 Unilever N.V. Composition nettoyante contenant un métal oligodynamique et un agent améliorant l'efficacité
WO2015113785A1 (fr) * 2014-01-29 2015-08-06 Unilever N.V. Compositions de nettoyage contenant de l'argent stable

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414127A (en) * 1981-07-06 1983-11-08 Syntex (U.S.A.) Inc. Contact lens cleaning solutions
EP2829179A1 (fr) * 2007-01-25 2015-01-28 Johann Landmann Produit de désinfection
US20120003326A1 (en) * 2009-03-20 2012-01-05 Henkel Ag & Co. Kgaa Detergent, cleaning agent, aftertreatment agent, or washing aid containing aldehydes and having an antibacterial effect
US20120003289A1 (en) * 2009-03-20 2012-01-05 Henkel Ag & Co. Kgaa Washing aid having an antibacterial effect
WO2015113782A1 (fr) * 2014-01-29 2015-08-06 Unilever N.V. Composition nettoyante contenant un métal oligodynamique et un agent améliorant l'efficacité
WO2015113785A1 (fr) * 2014-01-29 2015-08-06 Unilever N.V. Compositions de nettoyage contenant de l'argent stable

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021224114A1 (fr) * 2020-05-04 2021-11-11 Unilever Ip Holdings B.V. Composition antibactérienne

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