WO2017068388A3 - Use of synthetic pntx-19 peptide for the treatment of pain - Google Patents

Use of synthetic pntx-19 peptide for the treatment of pain Download PDF

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Publication number
WO2017068388A3
WO2017068388A3 PCT/IB2015/057220 IB2015057220W WO2017068388A3 WO 2017068388 A3 WO2017068388 A3 WO 2017068388A3 IB 2015057220 W IB2015057220 W IB 2015057220W WO 2017068388 A3 WO2017068388 A3 WO 2017068388A3
Authority
WO
WIPO (PCT)
Prior art keywords
pntx
peptide
synthetic
pain
treatment
Prior art date
Application number
PCT/IB2015/057220
Other languages
French (fr)
Portuguese (pt)
Other versions
WO2017068388A2 (en
Inventor
Igor Dimitri Gama Duarte
Maria Elena DE LIMA PEREZ GARCIA
Ana Cristina NOGUEIRA FREITAS
Daniela DA FONSECA PACHECO
Original Assignee
Universidade Federal De Minas Gerais - Ufmg
Fundação De Amparo À Pesquisa Do Estado De Minas Gerais- Fapemig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal De Minas Gerais - Ufmg, Fundação De Amparo À Pesquisa Do Estado De Minas Gerais- Fapemig filed Critical Universidade Federal De Minas Gerais - Ufmg
Priority to PCT/IB2015/057220 priority Critical patent/WO2017068388A2/en
Publication of WO2017068388A2 publication Critical patent/WO2017068388A2/en
Publication of WO2017068388A3 publication Critical patent/WO2017068388A3/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to the use of the synthetic PnTx-19 peptide for preparing analgesic medicinal drugs for the treatment of patients suffering from neuropathic pain, nociceptive pain (sensitisation of nociceptors by prostaglandin E2) and inflammatory pain. The synthetic PnTx-19 peptide is a very interesting pharmacological tool for use as an analgesic medicinal drug, since it triggers an antinociceptive response via cannabinoid and opioid and probably does not develop drug tolerance or dependence.
PCT/IB2015/057220 2015-09-18 2015-09-18 Use of synthetic pntx-19 peptide for the treatment of pain WO2017068388A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IB2015/057220 WO2017068388A2 (en) 2015-09-18 2015-09-18 Use of synthetic pntx-19 peptide for the treatment of pain

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2015/057220 WO2017068388A2 (en) 2015-09-18 2015-09-18 Use of synthetic pntx-19 peptide for the treatment of pain

Publications (2)

Publication Number Publication Date
WO2017068388A2 WO2017068388A2 (en) 2017-04-27
WO2017068388A3 true WO2017068388A3 (en) 2017-08-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/057220 WO2017068388A2 (en) 2015-09-18 2015-09-18 Use of synthetic pntx-19 peptide for the treatment of pain

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WO (1) WO2017068388A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10905738B2 (en) * 2018-07-05 2021-02-02 Biozeus Desenvolvimento De Produtos Biofarmacêuticos Synthetic peptides, prodrugs, pharmaceutical compositions and uses
EP4025234A4 (en) * 2019-09-03 2023-09-20 Biozeus Desenvolvimento de Produtos Biofarmacêuticos Method and use of pnpp-19 for preventing and treating eye diseases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0800596A2 (en) * 2008-01-31 2009-09-22 Univ Minas Gerais method for potentiation of erectile function through the use of pharmaceutical compositions of the toxin tx2-6 from the phoneutria nigriventer spider
BRPI0605484A2 (en) * 2006-11-21 2009-12-29 Univ Minas Gerais ph (alpha) 1b toxin, ph (alpha) 1b toxin gene cdna, pharmaceutical compositions containing ph (alpha) 1b toxin, process for obtaining, process for obtaining cdna, and product
US20120015886A1 (en) * 2005-10-18 2012-01-19 Seoul National University Industry Foundation Method for preparing recombinant peptide from spider venom and method for relieving pain
BR102012020800A2 (en) * 2012-08-20 2014-12-16 Univ Minas Gerais PNTX SYNTHETIC PEPTIDE (19), PHARMACEUTICAL COMPOSITIONS AND USE

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120015886A1 (en) * 2005-10-18 2012-01-19 Seoul National University Industry Foundation Method for preparing recombinant peptide from spider venom and method for relieving pain
BRPI0605484A2 (en) * 2006-11-21 2009-12-29 Univ Minas Gerais ph (alpha) 1b toxin, ph (alpha) 1b toxin gene cdna, pharmaceutical compositions containing ph (alpha) 1b toxin, process for obtaining, process for obtaining cdna, and product
BRPI0800596A2 (en) * 2008-01-31 2009-09-22 Univ Minas Gerais method for potentiation of erectile function through the use of pharmaceutical compositions of the toxin tx2-6 from the phoneutria nigriventer spider
BR102012020800A2 (en) * 2012-08-20 2014-12-16 Univ Minas Gerais PNTX SYNTHETIC PEPTIDE (19), PHARMACEUTICAL COMPOSITIONS AND USE

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FREITAS, A. C. ET AL.: "Pntx-19 induces peripheral antinociception mediated by Mu- and Delta-opioid receptors", 15TH WORLD CONGRESS ON PAIN, October 2014 (2014-10-01), Buenos Aires , Argentina *
SILVA, C. N. ET AL.: "PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO /cGMP", J. UROL. JUNHO, vol. 194, no. 5, 2015, pages 1481 - 1490, XP055402767 *
TORRES, F. S. ET AL.: "Site-directed mutagenesis of recombinant Phoneutria nigriventer spider venom toxin (rPnTx2-6) reveals possible key residues involved in the pharmacological activities of this toxin that causes penile erection", XI CONGRESS OF THE PAN- AMERICAN SECTION OF THE INTERNATIONAL SOCIETY ON TOXINOLOGY E XII CONGRESS OF THE BRAZILIAN SOCIETY OF TOXINOLOGY, November 2013 (2013-11-01), Guarujá - SP *

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