WO2017068388A3 - Use of synthetic pntx-19 peptide for the treatment of pain - Google Patents
Use of synthetic pntx-19 peptide for the treatment of pain Download PDFInfo
- Publication number
- WO2017068388A3 WO2017068388A3 PCT/IB2015/057220 IB2015057220W WO2017068388A3 WO 2017068388 A3 WO2017068388 A3 WO 2017068388A3 IB 2015057220 W IB2015057220 W IB 2015057220W WO 2017068388 A3 WO2017068388 A3 WO 2017068388A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pntx
- peptide
- synthetic
- pain
- treatment
- Prior art date
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention relates to the use of the synthetic PnTx-19 peptide for preparing analgesic medicinal drugs for the treatment of patients suffering from neuropathic pain, nociceptive pain (sensitisation of nociceptors by prostaglandin E2) and inflammatory pain. The synthetic PnTx-19 peptide is a very interesting pharmacological tool for use as an analgesic medicinal drug, since it triggers an antinociceptive response via cannabinoid and opioid and probably does not develop drug tolerance or dependence.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/IB2015/057220 WO2017068388A2 (en) | 2015-09-18 | 2015-09-18 | Use of synthetic pntx-19 peptide for the treatment of pain |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2015/057220 WO2017068388A2 (en) | 2015-09-18 | 2015-09-18 | Use of synthetic pntx-19 peptide for the treatment of pain |
Publications (2)
Publication Number | Publication Date |
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WO2017068388A2 WO2017068388A2 (en) | 2017-04-27 |
WO2017068388A3 true WO2017068388A3 (en) | 2017-08-03 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2015/057220 WO2017068388A2 (en) | 2015-09-18 | 2015-09-18 | Use of synthetic pntx-19 peptide for the treatment of pain |
Country Status (1)
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WO (1) | WO2017068388A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10905738B2 (en) * | 2018-07-05 | 2021-02-02 | Biozeus Desenvolvimento De Produtos Biofarmacêuticos | Synthetic peptides, prodrugs, pharmaceutical compositions and uses |
EP4025234A4 (en) * | 2019-09-03 | 2023-09-20 | Biozeus Desenvolvimento de Produtos Biofarmacêuticos | Method and use of pnpp-19 for preventing and treating eye diseases |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0800596A2 (en) * | 2008-01-31 | 2009-09-22 | Univ Minas Gerais | method for potentiation of erectile function through the use of pharmaceutical compositions of the toxin tx2-6 from the phoneutria nigriventer spider |
BRPI0605484A2 (en) * | 2006-11-21 | 2009-12-29 | Univ Minas Gerais | ph (alpha) 1b toxin, ph (alpha) 1b toxin gene cdna, pharmaceutical compositions containing ph (alpha) 1b toxin, process for obtaining, process for obtaining cdna, and product |
US20120015886A1 (en) * | 2005-10-18 | 2012-01-19 | Seoul National University Industry Foundation | Method for preparing recombinant peptide from spider venom and method for relieving pain |
BR102012020800A2 (en) * | 2012-08-20 | 2014-12-16 | Univ Minas Gerais | PNTX SYNTHETIC PEPTIDE (19), PHARMACEUTICAL COMPOSITIONS AND USE |
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2015
- 2015-09-18 WO PCT/IB2015/057220 patent/WO2017068388A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120015886A1 (en) * | 2005-10-18 | 2012-01-19 | Seoul National University Industry Foundation | Method for preparing recombinant peptide from spider venom and method for relieving pain |
BRPI0605484A2 (en) * | 2006-11-21 | 2009-12-29 | Univ Minas Gerais | ph (alpha) 1b toxin, ph (alpha) 1b toxin gene cdna, pharmaceutical compositions containing ph (alpha) 1b toxin, process for obtaining, process for obtaining cdna, and product |
BRPI0800596A2 (en) * | 2008-01-31 | 2009-09-22 | Univ Minas Gerais | method for potentiation of erectile function through the use of pharmaceutical compositions of the toxin tx2-6 from the phoneutria nigriventer spider |
BR102012020800A2 (en) * | 2012-08-20 | 2014-12-16 | Univ Minas Gerais | PNTX SYNTHETIC PEPTIDE (19), PHARMACEUTICAL COMPOSITIONS AND USE |
Non-Patent Citations (3)
Title |
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FREITAS, A. C. ET AL.: "Pntx-19 induces peripheral antinociception mediated by Mu- and Delta-opioid receptors", 15TH WORLD CONGRESS ON PAIN, October 2014 (2014-10-01), Buenos Aires , Argentina * |
SILVA, C. N. ET AL.: "PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO /cGMP", J. UROL. JUNHO, vol. 194, no. 5, 2015, pages 1481 - 1490, XP055402767 * |
TORRES, F. S. ET AL.: "Site-directed mutagenesis of recombinant Phoneutria nigriventer spider venom toxin (rPnTx2-6) reveals possible key residues involved in the pharmacological activities of this toxin that causes penile erection", XI CONGRESS OF THE PAN- AMERICAN SECTION OF THE INTERNATIONAL SOCIETY ON TOXINOLOGY E XII CONGRESS OF THE BRAZILIAN SOCIETY OF TOXINOLOGY, November 2013 (2013-11-01), Guarujá - SP * |
Also Published As
Publication number | Publication date |
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WO2017068388A2 (en) | 2017-04-27 |
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