WO2017065495A3 - Composition for treatment of inflammatory bowel disease and atopic dermatitis - Google Patents
Composition for treatment of inflammatory bowel disease and atopic dermatitis Download PDFInfo
- Publication number
- WO2017065495A3 WO2017065495A3 PCT/KR2016/011434 KR2016011434W WO2017065495A3 WO 2017065495 A3 WO2017065495 A3 WO 2017065495A3 KR 2016011434 W KR2016011434 W KR 2016011434W WO 2017065495 A3 WO2017065495 A3 WO 2017065495A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- inflammatory bowel
- bowel disease
- atopic dermatitis
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/06—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a compound for inhibiting the secretion of thymic stromal lymphopoietin (TSLP) from mast cells, and a use thereof. It has been confirmed that the compound of the present invention significantly inhibits the secretion of TSLP from mast cells, and thus the compound can be used as a candidate material for the treatment and prevention of atopic dermatitis, allergic dermatitis and/or inflammatory bowel disease.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16855712.2A EP3363783B1 (en) | 2015-10-13 | 2016-10-12 | Composition for treatment of inflammatory bowel disease and atopic dermatitis |
JP2018519833A JP6885607B2 (en) | 2015-10-13 | 2016-10-12 | Compositions for the treatment of inflammatory bowel disease and atopic dermatitis |
US15/768,374 US10278931B2 (en) | 2015-10-13 | 2016-10-12 | Composition for treatment of inflammatory bowel disease and atopic dermatitis |
CN201680059836.6A CN108137490B (en) | 2015-10-13 | 2016-10-12 | Composition for treating inflammatory bowel disease and atopic dermatitis |
HK18113385.6A HK1254242A1 (en) | 2015-10-13 | 2018-10-18 | Composition for treatment of inflammatory bowel disease and atopic dermatitis |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2015-0142929 | 2015-10-13 | ||
KR20150142929 | 2015-10-13 | ||
KR1020160131313A KR101949451B1 (en) | 2015-10-13 | 2016-10-11 | A composition for treating inflammatory bowel disease and atopic dermatitis |
KR10-2016-0131313 | 2016-10-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2017065495A2 WO2017065495A2 (en) | 2017-04-20 |
WO2017065495A3 true WO2017065495A3 (en) | 2017-06-15 |
Family
ID=58517692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2016/011434 WO2017065495A2 (en) | 2015-10-13 | 2016-10-12 | Composition for treatment of inflammatory bowel disease and atopic dermatitis |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2017065495A2 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003037346A1 (en) * | 2001-10-31 | 2003-05-08 | Cell Therapeutics, Inc. | 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer |
WO2004005509A1 (en) * | 2002-07-02 | 2004-01-15 | Genox Research, Inc. | Method of examining allergic disaese and drug for treating the same |
KR20110010763A (en) * | 2008-05-09 | 2011-02-07 | 톨마 인코포레이티드 | Proguanil to treat skin/mucosal diseases |
US20130095140A1 (en) * | 2011-01-07 | 2013-04-18 | Elcelyx Therapeutics, Inc. | Biguanide Compositions and Methods of Treating Metabolic Disorders |
-
2016
- 2016-10-12 WO PCT/KR2016/011434 patent/WO2017065495A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003037346A1 (en) * | 2001-10-31 | 2003-05-08 | Cell Therapeutics, Inc. | 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer |
WO2004005509A1 (en) * | 2002-07-02 | 2004-01-15 | Genox Research, Inc. | Method of examining allergic disaese and drug for treating the same |
KR20110010763A (en) * | 2008-05-09 | 2011-02-07 | 톨마 인코포레이티드 | Proguanil to treat skin/mucosal diseases |
US20130095140A1 (en) * | 2011-01-07 | 2013-04-18 | Elcelyx Therapeutics, Inc. | Biguanide Compositions and Methods of Treating Metabolic Disorders |
Non-Patent Citations (3)
Title |
---|
CHEMICAL ABSTRACTS, 29 October 2002, Columbus, Ohio, US; abstract no. 467242-19-9 * |
CHEMICAL ABSTRACTS, 30 October 2000, Columbus, Ohio, US; abstract no. 300382-90-5, XP055545202 * |
See also references of EP3363783A4 * |
Also Published As
Publication number | Publication date |
---|---|
WO2017065495A2 (en) | 2017-04-20 |
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