WO2017064558A8 - 新規免疫賦活化剤 - Google Patents

新規免疫賦活化剤 Download PDF

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Publication number
WO2017064558A8
WO2017064558A8 PCT/IB2016/001543 IB2016001543W WO2017064558A8 WO 2017064558 A8 WO2017064558 A8 WO 2017064558A8 IB 2016001543 W IB2016001543 W IB 2016001543W WO 2017064558 A8 WO2017064558 A8 WO 2017064558A8
Authority
WO
WIPO (PCT)
Prior art keywords
immunostimulant
novel
novel immunostimulant
tetrahydropyrimido
indolizin
Prior art date
Application number
PCT/IB2016/001543
Other languages
English (en)
French (fr)
Other versions
WO2017064558A1 (ja
Inventor
和孝 宮寺
智史 深谷
芳美 青柳
Original Assignee
大鵬薬品工業株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2016148854A external-priority patent/JP2017075137A/ja
Application filed by 大鵬薬品工業株式会社 filed Critical 大鵬薬品工業株式会社
Publication of WO2017064558A1 publication Critical patent/WO2017064558A1/ja
Publication of WO2017064558A8 publication Critical patent/WO2017064558A8/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

この発明は、下記の式（Ｉ）で表される（Ｓ）－Ｎ（４－アミノ－５－（キノリン－３－イル）－６，７，８，９－テトラヒドロピリミド［５，４－ｂ］インドリジン－８－イル）アクリルアミドまたはその塩を有効成分として含有する免疫賦活化剤、および免疫賦活化により改善することができる疾患を予防または治療するための医薬組成物に関する。
PCT/IB2016/001543 2015-10-14 2016-10-28 新規免疫賦活化剤 WO2017064558A1 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2015-203282 2015-10-14
JP2015203282 2015-10-14
JP2016-148854 2016-07-28
JP2016148854A JP2017075137A (ja) 2015-10-14 2016-07-28 新規免疫賦活化剤

Publications (2)

Publication Number Publication Date
WO2017064558A1 WO2017064558A1 (ja) 2017-04-20
WO2017064558A8 true WO2017064558A8 (ja) 2017-08-17

Family

ID=58517074

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2016/001543 WO2017064558A1 (ja) 2015-10-14 2016-10-28 新規免疫賦活化剤

Country Status (1)

Country Link
WO (1) WO2017064558A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108101905A (zh) * 2016-11-24 2018-06-01 中国科学院上海药物研究所 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
CN115607573B (zh) * 2022-12-16 2023-05-23 北京大学第三医院（北京大学第三临床医学院） 一种用于调节杀伤性t细胞活性的方法、药物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012512883A (ja) * 2008-12-19 2012-06-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ウイルス感染の治療における上皮成長因子阻害剤の使用
ES2580530T3 (es) * 2012-02-23 2016-08-24 Taiho Pharmaceutical Co., Ltd. Compuesto con anillo fusionado de quinolilpirrolopirimidilo o sal del mismo
US20150079079A1 (en) * 2013-09-13 2015-03-19 Wake Forest University Health Sciences Methods and Compositions for Treatment of Chlamydial Infection and Related Diseases and Disorders

Also Published As

Publication number Publication date
WO2017064558A1 (ja) 2017-04-20

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