WO2017053469A3 - Cd3 binding polypeptides - Google Patents

Cd3 binding polypeptides Download PDF

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Publication number
WO2017053469A3
WO2017053469A3 PCT/US2016/052942 US2016052942W WO2017053469A3 WO 2017053469 A3 WO2017053469 A3 WO 2017053469A3 US 2016052942 W US2016052942 W US 2016052942W WO 2017053469 A3 WO2017053469 A3 WO 2017053469A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
binding
binding domain
cells
protein
Prior art date
Application number
PCT/US2016/052942
Other languages
French (fr)
Other versions
WO2017053469A2 (en
Inventor
Philip Tan
John W. Blankenship
Original Assignee
Aptevo Research And Development Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2018513821A priority Critical patent/JP7002446B2/en
Application filed by Aptevo Research And Development Llc filed Critical Aptevo Research And Development Llc
Priority to EA201890613A priority patent/EA201890613A1/en
Priority to CA2999138A priority patent/CA2999138A1/en
Priority to KR1020187009336A priority patent/KR20180053322A/en
Priority to MYPI2018701059A priority patent/MY197562A/en
Priority to EP16849533.1A priority patent/EP3352760A4/en
Priority to MX2018003292A priority patent/MX2018003292A/en
Priority to US15/761,499 priority patent/US11352426B2/en
Priority to CN201680054840.3A priority patent/CN108367004B/en
Priority to AU2016326449A priority patent/AU2016326449A1/en
Priority to UAA201803341A priority patent/UA126278C2/en
Priority to BR112018005573A priority patent/BR112018005573A2/en
Publication of WO2017053469A2 publication Critical patent/WO2017053469A2/en
Publication of WO2017053469A3 publication Critical patent/WO2017053469A3/en
Priority to PH12018500520A priority patent/PH12018500520A1/en
Priority to IL258202A priority patent/IL258202B2/en
Priority to ZA2018/02440A priority patent/ZA201802440B/en
Priority to CONC2018/0004094A priority patent/CO2018004094A2/en
Priority to HK18110709.1A priority patent/HK1251175A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Abstract

The present disclosure relates to protein molecules that specifically bind to CD3, which may have at least one humanized CD3-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD3 may have a second binding domain that binds to another target. In one embodiment, multispecific polypeptide molecules bind both tumor antigen-expressing cells and the CD3 subunit of a T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD3-binding poypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.
PCT/US2016/052942 2015-09-21 2016-09-21 Cd3 binding polypeptides WO2017053469A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
US15/761,499 US11352426B2 (en) 2015-09-21 2016-09-21 CD3 binding polypeptides
EA201890613A EA201890613A1 (en) 2015-09-21 2016-09-21 POLYPEPTIDES CONNECTING CD3
CA2999138A CA2999138A1 (en) 2015-09-21 2016-09-21 Cd3 binding polypeptides
KR1020187009336A KR20180053322A (en) 2015-09-21 2016-09-21 CD3 binding polypeptide
MYPI2018701059A MY197562A (en) 2015-09-21 2016-09-21 Cd3 binding polypeptides
EP16849533.1A EP3352760A4 (en) 2015-09-21 2016-09-21 Cd3 binding polypeptides
AU2016326449A AU2016326449A1 (en) 2015-09-21 2016-09-21 CD3 binding polypeptides
CN201680054840.3A CN108367004B (en) 2015-09-21 2016-09-21 CD3 binding polypeptides
MX2018003292A MX2018003292A (en) 2015-09-21 2016-09-21 Cd3 binding polypeptides.
JP2018513821A JP7002446B2 (en) 2015-09-21 2016-09-21 CD3 binding polypeptide
UAA201803341A UA126278C2 (en) 2015-09-21 2016-09-21 Cd3 binding polypeptides
BR112018005573A BR112018005573A2 (en) 2015-09-21 2016-09-21 "cd3 binding polypeptides"
PH12018500520A PH12018500520A1 (en) 2015-09-21 2018-03-09 Cd3 binding polypeptides
IL258202A IL258202B2 (en) 2015-09-21 2018-03-18 Cd3-binding polypeptides, method for their preparation, pharmaceutical compositions, nucleic acids, vectors and use of such polypeptides
ZA2018/02440A ZA201802440B (en) 2015-09-21 2018-04-13 Cd3 binding polypeptides
CONC2018/0004094A CO2018004094A2 (en) 2015-09-21 2018-04-17 Cd3 binding polypeptides
HK18110709.1A HK1251175A1 (en) 2015-09-21 2018-08-21 Cd3 binding polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562221190P 2015-09-21 2015-09-21
US62/221,190 2015-09-21

Publications (2)

Publication Number Publication Date
WO2017053469A2 WO2017053469A2 (en) 2017-03-30
WO2017053469A3 true WO2017053469A3 (en) 2017-05-04

Family

ID=58387225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/052942 WO2017053469A2 (en) 2015-09-21 2016-09-21 Cd3 binding polypeptides

Country Status (19)

Country Link
US (1) US11352426B2 (en)
EP (1) EP3352760A4 (en)
JP (1) JP7002446B2 (en)
KR (1) KR20180053322A (en)
CN (1) CN108367004B (en)
AU (1) AU2016326449A1 (en)
BR (1) BR112018005573A2 (en)
CA (1) CA2999138A1 (en)
CO (1) CO2018004094A2 (en)
EA (1) EA201890613A1 (en)
HK (2) HK1251175A1 (en)
IL (1) IL258202B2 (en)
MX (1) MX2018003292A (en)
MY (1) MY197562A (en)
PH (1) PH12018500520A1 (en)
SG (1) SG10202002577XA (en)
UA (1) UA126278C2 (en)
WO (1) WO2017053469A2 (en)
ZA (1) ZA201802440B (en)

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EA201891066A1 (en) 2015-10-30 2018-10-31 ЭнБиИ-ТЕРАПЬЮТИКС АГ ANTIBODIES TO ROR1
AU2017210327A1 (en) 2016-01-20 2018-08-09 Nbe-Therapeutics Ag ROR1 antibody compositions and related methods
BR112019005333A2 (en) 2016-09-21 2019-06-11 Aptevo Research And Development Llc cd123 binding proteins and related compositions and methods
EP3409322A1 (en) 2017-06-01 2018-12-05 F. Hoffmann-La Roche AG Treatment method
SG11202000503QA (en) 2017-07-20 2020-02-27 Aptevo Res & Development Llc Antigen binding proteins binding to 5t4 and 4-1bb and related compositions and methods
EP3655435A1 (en) * 2017-07-20 2020-05-27 NBE-Therapeutics AG Multispecific antibody product that binds to different ror1 epitopes
SG11202000846WA (en) 2017-08-07 2020-02-27 Nbe Therapeutics Ag Anthracycline-based antibody drug conjugates having high in vivo tolerability
AU2018334886A1 (en) 2017-09-22 2020-04-09 WuXi Biologics Ireland Limited Novel bispecific polypeptide complexes
MA50185A (en) * 2017-09-22 2020-07-29 Wuxi Biologics Ireland Ltd NEW BISPECIFIC CD3 / CD19 POLYPEPTID COMPLEXES
JP7337079B2 (en) 2018-02-15 2023-09-01 マクロジェニクス，インコーポレーテッド Mutant CD3 binding domains and their use in combination therapy for the treatment of disease
KR102353568B1 (en) 2018-11-14 2022-01-20 주식회사 헬릭스미스 Anti c-Met Antibody or Antigen binding fragment thereof with Improved Stability
CA3164385A1 (en) 2020-01-13 2021-07-22 Aptevo Research And Development Llc Formulations for protein therapeutics
KR20220140500A (en) * 2020-01-13 2022-10-18 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Methods and compositions for preventing adsorption of therapeutic proteins to components of drug delivery systems
IL300760A (en) * 2020-08-24 2023-04-01 Epimab Biotherapeutics Hk Ltd Anti-ror1 antibodies and related bispecific binding proteins
EP4255574A1 (en) * 2020-12-01 2023-10-11 Aptevo Research and Development LLC Heterodimeric psma and cd3-binding bispecific antibodies
KR20240024819A (en) 2021-05-21 2024-02-26 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Dosage regimen of protein therapeutics
WO2023288191A1 (en) * 2021-07-13 2023-01-19 University Of Washington Multiple de novo designed protein binding proteins
WO2023061419A1 (en) * 2021-10-12 2023-04-20 Concept To Medicine Biotech Co., Ltd. Anti-cd3 antibodies with cross-reactivity to human and cynomolgus proteins
WO2023169419A1 (en) * 2022-03-09 2023-09-14 Antengene (Hangzhou) Biologics Co., Ltd. Novel anti-cd3 antibodies and uses thereof

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