WO2017037871A1 - Measurement device - Google Patents

Measurement device Download PDF

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Publication number
WO2017037871A1
WO2017037871A1 PCT/JP2015/074859 JP2015074859W WO2017037871A1 WO 2017037871 A1 WO2017037871 A1 WO 2017037871A1 JP 2015074859 W JP2015074859 W JP 2015074859W WO 2017037871 A1 WO2017037871 A1 WO 2017037871A1
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WIPO (PCT)
Prior art keywords
wavelength
laser light
transmittance
sensitivity
wavelength dependency
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PCT/JP2015/074859
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French (fr)
Japanese (ja)
Inventor
育也 菊池
敦也 伊藤
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パイオニア株式会社
日機装株式会社
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Priority to PCT/JP2015/074859 priority Critical patent/WO2017037871A1/en
Publication of WO2017037871A1 publication Critical patent/WO2017037871A1/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59Transmissivity

Definitions

  • the present invention relates to a technical field of a measuring apparatus that acquires information on information to be measured using laser light.
  • Patent Document 1 discloses an apparatus that irradiates blood with light and measures blood concentration from the amount of transmitted light.
  • An object of the present invention is to provide a measuring apparatus that can suitably realize measurement using laser light.
  • a measuring apparatus for solving the above problems includes a laser light source that emits laser light toward a measurement target having a transmittance wavelength dependency in which the transmittance changes according to the wavelength of the laser light, and the wavelength of the laser light.
  • the detection wavelength has a sensitivity wavelength dependency that changes in response, and includes a detection unit that detects the laser light transmitted or reflected by the measurement target, and the sensitivity wavelength dependency of the detection unit is In the wavelength range of the laser beam, the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the measurement target is smaller than the transmittance wavelength dependency of the measurement target. Is set.
  • the measurement apparatus includes a laser light source that emits laser light toward a measurement target having a transmittance wavelength dependency in which the transmittance changes according to the wavelength of the laser light, and the wavelength of the laser light.
  • a detection unit that detects the laser beam transmitted or reflected on the object to be measured, and the sensitivity wavelength dependency of the detection unit In the light wavelength range, the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the measurement target is set to be smaller than the transmittance wavelength dependency of the measurement target. ing.
  • laser light is emitted from the laser light source toward the measurement target.
  • the laser light source include a Fabry-Perot (FP) laser light source and a distributed feedback (DFB) laser light source, but the type of the light source is not particularly limited in this embodiment.
  • the measurement target include blood and the like, but are not limited to those related to a living body, and may be gas, liquid, or solid.
  • the laser light emitted from the laser light source is detected or detected by the detection unit after being transmitted or reflected by the measurement target.
  • the detection unit is configured as a photodiode, for example, and configured to be able to detect the intensity of the laser beam.
  • the intensity of the laser light transmitted or reflected by the measurement target changes in accordance with the transmittance or reflectance of the measurement target. Therefore, if the intensity of the laser beam detected by the detection unit is used, information (for example, concentration) about the measurement target can be acquired.
  • the detection unit described above has a sensitivity wavelength dependency in which the detection sensitivity changes according to the wavelength of the laser light.
  • the sensitivity wavelength dependency of the detection unit is the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the measurement target in the wavelength range of the laser light. It is set to be smaller. That is, the detection unit has a sensitivity wavelength dependency that at least partially cancels the transmittance wavelength dependency of the measurement target.
  • the “transmission wavelength dependency” is a value indicating how much the ratio of the intensity of the laser beam incident on the object to be measured and the intensity of the emitted laser beam changes depending on the wavelength. This is a concept that also includes reflectance wavelength dependency in which the reflectance changes in accordance with the wavelength of.
  • the product of the sensitivity wavelength dependency and the transmittance wavelength dependency of the object to be measured is a value indicating the wavelength dependency obtained by combining the sensitivity wavelength dependency and the transmittance wavelength dependency. It shows how much the intensity of the emitted laser light changes depending on the wavelength in the measurement target and the detection unit. For this reason, the “product” here is not limited to a value obtained by simple multiplication.
  • the object to be measured has transmittance wavelength dependency
  • the intensity of the laser light emitted from the object to be measured changes.
  • the detection unit does not have sensitivity wavelength dependency, the intensity of the laser beam detected by the detection unit varies depending on the wavelength. That is, even for the same object to be measured, different measurement results are obtained due to the transmittance wavelength dependency of the object to be measured.
  • the transmittance wavelength dependency of the measurement target is reduced due to the sensitivity wavelength dependency of the detection unit.
  • the change in the intensity of the detection light due to the difference in the wavelength of the laser light can be reduced. Therefore, the deviation of the measurement result due to the difference in the wavelength of the laser beam can be reduced. Therefore, accurate measurement can be performed even when the wavelength of the laser light source fluctuates or even when the laser light source has individual differences.
  • the product of the sensitivity wavelength dependency and the transmittance wavelength dependency of the object to be measured is as small as possible (that is, a value close to a state having no wavelength dependency). ).
  • the measuring apparatus According to the measuring apparatus according to the present embodiment, it is possible to accurately measure even when the measurement target has transmittance wavelength dependency.
  • the laser light source is a Fabry-Perot laser light source.
  • Fabry-Perot laser light sources are considered to be inexpensive and highly reliable compared to different types of laser light sources such as distributed feedback laser light sources. For this reason, if a Fabry-Perot type laser light source is used, cost reduction and reliability improvement can be realized.
  • the Fabry-Perot type laser light source varies the wavelength of the laser beam to be irradiated due to temperature characteristics.
  • the transmittance wavelength dependency of the measurement target is at least partially offset by the sensitivity wavelength dependency of the detection unit. Therefore, even if the wavelength fluctuates, the deviation of the measurement result can be effectively suppressed.
  • the laser light source emits laser light in a wavelength range in which the transmittance wavelength dependency of the measurement target is linear.
  • the transmittance wavelength dependence of the measurement target is not linear when viewed in the entire wavelength range, it is linear when viewed only in the wavelength range of the laser light source. Can be considered. Therefore, it is possible to effectively cancel out the transmittance wavelength dependency of the object to be measured by using the detection unit whose sensitivity wavelength dependency is linear.
  • the detection unit whose sensitivity wavelength dependency is linear.
  • a detection unit that increases the intensity of the laser beam to be detected may be used.
  • the transmittance wavelength dependency of the measurement target can be regarded as linear, it is easy to select an appropriate detection unit, and the influence of the transmittance wavelength dependency of the measurement target is suitably reduced. be able to.
  • the laser light source emits laser light in a wavelength range that does not include a wavelength at which the detection sensitivity of the detection unit is maximized.
  • the detection sensitivity of the detection unit typically increases linearly until the detection sensitivity reaches a maximum according to the wavelength, and then decreases linearly. That is, the detection sensitivity increases or decreases linearly except for the wavelength vicinity where the detection sensitivity is maximum. Therefore, if the wavelength range of the laser light does not include a wavelength that maximizes the detection sensitivity of the detection unit, it can be considered that the detection sensitivity of the detection unit increases or decreases linearly. Therefore, it is possible to suitably cancel out the transmittance wavelength dependency of the measurement target using the sensitivity wavelength dependency of the detection unit.
  • the optical device further includes an optical element that is disposed on the optical path of the laser light and has the transmittance wavelength dependency, and the transmittance wavelength dependency of the optical element is In the wavelength range of the laser beam, the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the optical element and the measurement target is the sensitivity wavelength dependency of the detection unit and the It is set to be smaller than the product of the transmittance wavelength dependency of the object to be measured.
  • the optical element is arranged on the optical path of the laser beam. For this reason, the laser light emitted from the laser light source enters the detection unit via the measurement target and the optical element.
  • the optical element may be disposed between the laser light source and the measurement target, or may be disposed between the measurement target and the detection unit.
  • a plurality of optical elements may be arranged on the optical path of the laser beam.
  • the optical element described above has a transmittance wavelength dependency in which the transmittance changes in accordance with the wavelength of the laser light, similarly to the object to be measured.
  • the transmittance wavelength dependency of the optical element is the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the optical element and the object to be measured in the wavelength range of the laser light. It is set to be smaller than the product of the sensitivity wavelength dependency and the transmittance wavelength dependency of the object to be measured. That is, the optical element has a transmittance wavelength dependency that at least partially cancels the wavelength dependency of the object to be measured and the detection unit.
  • the influence of the wavelength dependency of the optical element on the wavelength of the optical element cannot be reduced sufficiently by the sensitivity wavelength dependency of the detector alone.
  • the influence of wavelength dependency on the entire apparatus can be further reduced. Therefore, It is possible to more effectively suppress the deviation in the measurement result due to the difference in the wavelength of the laser light.
  • FIG. 1 is a schematic configuration diagram illustrating the overall configuration of the measurement apparatus according to the embodiment.
  • the measuring apparatus includes a laser light source 110 and a detector 120.
  • the laser light source 110 is configured as a Fabry-Perot laser light source, for example, and irradiates blood 500 flowing through the tube 510 with laser light in a predetermined wavelength range. Blood 500 is a specific example of “object to be measured”.
  • the detector 120 is configured as a photodiode, for example, and detects laser light emitted from the laser light source 110 and transmitted through the optical element 200 and the blood 500.
  • the detector 120 is configured to output a detection signal corresponding to the intensity of the detected laser beam, for example, to an analysis device (not shown).
  • the detector 120 has a sensitivity wavelength dependency in which the detection sensitivity changes according to the wavelength of the incident laser light.
  • the detector 120 is a specific example of “detection unit”.
  • FIG. 2 is a graph showing the wavelength dependency of the absorbance of blood
  • FIG. 3 is a graph (part 1) showing the sensitivity wavelength dependency of the detector
  • FIG. 4 is a graph showing the wavelength dependency of the water-soluble processing oil
  • FIG. 5 is a graph (No. 2) showing the sensitivity wavelength dependency of the detector.
  • the absorbance (transmittance) of blood 500 varies according to the wavelength of the incident laser light.
  • HbO 2 and Hb the absorbance of HbO 2 and Hb, it will be described here HbO 2, measured as blood concentration in the example dialysis.
  • the absorbance of HbO 2 varies while repeatedly increasing and decreasing in the wavelength range of 650 nm to 1200 nm. Therefore, when the wavelength of the laser light varies, the intensity of the laser light emitted from the blood 500 changes. Further, when there is a difference in the wavelength of the laser light emitted due to individual differences in the laser light source 110, even when the same type of laser light source 110 is used, the laser light emitted from the blood 500 due to the difference in wavelength. Changes in the strength. Therefore, if the detector 120 does not have sensitivity wavelength dependency, the intensity of the detected laser light varies according to the wavelength. That is, even if the same object to be measured is used, different measurement results are obtained due to the different wavelengths of the laser light.
  • the present embodiment aims to reduce the above-described transmittance wavelength dependency by making the detector 120 have sensitivity wavelength dependency.
  • the transmittance wavelength dependency of blood 500 is at least partially offset by the sensitivity wavelength dependency of detector 120.
  • the transmittance wavelength dependency of HbO 2 is preferably linear with respect to the wavelength. Therefore, in this embodiment, the wavelength range of the laser light emitted by the laser light source 110 is set to a specific wavelength range so that the transmittance wavelength dependency of HbO 2 can be regarded as substantially linear.
  • the laser light source 110 according to the present embodiment irradiates laser light having a wavelength range of 750 nm to 900 nm in which the absorbance of HbO 2 increases linearly with an increase in wavelength.
  • a detector 120 whose sensitivity increases as the wavelength becomes longer may be used. In this way, when the wavelength of the laser beam is increased, the intensity of the laser beam that passes through the blood 500 is decreased, whereas the detection sensitivity of the detector 120 is increased (that is, the detected light amount is increased). ). Therefore, fluctuations in the intensity of the laser light according to the wavelength can be reduced, and deviations in measurement results can be suppressed.
  • the object to be measured is not limited to blood 500, and may be, for example, a water-soluble processing oil used in industrial applications.
  • the wavelength range of the laser light emitted by the laser light source 110 is 630 nm to 680 nm
  • the transmittance wavelength dependency of the water-soluble processing oil can be regarded as linear.
  • the laser light source 110 that can irradiate a laser beam in the wavelength range of 630 nm to 680 nm include a laser light source used for reading a DVD. For this reason, when utilizing the said wavelength range, the cheap component generally spread can be utilized and cost reduction can be aimed at.
  • a detector 120 whose detection sensitivity decreases as the wavelength becomes longer may be used.
  • the intensity of the laser beam that passes through the water-soluble processing oil increases, whereas the detection sensitivity of the detector 120 decreases (that is, the detected light amount decreases). Smaller). Therefore, fluctuations in the intensity of the laser light according to the wavelength can be reduced, and deviations in measurement results can be suppressed.
  • FIG. 6 is a graph showing the wavelength dependence of the normalized transmitted light amount.
  • FIG. 7 is a graph showing the sensitivity wavelength dependency of the detector together with the wavelength range of the laser beam.
  • FIG. 8 is a graph showing the combined transmitted light rate and the sensitivity wavelength dependency of the detector, and
  • FIG. 9 is a graph showing the wavelength dependency of the normalized detected light amount for each detector.
  • the wavelength range of the laser light source 110 is 850 ⁇ 15 nm
  • the wavelength with the maximum detection sensitivity is included in the wavelength range of 850 ⁇ 15 nm of the laser light source 110.
  • the wavelength range of the laser light source 110 that is 850 ⁇ 15 nm does not include the wavelength that maximizes the detection sensitivity. If only the detection sensitivity is taken into consideration, the detector A having a high detection sensitivity in the wavelength range of the laser light source 110 may be used. In order to reduce the transmittance wavelength dependency of the measurement target, the sensitivity Trends in wavelength dependence should also be considered.
  • the detector A has a wavelength dependence on the sensitivity wavelength because the wavelength range of the laser light source 110 includes the wavelength with the maximum detection sensitivity.
  • the detector B does not include the wavelength at which the detection sensitivity is maximized in the wavelength range of the laser light source 110, the sensitivity wavelength dependency is linear. Further, the sensitivity wavelength dependency of the detector B has a tendency that is almost opposite to the transmittance wavelength dependency of the measurement target.
  • the wavelength dependency of the transmittance of the linear object to be measured cannot be offset appropriately because the sensitivity wavelength dependency is piled up.
  • the amount of light detected when the detector A is used varies depending on the wavelength of the laser light. Specifically, when the detector A is used, the detected light quantity decreases as the wavelength of the laser light increases.
  • the detector B since the sensitivity wavelength dependency is linear, the wavelength dependency of the transmittance of the measurement target can be offset appropriately. As a result, the amount of light detected when the detector B is used hardly changes even if the wavelength of the laser light changes.
  • the detected light amount is standardized with the maximum value being “1”.
  • the wavelength range of the laser light source 110 includes the wavelength with the maximum detection sensitivity.
  • the one that is not (ie detector B) should be used.
  • FIGS. 10 to 13 are schematic configuration diagrams showing the overall configuration of the measuring apparatus according to the first to fourth modifications, respectively.
  • an optical element 200 is disposed between the laser light source 110 and the blood 500.
  • the optical element 200 has a transmittance wavelength dependency in which the transmittance changes according to the wavelength of the laser light.
  • the optical element 200 is configured, for example, as an optical filter using a dielectric multilayer film, or a resin or the like mixed with a specific wavelength light absorbing material such as an infrared blocking film and an ultraviolet blocking film.
  • the optical element 200 is disposed between the blood 500 and the detector 120. For this reason, the laser beam after passing through the blood 500 is incident on the optical element 200 according to the second modification.
  • the effect obtained by the measuring apparatus according to the modified example described later does not change. That is, as long as the optical element 200 is disposed on the optical path between the laser light source 110 and the detector 120, the position of the optical element 200 is not particularly limited.
  • a collimator lens 150 for making laser light parallel light is disposed between the laser light source 110 and the blood 500.
  • the collimator lens 150 is coated to give wavelength dependency. Therefore, in the second modification, the collimator lens 150 functions as the optical element 200. In this manner, an existing member can be made to function as the optical element 200 without providing the optical element 200 separately.
  • a mold member 125 for protecting the detector 120 is provided on the surface of the detector 120 (more specifically, the surface on which the laser light is incident). ing.
  • the mold member 125 is mixed with a material that absorbs laser light having a specific wavelength (for example, glass powder doped with an organic dye substance or a wavelength selective substance (CdS or the like)). Therefore, in the fourth modification, the mold member 125 of the detector 120 functions as the optical element 200.
  • the collimator lens 150 may function as the optical element 200 in addition to the mold member 125.
  • a plurality of optical elements 200 may be arranged on the optical path of the laser light.
  • FIG. 14 is a graph showing the wavelength dependence of the object to be measured, the detector, and the optical element.
  • FIG. 15 is a graph showing the wavelength dependence of the standardized detected light amount divided by the presence or absence of an optical element.
  • the detector B is used among the detectors described with reference to FIGS.
  • the transmission wavelength dependency of the measurement target may not be sufficiently reduced only by the detection sensitivity of the detector 120.
  • the sensitivity wavelength dependency of the detector 120 may be changed to a larger one, but it can be dealt with by using the optical element 200 in combination.
  • the object to be measured has a transmittance wavelength dependency in which the transmittance decreases relatively rapidly as the wavelength increases.
  • the detector B has a sensitivity wavelength dependency in which the detection sensitivity increases relatively gradually as the wavelength increases.
  • the optical element 200 also has a sensitivity wavelength dependency that the detection sensitivity increases as the wavelength increases.
  • the detected light amount changes according to the wavelength because the sensitivity wavelength dependency of the detector B is small. Specifically, the detected light amount decreases as the wavelength increases.
  • the optical element 200 when the optical element 200 is added, the transmittance wavelength dependency of the object to be measured can be canceled by both the detector B and the optical element 200, so that the detected light amount hardly changes even if the wavelength varies. .
  • by adding the optical element 200 it is possible to more suitably reduce the transmittance wavelength dependency of the measurement target.
  • the measuring apparatus According to the measuring apparatus according to the present embodiment, it is possible to reduce the transmittance wavelength dependency of the measurement target, and therefore it is possible to realize a suitable measurement independent of the wavelength of the laser beam. .

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Abstract

This measurement device comprises: a laser light source (110) that emits a laser light toward an object (500) to be measured, said object exhibiting wavelength-dependent transmittance such that the transmittance varies according to the wavelength of the laser light; and a detection unit (120) that detects the laser light transmitted through or reflected off the object to be measured, and exhibits wavelength-dependent sensitivity such that the detection sensitivity varies according to the wavelength of the laser light. The wavelength dependence of the sensitivity of the detection unit is set so that, within the range of wavelengths of the laser light, the product of the wavelength dependence of the sensitivity of the detection unit and the wavelength dependence of the transmittance of the object to be measured is smaller than the wavelength dependence of the transmittance of the object to be measured. As a result, discrepancies in the measurement results caused by fluctuations of the laser light wavelength can be minimized.

Description

測定装置measuring device
 本発明は、レーザ光を利用して被測定対象情報に関する情報を取得する測定装置の技術分野に関する。 The present invention relates to a technical field of a measuring apparatus that acquires information on information to be measured using laser light.
 この種の装置として、例えば被測定対象に光を照射すると共に、透過又は反射された光を検出して被測定対象に関する情報を取得する装置が知られている。例えば特許文献1では、血液に対して光を照射して、その透過光量から血中濃度を測定するという装置が開示されている。 As this type of device, for example, a device that irradiates light to be measured and detects information transmitted or reflected to acquire information on the measured object is known. For example, Patent Document 1 discloses an apparatus that irradiates blood with light and measures blood concentration from the amount of transmitted light.
特開平11-226119号公報Japanese Patent Laid-Open No. 11-226119
 しかしながら、血液は、光の波長に依存して透過量が変化する透過量波長依存性を有している。このため、仮に照射する光の波長が変化すると透過光量も変化することになる。よって、透過光量から血中濃度を測定する特許文献1のような技術では、照射する光の波長が変化してしまうと、正確な血中濃度を測定することができなくなるという技術的問題点が生ずる。 However, blood has a transmission wavelength dependency in which the transmission amount changes depending on the wavelength of light. For this reason, if the wavelength of the light to irradiate changes, the amount of transmitted light also changes. Therefore, in the technique such as Patent Document 1 that measures the blood concentration from the amount of transmitted light, there is a technical problem that the accurate blood concentration cannot be measured if the wavelength of the irradiated light changes. Arise.
 なお、波長が変化しない光源を利用すれば透過光量の変化も抑制できるが、その場合にはコストが増加してしまう等の新たな技術的問題点が生じ得る。 It should be noted that if a light source whose wavelength does not change is used, a change in the amount of transmitted light can be suppressed, but in that case, a new technical problem such as an increase in cost may occur.
 本発明が解決しようとする課題には上記のようなものが一例として挙げられる。本発明は、レーザ光を利用した測定を好適に実現可能な測定装置を提供することを課題とする。 Examples of problems to be solved by the present invention include the above. An object of the present invention is to provide a measuring apparatus that can suitably realize measurement using laser light.
 上記課題を解決するための測定装置は、レーザ光の波長に応じて透過率が変化する透過率波長依存性を有する被測定対象に向けてレーザ光を発するレーザ光源と、前記レーザ光の波長に応じて検出感度が変化する感度波長依存性を有しており、前記被測定対象において透過又は反射された前記レーザ光を検出する検出部とを備え、前記検出部の前記感度波長依存性は、前記レーザ光の波長範囲において、前記検出部の感度波長依存性と前記被測定対象の前記透過率波長依存性との積が、前記被測定対象の前記透過率波長依存性よりも小さくなるように設定されている。 A measuring apparatus for solving the above problems includes a laser light source that emits laser light toward a measurement target having a transmittance wavelength dependency in which the transmittance changes according to the wavelength of the laser light, and the wavelength of the laser light. The detection wavelength has a sensitivity wavelength dependency that changes in response, and includes a detection unit that detects the laser light transmitted or reflected by the measurement target, and the sensitivity wavelength dependency of the detection unit is In the wavelength range of the laser beam, the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the measurement target is smaller than the transmittance wavelength dependency of the measurement target. Is set.
実施例に係る測定装置の全体構成を示す概略構成図である。It is a schematic block diagram which shows the whole structure of the measuring apparatus which concerns on an Example. 血液の吸光度の波長依存性を示すグラフである。It is a graph which shows the wavelength dependence of the light absorbency of blood. 検出器の感度波長依存性を示すグラフ(その1)である。It is a graph (the 1) which shows the sensitivity wavelength dependence of a detector. 水溶加工油剤の波長依存性を示すグラフである。It is a graph which shows the wavelength dependence of a water-soluble processing oil agent. 検出器の感度波長依存性を示すグラフ(その2)である。It is a graph (the 2) which shows the sensitivity wavelength dependence of a detector. 規格化した検出光量の波長依存性を示すグラフである。It is a graph which shows the wavelength dependence of the standardized detection light quantity. 検出器の感度波長依存性をレーザ光の波長範囲と共に示すグラフである。It is a graph which shows the sensitivity wavelength dependence of a detector with the wavelength range of a laser beam. 合成透過光率及び検出器の感度波長依存性を示すグラフである。It is a graph which shows the synthetic transmittance and the sensitivity wavelength dependence of a detector. 規格化した検出光量の波長依存性を検出器毎に示すグラフである。It is a graph which shows the wavelength dependence of the standardized detection light quantity for every detector. 第1変形例に係る測定装置の全体構成を示す概略構成図である。It is a schematic block diagram which shows the whole structure of the measuring apparatus which concerns on a 1st modification. 第2変形例に係る測定装置の全体構成を示す概略構成図である。It is a schematic block diagram which shows the whole structure of the measuring apparatus which concerns on a 2nd modification. 第3変形例に係る測定装置の全体構成を示す概略構成図である。It is a schematic block diagram which shows the whole structure of the measuring apparatus which concerns on a 3rd modification. 第4変形例に係る測定装置の全体構成を示す概略構成図である。It is a schematic block diagram which shows the whole structure of the measuring apparatus which concerns on a 4th modification. 被測定対象、検出器及び光学素子の波長依存性を示すグラフである。It is a graph which shows the wavelength dependence of a to-be-measured object, a detector, and an optical element. 規格化した検出光量の波長依存性を光学素子の有無で分けて示すグラフである。It is a graph which shows the wavelength dependence of the standardized detection light quantity separately according to the presence or absence of an optical element.
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 本実施形態に係る測定装置は、レーザ光の波長に応じて透過率が変化する透過率波長依存性を有する被測定対象に向けてレーザ光を発するレーザ光源と、前記レーザ光の波長に応じて検出感度が変化する感度波長依存性を有しており、前記被測定対象において透過又は反射された前記レーザ光を検出する検出部とを備え、前記検出部の前記感度波長依存性は、前記レーザ光の波長範囲において、前記検出部の感度波長依存性と前記被測定対象の前記透過率波長依存性との積が、前記被測定対象の前記透過率波長依存性よりも小さくなるように設定されている。
<1>
The measurement apparatus according to the present embodiment includes a laser light source that emits laser light toward a measurement target having a transmittance wavelength dependency in which the transmittance changes according to the wavelength of the laser light, and the wavelength of the laser light. A detection unit that detects the laser beam transmitted or reflected on the object to be measured, and the sensitivity wavelength dependency of the detection unit In the light wavelength range, the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the measurement target is set to be smaller than the transmittance wavelength dependency of the measurement target. ing.
 本実施形態に係る測定装置の動作時には、レーザ光源から被測定対象に向けてレーザ光が照射される。なお、レーザ光源の具体例としては、ファブリペロー型(FP)レーザ光源や分布帰還型(DFB)レーザ光源等が挙げられるが、本実施形態では光源のタイプが特に限定される訳ではない。また、被測定対象としては、例えば血液等が挙げられるが、生体に関するものに限られる訳ではなく、また気体、液体、固体の別も問わない。 During the operation of the measuring apparatus according to the present embodiment, laser light is emitted from the laser light source toward the measurement target. Specific examples of the laser light source include a Fabry-Perot (FP) laser light source and a distributed feedback (DFB) laser light source, but the type of the light source is not particularly limited in this embodiment. Further, examples of the measurement target include blood and the like, but are not limited to those related to a living body, and may be gas, liquid, or solid.
 レーザ光源から照射されたレーザ光は、被測定対象において透過又は反射された後に、検出部において検出される。検出部は、例えばフォトダイオードとして構成されており、レーザ光の強度を検出可能に構成されている。ここで、被測定対象において透過又は反射されたレーザ光は、被測定対象の透過率又は反射率に応じて強度が変化している。よって、検出部において検出されたレーザ光の強度を利用すれば、被測定対象に関する情報(例えば、濃度等)を取得することができる。 The laser light emitted from the laser light source is detected or detected by the detection unit after being transmitted or reflected by the measurement target. The detection unit is configured as a photodiode, for example, and configured to be able to detect the intensity of the laser beam. Here, the intensity of the laser light transmitted or reflected by the measurement target changes in accordance with the transmittance or reflectance of the measurement target. Therefore, if the intensity of the laser beam detected by the detection unit is used, information (for example, concentration) about the measurement target can be acquired.
 本実施形態では特に、上述した検出部がレーザ光の波長に応じて検出感度が変化する感度波長依存性を有している。そして特に、検出部の感度波長依存性は、レーザ光の波長範囲において、検出部の感度波長依存性と被測定対象の透過率波長依存性との積が、被測定対象の透過率波長依存性よりも小さくなるように設定されている。即ち、検出部は、被測定対象の透過率波長依存性を少なくとも部分的に相殺するような感度波長依存性を有している。 In the present embodiment, in particular, the detection unit described above has a sensitivity wavelength dependency in which the detection sensitivity changes according to the wavelength of the laser light. In particular, the sensitivity wavelength dependency of the detection unit is the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the measurement target in the wavelength range of the laser light. It is set to be smaller. That is, the detection unit has a sensitivity wavelength dependency that at least partially cancels the transmittance wavelength dependency of the measurement target.
 なお、「透過率波長依存性」は、被測定対象に入射したレーザ光の強度と出射するレーザ光の強度との比が、波長に応じてどの程度変化するのかを示す値であり、レーザ光の波長に応じて反射率が変化する反射率波長依存性も含む概念である。また、「感度波長依存性と被測定対象の透過率波長依存性との積」とは、感度波長依存性と透過率波長依存性とを合成した波長依存性を示す値であり、レーザ光源から出射されたレーザ光の強度が、被測定対象及び検出部において、波長に応じてどの程度変化するのかを示すものである。このため、ここでの「積」とは、単純な乗算によって求められる値に限定される訳ではない。 The “transmission wavelength dependency” is a value indicating how much the ratio of the intensity of the laser beam incident on the object to be measured and the intensity of the emitted laser beam changes depending on the wavelength. This is a concept that also includes reflectance wavelength dependency in which the reflectance changes in accordance with the wavelength of. The product of the sensitivity wavelength dependency and the transmittance wavelength dependency of the object to be measured is a value indicating the wavelength dependency obtained by combining the sensitivity wavelength dependency and the transmittance wavelength dependency. It shows how much the intensity of the emitted laser light changes depending on the wavelength in the measurement target and the detection unit. For this reason, the “product” here is not limited to a value obtained by simple multiplication.
 被測定対象が透過率波長依存性を有している場合、レーザ光源から照射されるレーザ光の波長が変動してしまうと、被測定対象から出射されるレーザ光の強度に変化が生ずる。また、レーザ光源の個体差によって出射されるレーザ光の波長に違いが生じるような場合、同種のレーザ光源を使用した場合でも、波長の違いに起因して被測定対象から出射されるレーザ光の強度に変化が生ずる。よって、仮に検出部が感度波長依存性を有していないとすると、検出部において検出されるレーザ光の強度が波長に応じて変動することになる。即ち、同一の被測定対象であっても、被測定対象の透過率波長依存性に起因して異なる測定結果が得られてしまう。 When the object to be measured has transmittance wavelength dependency, if the wavelength of the laser light emitted from the laser light source fluctuates, the intensity of the laser light emitted from the object to be measured changes. Also, when there is a difference in the wavelength of the laser light emitted due to individual differences in the laser light source, even when the same type of laser light source is used, the laser light emitted from the measurement target due to the difference in wavelength There is a change in strength. Therefore, if the detection unit does not have sensitivity wavelength dependency, the intensity of the laser beam detected by the detection unit varies depending on the wavelength. That is, even for the same object to be measured, different measurement results are obtained due to the transmittance wavelength dependency of the object to be measured.
 しかるに本実施形態では、上述したように、検出部の感度波長依存性により被測定対象の透過率波長依存性が小さくされる。この結果、レーザ光の波長の違いに起因する検出光の強度変化を小さくできる。よって、レーザ光の波長の違いに起因する測定結果のずれを小さくすることができる。従って、レーザ光源の波長が変動するような場合、或いはレーザ光源に個体差がある場合であっても、正確な測定を行うことが可能となる。なお、測定結果のずれを効果的に抑制するためには、感度波長依存性と被測定対象の透過率波長依存性との積が、できるだけ小さい値(即ち、波長依存性がない状態に近い値)とされることが好ましい。 However, in this embodiment, as described above, the transmittance wavelength dependency of the measurement target is reduced due to the sensitivity wavelength dependency of the detection unit. As a result, the change in the intensity of the detection light due to the difference in the wavelength of the laser light can be reduced. Therefore, the deviation of the measurement result due to the difference in the wavelength of the laser beam can be reduced. Therefore, accurate measurement can be performed even when the wavelength of the laser light source fluctuates or even when the laser light source has individual differences. In order to effectively suppress the deviation of the measurement result, the product of the sensitivity wavelength dependency and the transmittance wavelength dependency of the object to be measured is as small as possible (that is, a value close to a state having no wavelength dependency). ).
 以上説明したように、本実施形態に係る測定装置によれば、被測定対象が透過率波長依存性を有する場合であっても、正確に測定が行える。 As described above, according to the measuring apparatus according to the present embodiment, it is possible to accurately measure even when the measurement target has transmittance wavelength dependency.
 <2>
 本実施形態に係る測定装置の一態様では、前記レーザ光源は、ファブリペロー型レーザ光源である。
<2>
In one aspect of the measuring apparatus according to this embodiment, the laser light source is a Fabry-Perot laser light source.
 ファブリペロー型レーザ光源は、例えば分布帰還型レーザ光源等の異なるタイプのレーザ光源と比較して、安価且つ信頼性が高いとされている。このため、ファブリペロー型レオーザ光源を利用すれば、コストの低減及び信頼性の向上を実現できる。 Fabry-Perot laser light sources are considered to be inexpensive and highly reliable compared to different types of laser light sources such as distributed feedback laser light sources. For this reason, if a Fabry-Perot type laser light source is used, cost reduction and reliability improvement can be realized.
 一方で、ファブリペロー型レーザ光源は、温度特性により照射するレーザ光の波長が変動することが知られている。しかしながら本態様では、検出部の感度波長依存性により被測定対象の透過率波長依存性が少なくとも部分的に相殺される。よって、波長が変動した場合であっても、測定結果のずれを効果的に抑制することができる。 On the other hand, it is known that the Fabry-Perot type laser light source varies the wavelength of the laser beam to be irradiated due to temperature characteristics. However, in this aspect, the transmittance wavelength dependency of the measurement target is at least partially offset by the sensitivity wavelength dependency of the detection unit. Therefore, even if the wavelength fluctuates, the deviation of the measurement result can be effectively suppressed.
 <3>
 本実施形態に係る測定装置の他の態様では、前記レーザ光源は、前記被測定対象の前記透過率波長依存性が直線的である波長範囲のレーザ光を発する。
<3>
In another aspect of the measuring apparatus according to the present embodiment, the laser light source emits laser light in a wavelength range in which the transmittance wavelength dependency of the measurement target is linear.
 この態様によれば、被測定対象の透過率波長依存性が全ての波長範囲で見た場合に直線的でない場合であっても、レーザ光源の波長範囲だけで見た場合には直線的であるとみなせる。よって、感度波長依存性が直線的である検出部を用いて、被測定対象の透過率波長依存性を効果的に相殺できる。具体的には、例えば被測定対象に入射するレーザ光の波長が大きくなる程、被測定対象から出射されるレーザ光の強度が小さくなる場合には、入射するレーザ光の波長が大きくなる程、検出されるレーザ光の強度が大きくなるような検出部を利用すればよい。 According to this aspect, even if the transmittance wavelength dependence of the measurement target is not linear when viewed in the entire wavelength range, it is linear when viewed only in the wavelength range of the laser light source. Can be considered. Therefore, it is possible to effectively cancel out the transmittance wavelength dependency of the object to be measured by using the detection unit whose sensitivity wavelength dependency is linear. Specifically, for example, when the wavelength of the laser light emitted from the measurement target decreases as the wavelength of the laser light incident on the measurement target increases, the greater the wavelength of the incident laser light, A detection unit that increases the intensity of the laser beam to be detected may be used.
 以上のように、被測定対象の透過率波長依存性を直線的とみなすことができれば、適切な検出部の選択が容易であり、被測定対象の透過率波長依存性の影響を好適に小さくすることができる。 As described above, if the transmittance wavelength dependency of the measurement target can be regarded as linear, it is easy to select an appropriate detection unit, and the influence of the transmittance wavelength dependency of the measurement target is suitably reduced. be able to.
 <4>
 本実施形態に係る測定装置の他の態様では、前記レーザ光源は、前記検出部の検出感度が最大となる波長を含まない波長範囲のレーザ光を発する。
<4>
In another aspect of the measuring apparatus according to this embodiment, the laser light source emits laser light in a wavelength range that does not include a wavelength at which the detection sensitivity of the detection unit is maximized.
 検出部の検出感度は、典型的には、波長に応じて検出感度が最大となるまで直線的に増加し、その後は直線的に減少する。即ち、検出感度が最大となる波長周辺を除けば、検出感度は直線的に増加又は減少する。従って、レーザ光の波長範囲が、検出部の検出感度が最大となる波長を含まないものであれば、検出部の検出感度は直線的に増加又は減少するとみなせる。よって、検出部の感度波長依存性を利用して、被測定対象が有する透過率波長依存性を好適に相殺することが可能となる。 The detection sensitivity of the detection unit typically increases linearly until the detection sensitivity reaches a maximum according to the wavelength, and then decreases linearly. That is, the detection sensitivity increases or decreases linearly except for the wavelength vicinity where the detection sensitivity is maximum. Therefore, if the wavelength range of the laser light does not include a wavelength that maximizes the detection sensitivity of the detection unit, it can be considered that the detection sensitivity of the detection unit increases or decreases linearly. Therefore, it is possible to suitably cancel out the transmittance wavelength dependency of the measurement target using the sensitivity wavelength dependency of the detection unit.
 <5>
 本実施形態に係る測定装置の他の態様では、前記レーザ光の光路上に配置されており、前記透過率波長依存性を有する光学素子を更に備え、前記光学素子の前記透過率波長依存性は、前記レーザ光の波長範囲において、前記検出部の感度波長依存性と前記光学素子及び前記被測定対象を合わせた前記透過率波長依存性との積が、前記検出部の感度波長依存性と前記被測定対象の前記透過率波長依存性との積よりも小さくなるように設定されている。
<5>
In another aspect of the measuring apparatus according to the present embodiment, the optical device further includes an optical element that is disposed on the optical path of the laser light and has the transmittance wavelength dependency, and the transmittance wavelength dependency of the optical element is In the wavelength range of the laser beam, the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the optical element and the measurement target is the sensitivity wavelength dependency of the detection unit and the It is set to be smaller than the product of the transmittance wavelength dependency of the object to be measured.
 この態様によれば、レーザ光の光路上に光学素子が配置されている。このため、レーザ光源から照射されたレーザ光は、被測定対象及び光学素子を経由して、検出部に入射されることになる。なお、光学素子は、レーザ光源と被測定対象との間に配置されてもよいし、被測定対象と検出部との間に配置されてもよい。また、レーザ光の光路上には、複数の光学素子が配置されていても構わない。 According to this aspect, the optical element is arranged on the optical path of the laser beam. For this reason, the laser light emitted from the laser light source enters the detection unit via the measurement target and the optical element. The optical element may be disposed between the laser light source and the measurement target, or may be disposed between the measurement target and the detection unit. A plurality of optical elements may be arranged on the optical path of the laser beam.
 上述した光学素子は、被測定対象と同様に、レーザ光の波長に応じて透過率が変化する透過率波長依存性を有している。そして特に、光学素子の透過率波長依存性は、レーザ光の波長範囲において、検出部の感度波長依存性と光学素子及び被測定対象を合わせた透過率波長依存性との積が、検出部の感度波長依存性と被測定対象の透過率波長依存性との積よりも小さくなるように設定されている。即ち、光学素子は、被測定対象及び検出部を合わせた波長依存性を少なくとも部分的に相殺するような透過率波長依存性を有している。 The optical element described above has a transmittance wavelength dependency in which the transmittance changes in accordance with the wavelength of the laser light, similarly to the object to be measured. In particular, the transmittance wavelength dependency of the optical element is the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the optical element and the object to be measured in the wavelength range of the laser light. It is set to be smaller than the product of the sensitivity wavelength dependency and the transmittance wavelength dependency of the object to be measured. That is, the optical element has a transmittance wavelength dependency that at least partially cancels the wavelength dependency of the object to be measured and the detection unit.
 光学素子を配置すれば、検出部の感度波長依存性だけでは被測定対象の透過率波長依存性の影響を十分に小さくすることができない場合であっても、光学素子の透過率波長依存性により、装置全体としての波長依存性の影響を更に小さくすることができる。従って、
レーザ光の波長の違いに起因する測定結果のずれを一層効果的に抑制することが可能である。
If the optical element is arranged, the influence of the wavelength dependency of the optical element on the wavelength of the optical element cannot be reduced sufficiently by the sensitivity wavelength dependency of the detector alone. Thus, the influence of wavelength dependency on the entire apparatus can be further reduced. Therefore,
It is possible to more effectively suppress the deviation in the measurement result due to the difference in the wavelength of the laser light.
 本実施形態に係る測定装置の作用及び他の利得については、以下に示す実施例において、より詳細に説明する。 The operation and other gains of the measuring apparatus according to this embodiment will be described in more detail in the following examples.
 以下では、図面を参照して測定装置の実施例について詳細に説明する。 Hereinafter, embodiments of the measuring apparatus will be described in detail with reference to the drawings.
 <装置構成>
 先ず、図1を参照して、本実施例に係る測定装置の構成について説明する。ここに図1は、実施例に係る測定装置の全体構成を示す概略構成図である。
<Device configuration>
First, the configuration of the measurement apparatus according to the present embodiment will be described with reference to FIG. FIG. 1 is a schematic configuration diagram illustrating the overall configuration of the measurement apparatus according to the embodiment.
 図1において、本実施例に係る測定装置は、レーザ光源110と、検出器120とを備えて構成されている。 In FIG. 1, the measuring apparatus according to the present embodiment includes a laser light source 110 and a detector 120.
 レーザ光源110は、例えばファブリペロー型レーザ光源として構成されており、所定の波長範囲のレーザ光を、チューブ510を流れる血液500に照射する。なお、血液500は「被測定対象」の一具体例である。 The laser light source 110 is configured as a Fabry-Perot laser light source, for example, and irradiates blood 500 flowing through the tube 510 with laser light in a predetermined wavelength range. Blood 500 is a specific example of “object to be measured”.
 検出器120は、例えばフォトダイオードとして構成されており、レーザ光源110から照射され、光学素子200及び血液500を透過したレーザ光を検出する。検出器120は、例えば図示せぬ解析装置等に、検出したレーザ光の強度に応じた検出信号を出力可能に構成されている。また検出器120は、入射するレーザ光の波長に応じて検出感度が変化する感度波長依存性を有している。なお、検出器120は「検出部」の一具体例である。 The detector 120 is configured as a photodiode, for example, and detects laser light emitted from the laser light source 110 and transmitted through the optical element 200 and the blood 500. The detector 120 is configured to output a detection signal corresponding to the intensity of the detected laser beam, for example, to an analysis device (not shown). The detector 120 has a sensitivity wavelength dependency in which the detection sensitivity changes according to the wavelength of the incident laser light. The detector 120 is a specific example of “detection unit”.
 <検出器の感度波長依存性>
 次に、図2から図5を参照して、上述した光学素子200の透過率波長依存性について詳細に説明する。ここに図2は、血液の吸光度の波長依存性を示すグラフであり、図3は、検出器の感度波長依存性を示すグラフ(その1)である。また図4は、水溶加工油剤の波長依存性を示すグラフであり、図5は、検出器の感度波長依存性を示すグラフ(その2)である。
<Detector wavelength dependence>
Next, the transmittance wavelength dependency of the optical element 200 described above will be described in detail with reference to FIGS. FIG. 2 is a graph showing the wavelength dependency of the absorbance of blood, and FIG. 3 is a graph (part 1) showing the sensitivity wavelength dependency of the detector. FIG. 4 is a graph showing the wavelength dependency of the water-soluble processing oil, and FIG. 5 is a graph (No. 2) showing the sensitivity wavelength dependency of the detector.
 図2において、血液500は、入射されるレーザ光の波長に応じて吸光度(透過率)が変動する。なお、図ではHbO及びHbの吸光度を示しているが、ここでは例えば人工透析中の血中濃度として測定されるHbOについて説明する。 In FIG. 2, the absorbance (transmittance) of blood 500 varies according to the wavelength of the incident laser light. Although the figure shows the absorbance of HbO 2 and Hb, it will be described here HbO 2, measured as blood concentration in the example dialysis.
 HbOの吸光度は、波長650nm~1200nmの範囲において増加と減少を繰り返しながら変動する。よって、レーザ光の波長が変動すると、血液500から出射されるレーザ光の強度に変化が生ずる。また、レーザ光源110の個体差によって出射されるレーザ光の波長に違いが生じるような場合、同種のレーザ光源110を使用した場合でも、波長の違いに起因して血液500から出射されるレーザ光の強度に変化が生ずる。よって、仮に検出器120が感度波長依存性を有していないとすると、検出されるレーザ光の強度が波長に応じて変動することになる。即ち、同一の被測定対象であっても、レーザ光の波長が異なることに起因して異なる測定結果が得られてしまう。 The absorbance of HbO 2 varies while repeatedly increasing and decreasing in the wavelength range of 650 nm to 1200 nm. Therefore, when the wavelength of the laser light varies, the intensity of the laser light emitted from the blood 500 changes. Further, when there is a difference in the wavelength of the laser light emitted due to individual differences in the laser light source 110, even when the same type of laser light source 110 is used, the laser light emitted from the blood 500 due to the difference in wavelength. Changes in the strength. Therefore, if the detector 120 does not have sensitivity wavelength dependency, the intensity of the detected laser light varies according to the wavelength. That is, even if the same object to be measured is used, different measurement results are obtained due to the different wavelengths of the laser light.
 本実施例では、上述した透過率波長依存性を検出器120に感度波長依存性を持たせることにより小さくすることを目的としている。具体的には、血液500の透過率波長依存性を、検出器120の感度波長依存性によって少なくとも部分的に相殺する。その際、透過率波長依存性を効果的に相殺するためにも、HbOの透過率波長依存性は波長に対して直線的であることが好ましい。そこで本実施例では、HbOの透過率波長依存性を実質的に直線的とみなせるように、レーザ光源110が照射するレーザ光の波長範囲が特定の波長範囲とされている。具体的には、本実施例に係るレーザ光源110は、HbOの吸光度が波長の増加に対して直線的に大きくなる750nm~900nmの波長範囲のレーザ光を照射する。 The present embodiment aims to reduce the above-described transmittance wavelength dependency by making the detector 120 have sensitivity wavelength dependency. Specifically, the transmittance wavelength dependency of blood 500 is at least partially offset by the sensitivity wavelength dependency of detector 120. At that time, in order to effectively cancel the transmittance wavelength dependency, the transmittance wavelength dependency of HbO 2 is preferably linear with respect to the wavelength. Therefore, in this embodiment, the wavelength range of the laser light emitted by the laser light source 110 is set to a specific wavelength range so that the transmittance wavelength dependency of HbO 2 can be regarded as substantially linear. Specifically, the laser light source 110 according to the present embodiment irradiates laser light having a wavelength range of 750 nm to 900 nm in which the absorbance of HbO 2 increases linearly with an increase in wavelength.
 図3において、上述したHbOの透過率波長依存性を小さくするためには、波長が長くなる程に感度が高くなるような検出器120を利用すればよい。このようにすれば、レーザ光の波長が長くなる場合において、血液500を透過するレーザ光の強度が小さくなるのに対して、検出器120の検出感度は大きくなる(即ち、検出光量が大きくなる)。よって、波長に応じたレーザ光の強度の変動を小さくでき、測定結果のずれを抑制することができる。 In FIG. 3, in order to reduce the transmittance wavelength dependency of HbO 2 described above, a detector 120 whose sensitivity increases as the wavelength becomes longer may be used. In this way, when the wavelength of the laser beam is increased, the intensity of the laser beam that passes through the blood 500 is decreased, whereas the detection sensitivity of the detector 120 is increased (that is, the detected light amount is increased). ). Therefore, fluctuations in the intensity of the laser light according to the wavelength can be reduced, and deviations in measurement results can be suppressed.
 図4において、被測定対象は血液500に限られず、例えば工業用途で用いられる水溶性加工油剤であってもよい。この場合、レーザ光源110が照射するレーザ光の波長範囲を630nm~680nmとすれば、水溶性加工油剤の透過率波長依存性が直線的であるとみなせる。なお、630nm~680nmの波長範囲でレーザ光を照射可能なレーザ光源110としては、例えばDVDの読み取りに利用されるレーザ光源が挙げられる。このため、上記波長範囲を利用する場合には、一般的に普及した安価な部品を利用することができ、コストの低減を図ることができる。 In FIG. 4, the object to be measured is not limited to blood 500, and may be, for example, a water-soluble processing oil used in industrial applications. In this case, if the wavelength range of the laser light emitted by the laser light source 110 is 630 nm to 680 nm, the transmittance wavelength dependency of the water-soluble processing oil can be regarded as linear. Examples of the laser light source 110 that can irradiate a laser beam in the wavelength range of 630 nm to 680 nm include a laser light source used for reading a DVD. For this reason, when utilizing the said wavelength range, the cheap component generally spread can be utilized and cost reduction can be aimed at.
 図5において、上述した水溶性加工油剤の透過率波長依存性を小さくするためには、波長が長くなる程に検出感度が低くなるような検出器120を利用すればよい。このようにすれば、レーザ光の波長が長くなる場合において、水溶性加工油剤を透過するレーザ光の強度が大きくなるのに対して、検出器120の検出感度は小さくなる(即ち、検出光量が小さくなる)。よって、波長に応じたレーザ光の強度の変動を小さくでき、測定結果のずれを抑制することができる。 In FIG. 5, in order to reduce the transmittance wavelength dependency of the water-soluble processing oil described above, a detector 120 whose detection sensitivity decreases as the wavelength becomes longer may be used. In this way, when the wavelength of the laser beam becomes longer, the intensity of the laser beam that passes through the water-soluble processing oil increases, whereas the detection sensitivity of the detector 120 decreases (that is, the detected light amount decreases). Smaller). Therefore, fluctuations in the intensity of the laser light according to the wavelength can be reduced, and deviations in measurement results can be suppressed.
 次に、図6を参照して、検出器120の感度波長依存性によって得られる効果について具体的に説明する。ここに図6は、規格化した透過光量の波長依存性を示すグラフである。 Next, the effect obtained by the sensitivity wavelength dependency of the detector 120 will be described in detail with reference to FIG. FIG. 6 is a graph showing the wavelength dependence of the normalized transmitted light amount.
 図6において、波長の増加に応じて透過光量が大きくなる血液500に対して、波長の増加に応じて検出感度が小さくなる検出器120を適用すると、検出光量は波長によらず概ね一定となる(なお、ここでの検出光量は、最短波長時の光量を“1”として規格化している)。この結果、例えばレーザ光源110の温度特性等によりレーザ光の波長が使用中に変動したとしても、検出されるレーザ光の強度は一定となる。また、レーザ光源110の個体差によってレーザ光の波長範囲にばらつきが存在している場合でも、検出されるレーザ光の強度は一定となる。以上のように、被測定対象の透過率波長依存性を相殺するような検出器120を用いれば、レーザ光の波長に起因する測定結果のずれを効果的に抑制できる。 In FIG. 6, when the detector 120 whose detection sensitivity decreases as the wavelength increases is applied to the blood 500 whose transmitted light amount increases as the wavelength increases, the detected light amount becomes substantially constant regardless of the wavelength. (Note that the detected light amount here is normalized with the light amount at the shortest wavelength being “1”). As a result, even if the wavelength of the laser beam fluctuates during use due to, for example, the temperature characteristics of the laser light source 110, the intensity of the detected laser beam is constant. Further, even when there is a variation in the wavelength range of the laser light due to individual differences of the laser light sources 110, the intensity of the detected laser light is constant. As described above, if the detector 120 that cancels the transmittance wavelength dependency of the object to be measured is used, the deviation of the measurement result due to the wavelength of the laser light can be effectively suppressed.
 次に、図7から図9を参照して、検出器120の選択方法について詳細に説明する。ここに図7は、検出器の感度波長依存性をレーザ光の波長範囲と共に示すグラフである。また図8は、合成透過光率及び検出器の感度波長依存性を示すグラフであり、図9は、規格化した検出光量の波長依存性を検出器毎に示すグラフである。 Next, a method for selecting the detector 120 will be described in detail with reference to FIGS. FIG. 7 is a graph showing the sensitivity wavelength dependency of the detector together with the wavelength range of the laser beam. FIG. 8 is a graph showing the combined transmitted light rate and the sensitivity wavelength dependency of the detector, and FIG. 9 is a graph showing the wavelength dependency of the normalized detected light amount for each detector.
 図7において、レーザ光源110の波長範囲が850±15nmである場合に、互いに異なる感度波長依存性を有する検出器A及び検出器Bを利用する例を考える。検出器Aは、レーザ光源110の波長範囲である850±15nmに、検出感度が最大となる波長が含まれている。一方で、検出器Bは、レーザ光源110の波長範囲である850±15nmに、検出感度が最大となる波長が含まれていない。単純に検出感度だけを考慮するのであれば、レーザ光源110の波長範囲において検出感度が高い検出器Aを利用すればよいが、被測定対象の透過率波長依存性を小さくするためには、感度波長依存性の傾向も考慮すべきである。 In FIG. 7, when the wavelength range of the laser light source 110 is 850 ± 15 nm, consider an example in which a detector A and a detector B having different sensitivity wavelength dependencies are used. In the detector A, the wavelength with the maximum detection sensitivity is included in the wavelength range of 850 ± 15 nm of the laser light source 110. On the other hand, in the detector B, the wavelength range of the laser light source 110 that is 850 ± 15 nm does not include the wavelength that maximizes the detection sensitivity. If only the detection sensitivity is taken into consideration, the detector A having a high detection sensitivity in the wavelength range of the laser light source 110 may be used. In order to reduce the transmittance wavelength dependency of the measurement target, the sensitivity Trends in wavelength dependence should also be considered.
 図8において、検出器Aは、レーザ光源110の波長範囲に検出感度が最大となる波長が含まれているため、感度波長依存性が山なりになっている。一方で、検出器Bは、レーザ光源110の波長範囲に検出感度が最大となる波長が含まれていないため、感度波長依存性が直線的になっている。また、検出器Bの感度波長依存性は、被測定対象の透過率波長依存性と概ね真逆の傾向を有している。 In FIG. 8, the detector A has a wavelength dependence on the sensitivity wavelength because the wavelength range of the laser light source 110 includes the wavelength with the maximum detection sensitivity. On the other hand, since the detector B does not include the wavelength at which the detection sensitivity is maximized in the wavelength range of the laser light source 110, the sensitivity wavelength dependency is linear. Further, the sensitivity wavelength dependency of the detector B has a tendency that is almost opposite to the transmittance wavelength dependency of the measurement target.
 図9において、検出器Aを利用した場合、感度波長依存性が山なりになっているために、直線的な被測定対象の透過率の波長依存性を好適に相殺できない。その結果、検出器Aを利用した場合の検出光量は、レーザ光の波長に応じて変動してしまう。具体的には、検出器Aを利用した場合には、レーザ光の波長が長くなるほど、検出光量が低下してしまう。一方、検出器Bを利用した場合、感度波長依存性が直線的であるため、被測定対象の透過率の波長依存性を好適に相殺できる。その結果、検出器Bを利用した場合の検出光量は、レーザ光の波長が変化しても殆ど変動しない。なお、ここでの検出光量は、最大値を“1”として規格化したものである。 In FIG. 9, when the detector A is used, the wavelength dependency of the transmittance of the linear object to be measured cannot be offset appropriately because the sensitivity wavelength dependency is piled up. As a result, the amount of light detected when the detector A is used varies depending on the wavelength of the laser light. Specifically, when the detector A is used, the detected light quantity decreases as the wavelength of the laser light increases. On the other hand, when the detector B is used, since the sensitivity wavelength dependency is linear, the wavelength dependency of the transmittance of the measurement target can be offset appropriately. As a result, the amount of light detected when the detector B is used hardly changes even if the wavelength of the laser light changes. Here, the detected light amount is standardized with the maximum value being “1”.
 以上の結果、検出器120の感度波長依存性を利用して、合成透過率の波長依存性を相殺しようとする場合には、レーザ光源110の波長範囲に検出感度が最大となる波長が含まれていないもの(即ち、検出器B)を利用すべきである。 As a result, when trying to cancel the wavelength dependency of the combined transmittance using the sensitivity wavelength dependency of the detector 120, the wavelength range of the laser light source 110 includes the wavelength with the maximum detection sensitivity. The one that is not (ie detector B) should be used.
 <変形例>
 次に、図10から図15を参照して、変形例に係る測定装置について説明する。
<Modification>
Next, a measuring apparatus according to a modification will be described with reference to FIGS.
 <装置構成>
 先ず、図10から図13を参照して、変形例に係る測定装置の構成について説明する。ここに図10から図13は夫々、第1から第4変形例に係る測定装置の全体構成を示す概略構成図である。
<Device configuration>
First, with reference to FIGS. 10 to 13, a configuration of a measuring apparatus according to a modification will be described. FIGS. 10 to 13 are schematic configuration diagrams showing the overall configuration of the measuring apparatus according to the first to fourth modifications, respectively.
 図10において、第1変形例に係る測定装置では、レーザ光源110と血液500との間に光学素子200が配置されている。光学素子200は、レーザ光の波長に応じて透過率が変化する透過率波長依存性を有している。光学素子200は、例えば誘電体多層膜を用いた光学フィルターや、赤外線遮断フィルム及び紫外線遮断フィルムのように樹脂等に特定波長光吸収物質を混合したものとして構成される。 In FIG. 10, in the measuring apparatus according to the first modification, an optical element 200 is disposed between the laser light source 110 and the blood 500. The optical element 200 has a transmittance wavelength dependency in which the transmittance changes according to the wavelength of the laser light. The optical element 200 is configured, for example, as an optical filter using a dielectric multilayer film, or a resin or the like mixed with a specific wavelength light absorbing material such as an infrared blocking film and an ultraviolet blocking film.
 図11において、第2変形例に係る測定装置では、光学素子200が血液500と検出器120との間に配置されている。このため、第2変形例に係る光学素子200には、血液500を透過した後のレーザ光が入射される。このように、光学素子200を被測定対象から見て検出器120側に配置した場合であっても、後述する変形例に係る測定装置で得られる効果は変わらない。即ち、光学素子200は、レーザ光源110及び検出器120間の光路上に配置されるのであれば、特に配置位置が限定される訳ではない。 In FIG. 11, in the measuring apparatus according to the second modification, the optical element 200 is disposed between the blood 500 and the detector 120. For this reason, the laser beam after passing through the blood 500 is incident on the optical element 200 according to the second modification. Thus, even when the optical element 200 is arranged on the detector 120 side when viewed from the object to be measured, the effect obtained by the measuring apparatus according to the modified example described later does not change. That is, as long as the optical element 200 is disposed on the optical path between the laser light source 110 and the detector 120, the position of the optical element 200 is not particularly limited.
 図12において、第3変形例に係る測定装置では、レーザ光源110と血液500との間に、レーザ光を平行光にするためのコリメータレンズ150が配置されている。コリメータレンズ150には、波長依存性を持たせるためのコーティングが施されている。よって、第2変形例では、コリメータレンズ150が光学素子200として機能する。このように、光学素子200を別途設けずとも、既存の部材を光学素子200として機能させることも可能である。 12, in the measurement apparatus according to the third modification, a collimator lens 150 for making laser light parallel light is disposed between the laser light source 110 and the blood 500. The collimator lens 150 is coated to give wavelength dependency. Therefore, in the second modification, the collimator lens 150 functions as the optical element 200. In this manner, an existing member can be made to function as the optical element 200 without providing the optical element 200 separately.
 図13において、第4変形例に係る測定装置では、検出器120の表面(より具体的には、レーザ光が入射される面)に、検出器120を保護するためのモールド部材125が設けられている。モールド部材125には、特定波長のレーザ光を吸収する材料(例えば、有機色素物質や波長選択性物質(CdS等)をドープしたガラス粉末)が混合されている。よって、第4変形例では、検出器120のモールド部材125が光学素子200として機能する。 In FIG. 13, in the measuring apparatus according to the fourth modification, a mold member 125 for protecting the detector 120 is provided on the surface of the detector 120 (more specifically, the surface on which the laser light is incident). ing. The mold member 125 is mixed with a material that absorbs laser light having a specific wavelength (for example, glass powder doped with an organic dye substance or a wavelength selective substance (CdS or the like)). Therefore, in the fourth modification, the mold member 125 of the detector 120 functions as the optical element 200.
 なお、第4変形例では、モールド部材125に加えて、コリメータレンズ150を光学素子200として機能させてもよい。このように、レーザ光の光路上には複数の光学素子200が配置されてもよい。 In the fourth modification, the collimator lens 150 may function as the optical element 200 in addition to the mold member 125. Thus, a plurality of optical elements 200 may be arranged on the optical path of the laser light.
 <光学素子の透過率波長依存性>
 次に、図14及び図15を参照して、光学素子の透過率波長依存性について詳細に説明する。ここに図14は、被測定対象、検出器及び光学素子の波長依存性を示すグラフである。また図15は、規格化した検出光量の波長依存性を光学素子の有無で分けて示すグラフである。なお、図14及び図15に示す例では、図7から図9を用いて説明した検出器のうち検出器Bを用いている。
<Transmission wavelength dependency of optical element>
Next, the transmittance wavelength dependency of the optical element will be described in detail with reference to FIGS. FIG. 14 is a graph showing the wavelength dependence of the object to be measured, the detector, and the optical element. FIG. 15 is a graph showing the wavelength dependence of the standardized detected light amount divided by the presence or absence of an optical element. In the example shown in FIGS. 14 and 15, the detector B is used among the detectors described with reference to FIGS.
 被測定対象の透過率波長依存性が大きい場合、検出器120の検出感度だけでは、被測定対象の透過率波長依存性を十分に小さくできない可能性がある。この場合、検出器120の感度波長依存性をより大きいものに変更してもよいが、光学素子200を組み合わせて利用することで対応することもできる。 When the transmittance wavelength dependency of the measurement target is large, the transmission wavelength dependency of the measurement target may not be sufficiently reduced only by the detection sensitivity of the detector 120. In this case, the sensitivity wavelength dependency of the detector 120 may be changed to a larger one, but it can be dealt with by using the optical element 200 in combination.
 図14に示す例では、被測定対象が波長の増加に応じて透過率が比較的急激に低下する透過率波長依存性を有している。一方で、検出器Bは、波長の増加に応じて検出感度が比較的緩やかに増加する感度波長依存性を有している。また、光学素子200も、波長の増加に応じて検出感度が増加する感度波長依存性を有している。 In the example shown in FIG. 14, the object to be measured has a transmittance wavelength dependency in which the transmittance decreases relatively rapidly as the wavelength increases. On the other hand, the detector B has a sensitivity wavelength dependency in which the detection sensitivity increases relatively gradually as the wavelength increases. The optical element 200 also has a sensitivity wavelength dependency that the detection sensitivity increases as the wavelength increases.
 図15において、検出器Bのみで被測定対象の透過率波長依存性を相殺しようとすると、検出器Bの感度波長依存性が小さいために、検出光量が波長に応じて変化してしまう。具体的には、波長が長くなるほど検出光量は小さくなってしまう。一方で、光学素子200を追加した場合、被測定対象の透過率波長依存性を検出器B及び光学素子200の両方で相殺することができるため、波長が変動しても検出光量は殆ど変化しない。このように、光学素子200を追加することで、被測定対象の透過率波長依存性をより好適に小さくすることが可能となる。 In FIG. 15, if it is attempted to cancel out the transmittance wavelength dependency of the object to be measured using only the detector B, the detected light amount changes according to the wavelength because the sensitivity wavelength dependency of the detector B is small. Specifically, the detected light amount decreases as the wavelength increases. On the other hand, when the optical element 200 is added, the transmittance wavelength dependency of the object to be measured can be canceled by both the detector B and the optical element 200, so that the detected light amount hardly changes even if the wavelength varies. . As described above, by adding the optical element 200, it is possible to more suitably reduce the transmittance wavelength dependency of the measurement target.
 ちなみに、複数の光学素子200を利用する場合には、複数の光学素子200の各々の透過率波長依存性を合成したものが、図14に示すような値になればよい。 Incidentally, in the case of using a plurality of optical elements 200, it is sufficient that a value obtained by synthesizing the transmittance wavelength dependency of each of the plurality of optical elements 200 has a value as shown in FIG.
 以上説明したように、本実施例に係る測定装置によれば、被測定対象が有する透過率波長依存性を小さくすることができるため、レーザ光の波長によらない好適な測定を実現可能である。 As described above, according to the measuring apparatus according to the present embodiment, it is possible to reduce the transmittance wavelength dependency of the measurement target, and therefore it is possible to realize a suitable measurement independent of the wavelength of the laser beam. .
 本発明は、上述した実施形態に限られるものではなく、特許請求の範囲及び明細書全体から読み取れる発明の要旨或いは思想に反しない範囲で適宜変更可能であり、そのような変更を伴う測定装置もまた本発明の技術的範囲に含まれるものである。 The present invention is not limited to the above-described embodiment, and can be appropriately changed without departing from the gist or concept of the invention that can be read from the claims and the entire specification. Moreover, it is included in the technical scope of the present invention.
 110 レーザ光源
 120 検出器
 125 モールド
 150 コリメータレンズ
 200 光学素子
 500 血液
 510 チューブ
DESCRIPTION OF SYMBOLS 110 Laser light source 120 Detector 125 Mold 150 Collimator lens 200 Optical element 500 Blood 510 Tube

Claims (5)

  1.  レーザ光の波長に応じて透過率が変化する透過率波長依存性を有する被測定対象に向けてレーザ光を発するレーザ光源と、
     前記レーザ光の波長に応じて検出感度が変化する感度波長依存性を有しており、前記被測定対象において透過又は反射された前記レーザ光を検出する検出部と
     を備え、
     前記検出部の前記感度波長依存性は、前記レーザ光の波長範囲において、前記検出部の感度波長依存性と前記被測定対象の前記透過率波長依存性との積が、前記被測定対象の前記透過率波長依存性よりも小さくなるように設定されている
     ことを特徴とする測定装置。
    A laser light source that emits laser light toward a measurement target having a transmittance wavelength dependency in which the transmittance changes according to the wavelength of the laser light;
    It has a sensitivity wavelength dependency in which detection sensitivity changes according to the wavelength of the laser light, and includes a detection unit that detects the laser light transmitted or reflected on the measurement target.
    The sensitivity wavelength dependency of the detection unit is the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the measurement target in the wavelength range of the laser light. A measuring apparatus that is set to be smaller than the transmittance wavelength dependency.
  2.  前記レーザ光源は、ファブリペロー型レーザ光源であることを特徴とする請求項1に記載の測定装置。 2. The measuring apparatus according to claim 1, wherein the laser light source is a Fabry-Perot laser light source.
  3.  前記レーザ光源は、前記被測定対象の前記透過率波長依存性が直線的である波長範囲のレーザ光を発することを特徴とする請求項1又は2に記載の測定装置。 3. The measuring apparatus according to claim 1, wherein the laser light source emits a laser beam in a wavelength range in which the transmittance wavelength dependency of the object to be measured is linear.
  4.  前記レーザ光源は、前記検出部の検出感度が最大となる波長を含まない波長範囲のレーザ光を発することを特徴とする請求項1から3いずれか一項に記載の測定装置。 The measurement apparatus according to any one of claims 1 to 3, wherein the laser light source emits laser light in a wavelength range that does not include a wavelength at which the detection sensitivity of the detection unit is maximum.
  5.  前記レーザ光の光路上に配置されており、前記透過率波長依存性を有する光学素子を更に備え、
     前記光学素子の前記透過率波長依存性は、前記レーザ光の波長範囲において、前記検出部の感度波長依存性と前記光学素子及び前記被測定対象を合わせた前記透過率波長依存性との積が、前記検出部の感度波長依存性と前記被測定対象の前記透過率波長依存性との積よりも小さくなるように設定されている
     ことを特徴とする請求項1から4のいずれか一項に記載の測定装置。
    An optical element that is disposed on the optical path of the laser light and has the transmittance wavelength dependency;
    The transmittance wavelength dependency of the optical element is the product of the sensitivity wavelength dependency of the detection unit and the transmittance wavelength dependency of the optical element and the object to be measured in the wavelength range of the laser beam. 5. It is set so that it may become smaller than the product of the sensitivity wavelength dependence of the said detection part, and the said transmittance | permeability wavelength dependence of the said to-be-measured object. The measuring device described.
PCT/JP2015/074859 2015-09-01 2015-09-01 Measurement device WO2017037871A1 (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63275327A (en) * 1987-05-08 1988-11-14 Hamamatsu Photonics Kk Diagnostic apparatus
JP2008531212A (en) * 2005-03-01 2008-08-14 マシモ・ラボラトリーズ・インコーポレーテッド Multi-wavelength sensor equalization
WO2008114401A1 (en) * 2007-03-20 2008-09-25 Pioneer Corporation Bioinformation measuring instrument
WO2009093453A1 (en) * 2008-01-25 2009-07-30 Panasonic Corporation Analysis device and analysis method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63275327A (en) * 1987-05-08 1988-11-14 Hamamatsu Photonics Kk Diagnostic apparatus
JP2008531212A (en) * 2005-03-01 2008-08-14 マシモ・ラボラトリーズ・インコーポレーテッド Multi-wavelength sensor equalization
WO2008114401A1 (en) * 2007-03-20 2008-09-25 Pioneer Corporation Bioinformation measuring instrument
WO2009093453A1 (en) * 2008-01-25 2009-07-30 Panasonic Corporation Analysis device and analysis method

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