WO2017025953A1 - Système de lentilles de contact pour la correction de la vision - Google Patents

Système de lentilles de contact pour la correction de la vision Download PDF

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Publication number
WO2017025953A1
WO2017025953A1 PCT/IL2016/050858 IL2016050858W WO2017025953A1 WO 2017025953 A1 WO2017025953 A1 WO 2017025953A1 IL 2016050858 W IL2016050858 W IL 2016050858W WO 2017025953 A1 WO2017025953 A1 WO 2017025953A1
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WO
WIPO (PCT)
Prior art keywords
lens
tether
elastic
lens system
contact lens
Prior art date
Application number
PCT/IL2016/050858
Other languages
English (en)
Inventor
Yair Alster
Omer Rafaeli
Ofer Pintel
Original Assignee
Pres-By Vision Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pres-By Vision Ltd filed Critical Pres-By Vision Ltd
Publication of WO2017025953A1 publication Critical patent/WO2017025953A1/fr

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/041—Contact lenses for the eyes bifocal; multifocal
    • G02C7/043—Translating type
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
    • G02B26/0875—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more refracting elements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/12—Fluid-filled or evacuated lenses
    • G02B3/14—Fluid-filled or evacuated lenses of variable focal length
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/048—Means for stabilising the orientation of lenses in the eye
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/08—Auxiliary lenses; Arrangements for varying focal length
    • G02C7/086—Auxiliary lenses located directly on a main spectacle lens or in the immediate vicinity of main spectacles

Definitions

  • the present invention relates to a lens system and, more particularly, to a contact lens system which can be used to correct vision problems such as presbyopia.
  • Typical vision problems such as myopia (nearsightedness), hyperopia (farsightedness) or presbyopia (loss of accommodation and subsequent loss of near and intermediate vision) are readily correctable using eyeglasses.
  • myopia nearsightedness
  • hyperopia farsightedness
  • presbyopia loss of accommodation and subsequent loss of near and intermediate vision
  • eyeglasses some individuals prefer contact lenses for vision correction due to an active life style or aesthetic preferences.
  • multifocal lenses which simultaneously focus light from a range of distances via several focal regions and bifocal lenses that include two simultaneously distinct lens powers, a central region for correction of myopia and a surrounding region for correction of hyperopia.
  • the latter lenses translate with respect to the optical axis of the eye to provide both near and far vision correction depending on the eye gaze angle.
  • bifocal and multifocal lenses can correct presbyopia
  • translation of the bifocal lens with respect to the cornea - anywhere from 2-6 mm (significantly more than standard contact lenses that typically translate about 0 to 0.5 mm) - can cause irritation and significant discomfort to the user while simultaneous focusing of light from several distances - as is the case for multifocal lenses - requires the user to 'process' light coming in from several distances.
  • anatomical variability with respect to the distance between the optical axis and lower lid margin necessitates individual fitting of lenses and patient adjustment to correctly align the near- vision correction region of the bifocal lens to the optical axis during near vision tasks.
  • the present invention successfully addresses the shortcomings of the presently known configurations by providing a lens system that includes a first lens positionable over a cornea and a second lens attached to the first lens via elastic tethers.
  • the lens system is configured such that the second lens is translatable over the first lens without appreciable movement of the first lens over the cornea when the system is positioned in an eye and the eye is rotated up and down.
  • FIGs. la-b illustrate one embodiment of the lens system of the present invention with the outer (second) lens in a home position ( Figure la) and in a translated position ( Figure lb) with respect to the inner (first) lens.
  • FIGs. 2a-l illustrate several tether patterns which can be used to interconnect the lenses of the present lens system.
  • FIGs. 3a-f illustrate several approaches for attaching the elastic tether(s) to the inner and outer lenses.
  • FIGs 4a-d illustrate several cross sectional shapes of elastic tether.
  • FIG. 5 illustrate the frictional forces generated between the lenses and elastic tether when elongated by translation of the outer lens with respect to the inner lens.
  • FIGs. 6a-c illustrate bench testing of a prototype of the present lens system.
  • FIGs. 7a-b illustrate testing of a prototype lens system in a subject.
  • the present invention is of a lens system that can be used to correct visions in hyperopic, myopic or emmetropic individuals with presbyopia. Specifically, the present invention can be used to provide both near, intermediate and far vision while traversing comfort and usability problems of prior art bifocal and multifocal lenses.
  • Multifocal contact lenses as well as translating lenses (both rigid and soft) are available commercially but have not gained significant market share. Multifocal contact lens reduce vision quality while bifocal lenses require significant fitting effort and cause significant discomfort in many individuals.
  • US20080097600 describes a movable ophthalmic lens system which includes a carrier positionable on a portion of an eye, and a movable ophthalmic lens arranged for movement over a surface of the carrier.
  • the assembly is configured such that the movable ophthalmic lens is responsive to ocular movement so as to move in translatory motion over the surface of the carrier.
  • LLM-COP Lower Lid Margin to the center of pupil
  • the present inventors have devised a contact lens system for correcting visions problems in, for example, presbyopic individuals.
  • the present system includes a first lens positionable over the cornea and a second lens positionable over the first lens and attached thereto via one or more elastic tethers.
  • the position, length and elasticity of the tether(s) are selected so as to enable the second lens to slide with respect to the first lens from a home position (e.g. centered, no/minimum tension in tether) to a translated position (e.g. gaze down position) thereby tensioning the tether(s), and return to the home position - at gaze forward - under the elastic return forces generated by the tensioned tether(s).
  • a contact lens system for correcting vision problems such as presbyopia with or without correcting for additional refractive errors.
  • lens system can provide a solution for low (near) vision magnification.
  • lens refers to a light-passing element.
  • lens system refers to two or more lenses that are formed from two or more attached surfaces. The lenses can be any shape and configuration and can have zero, negative or positive optical power as well as cylindrical power.
  • the lens system of the present invention includes a first (also referred to herein as inner or back) lens configured for positioning over a cornea and a second (also referred to herein as outer or front) lens positionable over the first lens and attached thereto via one or more elastic tethers (e.g. elastic strings).
  • a first also referred to herein as inner or back
  • a second also referred to herein as outer or front
  • elastic tethers e.g. elastic strings
  • the inner lens should be stable over the cornea with little or no movement during use;
  • the outer lens should easily translate over the inner lens without causing substantial movement of the inner lens over the cornea;
  • attachment between the inner and outer lenses should enable movement of outer lens from a first position to a second position and facilitate movement of the outer lens from the second position to the first position;
  • attachment between the inner and outer lenses should result in minimal spacing (micrometers) between the lenses and yet provide substantial translation distances (millimeters);
  • attachment between the lenses should stabilize both lenses as one integrated system and prevent significant rotation on the cornea; (viii) attachment between the lenses should not deform the optical zones of the lenses during translation;
  • the present inventors designed a lens system which incorporates the following features:
  • tether characteristics cross sectional shape, surface qualities (e.g. roughness, stickiness), material, modulus of elasticity] selected so as to control friction between tether and lenses during elastic elongation of tether;
  • Figures la-5 illustrate the present lens system which is referred to herein as system 10.
  • System 10 includes an inner lens 12 attached to an outer lens 14 via one or more tethers 16 (two shown).
  • Tethers 16 are fabricated from an elastic material capable of elastically elongating by at least 500%.
  • Tethers 16 are attached to an outer surface 18 of lens 12 and an inner surface 20 of lens 14 by: forming tether 16 from an adhesive applied to lens 12 and/or lens 14 (Figure 3), co-molding tether 16 with lens 12 and/or lens 14 (Figure 3ab), molding Figure 3b, threading tether 16 through the material of lens 12 and/or lens 14 (Figure 3c), bonding tether 16 to a surface of lens 12 and/or lens 14 ( Figure 3d) using a silicon -based adhesive , or mechanically attaching tether 16 to lens 12 and/or lens 14 by embedding a flat (Figure 3e) or wedge (Figure 3f) -shaped end region of tether 16 within (or through) the wall of lens 12 and/or lens 14.
  • Tether 16 can be fabricated from any material capable of elastic elongation in the ranges specified. Suitable materials include silicone (e.g. Shore 20-100), a modified silicone (e.g. fluoro-silicone) or a polyether block amide (PEBA).
  • silicone e.g. Shore 20-100
  • modified silicone e.g. fluoro-silicone
  • PEBA polyether block amide
  • Tether 16 is preferably 200-800 microns in length and 50-250 microns in diameter. Tether 16 is configured and/or attached between lenses 12 and 14 such that a distance therebetween (lens spacing) is 20-150 microns. Tether can be linear and attached at an angle between outer surface 18 of lens 12 and an inner surface 20 of lens 14 (e.g. an angle of 0-45 degrees) or it can be non-linear (e.g. the curved strut shown in Figure la) and attached at a substantially perpendicular angle.
  • a tether 200 microns in length can be curved and attached substantially perpendicularly (90 degrees +/- 20%) to outer surface 18 of lens 12 and an inner surface 20 of lens 14 (as is shown in Figure la) to space apart lenses 12 and 14 by about 120 microns.
  • Tether 16 can be configured such that elastic elongation thereof is uniform or not. In a non -uniform elongation, tether 16 may progressively become easier or harder to stretch. For example, tether 16 may require less force to stretch to a first length (e.g. 75% of final length) and more force to stretch from the first length to a final length.
  • Figure la illustrates tethers 16 in a non-elongated state when lens 14 is in a home position over lens 12.
  • the optical centers of lenses 12 and 14 do not co-align at optical axis 28 which runs through a non-optical center region of lens 14 and an optical region 24 of lens 12.
  • This is the case during gaze forward ( Figure la, inset - top left) when lens 12 provides far vision correction and lens 14 merely allows transfer of light with no optical correction of region 26.
  • gaze down Figure lb, inset - top right
  • lens 14 translates up over lens 12, elastic tethers 16 elongate, and optical centers 24 and 26 (of lenses 12 and 14 respectively) align to provide near vision correction.
  • Lens 14 translates up during eye roll down (at gaze down) under the forces applied by the rim of lower lid to lens 14. These forces overcome the elastic force of tethers 16 and the frictional forces between lenses and tethers 16 (further discussed hereinbelow).
  • a lid engagement element 30 protrusion shown in Figure la, or high friction region
  • Lid engagement element 30 would increase the lateral forces applied to the second lens by the lower lid thus further contributing to the forces that overcome elastic recoil of tethers 16 and friction between lenses and lenses-tethers.
  • any number of tethers can be attached between lenses 12 and 14.
  • 50-5000 tethers 16 can be attached between lenses 12 and 14 in a patterns that surrounds optical regions 24 and 26 of these lenses and provides a guide path for lens 14 as it translates over lens 12.
  • Figures 2b-l illustrate several such patterns of tethers attached between lenses 12 and 14 (indicated in Figure 2a).
  • Figure 2b-c illustrates a discontinuous ( Figure 2b) or continuous (Figure 2c) circle pattern formed by a plurality of adjacent tethers positioned between lenses 12 and 14.
  • Figure 2d illustrates a discontinuous circle pattern formed by spaced apart tethers.
  • Figure 2e illustrates four tethers positioned along a circumferential region of lens 134.
  • Figure 2f illustrates two segments of 5 tethers each positioned symmetrically across a 45 degree line dividing lens 14.
  • Figure 2g illustrates an arc-shaped pattern formed from 10 tethers at bottom of lens 12.
  • Figure 2h illustrates a 10-tether circular pattern positioned along a circumferential region of lens 14.
  • Figure 2i illustrates a 4 tether pairs pattern positioned at the four corners of an imaginary square superimposed on lens 14.
  • Figure 2j illustrates an arc pattern formed from 10 tethers and positioned at the top of lens 14.
  • Figure 2k illustrates a pattern similar to that of Figure 2i with the tethers adjacent to one another.
  • Figure 21 illustrates a pattern formed from adjacent and spaced apart tethers positioned along a circumferential region of lens 14.
  • the region and pattern of attachment of tethers 16 are also selected such that elongation of tethers 16 does not deform the shape of lenses 12 and 14 or affect the optical focusing capabilities thereof or stability of lens 12 on the cornea.
  • the cross sectional shape of tether 16 can be uniform or varying over its length.
  • the cross sectional shape can be circular (Figure 4a), rectangular ( Figure 4b), triangular (Figure 4c) or ovoid ( Figure 4d) and any combination thereof.
  • the thickness of tether 16 can be uniform or variable over a length.
  • the cross sectional shape and thickness are selected so as to control the frictional forces between tether 16 and outer surface 18 of lens 12 and inner surface 20 of lens 14 so as to control movement of lens 14 over lens 12 during translation at gaze down and (elastic) return at gaze forward.
  • a tether 16 having a round cross section with a diameter of 100 ⁇ (Figure 5) will ovalize when stretched and trapped between surfaces 18 and 20. Such ovalization will increase surface friction between tether 16 and surfaces 18 and 20.
  • a rounded tether will ovalize when compressed between lenses 12 and 14 and as such its co-efficient of friction will change and should be taken into consideration when optimizing tether over all structure, cross section and material.
  • lenses 12 and 14 are also selected so to control translation of lens 14 and stability of lens 12.
  • lenses 12 and 14 and/or coatings of their surfaces can be selected such that the interface between lens 12 and the cornea and lenses 12 and 14, as well as the interface between lenses 12 and 14 and inner lid surfaces (lower and upper lid) exhibit a differential (static) coefficient of friction (CoF).
  • CoF differential coefficient of friction
  • Materials suitable for fabrication of the lenses include, but are not limited to hydrogel materials such as tefilcon, lidofilcon B, etafilcon, bufilcon A, tetrafilcon A surfilcon bufilcon A perfilcon crofilcon lidofilcon A deltafilcon A etafilcon A dimefilcon ofilcon A, droxifilcon A, ocufilcon Bhefilcon A & B xylofilcon A, phemfilcon A, phemfilcon A, phemfilcon A scafilcon A, ocufilcon, tetrafilcon B, isofilcon, methafilcon, mafilcon, vifilcon A,polymacon with the use of monomers such as HEMA, MMA, NVP, PVP, MA, PC, Modified PVA, PVA.
  • hydrogel materials such as tefilcon, lidofilcon B, etafilcon, bufilcon A, tetrafilcon A
  • Silicone Hydrogel materials can also be used such as but not limited to Balafilcon A or Lotrafilcon A with monomers such as NVP, TPVC, NCVE, PBVC, DMA, TRIS, siloxane macromere.
  • monomers such as NVP, TPVC, NCVE, PBVC, DMA, TRIS, siloxane macromere.
  • rigid permeable gas contact lens material or pure silicone lenses can be used.
  • Silicone can be made at different rigidities ranging from Silicone Shore A 10 to silicone Shore A 95.
  • Such materials can be selected to provide the differential friction between the lenses of the present system or selectively coated with various material in order to meet such frictional constraints.
  • Such materials can be further undergo surface treatment such as but not limited to plasma oxidation or include internal wetting monomers such as but not limited to PVP.
  • the inner surface lens 12 can be fabricated from a material (e.g. Silicone) having a relatively high static CoF (against the cornea) to thereby increase the CoF of the first interface (between inner surface of lens 12 and cornea) and the resistance of lens 12 to lateral forces applied by the lids.
  • the second lens can be fabricated from a material (e.g. Hydrogel) having a relatively low CoF (against the outer surface of the first lens) such that the second interface exhibits a static CoF which is lower than that of the first interface. This will ensure that the second lens translates over the first lens in the eye while the first lens remains stable.
  • Another approach for decreasing the static CoF of the second interface is to fabricate the outer surface of lens 12 from a hydrophilic material (e.g. hydrogel) and at least the inner surface of lens 14 from a hydrophobic material (e.g. silicone).
  • the lenses can be composed of the same material with different surface treatment.
  • the two lenses can also be of different materials.
  • each lens can also have one layer that is made of one material (e.g. Hydrogel) and another layer made of another material (e.g. Silicone).
  • the contact area of any lens with its opposing surface can have similar properties over the entire contact area or it can have an area with one set or properties and at least one more area with different set of properties. Such properties can be achieved with combinations of materials, layers, coatings or surface treatments or roughness.
  • the surfaces can also have mixed hydrophobic and hydrophilic properties in different zones, for example hydrophobic surface with hydrophilic islands where a fluid droplet makes contact with the surface only at small isolated regions, prevent adhesion and reduce friction [K Hiratsuka, Journal of Physics: Conference Series 89 (2007)].
  • the size of lenses 12 and 14 can be selected such that the ratio between the surface area of the first interface and that of the second interface ensures that the force of friction created by the first interface is much higher than that created by the second interface.
  • first lens can be of standard size of about 14mm in diameter and second lens can have a diameter of about 7mm.
  • second lens can have a diameter of about 7mm.
  • a ratio of 5: 1 to 1.5: 1 between the area of the first lens and second lens can be used to achieve differential translation of the second lens.
  • Lens 14 can be made more rigid, such rigidity can be achieved using rigid gas permeable contact lens material or silicone with higher shore A such as Silicone shore A 60 or above.
  • each of lenses 12 and 14 can have zero optical power, a positive optical power or a negative optical power with each lens having one or more optical centers.
  • lens 12 can have a single optical center with negative optical power for far vision correction (e.g. -1.0 to -5.0 Diopters), while lens 14 can have a single optical center with positive optical power for near vision correction (e.g. +1.25 to +4.0 Diopters) or two or more optical centers with positive optical powers for intermediate and near vision corrections.
  • Lenses 12 and 14 can also have cylindrical powers (different vertical and horizontal powers).
  • the present lens system can be fabricated using well known approaches such as injection molding, vacuum forming, machining and the like. Approaches used for fabricating multifocal lenses can also be used in the present invention.
  • Each lens 12 and 14 can be fabricated separately or both lenses 12 and 14 can be fabricated along with tethers 16 using overmolding techniques.
  • Coating of materials on the inner and outer surfaces of lenses 12 and 14 can be effected using plasma deposition and the like.
  • Two lenses a back lens made of silicon with an optical power -3D, external diameter 14mm and 8.5 BC, and a front lens made of SH74 with optical power of 2D, outside diameter of 14.5 mm and 8.9BC were interconnected using two tethers attached at a vertical or horizontal orientation (side by side or top bottom respectively). Attachment to the front surface of the back lens was zero (tether flat with surface of back lens), 45 or 90 degrees.
  • a vertical connection at the front lens and a 45 or 90 degree connection at the back lens was less effective and lead to local deformation of the lenses.
  • a lens system with a horizontal connection at the front lens (two tethers positioned at top and bottom) and a 0, 45 or 90 degree connection at the back lens was less functional since the tension in the tethers was different at different positions of the front lens over the back lens. For example, when the front lens was manually shifted to the near sight position (gaze down), the tension in the bottom tether increased while the tension in the top tether decreased.
  • a lens system in which the tethers were attached side by side (vertical) with a zero degree attachment at the back lens was utilized for further testing on the model and human eye.
  • the lens system was placed over the eyeball model and friction and movement were evaluated when the front lens was manually translated over the back lens. A force of a few grams was needed to move the front lens 4mm from home position on top of the back lens; when that force was removed, the front translated back to the home position in about a second. Translation was smooth and uninterrupted. The lens system was then tested in an eye of a human subject ( Figures 7a-b). The lens system was placed in a human eye for 15 minutes and comfort, translation, movement and rotation were evaluated.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Eyeglasses (AREA)

Abstract

L'invention concerne un système de lentilles de contact. Le système de lentilles de contact comprend une première lentille conçue pour être positionnée sur une cornée et une seconde lentille positionnée au-dessus de la première lentille et fixée à celle-ci par l'intermédiaire d'au moins une attache élastique. La distance comprise entre la première lentille et la seconde lentille est inférieure ou égale à 150 micromètres et la seconde lentille est susceptible de se déplacer au-dessus de la première lentille sur une distance d'environ 2 à 6 mm.
PCT/IL2016/050858 2015-08-09 2016-08-04 Système de lentilles de contact pour la correction de la vision WO2017025953A1 (fr)

Applications Claiming Priority (2)

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US201562202847P 2015-08-09 2015-08-09
US62/202,847 2015-08-09

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WO2017025953A1 true WO2017025953A1 (fr) 2017-02-16

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100137891A1 (en) * 2007-06-04 2010-06-03 Svip 8Llc Tissue anchorable devices
US20150153588A1 (en) * 2012-07-13 2015-06-04 University Of Florida Research Foundation, Inc. Contact lens with spatially heterogenous surface patterns for improved lubricity
WO2015114628A1 (fr) * 2014-01-28 2015-08-06 Pres-By Vision Ltd. Système de lentilles pour la correction de la vision

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100137891A1 (en) * 2007-06-04 2010-06-03 Svip 8Llc Tissue anchorable devices
US20150153588A1 (en) * 2012-07-13 2015-06-04 University Of Florida Research Foundation, Inc. Contact lens with spatially heterogenous surface patterns for improved lubricity
WO2015114628A1 (fr) * 2014-01-28 2015-08-06 Pres-By Vision Ltd. Système de lentilles pour la correction de la vision

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