WO2017025775A1 - Dispositif destiné à une imagerie de photopléthysmographie adaptative - Google Patents

Dispositif destiné à une imagerie de photopléthysmographie adaptative Download PDF

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Publication number
WO2017025775A1
WO2017025775A1 PCT/IB2015/056097 IB2015056097W WO2017025775A1 WO 2017025775 A1 WO2017025775 A1 WO 2017025775A1 IB 2015056097 W IB2015056097 W IB 2015056097W WO 2017025775 A1 WO2017025775 A1 WO 2017025775A1
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WO
WIPO (PCT)
Prior art keywords
illuminator
region
light
interest
video
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Application number
PCT/IB2015/056097
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English (en)
Inventor
Uldis Rubins
Janis ZAHARANS
Janis Spigulis
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Latvijas Universitate
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Priority to PCT/IB2015/056097 priority Critical patent/WO2017025775A1/fr
Publication of WO2017025775A1 publication Critical patent/WO2017025775A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases

Definitions

  • the present invention relates to a device for photoplethysmography imaging, which can be used for adaptive remote photoplethysmography and mapping of hemodinamic parameters in human skin.
  • Remote PPG utilizes radiation sources (visible or near infrared) and video camera (detector), disposed remotely from the subject skin.
  • the technique of PPG imaging is described, for instance, in W. Verkruysse et al., "Remote plethysmography imaging using ambient light", Optics Express 16(26), 2008. It is based on the principle that pulsed temporal variations of blood volume lead to variations in light absorptions by the skin, and, consequently, in intensity of the reflected radiation. Small blood volume pulsations can be registered by video camera that takes video images of a fixed skin area.
  • Video processing allows calculating the averaged pixel values over selected region of interest (Rol) and extracting the PPG signal.
  • hemodynamic parameters e.g. pulse rate, breathing rate, PPG amplitude and phase, waveform parameters
  • the set of signals are derived and the set of hemodynamic parameters are calculated from signals.
  • This technique is called PPG imaging where detailed spatial information is derived simultaneously from multiple sites of skin, which allows mapping of physiological parameters such as blood perfusion or blood oxygen saturation.
  • the PPG imaging could be usable in clinical monitoring in the cases where contact measurements are not possible (wounds, sterile surfaces, fracture sites, hyperalgesia areas, etc.).
  • WO/2009/030934 discloses the method of blood oxygen saturation mapping over the skin by using remote PPG technique.
  • images are created which provide a penetration depth due to the varying scatter and absorption effects at the different excitation wavelengths.
  • the sequence of images can be consolidated in order to provide a substantially real time view of PPG signals dependent upon blood oxygen saturation within the blood circulation system.
  • the invention relates to a processing method for obtaining vital sign information of a living being from an image signal generated from spatio-temporal variations of received light.
  • the device comprises a control unit analyzing derived vital sign information and generating control information for controlling the setting of one or more parameters of registration unit to optimize the quality of the vital sign information derived from obtained image signals.
  • the device and method for obtaining vital signs of a subject are described.
  • the invention proposes to determine an optimal binning configuration of sensor based on a determined feature of the extracted PPG signal and a specific vital sign to be extracted from it.
  • the binning configuration is chosen automatically and allows reliably and accurately obtaining a vital sign of a subject under varying lighting conditions ranging, potentially from full sun light to bedroom light levels at night.
  • WO/2014/128273 discloses the device of automotive vehicle occupant monitoring using near-infrared light.
  • the device inside a car looks at occupants (driver, front passenger, rear passengers) and covers multiple security, comfort, driver assistance and occupant state related functions, as well as measures occupants' vital sign parameters (heart rate, respiration rate, blood oxygen saturation) using contactless imaging photoplethysmography.
  • Aim of the present invention is to provide a device and method for reliable and accurate obtaining of hemodynamic parameter maps characterized by higher quality in terms of increased dynamic range and better signal-to-noise ratio compared to the known devices and methods.
  • a device for obtaining hemodynamic parameter maps comprising: a video registration unit adapted for registering set of video frames of region of interest of subject's skin, said region having a number of sub-regions; a data processing unit adapted for processing obtained video signals and extracting photoplethysmography signals and set of hemodynamic parameters from each of the sub-regions; a display unit adapted to display hemodynamic parameter maps; an illuminator adapted to provide uniform illumination of the region of interest, which is controlled by a driver for regulating a power of illuminator, wherein the device further comprises a triggering unit adapted to provide synchronous triggering of the illuminator and the video registration unit; a feedback unit adapted to receive from the data processing unit the PPG signals from each of the sub-regions and to provide control of the illuminator to maintain uniform illumination of the region of interest.
  • the feedback unit is (electrically) connected with the data processing unit and the driver of the illuminator.
  • the data processing unit is connected with the video registration unit, the feedback unit and the display unit.
  • the triggering unit is connected with the driver and the registration unit.
  • the feedback unit comprises a low -pass filter adapted to filter PPG signals to remove the fast varying component and a proportional-integral-derivative controller adapted to minimize the amplitude of slow PPG component by adjusting the intensity of light source.
  • the skin should be illuminated spatially uniformly.
  • the image pixel values should be in range where the image sensor has linear sensitivity.
  • the pixels should generate possibly high values while preserving linearity of sensor.
  • One possibility to reach this goal is to provide spatially uniform illumination of skin area.
  • Several light sources placed in a proper distance from each other and skin surface provide spatially distributed illumination. Based on image analysis, intensity of every light source could be adjusted to reach light saturation almost in all pixels of image. This adjustment is needed when the skin surface has uneven structure or in cases of heterogeneous blood perfusion in the skin tissue.
  • the analog to digital convertor (ADC) of video system should have high bit range or high enough quantization resolution.
  • the disadvantage of this approach is high complexity and costs.
  • the quality of PPG signal could be improved if the image pixel values remain saturated during large variations of reflected light, in cases of rapid hemodynamic changes in skin tissue. This is important when continuous monitoring of vital signs in clinical environment is needed.
  • the invention proposes solution: to provide feedback between the measured PPG signal and intensity emitted from each of the light sources which is adjusted to reach optimal spatial and temporal distribution of illumination over the specified region of interest of the skin.
  • Fig. 1 is a schematic illustration of a device for obtaining hemodynamic parameter maps according to the present invention.
  • Fig. 2 shows illuminator comprising a set of light sources illuminating region of interest of skin.
  • Fig. 3 shows the image of region of interest which is illuminated by several light sources and a PPG signal obtained from binned pixels in the illuminated sub-region.
  • Fig. 4 shows detailed block-diagram of working principle of the device.
  • Fig. 1 shows an embodiment of a device 1 for obtaining hemodynamic parameter maps according to the present invention.
  • the living being e.g. human (palm) skin 2 can be illuminated by a light source - illuminator 10.
  • a video registration unit (video camera) 5 is adapted to capture image frames from the region of interest 3 of skin, which is illuminated by the illuminator 10.
  • the video registration unit 5 is adapted to forward recorded images to a data processing unit 7 which is adapted to convert video data to PPG signals 14.
  • the data processing unit performs calculation of hemodynamic parameters (e.g. heart rate, breathing rate, the amplitude and phase of PPG pulse, waveform parameters etc.) from the PPG signals and forwards the parameter set to output device 11 , such as touch sensitive monitor screen.
  • the hemodynamic parameters can be visualized on the monitor as a 2-D parametric map.
  • the device 1 further comprises a driver 16, which is adapted to regulate power of the illuminator 10.
  • the driver 16 is adapted to be controlled by a feedback unit 9 (Fig. 1) to maintain uniform illumination of the region of interest 3.
  • the illuminator 10 preferably comprises an array of light emitting diodes (LED) or similar light emitters 12.
  • LED light emitting diodes
  • This illuminator 10 is adapted to be placed at the preferred distance from the skin surface.
  • the light emitters 12 can be arranged in regular array or may be located irregularly.
  • the illuminator system 10 is adapted to perform spatially uniform illumination of skin. It can consist of several light emitters 12 with wide angle of illumination so that the light beams from them cover each other, but sum of all beams produce light field of uniform illumination. In another embodiment of the illuminator 10 large number of light elements 12 (e.g.
  • the illuminator 10 comprises a curved screen adapted to provide spatially uniform illumination of the region of interest 3.
  • the illuminator 10 comprises a set of light emitters 12 with multiple excitation frequencies, that are switched on and off in a sequential order synchronously with the video registration unit 5 which is configured for trigger mode.
  • the illuminator 10 can be adapted to emit light pulses, as well as to emit light at several wavelength intervals in the range between 450 and 1300 nm.
  • the light sources 12 emit the radiation in at least one wavelength interval, preferably in the green or near infrared region.
  • the driver 16 is adapted to regulate power of each light source 12.
  • the illuminator 10 and the registration unit 5 are controlled by triggering unit 15 which is configured to provide synchronous switching of the illuminator 10 with capturing of current video frame.
  • the image frames of a specified skin area - the region of interest 3 are captured by the video registration unit 5 comprising suitable image sensor or several arrays of image sensors.
  • the video registration unit 5 comprises a charge-coupled device (CCD), complementary metal-oxide-semiconductor (CMOS) sensor, hybrid or similar sensor-matrix which is able to transform the recorded light field into a set of pixel values.
  • the device is configured to transfer video frames to the data processing unit 7.
  • Fig. 3 shows the image frame from video in the case when the skin area is illuminated by N semi-parallel beams from N light emitters. First the proper binning of image pixels in each of the illuminated sub-areas 13 is performed. Then N PPG signals are derived from each sub-area from the video frames.
  • Remaining slow varying PPG signal is used to adjust the intensity of corresponding light source 12 aiming to keep the average pixel values from corresponding sub-region 13 close to video sensor saturation level and to achieve uniform illumination distribution in the image.
  • Fast and precise feedback to light intensity control can be achieved using PID controller, which is configured to minimize the amplitude of the slow PPG component obtained from the corresponding sub-region 13.
  • the frame rate of video is considered to be fast enough for extraction of fast periodic component of PPG and the hemodynamic parameters (e.g. heart rate, breathing rate, the amplitude and phase of PPG pulse, waveform parameters etc.).
  • the presented device and method allows to track the video signal and to stabilize the pixel values of individual video frames by adjusting the illuminating light intensities spatially and temporally.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un dispositif pour la détection de cartes de paramètres hémodynamiques dans une peau humaine au moyen d'imagerie de photopléthysmographie à distance avec un éclairage adaptatif. Le dispositif comprend une unité d'enregistrement vidéo adaptée pour enregistrer un ensemble de trames vidéo de région d'intérêt de la peau d'un sujet, ladite région ayant un certain nombre de sous-régions ; une unité de traitement de données, adaptée pour traiter des signaux vidéo obtenus et extraire des signaux de photopléthysmographie et un ensemble de paramètres hémodynamiques à partir de chacune des sous-régions ; une unité d'affichage adaptée pour afficher des cartes de paramètres hémodynamiques ; un illuminateur adapté pour fournir un éclairage uniforme de la région d'intérêt ; un circuit d'attaque pour réguler une puissance d'illuminateur ; le dispositif comprenant en outre une unité de rétroaction adaptée pour recevoir, en provenance de l'unité de traitement de données, les signaux PPG provenant de chacune des sous-régions et pour fournir la commande de l'illuminateur pour maintenir un éclairage uniforme de la région d'intérêt ; une unité de déclenchement pour le déclenchement synchrone d'illuminateur et d'unité d'enregistrement vidéo.
PCT/IB2015/056097 2015-08-11 2015-08-11 Dispositif destiné à une imagerie de photopléthysmographie adaptative WO2017025775A1 (fr)

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Cited By (20)

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Publication number Priority date Publication date Assignee Title
CN108742549A (zh) * 2018-06-26 2018-11-06 京东方科技集团股份有限公司 一种图像信息生成方法和脉搏波测量系统
CN109171649A (zh) * 2018-08-30 2019-01-11 合肥工业大学 智能影像式生命体征探测仪
EP3488770A1 (fr) * 2017-11-23 2019-05-29 Samsung Electronics Co., Ltd. Procédé et appareil de traitement de signaux optiques
CN111050638A (zh) * 2017-08-30 2020-04-21 康比姆公司 用于接触式光学体积描记术(ppg)的计算机实现的方法和系统
CN111759292A (zh) * 2020-06-24 2020-10-13 中国科学院西安光学精密机械研究所 一种人体心率、呼吸及血氧综合测量装置与方法
CN112074226A (zh) * 2018-05-16 2020-12-11 三菱电机株式会社 用于生命体征的远程测量的系统和方法
EP3658874A4 (fr) * 2017-07-28 2021-06-23 Temple University - Of The Commonwealth System of Higher Education Imagerie induite par compression de plateforme mobile pour caractérisation de subsurface et d'objet de surface
CN113453610A (zh) * 2018-12-14 2021-09-28 皇家飞利浦有限公司 用于检测组织炎症的装置
US11207497B1 (en) 2020-08-11 2021-12-28 Imperative Care, Inc. Catheter with enhanced tensile strength
US11224434B2 (en) 2017-01-06 2022-01-18 Incept, Llc Thromboresistant coatings for aneurysm treatment devices
US11253277B2 (en) 2019-12-18 2022-02-22 Imperative Care, Inc. Systems for accessing a central pulmonary artery
US11311303B2 (en) 2018-05-01 2022-04-26 Incept, Llc Enhanced flexibility neurovascular catheter with tensile support
US11395665B2 (en) 2018-05-01 2022-07-26 Incept, Llc Devices and methods for removing obstructive material, from an intravascular site
US11439799B2 (en) 2019-12-18 2022-09-13 Imperative Care, Inc. Split dilator aspiration system
US11471582B2 (en) 2018-07-06 2022-10-18 Incept, Llc Vacuum transfer tool for extendable catheter
US11504020B2 (en) 2019-10-15 2022-11-22 Imperative Care, Inc. Systems and methods for multivariate stroke detection
US11517335B2 (en) 2018-07-06 2022-12-06 Incept, Llc Sealed neurovascular extendable catheter
US11553935B2 (en) 2019-12-18 2023-01-17 Imperative Care, Inc. Sterile field clot capture module for use in thrombectomy system
US11565082B2 (en) 2020-03-10 2023-01-31 Imperative Care, Inc. Enhanced flexibility neurovascular catheter
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US11940650B2 (en) 2017-07-28 2024-03-26 Temple University—Of the Commonwealth System of Higher Education Mobile-platform compression-induced imaging for subsurface and surface object characterization
EP3658874A4 (fr) * 2017-07-28 2021-06-23 Temple University - Of The Commonwealth System of Higher Education Imagerie induite par compression de plateforme mobile pour caractérisation de subsurface et d'objet de surface
CN111050638A (zh) * 2017-08-30 2020-04-21 康比姆公司 用于接触式光学体积描记术(ppg)的计算机实现的方法和系统
CN111050638B (zh) * 2017-08-30 2023-07-25 康比姆公司 用于接触式光学体积描记术(ppg)的计算机实现的方法和系统
CN109827907A (zh) * 2017-11-23 2019-05-31 三星电子株式会社 光学信号处理方法和装置
US10545050B2 (en) 2017-11-23 2020-01-28 Samsung Electronics Co., Ltd. Optical signal processing method and apparatus
KR20190059668A (ko) * 2017-11-23 2019-05-31 삼성전자주식회사 광 신호 처리 방법 및 장치
EP3488770A1 (fr) * 2017-11-23 2019-05-29 Samsung Electronics Co., Ltd. Procédé et appareil de traitement de signaux optiques
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US11395665B2 (en) 2018-05-01 2022-07-26 Incept, Llc Devices and methods for removing obstructive material, from an intravascular site
US11311303B2 (en) 2018-05-01 2022-04-26 Incept, Llc Enhanced flexibility neurovascular catheter with tensile support
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CN108742549B (zh) * 2018-06-26 2021-01-26 京东方科技集团股份有限公司 一种图像信息生成方法和脉搏波测量系统
CN108742549A (zh) * 2018-06-26 2018-11-06 京东方科技集团股份有限公司 一种图像信息生成方法和脉搏波测量系统
US11850349B2 (en) 2018-07-06 2023-12-26 Incept, Llc Vacuum transfer tool for extendable catheter
US11471582B2 (en) 2018-07-06 2022-10-18 Incept, Llc Vacuum transfer tool for extendable catheter
US11517335B2 (en) 2018-07-06 2022-12-06 Incept, Llc Sealed neurovascular extendable catheter
CN109171649A (zh) * 2018-08-30 2019-01-11 合肥工业大学 智能影像式生命体征探测仪
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US11766539B2 (en) 2019-03-29 2023-09-26 Incept, Llc Enhanced flexibility neurovascular catheter
US11504020B2 (en) 2019-10-15 2022-11-22 Imperative Care, Inc. Systems and methods for multivariate stroke detection
US11819228B2 (en) 2019-12-18 2023-11-21 Imperative Care, Inc. Methods and systems for treating a pulmonary embolism
US11633272B2 (en) 2019-12-18 2023-04-25 Imperative Care, Inc. Manually rotatable thrombus engagement tool
US11638637B2 (en) 2019-12-18 2023-05-02 Imperative Care, Inc. Method of removing embolic material with thrombus engagement tool
US11553935B2 (en) 2019-12-18 2023-01-17 Imperative Care, Inc. Sterile field clot capture module for use in thrombectomy system
US11253277B2 (en) 2019-12-18 2022-02-22 Imperative Care, Inc. Systems for accessing a central pulmonary artery
US11457936B2 (en) 2019-12-18 2022-10-04 Imperative Care, Inc. Catheter system for treating thromboembolic disease
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