WO2017012032A1 - 光源驱动的视网膜芯片 - Google Patents

光源驱动的视网膜芯片 Download PDF

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Publication number
WO2017012032A1
WO2017012032A1 PCT/CN2015/084603 CN2015084603W WO2017012032A1 WO 2017012032 A1 WO2017012032 A1 WO 2017012032A1 CN 2015084603 W CN2015084603 W CN 2015084603W WO 2017012032 A1 WO2017012032 A1 WO 2017012032A1
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Prior art keywords
light
light source
background
retina
chip
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PCT/CN2015/084603
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English (en)
French (fr)
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林伯刚
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林伯刚
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Priority to PCT/CN2015/084603 priority Critical patent/WO2017012032A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0543—Retinal electrodes

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  • the present disclosure relates to a retina chip, and more particularly to a retina chip driven using a light source.
  • the eyeballs are followed by the following: cornea, pupil, hydrocrystal, vitreous and retina.
  • the retina converts the light focused by the crystal into electrical and chemical signals, which are transmitted into the brain through the optic nerve, enabling people to see the image.
  • the structure of the retina is very complex and can be roughly divided into three layers: after the light enters the fundus, it will first pass through the transparent outer layer and the middle layer, and then to the innermost "photosensitive cells".
  • the photoreceptor cells convert the light signal into an electrical signal and a chemical signal, which are transmitted to the cells in the middle layer for processing, and the processed signal is transmitted to the outermost ganglion cells, and then the signal is transmitted back to the brain.
  • retinitis pigmentosa retinitis pigmentosa
  • senile macular degeneration retina chip
  • a user using a retina chip must wear special glasses 11 on which a micro camera 12 is placed.
  • the micro camera 12 converts the photographed light signal into an electrical signal, and transmits it to the processing chip 14 attached to the ear by the electric wire 13, and the processing chip 14 converts the electrical signal into an electrical pulse signal readable by the ganglion cells.
  • the electrical pulse signal is encoded and transmitted to the decoding chip 15 buried under the skin of the ear. After decoding, the circuit is connected to the eyelid along the wire 16 buried under the skin of the face, and finally passed to the outermost nerve of the retina.
  • the energy source of the micro camera 12 and the processing chip 14 is powered by the battery case 18 by the battery case 18 connected to the special glasses 11.
  • the electrode plate 17 and the decoding chip 15 attached to the retina power can be supplied as long as the power is transmitted while transmitting a signal by radio waves.
  • the glasses 21 are provided with a micro camera 22, and the special glasses 21 are provided with a processing chip 23, which can convert the electrical signals transmitted from the micro camera 22 into optical pulse signals, and then directly enter the electrode plate 24 buried under the photoreceptor cells. .
  • the electrode plate 24 is made of photoelectric material, and can directly convert the light pulse signal into an electrical pulse signal, and transmit it to the cells in the middle layer of the retina, and then the ganglion cells are sent to the brain for integration. Since the processing chip 23 is also made of a photoelectric material, the illumination can have a power generation function, so that the user does not have to carry the battery case separately, which is much more advanced than the retina chip of the previous generation.
  • the optoelectronic material of the processing chip can receive the optical signal on the one hand and the optical signal on the other hand, the result of the synchronous use of the two functions will make the optical signal difficult to recognize, and the recognition effect of the retina chip is deteriorated. Therefore, how to design a retina chip that can generate electricity by optical signals and has high recognition will be a technical problem that various circles are currently trying to solve.
  • the light source-driven retina chip receives a signal light and a background light
  • the light source driven retina chip includes: a photodiode array including a plurality of photodiodes and a plurality of current amplifications a circuit, wherein the plurality of photodiodes convert the signal light into an electrical signal and convert the background light into a plurality of background photocurrents, the plurality of photodiodes being correspondingly coupled to the plurality of current amplifications a circuit, the plurality of current amplifying circuits of the photodiode array amplifying the electrical signal and the plurality of background photocurrents; and a plurality of background light subtracting units including a plurality of background light sensing circuits and a plurality of current reductions a circuit, wherein the plurality of current reduction circuits are electrically connected to the plurality of photodiodes of the photodiode array, respectively, and the electrical signals are weighted, and the plurality of
  • the light source driven retina chip of the present disclosure may further include a photoelectric conversion module electrically connected to the photodiode array and the plurality of background light reduction units and converting light energy into electrical energy to supply the Electrical energy to the photodiode array and the plurality of backlight abatement units.
  • a photoelectric conversion module electrically connected to the photodiode array and the plurality of background light reduction units and converting light energy into electrical energy to supply the Electrical energy to the photodiode array and the plurality of backlight abatement units.
  • the light source driven retina chip can be disposed on a user's retina, weighted
  • the subsequent electrical signal can be transmitted to the ganglion cells of the user's retina.
  • the photodiode array may be disposed at a central location of the light source driven retina chip.
  • the photodiode array can be a 64x64 photodiode array.
  • the plurality of background light reduction units may include a first background light reduction unit, a second background light reduction unit, a third background light reduction unit, and a fourth background light reduction unit, respectively The corner of the retina chip.
  • the signal light may be one of a red signal light, a green signal light, and a blue signal light, or a combination thereof.
  • the background light may be an infrared background light.
  • the photoelectric conversion module can be a solar chip module.
  • the present disclosure synchronously receives signal light and background light to drive the retina chip, in addition to effectively converting infrared and visible light into electrical energy through the photoelectric conversion module for operation of the photodiode array and the plurality of background light reduction units, the photodiode array
  • the present invention is capable of efficiently identifying signal light to generate a corresponding stimulation current to the ganglion cells of the retina, which has the advantages of high performance and high recognition compared to retinal chips of the prior art.
  • FIG. 1 is a schematic view showing the use of a retina chip according to a first known technique
  • FIG. 2 is a schematic view showing the use of a retina chip according to a second known technique
  • FIG. 3 is a schematic diagram showing a light source driven retina chip of the present disclosure
  • FIG. 4 is a schematic diagram showing the use of a light source driven retina chip of the present disclosure.
  • FIG. 3 is a schematic diagram of a light source driven retina chip of the present disclosure.
  • the light source-driven retina chip 3 of the present disclosure receives a signal light X and a background light Y.
  • the light source-driven retina chip 3 includes a photodiode array 31 including a plurality of photodiodes 311 and a plurality of currents.
  • the light reduction unit 32 reduces the plurality of background photocurrents generated by the plurality of photodiodes 311 due to the background light Y, thereby enhancing the dynamic range of the retina chip 3.
  • the light source driven retina chip of the present disclosure further includes a photoelectric conversion module 33 electrically connected to the photodiode array 31 and the plurality of background light reduction units 32.
  • the photoelectric conversion module 33 can convert the signal light X and the background light Y into electrical energy to provide the photodiode array 31 and the plurality of background light reduction units 32 to operate.
  • FIG. 4 is a schematic diagram showing the installation of the retina chip driven by the light source of the present disclosure.
  • the light source driven retina chip 3 can be placed in a user's retina, and the weighted electrical signal can be transmitted to the ganglion cells of the user's retina.
  • the photodiode array 31 can be disposed at a central position of the light source driven retina chip 3 , but is not limited thereto.
  • the photodiode array 31 can be a 64 ⁇ 64 photodiode array, but is not limited thereto.
  • photodiode array 31 can also be a 128x128 photodiode array.
  • the plurality of background light reduction units 32 may include a first background light reduction unit 32a, a second background light reduction unit 32b, a third background light reduction unit 32c, and a fourth background light reduction.
  • Units 32d are respectively disposed at corners of the retina chip 3 to effectively detect the background light Y.
  • the signal light X may be one of a red signal light, a green signal light, and a blue signal light, or a combination of the plurality of signal lights, such as an orange signal light, a yellow signal light, Twilight signal light, purple signal light, etc.
  • the background light Y may be an infrared background light, but is not limited thereto.
  • the background light Y may also be an ultraviolet background light without damaging the user's eyes.
  • the photoelectric conversion module 33 can be a solar chip module that converts infrared and visible light into electrical energy.
  • the use of the solar chip module may be adjusted corresponding to the light source driven retina chip 3 of the present disclosure, and is not limited thereto.
  • the present disclosure synchronously receives the signal light X and the background light Y to drive the retina chip, except that the infrared and visible light are efficiently converted into electrical energy by the photoelectric conversion module 33 for operation by the photodiode array 31 and the plurality of backlight reduction units 32.
  • the photodiode array 31 can effectively recognize the signal light X to generate a corresponding stimulation current to the ganglion cells of the retina, and the present disclosure has the advantages of high performance and high recognition compared to the retina chip of the prior art.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

一种光源驱动的视网膜芯片(3)，接收一信号光(X)及一背景光(Y)，所述光源驱动的视网膜芯片(3)包括：一光电二极管阵列(31)，包含多个光电二极管(311)及多个电流放大电路(312)，其中，所述多个光电二极管(311)将所述信号光(X)转换成一电信号，以及将背景光(Y)转换成多个背景光电流，所述多个电流放大电路(312)放大电信号及所述多个背景光电流；以及多个背景光消减单元(32)，包含多个背景光感测电路及多个电流消减电路，其中，所述多个电流消减电路加权电信号并消减所述多个背景光电流，进而增强光源驱动的视网膜芯片(3)的动态范围。

Description

光源驱动的视网膜芯片 技术领域
本公开文本涉及一种视网膜芯片，并且尤其涉及一种使用光源驱动的视网膜芯片。
背景技术
根据世界卫生组织(WHO)统计，全球患有眼球疾病的人口超过4500万，估计至公元2020年，眼球疾病的人口将增加至7600万人。
眼球由前往后依序为：角膜、瞳孔、水晶体、玻璃体和视网膜，视网膜将水晶体聚焦后的光转成电信号和化学信号，通过视神经传进大脑，使得人能看到影像。
视网膜的构造非常复杂，大致可分为三层：光线射入眼底后，会先穿过透明的外层和中间层，再射到最内层的“感光细胞”。感光细胞把光信号转为电信号和化学信号，传给中间层的细胞进行处理，处理过的信号再传给最外层的神经节细胞，而后把信号传回大脑。
倘若视网膜的“感光细胞”损坏，则会丧失视觉。常见的视觉疾病有两种：一种是色素性视网膜炎，另一种是老年性黄斑部病变，这两种眼部的疾病可通过“视网膜芯片”来加以改善。
请参考图1，使用视网膜芯片的使用者必须戴着特制眼镜11，上面设置微型摄影机12。微型摄影机12将拍下的光信号转为电信号，用电线13传到贴在耳朵边的处理芯片14，处理芯片14会将电信号转换为神经节细胞可读取的电脉冲信号。电脉冲信号经过编码后，传给埋在耳后皮肤下的解码芯片15，解码后一路沿着埋在脸部皮肤下的电线16连到眼眶进入眼球，最后传到贴在视网膜最外层神经节细胞上的电极板17。微型摄影机12和处理芯片14的能量来源是靠连接至特制眼镜11的电池盒18，由电池盒18进行供电。至于贴在视网膜上的电极板17与解码芯片15，只要在以无线电波传送信号时传送电能进去即可进行供电。
再者，请参考图2所示，使用新世代视网膜芯片的使用者一样要配戴特 制眼镜21，其上装置有微型摄影机22，特制眼镜21上装有一处理芯片23，可将微型摄影机22传来的电信号转换为光脉冲信号，然后直接射入埋在感光细胞下的电极板24。电极板24是用光电材料制作的，可直接把光脉冲信号转换为电脉冲信号，传给视网膜中间层的细胞，处理后再由神经节细胞送进大脑整合。由于处理芯片23也是用光电材料制作的，照光就可兼具发电功能，所以使用者不必另外携带电池盒，相较于前一代的视网膜芯片进步许多。
然而，虽然处理芯片的光电材料可一方面接受光信号、另一方面通过光信号进行发电，但两种功能同步使用的结果将使得光信号不易辨识，使得视网膜芯片的辨识效果变差。因此，如何设计一种能通过光信号进行发电、且具有高辨识度的视网膜芯片，将是目前各界亟欲解决的技术问题。
发明内容
鉴于上述公知技术的缺点，本公开文本的一目的即在于提供一种光源驱动的视网膜芯片，以解决光信号不易辨识的问题。
为达上述目的，本公开文本所提供的光源驱动的视网膜芯片，接收一信号光及一背景光，所述光源驱动的视网膜芯片包括：一光电二极管阵列，包含多个光电二极管及多个电流放大电路，其中，所述多个光电二极管将所述信号光转换成一电信号，以及将所述背景光转换成多个背景光电流，所述多个光电二极管对应地连接至所述多个电流放大电路，所述光电二极管阵列的所述多个电流放大电路放大所述电信号及所述多个背景光电流；以及多个背景光消减单元，包含多个背景光感测电路及多个电流消减电路，其中，所述多个电流消减电路分别电连接至所述光电二极管阵列的所述多个光电二极管，且加权所述电信号，所述多个背景光消减单元消减所述多个光电二极管由于所述背景光所产生的所述多个背景光电流，进而增强所述视网膜芯片的动态范围。
可选地，本公开文本的光源驱动的视网膜芯片还可包含一光电转换模块，电连接至所述光电二极管阵列及所述多个背景光消减单元且将光能转换为电能，以供应所述电能至所述光电二极管阵列及所述多个背景光消减单元。
可选地，所述光源驱动的视网膜芯片可设置于一使用者的视网膜，加权 后的所述电信号可传送至所述使用者的视网膜的神经节细胞。
可选地，所述光电二极管阵列可设置于所述光源驱动的视网膜芯片的中央位置。
可选地，所述光电二极管阵列可为一64x64光电二极管阵列。
可选地，所述多个背景光消减单元可包括一第一背景光消减单元、一第二背景光消减单元、一第三背景光消减单元及一第四背景光消减单元，其分别设置于所述视网膜芯片的角落。
可选地，所述信号光可为一红色信号光、一绿色信号光及一蓝色信号光的其中之一或其组合。
可选地，所述背景光可为一红外线背景光。
可选地，所述光电转换模块可为一太阳能芯片模块。
本公开文本同步接收信号光与背景光以驱动视网膜芯片，除了有效地通过光电转换模块将红外线及可见光转换成电能以供光电二极管阵列及所述多个背景光消减单元运作之外，光电二极管阵列能有效地辨识信号光以产生相对应的刺激电流至视网膜的神经节细胞，相较于公知技术的视网膜芯片，本公开文本具有高效能与高辨识度的优点。
附图说明
图1是显示根据第一公知技术的视网膜芯片的使用示意图；
图2是显示根据第二公知技术的视网膜芯片的使用示意图；
图3是显示本公开文本的光源驱动的视网膜芯片的示意图；以及
图4是显示本公开文本的光源驱动的视网膜芯片的使用示意图。
附图标记说明
11    特制眼镜
12    微型摄影机
13    电线
14    处理芯片
15    解码芯片
16    电线
17    电极板
21    特制眼镜
22    微型摄影机
23    处理芯片
24    电极板
3     光源驱动的视网膜芯片
31    光电二极管阵列
311   光电二极管
312   电流放大电路
32    背景光消减单元
32a   第一背景光消减单元
32b   第二背景光消减单元
32c   第三背景光消减单元
32d   第四背景光消减单元
33    光电转换模块
X     信号光
Y     背景光
具体实施方式
以下是藉由特定的具体实施例说明本公开文本的实施方式，本领域技术人员可由本说明书所公开的内容轻易地了解本公开文本的其他优点及效果。本公开文本亦可藉由其他不同的具体实例加以施行或应用，本公开文本说明书中的各项细节亦可基于不同观点与应用在不悖离本公开文本的精神下进行各种修饰与变更。
须知，本说明书所附图式绘示的结构、比例、大小等，均仅用以配合说明书所公开的内容，以供本领域技术人员了解与阅读，并非用以限定本公开文本可实施的限定条件，故不具技术上的实质意义，任何结构的修饰、比例关系的改变或大小的调整，在不影响本公开文本所能产生的效果及所能达成的目的下，均应落在本公开文本所公开的技术内容能涵盖的范围内。
请参考图3，其是本公开文本光源驱动的视网膜芯片的示意图。如图所示，本公开文本的光源驱动的视网膜芯片3接收一信号光X及一背景光Y，光源驱动的视网膜芯片3包括：一光电二极管阵列31，包含多个光电二极管311及多个电流放大电路312，其中，所述多个光电二极管311将信号光X转换成一电信号，以及将背景光Y转换成多个背景光电流，所述多个光电二极管311对应地连接至所述多个电流放大电路312，光电二极管阵列31的所述多个电流放大电路312放大电信号及所述多个背景光电流；以及多个背景光消减单元32，包含多个背景光感测电路及多个电流消减电路(图中未示出)，其中，所述多个电流消减电路32分别电连接至光电二极管阵列31的所述多个光电二极管311，且加权所述电信号，所述多个背景光消减单元32消减所述多个光电二极管311由于背景光Y所产生的所述多个背景光电流，进而增强所述视网膜芯片3的动态范围。
在本公开文本的实施例中，本公开文本的光源驱动的视网膜芯片还包含有一光电转换模块33，电连接至光电二极管阵列31及所述多个背景光消减单元32。光电转换模块33可将信号光X及背景光Y转换成电能以提供光电二极管阵列31及所述多个背景光消减单元32进行运作。
接着，请一并参考图3及图4，图4是显示本公开文本光源驱动的视网膜芯片的装设示意图。在本公开文本的实施例中，光源驱动的视网膜芯片3可设置于一使用者的视网膜，加权后的电信号可传送至使用者的视网膜的神经节细胞。
请继续参考图3，在本公开文本的实施例中，光电二极管阵列31可设置于光源驱动的视网膜芯片3的中央位置，但并不以此为限。
在本公开文本的实施例中，光电二极管阵列31可为一64x64光电二极管阵列，但并不以此为限。例如，光电二极管阵列31亦可为一128x128光电二极管阵列。
在此实施例中，所述多个背景光消减单元32可包含有一第一背景光消减单元32a、一第二背景光消减单元32b、一第三背景光消减单元32c及一第四背景光消减单元32d，其分别设置于视网膜芯片3的角落，以有效地检测背景光Y。
在此实施例中，信号光X可为一红色信号光、一绿色信号光及一蓝色信号光、或所述多个信号光相组合中的一者，例如橙色信号光、黄色信号光、靛色信号光、紫色信号光等。
在此实施例中，背景光Y可为一红外线背景光，但并不以此为限。例如，在不伤害使用者眼睛的情况下，背景光Y亦可为一紫外线背景光。
在此实施例中，光电转换模块33可为一太阳能芯片模块，所述太阳能芯片模块可将红外线及可见光转换成电能。太阳能芯片模块的使用可对应于本公开文本的光源驱动的视网膜芯片3而有所调整，并不以此为限。
本公开文本同步接收信号光X与背景光Y以驱动视网膜芯片，除了有效地通过光电转换模块33将红外线及可见光转换成电能以供光电二极管阵列31及所述多个背景光消减单元32运作之外，光电二极管阵列31能有效地辨识信号光X以产生相对应的刺激电流至视网膜的神经节细胞，相较于公知技术的视网膜芯片，本公开文本具有高效能与高辨识度的优点。
然而，上述实施例仅例示性说明本公开文本的效果，而非用于限制本公开文本，任何本领域技术人员均可在不违背本公开文本的精神及范畴下，对上述实施例进行修饰与改变。此外，在上述这些实施例中的元件的数量仅为例示性说明，亦非用于限制本公开文本。因此本公开文本的权利保护范围，应如以下的权利要求书所列。

Claims (9)

  1. 一种光源驱动的视网膜芯片，接收一信号光及一背景光，所述光源驱动的视网膜芯片包括：
    一光电二极管阵列，包含多个光电二极管及多个电流放大电路，其中，所述多个光电二极管将所述信号光转换成一电信号，以及将所述背景光转换成多个背景光电流，所述多个光电二极管对应地连接至所述多个电流放大电路，所述光电二极管阵列的所述多个电流放大电路放大所述电信号及所述多个背景光电流；以及
    多个背景光消减单元，包含多个背景光感测电路及多个电流消减电路，其中，所述多个电流消减电路分别电连接至所述光电二极管阵列的所述多个光电二极管，且加权所述电信号，所述多个背景光消减单元消减所述多个光电二极管由于所述背景光所产生的所述多个背景光电流，进而增强所述视网膜芯片的动态范围。
  2. 如权利要求1所述的光源驱动的视网膜芯片，还包含一光电转换模块，电连接至所述光电二极管阵列及所述多个背景光消减单元，且将光能转换为电能，以供应所述电能至所述光电二极管阵列及所述多个背景光消减单元。
  3. 如权利要求2所述的光源驱动的视网膜芯片，其中，所述光电转换模块为一太阳能芯片模块。
  4. 如权利要求1所述的光源驱动的视网膜芯片，其中，所述光源驱动的视网膜芯片设置于一使用者的视网膜，加权后的所述电信号传送至所述使用者的视网膜的神经节细胞。
  5. 如权利要求1所述的光源驱动的视网膜芯片，其中，所述光电二极管阵列设置于所述光源驱动的视网膜芯片的中央位置。
  6. 如权利要求1所述的光源驱动的视网膜芯片，其中，所述光电二极管阵列为一64x64光电二极管阵列。
  7. 如权利要求1所述的光源驱动的视网膜芯片，其中，所述多个背景光消减单元包括一第一背景光消减单元、一第二背景光消减单元、一第三背景光消减单元及一第四背景光消减单元，其分别设置于所述视网膜芯片的角落。
  8. 如权利要求1所述的光源驱动的视网膜芯片，其中，所述信号光为一红色信号光、一绿色信号光及一蓝色信号光中的其中之一或其组合。
  9. 如权利要求1所述的光源驱动的视网膜芯片，其中，所述背景光为一红外线背景光。
PCT/CN2015/084603 2015-07-21 2015-07-21 光源驱动的视网膜芯片 WO2017012032A1 (zh)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060184245A1 (en) * 2003-06-23 2006-08-17 Heinz-Gerhard Graf Active retina implant with a multiplicity of pixel elements
CN101590305A (zh) * 2009-06-18 2009-12-02 重庆大学 用于视觉功能修复的人工视网膜电刺激像元电路
TW201334768A (zh) * 2012-02-16 2013-09-01 Univ Nat Chiao Tung 人工視網膜系統及眼內植入晶片

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060184245A1 (en) * 2003-06-23 2006-08-17 Heinz-Gerhard Graf Active retina implant with a multiplicity of pixel elements
CN101590305A (zh) * 2009-06-18 2009-12-02 重庆大学 用于视觉功能修复的人工视网膜电刺激像元电路
TW201334768A (zh) * 2012-02-16 2013-09-01 Univ Nat Chiao Tung 人工視網膜系統及眼內植入晶片

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