WO2017009658A3 - Method of treatment of dental disorders - Google Patents

Method of treatment of dental disorders Download PDF

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Publication number
WO2017009658A3
WO2017009658A3 PCT/GB2016/052147 GB2016052147W WO2017009658A3 WO 2017009658 A3 WO2017009658 A3 WO 2017009658A3 GB 2016052147 W GB2016052147 W GB 2016052147W WO 2017009658 A3 WO2017009658 A3 WO 2017009658A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
dental disorders
prevention
autophagy
atpase inhibitor
Prior art date
Application number
PCT/GB2016/052147
Other languages
French (fr)
Other versions
WO2017009658A2 (en
Inventor
Bing Hu
Heng ZHUANG
Christopher Jeremy TREDWIN
Original Assignee
University Of Plymouth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Plymouth filed Critical University Of Plymouth
Publication of WO2017009658A2 publication Critical patent/WO2017009658A2/en
Publication of WO2017009658A3 publication Critical patent/WO2017009658A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides an ATPase inhibitor for use in the treatment or prevention of tooth cell autophagy and/or for use in the treatment or prevention of autophagy in deciduous and/or permanent teeth. Methods of treatment of the same are also provided, as are compositions comprising a local anaesthetic and an ATPase inhibitor.
PCT/GB2016/052147 2015-07-16 2016-07-15 Method WO2017009658A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1512410.0 2015-07-16
GBGB1512410.0A GB201512410D0 (en) 2015-07-16 2015-07-16 Method

Publications (2)

Publication Number Publication Date
WO2017009658A2 WO2017009658A2 (en) 2017-01-19
WO2017009658A3 true WO2017009658A3 (en) 2017-03-16

Family

ID=54014020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2016/052147 WO2017009658A2 (en) 2015-07-16 2016-07-15 Method

Country Status (2)

Country Link
GB (1) GB201512410D0 (en)
WO (1) WO2017009658A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2471541A1 (en) * 2009-08-24 2012-07-04 Kuok Leong Tam Medicine for dissolving and eliminating wart and excrescence consisting of protein and its uses
CN103142701A (en) * 2013-03-29 2013-06-12 武汉中博绿亚生物科技有限公司 Ear dropping oil agent for mixed infection of pet ear canal and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2471541A1 (en) * 2009-08-24 2012-07-04 Kuok Leong Tam Medicine for dissolving and eliminating wart and excrescence consisting of protein and its uses
CN103142701A (en) * 2013-03-29 2013-06-12 武汉中博绿亚生物科技有限公司 Ear dropping oil agent for mixed infection of pet ear canal and preparation method thereof

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CHÈNE PATRICK: "ATPases as drug targets: learning from their structure.", NATURE REVIEWS. DRUG DISCOVERY SEP 2002, vol. 1, no. 9, September 2002 (2002-09-01), pages 665 - 673, XP002765396, ISSN: 1474-1776 *
DATABASE WPI Week 201402, Derwent World Patents Index; AN 2013-S00937, XP002765395 *
G. MORISSETTE: "Massive Cell Vacuolization Induced by Organic Amines Such as Procainamide", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 310, no. 1, 2 April 2004 (2004-04-02), US, pages 395 - 406, XP055330290, ISSN: 0022-3565, DOI: 10.1124/jpet.104.066084 *
GAVIN CARR ET AL: "Bafilomycins Produced in Culture by Streptomyces spp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy +", JOURNAL OF NATURAL PRODUCTS., vol. 73, no. 3, 26 March 2010 (2010-03-26), US, pages 422 - 427, XP055330243, ISSN: 0163-3864, DOI: 10.1021/np900632r *
H ZHUANG ET AL: "Local anesthetics induce autophagy in young permanent tooth pulp cells", CELL DEATH DISCOVERY, vol. 1, 15024, 7 September 2015 (2015-09-07), pages 1 - 9, XP055330361, DOI: 10.1038/cddiscovery.2015.24 *
JERRY SWEE ET AL: "Inferior alveolar nerve block and third-molar agenesis", JOURNAL OF THE AMERICAN DENTAL ASSOCIATION., vol. 144, no. 4, 1 April 2013 (2013-04-01), US, pages 389 - 395, XP055330504, ISSN: 0002-8177, DOI: 10.14219/jada.archive.2013.0132 *
MORISSETTE G ET AL: "Intense pseudotransport of a cationic drug mediated by vacuolar ATPase: Procainamide-induced autophagic cell vacuolization", TOXICOLOGY AND APPLIED PHARMACOLOGY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 228, no. 3, 1 May 2008 (2008-05-01), pages 364 - 377, XP022613665, ISSN: 0041-008X, [retrieved on 20080126], DOI: 10.1016/J.TAAP.2007.12.031 *
SHACKA JOHN J ET AL: "Autophagy, bafilomycin and cell death: the a-B-cs of plecomacrolide-induced neuroprotection", AUTOPHAGY, LANDES BIOSCIENCE, US, vol. 2, no. 3, 1 July 2006 (2006-07-01), pages 228 - 230, XP009115316, ISSN: 1554-8627 *
SUNDQUIST K T ET AL: "BAFILOMYCIN A1 INHIBITS BONE RESORPTION AND TOOTH ERUPTION IN VIVO", JOURNAL OF BONE AND MINERAL RESEARCH, BLACKWELL SCIENCE, INC, US, vol. 9, no. 10, 1 October 1994 (1994-10-01), pages 1575 - 1582, XP000920946, ISSN: 0884-0431 *
ZHUANG H ET AL: "Autophagy in dental tissues: a double-edged sword.", CELL DEATH & DISEASE, vol. 7, E2192, 14 April 2016 (2016-04-14), pages 1 - 2, XP002765397, ISSN: 2041-4889, DOI: 10.1038/cddis.2016.103 *

Also Published As

Publication number Publication date
WO2017009658A2 (en) 2017-01-19
GB201512410D0 (en) 2015-08-19

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