WO2017002125A2 - Systèmes et procédés de diagnostic et de surveillance de dépistage cardiovasculaire - Google Patents

Systèmes et procédés de diagnostic et de surveillance de dépistage cardiovasculaire Download PDF

Info

Publication number
WO2017002125A2
WO2017002125A2 PCT/IL2016/050708 IL2016050708W WO2017002125A2 WO 2017002125 A2 WO2017002125 A2 WO 2017002125A2 IL 2016050708 W IL2016050708 W IL 2016050708W WO 2017002125 A2 WO2017002125 A2 WO 2017002125A2
Authority
WO
WIPO (PCT)
Prior art keywords
lvd
time
indication
person
providing
Prior art date
Application number
PCT/IL2016/050708
Other languages
English (en)
Other versions
WO2017002125A3 (fr
Inventor
Yehonatan TIROSH
Daniel B. LEVIN
Original Assignee
M.I. Medical Incentive Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by M.I. Medical Incentive Ltd. filed Critical M.I. Medical Incentive Ltd.
Publication of WO2017002125A2 publication Critical patent/WO2017002125A2/fr
Publication of WO2017002125A3 publication Critical patent/WO2017002125A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1118—Determining activity level

Definitions

  • the present invention relates to medical screening, diagnostic and monitoring systems and methods generally and more particularly to screening, diagnosis and monitoring of Left Ventricular Dysfunction (LVD).
  • LPD Left Ventricular Dysfunction
  • a measured differential skin temperature is defined, preferably with respect to a measured skin temperature at a given point in time.
  • MDST(C) is defined as the measured skin temperature at a point in time minus the measured skin temperature at point in time C.
  • MDST(D - C) may thus be understood to refer to the measured skin temperature at point in time D minus the measure skin temperature at point in time C.
  • the present invention seeks to provide improved systems for screening, diagnosis and monitoring of LVD (Left Ventricular Dysfunction) as well as LVD severity and/or progression.
  • LVD Left Ventricular Dysfunction
  • a system for providing an indication of at least LVD (Left Ventricular Dysfunction)
  • the system including at least one temperature sensor providing an output indication based on skin temperature at at least one location on a person at a plurality of given times, at least one body activity sensor providing an output indication of at least termination of body activity, a time/temperature ascertainer operative to receive inputs from the at least one temperature sensor and from the at least one body activity sensor and to provide skin temperature change output indications based on the skin temperature at at least one of before the body activity, during the body activity and after termination of body activity and a correlator operative to correlate the skin temperature change output indications with accumulated clinical data relating changes in skin temperature at at least one of before body activity, during body activity and after body activity to existence of at least LVD, the correlator providing at least an output indication of at least one of presence of LVD and absence of LVD.
  • LVD Left Ventricular Dysfunction
  • the at least one body activity sensor also provides an output indication indicating at least onset of body activity and an output related to an extent of body activity.
  • the at least one temperature sensor and the at least one body activity sensor respectively measure temperature and body activity at two distinct regions of a person's body.
  • the at least one temperature sensor and the at least one body activity sensor respectively measure temperature and body activity at a single region of a person's body.
  • the at least one temperature sensor and the at least one body activity sensor respectively measure temperature and body activity such that the temperature represents skin temperature at a body region which is less active than a region which is principally undergoing body activity.
  • the at least one body activity sensor is embodied in a treadmill. Additionally or alternatively, the temperature sensor measures skin temperature on a person's wrist.
  • the body activity sensor is mounted on a portion of the person's body which is undergoing physical activity while the temperature sensor is mounted on a portion of the person's body other than that portion undergoing physical activity.
  • body temperature and physical activity of the person is measured from a point in time, designated A, at which the person starts to stand up from a sitting position after sitting at rest, preferably for a minimum of 5 minutes.
  • a point in time at which the person finishes standing up is designated point in time B.
  • physical exertion begins at a point in time C and the physical exertion is terminated at a point in time D.
  • Points in time A and B are preferably separated by approximately 5-10 seconds.
  • Points in time B and C are preferably separated by approximately 5 minutes.
  • Points in time C and D are preferably separated by approximately 5 minutes.
  • a further point in time E is selected approximately 5 minutes following point in time D.
  • a time separation between point in times B and C is approximately 5 minutes
  • a time separation between point in times C and D is approximately 5 minutes
  • a further measuring point in time, designated point in time E is established at approximately 5 minutes following point in time D.
  • an MDST dynamic for time periods B - C, C - D and D - E is equivalent to dynamics shown in one of lines 7, 8, 9, and 10 in the Dynamics Table of Fig.
  • an MDST dynamic for time periods B - C, C - D and D - E is equivalent to dynamics shown in one of lines 1, 2, 3, 4, 5, and 6 in the Dynamics Table of Fig. 1 for an LVD person.
  • the body activity sensor provides outputs indicating ONSET OF PHYSICAL ACTIVITY (OOPA), TERMINATION OF PHYSICAL ACTIVITY (TOPA) and DISTANCE TRAVELLED DURING PHYSICAL ACTIVITY (DTD A).
  • the system also includes a minimum exertion level calculator receiving the outputs of the body activity sensor and providing an output indicating whether a minimum threshold for physical exertion has been exceeded between the OOPA and the TOPA.
  • the system for providing an indication of at least LVD also includes at least one of at least one temperature sensor to measure ambient temperature during diagnosis and at least one humidity sensor to measure ambient humidity during diagnosis. Additionally, the at least one of at least one temperature sensor and at least one humidity sensor is operative to correct ambient effects on body during diagnosis.
  • the MDST dynamic is provided as an output from the time/temperature ascertainer to the correlator.
  • MDST dynamic is based on differences between the measured temperature during the time periods B - C, C - D and D - E.
  • a method for providing an indication of at least LVD (Left Ventricular Dysfunction)
  • the method including sensing a skin temperature of a subject at at least one location on a person at a plurality of given times, providing a plurality of skin temperature output indications based on the sensing, sensing body activity of the subject and providing an output indication of at least onset and termination of the body activity, ascertaining skin temperature change output indications of the subject at at least one of before the onset of the body activity, during the body activity and after termination of body activity based on the plurality of skin temperature output indications and the output indication of onset and termination of the body activity, correlating the skin temperature change output indications of the subject with accumulated clinical data relating changes in skin temperature at at least one of before body activity, during body activity and after body activity to existence of at least LVD and providing at least an output indication of at least one of presence of LVD and absence of LVD.
  • LVD Left Ventricular Dysfunction
  • the sensing a skin temperature and the sensing body activity respectively include sensing skin temperature and sensing body activity at two distinct regions of a person's body.
  • the sensing a skin temperature and the sensing body activity respectively include sensing skin temperature and sensing body activity at a single region of a person's body.
  • the sensing a skin temperature and the sensing body activity respectively include sensing skin temperature at a body region which is less active than a region which is principally undergoing body activity.
  • the method for providing an indication of at least LVD also includes sensing ambient temperature in order to correct ambient effects on body during diagnosis. Additionally or alternatively, the method for providing an indication of at least LVD also includes sensing ambient humidity in order to correct ambient effects on body during diagnosis.
  • LVD-RCTIFNTCRH a monitoring system for providing an indication of an LVD- related condition that if not treated could require hospitalization.
  • LVD-RCTIFNTCRH conditions include one or more of the following:
  • LVD Left Ventricular Dysfunction
  • a change in at least one of pulmonary arterial pressure, cardiac output, ejection fraction, atrial function, ventricular function, fluid management, thermoregulation, haemodynamics, valvular function, heart rhythm and functional capacity a change in at least one of pulmonary arterial pressure, cardiac output, ejection fraction, atrial function, ventricular function, fluid management, thermoregulation, haemodynamics, valvular function, heart rhythm and functional capacity
  • the monitoring system provides monitoring of patients who have previously been diagnosed with LVD or an LVD-RCTIFNTCRH.
  • the monitoring system preferably includes at least one temperature sensor, providing an output indication based on skin temperature at at least one location on a person at a plurality of given times, at least one body activity sensor providing an output indication of at least termination of body activity, a time/temperature ascertainer operative to receive inputs from the at least one temperature sensor and from the at least one body activity sensor to provide output indications of the skin temperature at at least one of onset of body activity, during body activity, termination of body activity and thereafter, and a monitoring comparator, operative to receive the output indications from the time/temperature ascertainer representing at least two monitoring sessions which are mutually separated in time and to compare the output indications, the monitoring comparator providing at least an output indication of an LVD-RCTIFNTCRH.
  • the monitoring comparator also receives an input from the at least one body activity sensor. Additionally or alternatively, the monitoring comparator also receives a personal data input.
  • the monitoring comparator also receives an input including stored results from one or more previous monitoring sessions of at least one LVD person other than the LVD person being monitored. Additionally, the monitoring comparator is operative to compare the output indications from the time/temperature ascertainer to the stored results from the one or more previous monitoring session of the at least one LVD person other than the LVD person being monitored.
  • the at least one temperature sensor and the at least one body activity sensor respectively measure temperature and body activity at a single region of a person's body.
  • the at least one temperature sensor and the at least one body activity sensor respectively measure temperature and body activity at two different regions of a person's body.
  • the at least one temperature sensor measures skin temperature at a body region which is less active than a region which is principally undergoing body activity.
  • the body activity sensor is mounted on a portion of the person's body which is undergoing physical exertion and the temperature sensor is mounted on a portion of the person's body other than that portion undergoing physical exertion.
  • the temperature sensor measures skin temperature on a person's wrist.
  • the at least one body activity sensor is embodied in a treadmill.
  • physical exertion of the person is measured from a starting point in time designated time A at which the person is standing and at rest, the onset of physical exertion begins at a point in time designated B and the physical exertion is terminated at a point in time designated C. Additionally, a time separation between points A and B is approximately 5 minutes, a time separation between points in time B and C is approximately 5 minutes and a further measuring point in time, designated point in time D, is established at approximately 5 minutes following point in time C.
  • measured differential skin temperature (MDST) relative to point in time C (MDST(C)) at at least one of points in time B and D is different from previous MDST(C) at the at least one point in time B and D following a change in LVD severity and/or progression, and/or following an indication of an LVD-related condition that if not treated could require hospitalization (LVD-RCTIFNTCRH).
  • MDST(C) at points in time B and D is similar to previous MDST(C) at the points in time B and D following a lack of change in LVD severity and/or progression and/or following an indication of an LVD-related condition that if not treated could require hospitalization (LVD-RCTIFNTCRH).
  • MDST(C) decreases from point in time C to point in time D for a typical LVD person.
  • the monitoring comparator is operative to compare measured differential skin temperature parameters, such as MDST(D - C), taken at different monitoring sessions.
  • measured differential skin temperature parameters such as MDST(D - C)
  • each monitoring session begins at point in time A and terminates at point in time D.
  • MDST(D - C) changes from one monitoring session to another, this may indicate a change in an LVD-RCTIFNTCRH.
  • the at least one body activity sensor provides outputs indicating ONSET OF PHYSICAL EXERTION (OOPE), TERMINATION OF PHYSICAL EXERTION (TOPE) and DISTANCE TRAVELLED DURING PHYSICAL EXERTION (DTDE).
  • the monitoring system for providing an indication of LVD-RCTIFNTCRH in an LVD person also includes a minimum exertion level calculator receiving the outputs of the at least one body activity sensor and providing an output indicating whether a minimum threshold for physical exertion has been exceeded between the OOPE and the TOPE.
  • the body activity of the person is measured from a starting point in time designated time E at which the person is sitting and at rest, the person begins to stand up at a point in time designated time Fl and the person completes standing up at a point in time designated time F2.
  • a time separation between points E and Fl is approximately 5 minutes
  • a time separation between points Fl and F2 is approximately 5 seconds
  • a time separation between point in time F2 and a reference point in time G is approximately 2 minutes
  • at least one further measuring point in time, designated at least one of HI, H2 & H3 is established at approximately at least one of 1 minute, 2 minutes and 3 minutes following point in time G.
  • at least two of the points in time HI, H2 & H3 are established following point in time G.
  • Most preferably, all of the points in time HI, H2 & H3 are established following point in time G.
  • a measured differential skin temperature (MDST) relative to point in time G (MDST(G)) at at least one of points in time HI, H2 and H3 is different from a previous MDST(G), at the at least one of points in time HI, H2 and H3 following a change in LVD severity and/or progression.
  • MDST(G) at points in time HI, H2 and H3 in an earlier test and MDST(G) at the points in time HI, H2 and H3 in a later test is indicative of a lack of change in LVD severity and/or progression between the earlier test and the later test.
  • the body activity sensor provides outputs indicating ONSET OF POSITION CHANGE (OOPC), TERMINATION OF POSITION CHANGE (TOPC) and POSITION CHANGE INERTIAL DATA (PCID).
  • the monitoring system for providing an indication of LVD-RCTIFNTCRH in an LVD person also includes a body position change calculator receiving the outputs of the body activity sensor and providing an output indicating whether a qualifying position change has been performed between the OOPC and the TOPC as well as the TYPE OF POSITION CHANGE (TYPC).
  • the monitoring system for providing an indication of LVD-RCTIFNTCRH in an LVD person also includes at least one of at least one temperature sensor to measure ambient temperature during monitoring and at least one humidity sensor to measure ambient humidity during monitoring of the person. Additionally, the at least one of at least one temperature sensor and at least one humidity sensor measures ambient conditions in order to correct ambient effects on the person during the monitoring.
  • a computerized method for providing an indication of LVD-RCTIFNTCRH in an LVD person including sensing a skin temperature of a subject at at least one location on a person at a plurality of given times, providing a plurality of skin temperature output indications based on the sensing, sensing body activity of the subject and providing an output indication of at least termination of the body activity, ascertaining skin temperature of the subject at at least one of onset of body activity, during body activity, termination of body activity and thereafter based on the plurality of skin temperature output indications and the output indication of at least termination of the body activity, correlating the skin temperature of the subject at the at least one of onset of body activity, during body activity, termination of body activity and thereafter with pre-established clinical skin temperature baseline data for the same specific individual relating changes in skin temperature indications at at least one of onset of body activity, during body activity and at termination of body activity and thereafter to severity and/or progression of at least LVD and providing
  • the sensing a skin temperature and the sensing body activity respectively include sensing skin temperature and sensing body activity at two distinct regions of a person's body.
  • the sensing a skin temperature and the sensing body activity respectively include sensing skin temperature and sensing body activity at a single region of a person's body.
  • the sensing a skin temperature and the sensing body activity respectively include sensing skin temperature at a body region which is less active than a region which is principally undergoing body activity.
  • the output indication of at least a change in LVD severity and/or progression indicates the absence of a change in LVD severity and/or progression when measured differential skin temperature relative to point in time C is similar to measured differential skin temperature relative to point in time C in previous measurements.
  • the output indication of at least a change in LVD severity and/or progression indicates the presence of a change in LVD severity and/or progression when measured differential skin temperature relative to point in time differs from measured differential skin temperature relative to point in time C in previous measurements.
  • the method also includes sensing at least one of ambient temperature and ambient humidity during the sensing a skin temperature. Additionally, the method also includes correcting ambient effects on the person during the sensing a skin temperature.
  • the correlating includes receiving a personal data input.
  • the correlating includes receiving stored results from one or more monitoring sessions of at least one LVD person other than the subject. Additionally, the correlating includes comparing the skin temperature of the subject to the stored results from the one or more monitoring sessions of the at least one LVD person other than the subject.
  • Fig. 1 is a simplified table ("Dynamics Table") of combinations of Measured Differential Skin Temperatures (MDSTs) during intervals between points in time B, C, D and E which indicate existence of Left Ventricular Dysfunction (LVD) or lack thereof;
  • MDSTs Measured Differential Skin Temperatures
  • Fig. 2 is a simplified illustration of a system which produces an output indication of change in MDST(D) as a time function of physical activity of a person and provides an indication of the presence or absence of LVD in accordance with a preferred embodiment of the present invention
  • Fig. 3 is a simplified functional block diagram of the system of Fig. 2;
  • Fig. 4 is a simplified flowchart illustrating operation of the system of Fig.
  • Fig. 5 is a simplified diagram showing experimental MDST(D) data for non-LVD subjects and LVD subjects;
  • Fig. 6 is a simplified diagram showing experimental MDST(D) data for non-LVD subjects and LVD subjects indicating standard deviations;
  • Fig. 7 is a simplified illustration of a system which provides an output indication of change in skin temperature as a time function of physical exertion for a typical person and provides an indication of an LVD (Left Ventricular Dysfunction) related condition that if not treated could require hospitalization (LVD-RCTIFNTCRH) in accordance with another preferred embodiment of the present invention;
  • LVD Left Ventricular Dysfunction
  • Fig. 8 is a simplified functional block diagram of the system of Fig. 7;
  • Fig. 9 is a simplified illustration of the values of MDST(D - C) for a given individual monitored on multiple occasions, in which OOPE, TOPE and DTDE and personal data regarding the individual being monitored did not significantly change;
  • Fig. 10 is a simplified flowchart illustrating operation of the system of
  • FIG. 7 - 9 for detection of an LVD-RCTIFNTCRH
  • FIG. 11 is a simplified illustration of a system, constructed and operative in accordance with yet another preferred embodiment of the present invention, which provides an output indication of change in skin temperature as a time function of physical activity for a typical person and provides an indication of an LVD- RCTIFNTCRH;
  • Fig. 12 is a simplified functional block diagram of the system of Fig. 11;
  • Fig. 13 is a simplified illustration of the values of MDST(H1 - G) for a given individual derived from multiple monitoring sessions using the system of Fig. 11;
  • Fig. 14 is a simplified flowchart illustrating operation of the system of
  • Figs. 11 - 13 for detection of an LVD -RCTIFNTCRH.
  • Fig. 1 is a simplified table (“Dynamics Table”) of combinations of measured differential skin temperatures (MDSTs) between points in time B, C, D and E, preferably separated by 5 minute intervals, which indicate the presence or absence of LVD.
  • MDSTs measured differential skin temperatures
  • a measured differential skin temperature is defined with respect to a measured skin temperature at a given point in time.
  • MDST(C) is defined as the measured skin temperature at a point in time minus the measured skin temperature at point in time C.
  • measured differential skin temperature (MDST) across at least one time interval between at least one pair of points in time B - C, C - D and D - E provides an indication of the presence or absence of LVD.
  • An increase (+) in MDST is defined as an increase in Skin Temperature (ST) from one point in time to another, preferably of at least 0.1 Degree Celsius, during a time period of no less than 45 seconds. This increase must be monotonous but may or may not be at a constant rate.
  • a decrease (-) in MDST is defined as a decrease in Skin Temperature
  • a flat line (0) in MDST is defined as the absence of an increase or decrease in Skin Temperature (ST) from one point in time to another, as defined above.
  • the entry +/- in the Dynamics Table shown in Fig. 1 indicates that an increase, as defined above, of at least 45 seconds duration, was followed by a decrease, as defined above, of at least 45 seconds duration, within the same time interval between points in time B - C, C - D or D - E.
  • the entry -/+ in the Dynamics Table shown in Fig. 1 indicates that a decrease of at least 45 seconds duration was followed by an increase of at least 45 seconds duration within the same time interval between points in time B - C, C - D or D - E.
  • various combinations of the increase/decrease/flat line may occur.
  • the system of the present invention will provide an indication of presence of LVD.
  • Line 4 in the Dynamics Table of Fig. 1 indicates that when the skin temperature measurement between points in time B and C shows either an increase or an increase followed by a decrease and the skin temperature measurement between points in time C and D shows a decrease and the skin temperature measurement between points in time D and E shows an increase, the system of the present invention will provide an indication of presence of LVD.
  • the system of the present invention will provide an indication of presence of LVD.
  • Line 6 in the Dynamics Table of Fig. 1 indicates that when the skin temperature measurement between points in time B and C shows either a decrease or an increase or a decrease followed by an increase and the skin temperature measurement between points in time C and D shows an increase and the skin temperature measurement between points in time D and E shows a decrease, the system of the present invention will provide an indication of presence of LVD.
  • Line 9 in the Dynamics Table of Fig. 1 indicates that when the skin temperature measurement between points in time B and C shows any increase or decrease, including an increase followed by a decrease or a decrease followed by an increase, and the skin temperature measurement between points in time C and D shows either an increase or an increase followed by a decrease and the skin temperature measurement between points in time D and E shows either an increase followed by a decrease or a decrease followed by an increase, the system of the present invention will provide an indication of absence of LVD.
  • the system of the present invention will provide an indication of absence of LVD.
  • the Dynamics Table of Fig. 1 is based on current clinical data and thus, there are combinations of dynamics for which clinical data is not currently available to provide an indication of presence or absence of LVD. Additionally, it is anticipated that, as additional clinical data relating to LVD becomes available, the Dynamics Table will be updated. In the event the dynamics of the individual being tested do not match any of the dynamics in the Dynamics Table of Fig. 1, the system of the present invention will provide an indication that it was unable to provide either an indication of presence or absence of LVD.
  • Fig. 2 is a simplified illustration of a system which produces an output indication of change in MDST(D) as a time function of physical activity of a person and provides an indication of the presence or absence of LVD in accordance with a preferred embodiment of the present invention.
  • MDST(D) is defined as the measured skin temperature at a point in time minus the measured skin temperature at point in time D.
  • MDST(D) is selected from among various MDST parameters, since it appears to provide an optimal distinction between LVD and non- LVD patients.
  • a person herein sometimes referred to as an individual, is shown undergoing a regimen of timed physical activity, here, for example, standing up, after resting while sitting down, and then running on a treadmill.
  • the physical activity of the person is measured by any suitable motion sensor 100, such as a DRM- 4000 motion sensor commercially available from Honeywell.
  • the skin temperature of the person is simultaneously measured by a temperature sensor 102, such as an ADT 7420 temperature sensor, commercially available from Analog Devices.
  • the motion sensor 100 is preferably mounted on a portion of the person's body which is undergoing physical exertion, such as the leg of the person, while the temperature sensor 102 is preferably mounted on a portion of the person's body other than that portion undergoing physical exertion, preferably the left wrist of the person.
  • the physical activity of the person is measured from a starting point in time, time 0, designated B, at which the person has finished standing up.
  • the person starts standing up, at a point in time, designated point in time A, prior to point in time B, preferably from a sitting position after sitting at rest, preferably for a minimum of 5 minutes.
  • the onset of physical exertion begins at a point of time designated C and the intensity of the physical exertion, increases in steps, typically, when the physical exertion is walking on a treadmill as in the illustrated embodiment, increasing to a speed of 2.7 km/hr.
  • the physical exertion is terminated at a point in time designated D.
  • the time separation between points B and C is typically and preferably 5 minutes and the time separation between point in times C and D is typically and preferably 5 minutes.
  • a further measuring point in time, designated point in time E, is typically and preferably 5 minutes following point in time D.
  • Fig. 2 indicates MDST(D) over time.
  • the indicated MDST(D) is thus appreciated to be a computed parameter, which is only provided following point in time D.
  • MDST(D) is typically approximately 0.25-0.15 °C at point in time B, decreases between points in time B and C and then continues to decrease, approximately one minute after point in time C generally linearly to zero at point in time D.
  • MDST(D) increases as shown from point in time D to point in time E and typically therebeyond.
  • the MDST(D) for a non-LVD individual is designated in Fig. 2 by NLVD.
  • a point in time B is typically approximately 0.18-0.05 °C, decreases between point in times B and C and then continues to decrease, approximately one minute after point in time C generally linearly to zero at point in time D.
  • MDST(D) continues to decrease as shown to point in time E and typically therebeyond.
  • the MDST(D) for a typical LVD individual is designated in Fig. 2 by LVD. Referring to the Dynamics Table of Fig. 1, the above-described changes in the MDST between points in time B, C, D and E are indicated at line 1.
  • Fig. 3 is a simplified functional block diagram of the system of Fig. 2.
  • motion sensor 100 provides outputs indicating ONSET OF
  • PHYSICAL ACTIVITY which preferably indicates point in time A and/or point in time C
  • TOPA TERMINATION OF PHYSICAL ACTIVITY
  • Physical Activity for the purposes of this description, is defined as any physical movement of a person, such as standing up, walking, running or doing calisthenics.
  • Physical Exertion for the purposes of this description, is defined as Physical Activity which meets at least a minimum threshold. This threshold may be defined by one or more measured metrics, such as, for example, heart rate, respiration rate, acceleration or speed of movement of a body part and perspiration.
  • a Minimum Physical Exertion Calculator 110 which is programmed to indicate whether the at least one minimum threshold has been reached, receives one or more, and preferably all, of the above outputs of motion sensor 100 and preferably provides a binary output to a time/temperature ascertainer, such as an MDST Calculator 120, indicating whether a minimum threshold for physical exertion has been exceeded between the OOPA and the TOPA.
  • a temperature sensor 102 operates continuously and provides a SKIN TEMPERATURE OUTPUT (STO) to MDST Calculator 120.
  • MDST Calculator 120 receives the TOPA and OOPA outputs from motion sensor 100 as well as an output from Minimum Exertion Level Calculator 110, indicating that at least an acceptable minimum level of Physical Exertion took place between points in time A and B and/or points in time C and D.
  • MDST Calculator 120 calculates the difference in skin temperature during at least one of the intervals between points in time B - C, C - D and D - E.
  • MDST Calculator 120 calculates the difference in skin temperature for all of the time intervals between points in time B - C, C - D and D - E.
  • B - C, C - D and D - E is based on a currently available collection of test results and may change with further experimental experience.
  • the MDST Calculator 120 provides at least one of the following outputs to LVD Determining Circuitry 130:
  • MDST Calculator 120 outputs an MDST dynamic for each of time intervals B - C, C - D and D - E.
  • LVD Determining Circuitry 130 preferably provides a binary output indicating whether there appears to be an LVD condition or not based on the MDST dynamics provided by MDST Calculator 120 and the Dynamics Table. Additionally or alternatively, the LVD Determining Circuitry 130 may provide an analog output indicating a degree of certainty and/or degree of severity of an LVD condition.
  • Fig. 4 is a simplified flowchart illustrating operation of the system of Figs. 1 - 3 for screening.
  • the motion sensor 100 provides the OOPA, TOPA and DTDA outputs to Minimum Exertion Level Calculator 110, which, in turn, provides an output to MDST Calculator 120 indicating that at least a minimum exertion level has been achieved.
  • DTDA is a cumulative metric which increases over the time duration of the physical exertion.
  • the physical exertion may not comprise walking or running, wherein a cumulative distance metric is appropriate, and may instead comprise a different type of physical exertion, having a different cumulative metric, which may be used instead of DTDA.
  • Minimum Exertion Level Calculator 110 is used by the MDST Calculator 120, which also receives measured temperature outputs from the temperature sensor 102 and the TOPA and OOPA outputs from motion sensor 100 to ascertain points in time B, C, D and E and to ascertain an MDST dynamic for at least one of time intervals B - C, C - D and D - E.
  • MDST calculator 120 calculates the differences between the measured temperature during at least one of the time intervals B - C, C - D and D - E and provides an MDST dynamic, as noted hereinabove, either a '+', '+/-', '-/+' or ⁇ ', for at least one of time intervals B - C, C - D and D - E.
  • MDST calculator 120 calculates the differences between the measured temperature during all of time intervals B - C, C - D and D - E and provides an MDST dynamic for all of time intervals B - C, C - D and D - E.
  • the LVD Determining Circuitry 130 receives the output MDST dynamics from the MDST Calculator 120 and provides an output indication of the presence or absence of LVD in the screened person, based on a comparison of at least one of the dynamics for time intervals B - C, C - D and D - E with corresponding dynamics for time intervals B - C, C - D and D - E in a Dynamics Table, such as the Dynamics Table of Fig. 1, known from established accumulated historical empirical clinical data relating to LVD subjects and non-LVD subjects.
  • the MDST dynamics for all three time intervals B - C, C - D and D - E is utilized by the LVD Determining Circuitry 130.
  • the established clinical data used in the LVD Determining Circuitry 130 may represent an undifferentiated sample population or may be grouped specifically by parameters such as age, sex, weight, height, average blood pressure, medicinal treatment, additional medical conditions, and matched to screened persons having similar parameters.
  • Fig. 5 is a simplified diagram showing averaged typical experimental MDST(D) data for non-LVD subjects, indicated by solid dots, and LVD subjects, indicated by triangles. It is seen that in accordance with a preferred embodiment of the present invention, LVD and non-LVD subjects may be readily and automatically distinguished by the increase or decrease in MDST values.
  • the above-described changes in the MDST between points in time B, C, D and E are indicated at line 1 for LVD subjects and at line 7 for non-LVD subjects.
  • Fig. 6 is a simplified diagram showing experimental MDST(D) data for non-LVD subjects, indicated by solid dots, and LVD subjects, indicated by triangles, from time point D through time point E and therebeyond indicating standard deviations, which are indicated respectively by small solid dots and small triangles.
  • a measured differential skin temperature is defined, preferably with respect to a measured skin temperature at a given point in time.
  • MDST(C) is defined as the measured skin temperature at a point in time minus the measured skin temperature at point in time C.
  • MDST(D - C) may thus be understood to refer to the measured skin temperature at point in time D minus the measured skin temperature at point in time C.
  • Fig. 7 is a simplified illustration of a system which provides an indication of a Left Ventricular Dysfunction (LVD) related condition that if not treated could require hospitalization (LVD-RCTIFNTCRH).
  • the system provides monitoring of patients who have previously been diagnosed with LVD or an LVD-RCTIFNTCRH.
  • a person herein sometimes referred to as an individual, is shown undergoing a regimen of timed physical exertion, here, for example, running on a treadmill.
  • the individual is a person who has been previously diagnosed with LVD or an LVD-RCTIFNTCRH.
  • the system of Fig. 7 is preferably employed for monitoring such an individual in a plurality of time-separated monitoring sessions. These sessions are typically separated by at least hours and more preferably by days.
  • Fig. 7 includes a simplified diagram showing a preferred example of MDST(C) data for the individual at an earlier monitoring session, indicated by a dotted line and labeled LVD-1, and a second measurement showing MDST(C) data for the same individual at a later monitoring session, indicated by a solid line and labeled LVD- 2.
  • the physical exertion of the person is measured by any suitable motion sensor 700, such as a DRM-4000 motion sensor commercially available from Honeywell.
  • the skin temperature of the person is preferably simultaneously measured by a temperature sensor 702, such as an ADT 7420 temperature sensor, commercially available from Analog Devices.
  • the motion sensor 700 is preferably mounted on a portion of the person's body which is undergoing physical exertion, such as the leg of the person, while the temperature sensor 702 is preferably mounted on a portion of the person's body other than that portion undergoing primary physical exertion, preferably the left wrist of the person.
  • the outputs of the motion sensor 700 and the temperature sensor 702 are preferably supplied to Analysis Circuitry 704, which preferably provides an output indication of changes in MDST(C).
  • the physical exertion of the person is measured from a point in time, time 0, designated A, at which the person is already standing and at rest and the onset of physical exertion is at a point of time designated B and increases in intensity in steps, typically, when the physical exertion is walking on a treadmill as in the illustrated embodiment, increasing to a walking rate of 2.7 km/hr.
  • the physical exertion is terminated at a point in time designated C.
  • the time separation between points in time A and B is typically and preferably 5 minutes.
  • the time separation between points in time B and C is typically and preferably 5 minutes.
  • a further measuring point in time, designated D, is established at typically and preferably 5 minutes following point in time C.
  • the graph in Fig. 7 indicates the difference calculated by subtracting the skin temperature at a base point in time, preferably at point in time C, from the sensed skin temperature at a given time prior to or following point in time C.
  • the graph of the output of Analysis Circuitry 704 is thus appreciated to be a computed graph which, in this preferred example, is only provided following point in time C.
  • the measured skin temperature minus the measured skin temperature at point in time C may change over time.
  • LVD-1 typically indicates MDST(C) data based on an initial, baseline measurement.
  • LVD-2 typically indicates MDST(C) data based on a later measurement following the initial measurement.
  • MDST(C) is typically approximately 0.1 °C between points in time A and B and then falls after point in time B to zero at point in time C.
  • Fig. 8 is a simplified functional block diagram of the system of Fig. 7 having the monitoring comparator functionality described above.
  • motion sensor 700 provides outputs indicating ONSET OF PHYSICAL EXERTION (OOPE), preferably indicating point in time B, TERMINATION OF PHYSICAL EXERTION (TOPE), preferably indicating point in time C, and DISTANCE TRAVELLED DURING PHYSICAL EXERTION (DTDE).
  • OOPE ONSET OF PHYSICAL EXERTION
  • TOPE TERMINATION OF PHYSICAL EXERTION
  • DTDE DISTANCE TRAVELLED DURING PHYSICAL EXERTION
  • a Minimum Exertion Level Calculator 710 receives one or more, and preferably all, of the above outputs of motion sensor 700 and preferably provides a binary output to a time/temperature ascertainer, such as an MDST(C) Calculator 720, also forming part of the Analysis Circuitry 704 (Fig. 7), indicating whether a minimum threshold for physical exertion has been exceeded between the OOPE and the TOPE.
  • a time/temperature ascertainer such as an MDST(C) Calculator 720
  • temperature sensor 702 operates continuously and provides a SKIN TEMPERATURE OUTPUT (STO) to MDST Calculator 720, which is preferably an MDST(C) Calculator.
  • MDST(C) Calculator 720 receives the TOPE output from motion sensor 700 as well an output from Minimum Exertion Level Calculator 710. If the output from Minimum Exertion Level Calculator 710 indicates that at least an acceptable minimum level of Physical Exertion took place between points in time B and C, MDST(C) Calculator 720 calculates the difference in skin temperature between the point in time C indicated by the TOPE output, corresponding to termination of physical exertion, and point in time D, typically 300 seconds following point in time C.
  • STO SKIN TEMPERATURE OUTPUT
  • time duration selected to separate points in time D and C is a function of the available data from test subjects and that the current time separation is based on a limited sample of test subjects and may change or have greater resolution as more subjects are tested.
  • a monitoring comparator 740 receives the MDST(D - C) output from MDST(C) calculator 720 as well as the OOPE, TOPE and DTDE outputs of motion sensor 700.
  • the monitoring comparator 740 also preferably receives data regarding the person undergoing testing, preferably including one or more of the following parameters: weight in kilograms, heart rate, average blood pressure, medicinal treatment and additional medical conditions. This data is hereafter referred to as "personal data". Additionally or alternatively, the personal data may also include at least one of identification, age in years, sex, and height in centimeters.
  • the monitoring comparator 740 also preferably receives stored data relating to the individual from one or more previous monitoring sessions, preferably including the MDST(D - C) output from MDST(C) calculator 720, as well as the OOPE, TOPE and DTDE outputs of motion sensor 700, as well as the personal data from the one or more previous monitoring sessions.
  • the output of the monitoring comparator 740 is preferably an indication of changes in MDST(D - C) calculated based on measurements taken in two different monitoring sessions separated in time, together with an indication as to whether any of OOPE, TOPE and DTDE outputs of motion sensor 700 or personal data, such as weight, heart rate, average blood pressure, medicinal treatment and additional medical conditions changed between the two monitoring sessions.
  • comparator 740 when a change in LVD condition is indicated by comparator 740, comparator 740 also preferably receives stored data from previous monitoring sessions relating to one or more other individuals, preferably including the MDST(D - C) output from MDST(C) calculator 720, as well as the OOPE, TOPE and DTDE outputs of motion sensor 700, as well as the personal data from one or more previous monitoring sessions. Comparator 740 preferably automatically identifies other individuals with MDST(C) changes, TOPE, OOPE, DTDE and/or personal data similar to those of the individual being monitored. Comparator 740 preferably automatically indicates a specific LVD-RCTIFNTCRH that is indicated by changes in MDST(C) in the other individuals similar to the change in MDST(C) seen in the individual being monitored.
  • Fig. 9 is a simplified illustration of the values of MDST(D-C) for a given individual monitored on multiple occasions, in which OOPE, TOPE and DTDE and the personal data regarding the individual being monitored did not significantly change.
  • Fig. 9 it is seen that although the MDST(D-C) for the individual remains stable and constant at measuring points in July, August, September and October, 2013, it falls precipitously in November, 2013, indicating the probability of a condition which requires clinical intervention.
  • Fig. 10 is a simplified flowchart illustrating operation of the system of Figs. 7 & 8 for detection of a change in an LVD metric useful in monitoring.
  • the motion sensor 700 provides the OOPE, TOPE and DTDE outputs to Minimum Exertion Level Calculator 710, which provides an output to MDST(C) Calculator 720 indicating that at least a minimum exertion level has been achieved.
  • MDST(C) Calculator 720 receives a measured temperature output from the temperature sensor 702 and the TOPE output from motion sensor 700 to initially ascertain the measured temperature at point in time C and the measured temperature at point in time D thereafter.
  • MDST(C) calculator 720 preferably calculates the difference between the measured temperature at points in time D and C, also referred to as MDST(D - C).
  • comparator 740 receives the DTDE output of the motion sensor 700 at time C, together with the OOPE and TOPE outputs of the motion sensor, the output of the MDST(C) calculator 720 as well as the personal data of the patient being monitored. Additionally, as noted above, comparator 740 also preferably receives stored data relating to the individual from one or more previous monitoring sessions, preferably including the MDST(D - C) output from MDST(C) calculator 720 as well as the OOPE, TOPE and DTDE outputs of motion sensor 700, as well as the personal data from the one or more previous monitoring sessions.
  • Comparator 740 automatically calculates differences in MDST(D - C) for that patient based on previous MDST(D - C) calculations for that patient and indicates the presence or absence of a LVD metric which indicates the presence or absence of an LVD-RCTIFNTCRH.
  • the comparator 740 preferably also indicates whether there has been a change in the personal data or the OOPE, TOPE or DTDE.
  • comparator 740 when a change in LVD condition is indicated by comparator 740, comparator 740 also preferably receives stored data from previous monitoring sessions relating to one or more other individuals, preferably including the MDST(D - C) output from MDST(C) calculator 720, as well as the OOPE, TOPE and DTDE outputs of motion sensor 700, as well as the personal data from one or more previous monitoring sessions. Comparator 740 preferably automatically identifies other individuals with MDST(C) changes, TOPE, OOPE, DTDE and/or personal data similar to those of the individual being monitored. Comparator 740 preferably automatically indicates a specific LVD-RCTIFNTCRH that is indicated by changes in MDST(C) in the other individuals similar to the change in MDST(C) seen in the individual being monitored.
  • Fig. 11 is a simplified illustration of a system which produces an output indication of measured difference in skin temperature (MDST) as a time function of position change for a specific person and provides an indication of an LVD-RCTIFNTCRH in accordance with another preferred embodiment of the present invention.
  • the system provides monitoring of patients who have previously been diagnosed with LVD or an LVD-RCTIFNTCRH.
  • a person herein sometimes referred to as an individual, is shown undergoing a position change, here, for example, standing up after sitting on a chair.
  • the individual is a person who has been previously diagnosed with LVD or an LVD-RCTIFNTCRH.
  • the system of Fig. 11 is preferably employed for monitoring such an individual in a plurality of time-separated monitoring sessions. These sessions are typically separated by at least hours and more preferably by days.
  • the position change of the person is measured by any suitable motion sensor 800, such as a DRM-4000 motion sensor commercially available from Honeywell.
  • the skin temperature of the person is preferably simultaneously measured by a temperature sensor 802, such as an ADT 7420 temperature sensor, commercially available from Analog Devices.
  • the motion sensor 800 may be mounted on a portion of the person's body which is undergoing position change, such as the torso of the person, while the temperature sensor 802 may be mounted on another portion of the person's body, preferably the left wrist of the person. Preferably, both the motion sensor 800 and the temperature sensor 802 are incorporated in a wrist-mounted device, as shown. Outputs of the motion sensor 800 and of the temperature sensor 802 are preferably provided to Analysis Circuitry 804. Considering now the output of the motion sensor 800, it is seen that the position change of the person is measured from point in time, time 0, designated E, at which the person is sitting down, designated in Fig. 11 as Position 1, and at rest and the position change takes place between points of time Fl and F2 when the person stands up, designated in Fig. 11 as Position 2.
  • the time separation between points in time E and Fl is typically and preferably 5 minutes and the time separation between points in time Fl and F2 is typically and preferably 5 seconds.
  • a further measuring point in time, typically 2 minutes following point in time F2, is designated as point in time G.
  • At least one of three alternative further measuring points in time, designated as points in time HI, H2 and H3, respectively, are established typically at 1 minute, 2 minutes and 3 minutes following point in time G.
  • the graph indicates the difference calculated by subtracting the skin temperature at point in time G from the sensed skin temperature at a given time on the graph.
  • the graph of the output of Analysis Circuitry 804 is thus appreciated to be a computed graph which is only provided, in this preferred example, following point in time G.
  • the measured skin temperature at a point of time minus the measured skin temperature at point in time G herein designated by reference MDST(G) is approximately 0.17 °C between points in time E and F2 and then falls, approximately three minutes after point in time F2, generally linearly to zero at point in time G.
  • MDST(G) continues to decrease as shown to point in time H2 and typically the decrease becomes less steep therebeyond.
  • the MDST(G) for the initial measurement of this LVD individual is designated as LVD-1.
  • the measured skin temperature at a point of time minus the measured skin temperature at point in time G is also approximately 0.17 °C between points in time E and F2 and then falls after point in time F2 to zero at point in time G.
  • MDST(G) For this individual, following the position change at point in time F, MDST(G) continues to decrease as shown for about one minute following point in time G. Immediately thereafter the MDST(G) decreases at an increased rate. MDST(G) based on the later measurement of this LVD individual is designated as LVD-2. It is seen that the individual appears to have experienced a deterioration in an LVD metric, which could indicate a deterioration in an LVD-RCTIFNTCRH during the time between the monitoring sessions.
  • Fig. 12 is a simplified functional block diagram of the system of Fig. 11 including Analysis Circuitry 804.
  • motion sensor 800 provides outputs indicating ONSET of
  • POSITION CHANGE preferably indicating point in time Fl
  • TOPC TERMINATION OF POSITION CHANGE
  • PCID POSITION CHANGE INERTIAL DATA
  • Position change calculator 810 receives these outputs and provides a TYPE OF POSITION CHANGE (TYPC) output.
  • TYPE OF POSITION CHANGE TYPC
  • a time/temperature ascertainer such as an MDST Calculator 820, preferably an MDST(G) Calculator, receives the TYPC output, the SKIN TEMPERATURE OUTPUT from temperature sensor 802 and the TOPC output of motion sensor 800 and provides an MDST output, preferably an MDST(G) output.
  • temperature sensor 802 operates continuously and the SKIN TEMPERATURE OUTPUT enables the MDST(G) Calculator 820 to calculate the difference in skin temperature between the point in time G, which is a predetermined time following point in time F2, indicated by the TOPC output, and points in time F2, HI, H2 and H3, which are at predetermined times relative to point in time G.
  • HI, H2 and H3 are typically 60, 120, and 180 seconds after point in time G. It is appreciated that the time durations selected to separate points in time HI, H2 & H3 and point in time G are a function of the available data from test subjects and the current time separations are based on a limited sample of test subjects and may change or have greater resolution as more subjects are tested.
  • the MDST(G) Calculator 820 provides an MDST(Hl-G), MDST(H2-G),
  • MDST(H3-G) and MDST(F2-G) output to a monitoring comparator such as an MDST Comparator 840, preferably an MDST(Hl-G) comparator.
  • MDST Comparator 840 preferably also receives the TYPC output of Position Change Calculator 810.
  • the MDST Comparator 840 also preferably receives personal data, as well as data relating to the person undergoing monitoring, preferably including the following parameters: weight, systolic and diastolic blood pressure, heart rate, data relating to medicinal treatment and additional medical conditions.
  • the comparator 840 also preferably receives stored data relating to the individual from one or more previous monitoring sessions, preferably including the MDST(Hl-G) output from MDST(G) calculator 820 as well as the OOPC, TOPC and PCID outputs of motion sensor 800, as well as the personal data from the one or more previous monitoring sessions.
  • the output of the MDST(Hl-G) comparator 840 is an indication of changes in MDST(Hl-G) calculated based on measurements taken in two separate monitoring sessions separated in time, together with an indication as to whether any of OOPC, TOPC and PCID outputs of motion sensor 800 or personal data, such as weight, heart rate, average blood pressure, medicinal treatment and additional medical conditions changed between the two monitoring sessions.
  • comparator 840 when a change in LVD condition is indicated by comparator 840, comparator 840 also preferably receives stored data from previous monitoring sessions relating to one or more other individuals, preferably including at least one of the MDST(Hl-G) output, the MDST(H2-G) output and the MDST(H3-G) output from MDST(G) calculator 820, as well as the OOPC, TOPC and PCID outputs of motion sensor 800, as well as the personal data from one or more previous monitoring sessions. Comparator 840 preferably automatically identifies other individuals with MDST(G) changes, TOPC, OOPC, PCID, TYPC, and/or personal data similar to those of the individual being monitored. Comparator 840 preferably automatically indicates a specific LVD-RCTIFNTCRH that is indicated by changes in MDST(G) in the other individuals similar to the change in MDST(G) seen in the individual being monitored.
  • Fig. 13 is a simplified illustration of the values of MDST(Hl-G) for a given individual monitored on multiple occasions, in which OOPC, TOPC and PCID and the personal data regarding the individual being monitored did not significantly change.
  • Fig. 13 it is seen that although the MDST(Hl-G) for the individual remains stable and constant at monitoring sessions in July, August, September and October, 2013, it falls precipitously in November, 2013, indicating the probability of a condition which requires clinical intervention.
  • FIG. 14 is a simplified flowchart illustrating operation of the system of Figs. 11 and 12 for detecting the presence or absence of an LVD-RCTIFNTCRH.
  • the motion sensor 800 provides the OOPC, TOPC and PCID outputs to Position Change Calculator 810, which provides an output to MDST Calculator 820, preferably MDST(G) calculator, indicating that at least a qualifying position change has occurred by indicating the type of position change that occurred.
  • MDST Calculator 820 preferably MDST(G) calculator
  • the MDST(G) Calculator 820 receives a measured temperature output from the temperature sensor 802 and the TOPC output from motion sensor 800 preferably to initially ascertain the measured temperature at point in time G and the measured temperature at point in time HI thereafter. MDST(G) calculator 820 calculates the difference between the measured temperature at points in time G and HI, also referred to as MDST(Hl-G).
  • the MDST(G) Calculator 820 may also ascertain the measured temperature at at least one of points in time H2 and H3 thereafter. MDST(G) calculator 820 may also calculate the difference between the measured temperature at points in time G and at least one of H2 and H3, also referred to as MDST(H2-G) and MDST(H3- G), respectively.
  • comparator 840 receives the TYPC output of the Position Change Calculator 810, the output of the MDST(G) calculator 820 as well as the personal data of the patient being monitored. Additionally, as noted above, comparator 840 also preferably receives stored data relating to the individual from one or more previous monitoring sessions, preferably including at least one of the MDST(Hl-G) output, the MDST(H2-G) output and the MDST(H3-G) output from MDST(G) calculator 820 as well as the OOPC, TOPC and PCID outputs of motion sensor 800, as well as the personal data from the one or more previous monitoring sessions.
  • Comparator 840 preferably automatically calculates differences in MDST(Hl-G) for that patient based on previous MDST(Hl-G) calculations for that patient and indicates the presence or absence of an LVD- RCTIFNTCRH.
  • the comparator 840 preferably also indicates whether there has been a change in the personal data or the TYPC.
  • a change in MDST is defined as a difference of an absolute value larger than 0.1 degree Celsius between skin temperature indications and previous skin temperature indications, at at least one specific and identical point in time relative to the onset and termination of physical activity.
  • an inversion of differential skin temperature may be observed, indicating change in general clinical condition of an individual.
  • a change in the general clinical condition of individual could indicate, but is not limited to, one or more of the following changes: a change in medicinal treatment regimen, an addition of a support device such as, but not limited to: LVAD, defibrillator, ICD, a change to clinical condition other than change in LVD condition.
  • LVAD LVAD
  • ICD a change to clinical condition other than change in LVD condition.
  • the magnitude of difference in MDST considered to be indicative of change in LVD condition is based on a limited sample of test subjects and may change or have greater resolution as more subjects are tested.
  • comparator 840 when a change in LVD condition is indicated by comparator 840, comparator 840 also preferably receives stored data from previous monitoring sessions relating to one or more other individuals, preferably including at least one of the MDST(Hl-G) output, the MDST(H2-G) output and the MDST(H3-G) output from MDST(G) calculator 820, as well as the OOPC, TOPC and PCID outputs of motion sensor 800, as well as the personal data from one or more previous monitoring sessions. Comparator 840 preferably automatically identifies other individuals with MDST(G) changes, TOPC, OOPC, PCID, TYPC, and/or personal data similar to those of the individual being monitored. Comparator 840 preferably automatically indicates a specific LVD-RCTIFNTCRH that is indicated by changes in MDST(G) in the other individuals similar to the change in MDST(G) seen in the individual being monitored.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

Système et procédé pour fournir une indication d'au moins un LVD (Dysfonctionnement Ventriculaire Gauche), le système comprenant au moins un capteur de température, au moins un capteur d'activité corporelle, un affirmateur de temps/température destiné à recevoir des entrées provenant du ou des capteurs de température et du ou des capteurs d'activité corporelle et à fournir des indications de sortie de la température de la peau avant que l'activité corporelle, pendant l'activité corporelle et après que l'activité corporelle, et un corrélateur conçu pour corréler les indications de sortie avec des données cliniques accumulées à l'existence d'au moins un LVD, le corrélateur fournissant au moins une indication de sortie de la présence de LVD et/ou de l'absence de LVD. Un système et un procédé de contrôle fournissent une indication d'un état associé au dysfonctionnement ventriculaire gauche (LVD) qui, s'il n'est pas traité, pourrait nécessiter une hospitalisation (LVD-RCTIFNTCRH) pour une personne ayant un LVD.
PCT/IL2016/050708 2015-07-02 2016-06-30 Systèmes et procédés de diagnostic et de surveillance de dépistage cardiovasculaire WO2017002125A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562187934P 2015-07-02 2015-07-02
US201562187917P 2015-07-02 2015-07-02
US62/187,934 2015-07-02
US62/187,917 2015-07-02

Publications (2)

Publication Number Publication Date
WO2017002125A2 true WO2017002125A2 (fr) 2017-01-05
WO2017002125A3 WO2017002125A3 (fr) 2017-03-09

Family

ID=57609400

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2016/050708 WO2017002125A2 (fr) 2015-07-02 2016-06-30 Systèmes et procédés de diagnostic et de surveillance de dépistage cardiovasculaire

Country Status (1)

Country Link
WO (1) WO2017002125A2 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015015574A2 (pt) * 2012-12-31 2017-07-11 M I Medical Incentive Ltd método e sistema de diagnóstico e monitoramento de exame cardiovascular

Also Published As

Publication number Publication date
WO2017002125A3 (fr) 2017-03-09

Similar Documents

Publication Publication Date Title
EP2925217B1 (fr) Procédé et système de détermination d'un seuil ventilatoire
JP7269916B2 (ja) 対象の血圧を決定する装置及び方法
CN107920758B (zh) 用于确定血压值的方法、装置和计算机程序
US20160317043A1 (en) Weighing scale with extended functions
US20180199824A1 (en) Device for measuring biological signals
TWI583352B (zh) 監控應力的方法和系統
EP3551060B1 (fr) Détermination de la vitesse des ondes d'impulsion, par exemple pour la surveillance de la pression sanguine
US11986324B2 (en) Apparatus for measuring degree of frailty on basis of athletic ability parameters
EP3643227B1 (fr) Approximation d'une valeur de rythme cardiaque minimum
US11147461B2 (en) Blood pressure analyzing apparatus, blood pressure measuring apparatus, and blood pressure analyzing method
US10925516B2 (en) Method and apparatus for estimating the aortic pulse transit time from time intervals measured between fiducial points of the ballistocardiogram
EP2845539A1 (fr) Dispositif et procédé permettant de normaliser automatiquement les signaux physiologiques d'un être vivant
US20200405216A1 (en) Cognitive function evaluation device, cognitive function evaluation system, cognitive function evaluation method, and recording medium
CN112272534A (zh) 用于估计血压替代物趋势的方法和装置
US20150313481A1 (en) Cardiovascular screening diagnostic and monitoring system and method
WO2017002125A2 (fr) Systèmes et procédés de diagnostic et de surveillance de dépistage cardiovasculaire
Austad et al. An unobtrusive wearable device for ambulatory monitoring of pulse transit time to estimate central blood pressure
US20200337570A1 (en) Physiological signal processing apparatus and method
RU2318432C2 (ru) Способ определения пульса человека
US11207033B2 (en) Determination system for determining a heart failure risk
EP4289367A1 (fr) Évaluation de fiabilité de mesures de paramètres cardiaques
Huang et al. Automatic Step Detection of Tandem Gait Test in Patients with Vestibular Hypofunction Using Wearable Sensors
CN116250813A (zh) 血压监测方法及监护装置
AU2019251933A1 (en) Exercise intensity estimation method, exercise intensity estimation device, and program

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16817384

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16817384

Country of ref document: EP

Kind code of ref document: A2