WO2016209695A1 - Compositions de filtre solaire ayant une combinaison synergétique de filtres uv - Google Patents

Compositions de filtre solaire ayant une combinaison synergétique de filtres uv Download PDF

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Publication number
WO2016209695A1
WO2016209695A1 PCT/US2016/037761 US2016037761W WO2016209695A1 WO 2016209695 A1 WO2016209695 A1 WO 2016209695A1 US 2016037761 W US2016037761 W US 2016037761W WO 2016209695 A1 WO2016209695 A1 WO 2016209695A1
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Prior art keywords
butyl methoxydibenzoylmethane
ratio
sulfonic acid
homosalate
octocrylene
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PCT/US2016/037761
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English (en)
Inventor
Susan Halpern Chirch
Anthony DIAZ-SANTANA
Anil Shah
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L'oreal
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Publication date
Priority claimed from US14/750,299 external-priority patent/US9572759B2/en
Priority claimed from US14/750,420 external-priority patent/US9539195B1/en
Priority claimed from US14/750,152 external-priority patent/US9539194B1/en
Application filed by L'oreal filed Critical L'oreal
Publication of WO2016209695A1 publication Critical patent/WO2016209695A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4966—Triazines or their condensed derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds

Definitions

  • the present disclosure relates to sunscreen compositions comprising a synergistic combination of ultra violet (“UV”) filters, and to methods of using the combination of UV filters to protect keratinous substrates such as skin and hair from UV radiation.
  • UV ultra violet
  • UV ultraviolet
  • UV light also contributes to aging by causing free radicals to form in the skin.
  • Free radicals include, for example, singlet oxygen, hydroxyl radical, the superoxide anion, nitric oxide and hydrogen radicals. Free radicals attack DNA, membrane lipids and proteins, generating carbon radicals. These in turn react with oxygen to produce a peroxyl radical that can attack adjacent fatty acids to generate new carbon radicals. This cascade leads to a chain reaction producing lipid peroxidation products. Damage to the cell membrane results in loss of cell permeability, increased intercellular ionic concentration, and decreased ability to excrete or detoxify waste products. The end result is a loss of skin elasticity and the
  • Sunscreens can be used to protect against UV damage and delay the signs of aging.
  • the degree of UV protection afforded by a sunscreen composition is directly related to the amount and type of UV filters contained therein. The higher the amount of UV filters, the greater the degree of UV protection. Nevertheless, it is desirable to achieve the best photo protection efficacy with the lowest amount of UV filters.
  • the inventors of the instant disclosure discovered ways to attain SPFs that were not previously attainable with such low amounts of overall UV filters.
  • the present disclosure relates to sunscreen compositions that have low amounts of UV filters yet excellent Sun Protection Factors (SPF).
  • SPDF Sun Protection Factors
  • the inventors discovered that when certain UV filters are combined in particular ratios, they interact synergistically to exhibit a surprisingly effective SPF. This allows for use of less total amounts of UV filters while achieving sufficient SPF.
  • the present disclosure relates to a sunscreen composition
  • a sunscreen composition comprising a combination of the UV filters set forth in the table below, wherein drometrizole trisiloxane and terephthalylidene dicamphor sulfonic acid are optionally present:
  • Mexoryl SX is 33% terephthalylidene dicamphor sulfonic acid.
  • the ratio of each filter relative to butyl methoxydibenzoylmethane in the sunscreen compositions is typically as follows:
  • the ratio of ethylhexyl triazone to butyl methoxydibenzoylmethane is 0.5: 1 .0 to 0.8:1 .0;
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0: 1 .0 to 0.5: 1 .0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.4: 1 .0 to 0.7: 1.0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.5: 1 .0 to 0.8:1 .0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 1 .0: 1 .0 to 1.5: 1 .0; and the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is about 0: 1 .0 to 0.1 : 1 .0.
  • the ratio of each filter relative to butyl methoxydibenzoylmethane may be about 1 .0 : 0.7 : 0.4 : 0.4 : 0.7 : 1.2 : 0.1 (butyl methoxydibenzoylmethane: ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • the ratio fo each filter relative to butyl methoxydibenzoylmethane may be about 1 .0 : 0.5 : 0.3 : 0.6 : 0.6 : 1 .1 : 0.1 (butyl methoxydibenzoylmethane: ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • UV filters can be separately, or in addition to the ratios set forth above, present in the following percentages by weight relative to the entire weight of the sunscreen composition:
  • the UV filters are present in the following percentages by weight relative to the entire weight of the sunscreen composition: about 3.4 wt.% butyl methoxydibenzoylmethane, about 2.3 wt.% ethylhexyl triazone, about 1 .4 wt.% drometrizole trisiloxane, about 1 .5 wt.% homosalate, about 2.2 wt.% ethylhexyl salicylate, about 4.2 wt.% octocrylene, and about 0.3 wt.% terephthalylidene dicamphor sulfonic acid.
  • the UV filters may be present in the following percentages by weight relative to the entire weight of the sunscreen composition: about 4.1 wt.% butyl methoxydibenzoylmethane, about 2.0 wt.% ethylhexyl triazone, about 1.4 wt.% drometrizole trisiloxane, about 2.6 wt.% homosalate, about 2.4 wt.% ethylhexyl salicylate, about 4.3 wt.% octocrylene, and about 0.3 wt.%
  • methoxydibenzoylmethane in the sunscreen compositions is typically as follows:
  • the ratio of ethylhexyl triazone to butyl methoxydibenzoylmethane is 0.67:1.0 to 1.14:1.0;
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0:1.0 to 0.57:1.0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.11:1.0 to 0.57:1.0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.76:1.0 to 1.29:1.0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 0.89:1.0 to 1.71:1.0;
  • the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is about 0: 1.0 to about 0.1:1.0.
  • the ratio of each filter relative to butyl methoxydibenzoylmethane may be about 1.0 : 1.0 :0.3 :0.2 :0.9 : 1.2 :0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • the ratio fo each filter relative to butyl methoxydibenzoylmethane may be about 1.0 : 0.9 : 0.3 : 0.5 : 0.9 : 1.3 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • UV filters can be separately, or in addition to the ratios set forth above, present in the following percentages by weight relative to the entire weight of the sunscreen composition:
  • the UV filters are present in the following percentages by weight relative to the entire weight of the sunscreen composition: about 4.2 wt.% butyl methoxydibenzoylmethane, about 4.0 wt.% ethylhexyl triazone, about 1 .4 wt.% drometrizole trisiloxane, about 1 .0 wt.% homosalate, about 3.8 wt.% ethylhexyl salicylate, about 5.0 wt.% octocrylene, and about 0.3 wt.% terephthalylidene dicamphor sulfonic acid.
  • the UV filters may be present in the following percentages by weight relative to the entire weight of the sunscreen composition: about 3.8 wt.% butyl methoxydibenzoylmethane, about 3.4 wt.% ethylhexyl triazone, about 1.0 wt.% drometrizole trisiloxane, about 1 .75 wt.% homosalate, about 3.4 wt.% ethylhexyl salicylate, about 5.0 wt.% octocrylene, and about 0.3 wt.%
  • methoxydibenzoylmethane in the sunscreen compositions is typically as follows:
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0: 1 .0 to 0.57:1 .0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.33: 1 .0 to 0.71 :1 .0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.33: 1 .0 to 0.71 : 1 .0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 0.89: 1 .0 to 1 .43:1 .0;
  • the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is 0: 1 .0 to 0.086: 1 .0.
  • the ratio of each filter relative to butyl methoxydibenzoylmethane may be about 1 .0 : 0.9 : 0.4 : 0.7 : 0.5 : 1.1 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • the UV filters can be separately, or in addition to the ratios set forth above, present in the following percentages by weight relative to the entire weight of the sunscreen composition:
  • the UV filters are present in the following percentages by weight relative to the entire weight of the sunscreen composition: about 3.8 wt.% butyl methoxydibenzoylmethane, about 3.4 wt.% ethylhexyl triazone, about 1 .4 wt.% drometrizole trisiloxane, about 2.5 wt.% homosalate, about 1 .8 wt.% ethylhexyl salicylate, about 4.2 wt.% octocrylene, and about 0.3 wt.% terephthalylidene dicamphor sulfonic acid.
  • the present disclosure is also directed to methods of protecting a keratinous substrate from ultraviolet radiation, methods of absorbing ultraviolet light, and method for preventing sun damage and/or sun burn to a keratinous substrate such as skin or hair.
  • Such methods encompass applying a sunscreen composition to a keratinous substrate (such as the skin or hair) and subjecting the keratinous substrate to ultraviolet radiation.
  • the expression “at least one” means one or more and thus includes individual components as well as mixtures/combinations.
  • Cosmetically acceptable means that the item in question is compatible with any keratinous substrate.
  • cosmetically acceptable carrier means a carrier that is compatible with any keratinous substrate.
  • a "physiologically acceptable medium” means a medium which is not toxic and can be applied to the skin, lips, hair, scalp, lashes, brows, nails or any other cutaneous region of the body.
  • the composition of the instant disclosure may
  • a “sunscreen composition” as used herein, is meant to include a composition for topical application to sun-exposed areas of the skin and/or hair of mammals, especially humans. Such a composition may be generally classified as leave-on or rinse off, and includes any product applied to a human body for also improving appearance, cleansing, odor control or general aesthetics.
  • the composition of the present invention can be in the form of a liquid, lotion, cream, foam, scrub, gel, soap bar or toner, or applied with an implement or via a face mask, pad or patch.
  • Non- limiting examples of such sunscreen compositions include leave-on skin lotions, creams, antiperspirants, deodorants, lipsticks, foundations, mascara, sunless
  • the sunscreen composition is clear.
  • the sunscreen composition may be a spray-on sunscreen composition.
  • stable emulsion refers to a composition that does not undergo phase separation up to a temperature of 45°C for at least two weeks.
  • a "clear" composition refers to a composition that is visually clear to the naked eye.
  • the compositions may have a turbidity measurement of less than 30 NTU.
  • Distilled water has a turbidity of 1 NTU and whole milk diluted 1 part in 350 parts of distilled water has a turbidity of 200 NTU.
  • the present disclosure relates to a sunscreen composition having a combination of the following UV filters: butyl methoxydibenzoylmethane, ethylhexyl triazone, drometrizole trisiloxane, homosalate, ethylhexyl salicylate, octocrylene, and terephthalylidene dicamphor sulfonic acid, wherein the ratio of each UV filter relative to butyl methoxydibenzoylmethane is as follows: The ratio of each filter relative to butyl methoxydibenzoylmethane in the sunscreen compositions is typically as follows:
  • the ratio of ethylhexyl triazone to butyl methoxydibenzoylmethane is 0.5: 1 .0 to 0.8:1 .0;
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0: 1 .0 to 0.5: 1 .0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.4: 1 .0 to 0.7: 1.0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.5: 1 .0 to 0.8:1 .0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 1 .0: 1 .0 to 1.5: 1 .0;
  • the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is about 0: 1 .0 to 0.1 : 1 .0.
  • the bottom range for the ratio of drometrizole trisiloxane and terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is zero (indicating that the UV filter is not present). In some cases one or both of these UV filters may be present, and the bottom end for the ratios is 0.05: 1 .0 (drometrizole trisiloxane or terephthalylidene dicamphor sulfonic acid : butyl
  • the ratio of each filter relative to butyl methoxydibenzoylmethane in the sunscreen compositions may be as follows:
  • the ratio of ethylhexyl triazone to butyl methoxydibenzoylmethane is 0.5: 1 .0 to 0.8:1 .0;
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0.3: 1 .0 to 0.5:1 .0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.4: 1 .0 to 0.7: 1.0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.5: 1 .0 to 0.8:1 .0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 1 .0: 1 .0 to 1.5: 1 .0; and the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is about 0.1 : 1 .0
  • the ratio of each filter relative to butyl methoxydibenzoylmethane may be about 1 .0 : 0.7 : 0.4 : 0.4 : 0.7 : 1.2 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • the ratio fo each filter relative to butyl methoxydibenzoylmethane may be about 1 .0 : 0.5 : 0.3 : 0.6 : 0.6 : 1 .1 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • the total amount of the combination of UV filters is at least 1 wt.% but not more than 40 wt.%, 35 wt.%,30 wt.%, 25 wt.%, or 20 wt.% based on the total weight of the sunscreen composition. Additionally, in some cases, none of the individual UV filters of the combination are present in an amount greater than 10 wt.%, 9 wt.%, 8 wt.%, 7 wt.%, 6 wt.%, or 5 wt.%.
  • the sunscreen composition may comprise:
  • the UV filters can be separately, or in addition to the ratios set forth above, present in the following percentages by weight relative to the entire weight of the sunscreen composition:
  • the drometrizole trisiloxane and the terephthalylidene dicamphor sulfonic acid may not be present in the sunscreen compositions.
  • drometrizole trisiloxane may be present in a positive amount, or from 0.1 wt.% to 2.8 wt.%.
  • the terephthalylidene dicamphor sulfonic acid may be present in a positive amount, or from 0.1 wt.% to 0.6 wt.%. In some cases, the amount of terephthalylidene dicamphor sulfonic acid is present in an amount of about 0.3 wt.%.
  • the sunscreen composition may have the following amounts of UV filters:
  • the terephthalylidene dicamphor sulfonic acid is in an amount of about 0.3 wt.%.
  • the total amount of the combination of UV filters can vary depending on the desired SPF and overall UV filtering strength of a final sunscreen composition.
  • the total amount of the combination of UV filters in a sunscreen combination is about 50, 40, 30, 25, 20, 19, 18, 17, 16, 15, 14, 13, 12, 1 1 , 10, 9, 8, 7, 6, 5, 4, 3, 2, or 1 wt.% or less, so long as a positive amount of the combination of UV filters is present.
  • the sunscreen formulation has an SPF value that is at least about 5, 10, 15, 16, 17, 18, 19, 20, 21 , 22, or 23 times the total weight percent of the combination of UV filters of the sunscreen compositions.
  • a composition comprising about 15.3 wt.% of a total combination of UV filters to exhibit an in vitro SPF of 329 (Example 1 ) (the SPF is about 21 .5 times higher than the total amount of the combination of UV filters used in the composition).
  • the SPF is about 23.7 times higher than the total amount of the combination of UV filters used in the composition.
  • boosters may be included in the sunscreen compositions of the instant disclosure, they are not required. In some cases, a booster is included in the sunscreen compositions to further raise the SPF beyond the amount achieved by the synergistic combination of UV filters alone.
  • Sunscreen compositions according to the present embodiment can be formulated to achieve a variety of different SPFs.
  • the sunscreen formulations can have an in vitro or in vivo SPF of at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 1 10, 1 15, 120, 125, 135, 150, 175, 200, 225, 250, 300. 325, 350, 375, 400 or higher (or in a range between any of these values).
  • the present disclosure relates to a sunscreen composition having a combination of the following UV filters: butyl
  • methoxydibenzoylmethane ethylhexyl triazone, drometrizole trisiloxane, homosalate, ethylhexyl salicylate, octocrylene, and terephthalylidene dicamphor sulfonic acid, wherein the ratio of each UV filter relative to butyl methoxydibenzoylmethane is as follows:
  • the ratio of ethylhexyl triazone to butyl methoxydibenzoylmethane is 0.67: 1 .0 to 1 .14: 1 .0;
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0: 1 .0 to 0.57:1 .0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.1 1 : 1 .0 to 0.57:1 .0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.76: 1 .0 to 1 .29: 1 .0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 0.89: 1 .0 to 1 .71 :1 .0;
  • the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is about about 0: 1 .0 to about 0.1 : 1 .0.
  • the bottom range for the ratio of drometrizole trisiloxane and terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is zero (indicating that the UV filter is not present). In some cases one or both of these UV filters may be present, and the bottom end for the ratios is 0.05:1.0 (drometrizole trisiloxane or terephthalylidene dicamphor sulfonic acid : butyl
  • the ratio of each filter relative to butyl methoxydibenzoylmethane in the sunscreen compositions may be as follows:
  • the ratio of ethylhexyl triazone to butyl methoxydibenzoylmethane is 0.67:1.0 to 1.14:1.0;
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0.22:1.0 to 0.57:1.0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.11:1.0 to 0.57:1.0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.76:1.0 to 1.29:1.0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 0.89:1.0 to 1.71:1.0;
  • the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is about 0.067:1.0 to about 0.086:1.0.
  • the ratio of each filter relative to butyl methoxydibenzoylmethane in the sunscreen compositions may be as follows:
  • the ratio of ethylhexyl triazone to butyl methoxydibenzoylmethane is 0.9:1.0to 1.0:1.0;
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0.32:1.0 to 0.35:1.0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.23:1.0 to 0.25:1.0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.86:1.0 to 0.95:1.0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 1.13:1.0 to 1.25:1.0; and the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is 0.068:1 .0 to 0.075: 1.0.
  • the ratio of each filter relative to butyl methoxydibenzoylmethane may be about 1 .0 : 1.0 : 0.3 : 0.2 : 0.9 : 1.2 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • the ratio fo each filter relative to butyl methoxydibenzoylmethane may be about 1 .0 : 0.9 : 0.3 : 0.5 : 0.9 : 1 .3 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • the total amount of the combination of UV filters is at least 1 wt.% but not more than 40 wt.%, 35 wt.%,30 wt.%, 25 wt.%, or 20 wt.% based on the total weight of the sunscreen composition. Additionally, in some cases, none of the individual UV filters of the combination are present in an amount greater than 10 wt.%, 9 wt.%, 8 wt.%, 7 wt.%, 6 wt.%, or 5 wt.%.
  • the sunscreen composition may comprise:
  • the UV filters can be separately, or in addition to the ratios set forth above, present in the following percentages by weight relative to the entire weight of the sunscreen composition:
  • the drometrizole trisiloxane and the terephthalylidene dicamphor sulfonic acid may not be present in the sunscreen compositions.
  • drometrizole trisiloxane may be present in a positive amount, or from 1.0 wt.% to 2.0 wt.%.
  • the terephthalylidene dicamphor sulfonic acid may be present in a positive amount, or from 0.1 wt.% to 0.6 wt.%. In some cases, the amount of terephthalylidene dicamphor sulfonic acid is present in an amount of about 0.3 wt.%.
  • the sunscreen composition may have the following amounts of UV filters:
  • the terephthalylidene dicamphor sulfonic acid is in an amount of about 0.3 wt.%.
  • the total amount of the combination of UV filters can vary depending on the desired SPF and overall UV filtering strength of a final sunscreen composition.
  • the total amount of the combination of UV filters in a sunscreen combination is about 50, 40, 30, 25, 20, 19, 18, 17, 16, 15, 14, 13, 12, 1 1 , 10, 9, 8, 7, 6, 5, 4, 3, 2, or 1 wt.% or less, so long as a positive amount of the combination of UV filters is present.
  • the sunscreen formulation has an SPF value that is at least about 5, 10, 15, 20, 21 , 22, 23, 24, 25, 26, 27, or 28 times the total weight percent of the combination of UV filters of the sunscreen compositions.
  • a composition comprising about 19.7 wt.% of a total combination of UV filters to exhibit an in vitro SPF of 555 (Example 1 ) (the SPF is about 28.2 times higher than the total amount of the combination of UV filters used in the composition).
  • the SPF is about 26.1 times higher than the total amount of the combination of UV filters used in the composition.
  • boosters may be included in the sunscreen compositions of the instant disclosure, they are not required. In some cases, a booster is included in the sunscreen compositions to further raise the SPF beyond the amount achieved by the synergistic combination of UV filters alone.
  • the sunscreen formulations can have an SPF of at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 1 10, 1 15, 120, 125, 135, 150, 175, 200, 225, 250, 300. 325, 350, 375, 400. 425, 450, 475, 500, 525, 550, or higher (or in a range between any of these values).
  • the present disclosure relates to a sunscreen composition having a combination of the following UV filters: butyl methoxydibenzoylmethane, ethylhexyl triazone, drometrizole trisiloxane, homosalate, ethylhexyl salicylate, octocrylene, and terephthalylidene dicamphor sulfonic acid, wherein the ratio of each UV filter relative to butyl methoxydibenzoylmethane is as follows:
  • the ratio of each filter relative to butyl methoxydibenzoylmethane in the sunscreen compositions is typically as follows:
  • the ratio of ethylhexyl triazone to butyl methoxydibenzoylmethane is 0.67: 1 .0 to 1 .14: 1 .0;
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0: 1 .0 to 0.57:1 .0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.33: 1 .0 to 0.71 :1 .0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.33: 1 .0 to 0.71 : 1 .0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 0.89: 1 .0 to 1 .43:1 .0; and the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is 0: 1.0 to 0.086: 1.0.
  • the bottom range for the ratio of drometrizole trisiloxane and terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is zero (indicating that the UV filter is not present). In some cases one or both of these UV filters may be present, and the bottom end for the ratios is 0.05:1.0 (drometrizole trisiloxane or terephthalylidene dicamphor sulfonic acid : butyl
  • the ratio of each filter relative to butyl methoxydibenzoylmethane in the sunscreen compositions may be as follows:
  • the ratio of ethylhexyl triazone to butyl methoxydibenzoylmethane is 0.67:1.0 to 1.14:1.0;
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0.30:1.0 to 0.57:1.0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.33:1.0 to 0.71:1.0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.33:1.0 to 0.71:1.0;
  • the ratio of octocrylene to butyl methoxydibenzoylmethane is 0.89:1.0 to 1.43:1.0;
  • the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is 0.050:1.0 to 0.086:1.0.
  • the ratio of each filter relative to butyl methoxydibenzoylmethane in the sunscreen compositions may be as follows:
  • the ratio of drometrizole trisiloxane to butyl methoxydibenzoylmethane is 0.35:1.0 to 0.39:1.0;
  • the ratio of homosalate to butyl methoxydibenzoylmethane is 0.63:1.0 to 0.69:1.0;
  • the ratio of ethylhexyl salicylate to butyl methoxydibenzoylmethane is 0.45:1.0 to 0.50:1.0; the ratio of octocrylene to butyl methoxydibenzoylmethane is 1 .05: 1 .0 to 1 .16:1 .0; and
  • the ratio of terephthalylidene dicamphor sulfonic acid to butyl methoxydibenzoylmethane is 0.075:1 .0 to 0.083: 1.0.
  • the ratio of each filter relative to butyl methoxydibenzoylmethane may be about 1 .0 : 0.9 : 0.4 : 0.7 : 0.5 : 1.1 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • the total amount of the combination of UV filters is at least 1 wt.% but not more than 40 wt.%, 35 wt.%,30 wt.%, 25 wt.%, or 20 wt.% based on the total weight of the sunscreen composition. Additionally, in some cases, none of the individual UV filters of the combination are present in an amount greater than 10 wt.%, 9 wt.%, 8 wt.%, 7 wt.%, 6 wt.%, or 5 wt.%.
  • the sunscreen composition may comprise:
  • the UV filters can be separately, or in addition to the ratios set forth above, present in the following percentages by weight relative to the entire weight of the sunscreen composition:
  • terephthalylidene dicamphor sulfonic acid 0 to 0.6 wt.% terephthalylidene dicamphor sulfonic acid.
  • the drometrizole trisiloxane and the terephthalylidene dicamphor sulfonic acid may not be present in the sunscreen compositions.
  • drometrizole trisiloxane may be present in a positive amount, or from 1.0 wt.% to 2.0 wt.%.
  • the terephthalylidene dicamphor sulfonic acid may be present in a positive amount, or from 0.1 wt.% to 0.6 wt.%. In some cases, the amount of terephthalylidene dicamphor sulfonic acid is present in an amount of about 0.3 wt.%.
  • the sunscreen composition may have the following amounts of UV filters:
  • the terephthalylidene dicamphor sulfonic acid is in an amount of about 0.3 wt.%.
  • the total amount of the combination of UV filters can vary depending on the desired SPF and overall UV filtering strength of a final sunscreen composition.
  • the total amount of the combination of UV filters in a sunscreen combination is about 50, 40, 30, 25, 20, 19, 18, 17, 16, 15, 14, 13, 12, 1 1 , 10, 9, 8, 7, 6, 5, 4, 3, 2, or 1 wt.% or less, so long as a positive amount of the combination of UV filters is present.
  • the sunscreen formulation has an SPF value that is at least about 5, 10, 1 1 , 12, 13, 14, 15, 16, 17, 18, 19, or 20 times the total weight percent of the combination of UV filters of the sunscreen compositions.
  • a composition comprising about 17.4 wt.% of a total combination of UV filters to exhibit an in vitro SPF of 358 (Example 1 ) (the SPF is about 20.6 times higher than the total amount of the combination of UV filters used in the composition).
  • the present disclosure makes it possible to achieve the described SPFs in sunscreen compositions without the use of boosters, or essentially free of boosters, e.g., sorbeth-2-hexaoleate.
  • boosters may be included in the sunscreen compositions of the instant disclosure, they are not required. In some cases, a booster is included in the sunscreen compositions to further raise the SPF beyond the amount achieved by the synergistic combination of UV filters alone.
  • Sunscreen compositions according to the third embodiment can be formulated to achieve a variety of different SPFs.
  • the sunscreen formulations can have an in vitro or in vivo SPF of at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 1 10, 1 15, 120, 125, 135, 150, 175, 200, 225, 250, 300. 325, 350, or higher (or in a range between any of these values).
  • the present disclosure is also directed to methods for protecting a keratinous substrate from ultraviolet radiation and to methods of absorbing ultraviolet light.
  • Such methods encompass applying a sunscreen composition to a keratinous substrate and subjecting the keratinous substrate to ultraviolet radiation.
  • oils/emollients that may be included in the sunscreen
  • compositions include: hydrocarbon-based oils of plant origin, such as liquid triglycerides of fatty acids containing from 4 to 10 carbon atoms, for instance heptanoic or octanoic acid triglycerides, or alternatively, for example, sunflower oil, corn oil, soybean oil, marrow oil, grapeseed oil, sesameseed oil, hazelnut oil, apricot oil, macadamia oil, arara oil, coriander oil, castor oil, avocado oil, caprylic/capric acid triglycerides, for instance those sold by the company Stearineries Dubois or those sold under the names Miglyol 810, 812 and 818 by the company Dynamit Nobel, jojoba oil, shea butter oil and caprylyl glycol; synthetic esters and ethers, especially of fatty acids, for instance Purcellin oil, 2-octyldodecyl stearate, 2-octyldodecyl erucate
  • Additional examples include benzoic acid esters of C9-C15 alcohols, isononyl iso-nonanoate, C12 - C15 alkyl benzoate, or any combinations thereof.
  • oils/emollients include cocoglyceride, cyclomethicone, dimethicone, dicapryl maleate, caprylic/capric triglyceride, isopropyl myristate, octyl stearate, isostearyl linoleate, lanolin oil, coconut oil, cocoa butter, olive oil, avocado oil, aloe extracts, jojoba oil, castor oil, fatty acid, oleic acid, stearic acid, fatty alcohol, cetyl alcohol, hexadecyl alcohol, diisopropyl adipate, hydroxybenzoate esters, benzoic acid esters of C 9 - C 15 alcohols, isononyl iso-nonanoate, alkanes, mineral oil, silicone, dimethyl polysiloxane, ether, polyoxypropylene butyl ether,
  • polyoxypropylene cetyl ether C 12 -C 15 alkyl benzoate, aryl alkyl benzoate, Isopropyl Lauroyl sarcosinate , and any combinations thereof.
  • hydrophilic organic solvents examples include:
  • monohydric C C 8 alcohols such as ethanol, propanol, butanol, isopropanol, isobutanol;
  • Polyethylene glycols from 6 to 80 ethylene oxides such as propylene glycol, isoprene glycol, butylene glycol, glycerol, sorbitol;
  • amphiphilic organic solvents include : polypropylene glycol (PPG) like propylene glycol alkyl ester or alkyl ether of PPG like PPG-23 oleyl ether and PPG-36 oleate.
  • the total amount of oils/emollient present in the compositions is typically about 0.1 , 0.5, 1 .0, or 2.5 wt.% to about 5.0, 7.5, 10.0, 15.0, 20.0, or 30 wt.% of the total weight of the composition.
  • Film-formers are often incorporated into sunscreen compositions to ensure even coverage of the UV filters and can be used to render the composition water resistant.
  • the film former is typically a hydrophobic material that imparts film forming and/or waterproofing characteristics.
  • One such agent is polyethylene, which is available from New Phase Technologies as Performalene® 400, a polyethylene having a molecular weight of 400.
  • Another suitable film former is polyethylene 2000 (molecular weight of 2000), which is available from New Phase Technologies as Performalene®.
  • another suitable film former is synthetic wax, also available from New Phase Technologies as Performa® V-825.
  • Other typical film-formers include acrylates/acrylamide copolymer, acrylates copolymer, acrylates/C 12 - C 2 2 alkylmethacrylate copolymer, polyethylene, waxes,
  • the film former is acrylates/C 12 - C 2 2 alkylmethacrylate copolymer sold under the tradename Allianz OPT ® by ISP.
  • compositions are not soluble in ethanol (such as PVP/Eicosene copolymer).
  • a common film-former employed in ethanol based sunscreen products is Dermacryl LT or Dermacryl 79 marketed by Akzo Nobel (I NCI Name: acrylates/octylacrylamide copolymner).
  • Dermacryl LT (CAS Number: 80570-62-3) is a hydrophobic, high molecular weight carboxylated acrylic copolymer. It functions as a film-former in a broad range of cosmetic formulations, imparting waterproofing, increased occlusivity and decreased rub-off of actives.
  • the total amount of film-formers present in the compositions is typically in an amount of about 0.1 , 0.5, 1.0, or 5 wt.% to about 5, 10, 20, or 25 wt.%, based on the total weight of the composition.
  • the sunscreen compositions typically include at least one emulsifier such as an amphoteric, anionic, cationic or nonionic emulsifier, used alone or as a mixture, and optionally a co-emulsifier.
  • the emulsifiers are chosen in an appropriate manner according to the emulsion to be obtained (W/O or O/W).
  • the emulsifier and the co- emulsifier are generally present in the composition in a proportion ranging from 0.3% to 30% by weight and preferably from 0.5% to 20% by weight relative to the total weight of the composition.
  • emulsifiers For W/O emulsions, examples of emulsifiers that may be mentioned include dimethicone copolyols, such as the mixture of cyclomethicone and dimethicone copolyol sold under the trade name DC 5225 C by the company Dow Corning, and alkyl dimethicone copolyols such as the lauryl dimethicone copolyol sold under the name Dow Corning 5200 Formulation Aid by the company Dow Corning, and the cetyl dimethicone copolyol sold under the name Abil EM 90TM by the company Goldschmidt.
  • dimethicone copolyols such as the mixture of cyclomethicone and dimethicone copolyol sold under the trade name DC 5225 C by the company Dow Corning
  • alkyl dimethicone copolyols such as the lauryl dimethicone copolyol sold under the name Dow Corning 5200 Formula
  • a crosslinked elastomeric solid organopolysiloxane comprising at least one oxyalkylene group such as those obtained according to the procedure of Examples 3, 4 and 8 of U.S. Pat. No. 5,412,004 and of the examples of U.S. Pat. No. 5,81 1 ,487, especially the product of Example 3 (synthesis example) of U.S. Pat. No. 5,412,004, such as the product sold under the reference KSG 21 by the company Shin-Etsu, may also be used as surfactants for W/O emulsions.
  • emulsifiers examples include nonionic emulsifiers such as oxyalkylenated (more particularly polyoxyethylenated) fatty acid esters of glycerol; oxyalkylenated fatty acid esters of sorbitan;
  • oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty alcohol ethers sugar esters such as sucrose stearate; and mixtures thereof.
  • the fatty acid esters of a sugar that can be used as nonionic amphiphilic lipids can be chosen in particular from the group comprising esters or mixtures of esters of a C 8 -C 2 2 fatty acid and of sucrose, of maltose, of glucose or of fructose, and esters or mixtures of esters of a Ci -C 2 2 fatty acid and of methylglucose.
  • the C 8 -C 2 2 or Ci -C 2 2 fatty acids forming the fatty unit of the esters that can be used in the emulsion comprise a saturated or unsaturated linear alkyl chain having, respectively, from 8 to 22 or from 14 to 22 carbon atoms.
  • the fatty unit of the esters can be chosen in particular from stearates, behenates, arachidonates, palmitates, myristates, laurates, caprates and mixtures thereof.
  • esters or of mixtures of esters of a fatty acid and of sucrose, of maltose, of glucose or of fructose mention may be made of sucrose monostearte, sucrose distearate, sucrose tristearate and mixtures thereof, such as the products sold by the company Croda under the name Crodesta F50, F70, F1 10 and F160 having, respectively, an HLB (Hydrophilic Lipophilic Balance) of 5, 7, 1 1 and 16; and, by way of example of esters or of mixtures of esters of a fatty acid and of methylglucose, mention may be made of the disearate of methylglucose and of polyglycerol-3, sold by the company Goldschmidt under the name Tego-care 450. Mention may also be made of glucose monoesters or maltose monoesters, such as methyl O-hexadecanoyl-6-D-glucoside and O-hexadecanoyl-6-D
  • the fatty alcohol ethers of a sugar that can be used as nonionic amphiphilic lipids can be chosen in particular form the group comprising ethers or mixtures of ethers of a C 8 -C 2 2 fatty alcohol and of glucose, of maltose, of sucrose or of fructose, and ethers or mixtures of ethers of a C 14 -C 2 2 fatty alcohol and of methylglucose. They are in particular alkylpolyglucosides.
  • the C 8 -C 22 or C 14 -C 22 fatty alcohols forming the fatty unit of the ethers that can be used in the emulsion of the instant disclosure comprise a saturated or unsaturated linear alkyl chain having, respectively, from 8 to 22 or from 14 to 22 carbon atoms.
  • the fatty unit of the ethers can be chosen in particular from decyl, cetyl, behenyl, arachidyl, stearyl, palmityl, myristyl, lauryl, capryl and hexadecanoyl units, and mixtures thereof such as cetearyl.
  • alkylpolyglucosides such as decylglucoside and laurylglucoside sold, for example, by the company Henkel under the respective names Plantaren 2000 and Plantaren 1200, cetostearylglucoside, optionally as a mixture with cetostearyl alcohol, sold, for example, under the name Montanov 68 by the company Seppic, under the name Tego-care CG90 by the company Goldschmidt and under the name Emulgade KE3302 by the company Henkel, and also arachidylglucoside, for example in the form of the mixture of arachidyl and behenyl alcohols and of arachidylglucoside sold under the name Montanov 202 by the company Seppic.
  • alkylpolyglucosides such as decylglucoside and laurylglucoside sold, for example, by the company Henkel under the respective names Plantaren 2000 and Plantaren 1200
  • cetostearylglucoside optionally as a
  • nonionic amphiphilic lipid of this type of sucrose monostearate, sucrose distearate, sucrose tristearate and mixtures thereof, the distearate of methylglucose and of polyglycerol-3, and alkylpolyglucosides.
  • the glycerol fatty esters that can be used as nonionic amphiphilic lipids can be chosen in particular from the group comprising the esters formed from at least one acid comprising a saturated linear alkyl chain having from 16 to 22 carbon atoms, and from 1 to 10 glycerol units. Use may be made of one or more of these glycerol fatty esters in the emulsion of the instant disclosure.
  • esters may be chosen in particular from stearates, behenates, arachidates, palmitates and mixtures thereof. Stearates and palmitates are preferably used.
  • CTFA names polyglyceryl-10 stearate, polyglyceryl-10 distearate, polyglyceryl-10 tristearate, polyglyceryl-10 pentastearate
  • CTFA name polyglyceryl-2 stearate
  • Nikkol DGMS diglyceryl monostearate
  • the sorbitan fatty esters that can be used as nonionic amphiphilic lipids chosen in particular from the group comprising esters of a Ci 6 -C 2 2 fatty acid and of sorbitan and oxyethylenated esters of a Ci 6 -C 2 2 fatty acid and of sorbitan. They are formed from at least one fatty acid comprising at least one saturated linear alkyl chain, having, respectively, from 16 to 22 carbon atoms, and from sorbitol or from ethoxylated sorbitol.
  • the oxyethylenated esters generally comprise from 1 to 100 ethylene oxide units, and preferably from 2 to 40 ethylene oxide (EO) units. These esters can be chosen in particular from stearates, behenates, arachidates, palmitates and mixtures thereof. Stearates and palmitates are
  • sorbitan fatty ester and of an oxyethylenated sorbitan fatty ester, mention may be made of sorbitan monostearate (CTFA name: sorbitan stearate) sold by the company ICI under the name Span 60, sorbitan monopalmitate (CTFA name: sorbitan palmitate) sold by the company ICI under the name Span 40, or sorbitan 20 EO tristearate (CTFA name: polysorbate 65) sold by the company ICI under the name Tween 65.
  • CFA name sorbitan monostearate
  • CTFA name sorbitan palmitate
  • sorbitan 20 EO tristearate CFA name: polysorbate 65
  • the ethoxylated fatty ethers are typically ethers made up of 1 to 100 ethylene oxide units and of at least one fatty alcohol chain having from 16 to 22 carbon atoms.
  • the fatty chain of the ethers can be chosen in particular from behenyl, arachidyl, stearyl and cetyl units, and mixtures thereof, such as cetearyl.
  • ethoxylated fatty ethers By way of example of ethoxylated fatty ethers, mention may be made of ethers of behenyl alcohol comprising 5, 10, 20 and 30 ethylene oxide units (CTFA names: beheneth-5, beheneth-10, beheneth-20 and beheneth-30), such as the products sold under the names Nikkol BB5, BB10, BB20 and BB30 by the company Nikko, and the ether of stearyl alcohol comprising 2 ethylene oxide units (CTFA name: steareth-2), such as the product sold under the name Brij 72 by the company ICI.
  • CTFA names behenyl alcohol comprising 5, 10, 20 and 30 ethylene oxide units
  • CTFA names beheneth-5, beheneth-10, beheneth-20 and beheneth-30
  • CTFA name ether of stearyl alcohol comprising 2 ethylene oxide units
  • the ethoxylated fatty esters that can be used as nonionic amphiphilic lipids are esters made up of 1 to 100 ethylene oxide units and of at least one fatty acid chain comprising from 16 to 22 carbon atoms.
  • the fatty chain of the esters can be chosen in particular from stearate, behenate, arachidate and palmitate units, and mixtures thereof.
  • ester of stearic acid comprising 40 ethylene oxide units, such as the product sold under the name Myrj 52 (CTFA name: PEG-40 stearate) by the company ICI, and the ester of behenic acid comprising 8 ethylene oxide units (CTFA name: PEG-8 behenate), such as the product sold under the name Compritol HD5 ATO by the company Gattefosse.
  • Poloxamer 282 such as the product sold by the company ICI under the name Plur
  • nonionic amphiphilic lipids mention may also be made of the mixtures of nonionic surfactants described in document EP-A-705593, incorporated herein for reference.
  • Suitable hydrophobically-modified emulsifiers include, for example, inulin lauryl carbamate, commercially available from Beneo Orafti under the tradename Inutec SPL
  • the total amount of emulsifier present in the compositions is typically in an amount of about 0.1 , 0.2, or 0.5 wt.% to about 4.0, 5.0, 6.0, or 7.5 wt.%, based on the total weight of the composition.
  • Gelling agents may also be included in the sunscreen compositions.
  • hydrophilic gelling agents include carboxyvinyl polymers such as the Carbopol products (carbomers) and the Pemulen products (acrylate/C10-C30- alkylacrylate copolymer); polyacrylamides, for instance the crosslinked copolymers sold under the names Sepigel 305 (CTFA name: polyacrylamide/C13-14
  • polyacryldimethyltauramide polyacryldimethyltauramide
  • cellulose-based derivatives such as hydroxyethyl- cellulose
  • polysaccharides and especially gums such as xanthan gum
  • mixtures thereof polyacryldimethyltauramide
  • Lipophilic gelling agents include modified clays such as hectorite and its derivatives, for instance the products sold under the name bentone. In some instances, the gelling agent is ammonium
  • acryloyldimethyltaurate/steareth-25 methacrylate crosspolymer commercially available from Clariant under the tradename Aristoflex HMS.
  • the gelling agent is typically used in an amount of about 0.05 to about 1 .5% by weight, from about 0.08 to about 1 .0% by weight, or about 0.1 to about 0.5% by weight, based on the total weight of the composition.
  • the sunscreen compositions can include additional sunscreen filters such as, for example, mineral UV filters.
  • mineral UV filters include pigments and nanopigments (mean size of the primary particles is generally is from 5 nm to 100 nm or from 10 nm to 50 nm) of treated or untreated metal oxides such as, for example, nanopigments of titanium oxide (amorphous or crystallized in rutile and/or anatase form), of iron oxide, of zinc oxide, of zirconium oxide or of cerium oxide.
  • the treated nanopigments are pigments that have undergone one or more surface treatments of chemical, electronic, mechanochemical and/or mechanical nature with compounds as described, for example, in Cosmetics & Toiletries, February 1990, Vol. 105, pp.
  • amino acids such as amino acids, beeswax, fatty acids, fatty alcohols, anionic surfactants, lecithins, sodium, potassium, zinc, iron or aluminium salts of fatty acids, metal (titanium or aluminium) alkoxides, polyethylene, silicones, proteins (collagen or elastin), alkanolamines, silicon oxides, metal oxides, sodium
  • the treated nanopigments may more particularly be titanium oxides treated with:
  • titanium oxide nanopigments treated with a silicone are TiO 2 treated with octyltrimethylsilane and for which the mean size of the elementary particles is between 25 and 40 nm, such as the product sold under the trade name "T805" by the company Degussa Silices, TiO 2 treated with a polydimethylsiloxane and for which the mean size of the elementary particles is 21 nm, such as the product sold under the trade name "70250 Cardre UF TiO2SI3" by the company Cardre, anatase/rutile TiO 2 treated with a polydimethylhydrogenosiloxane and for which the mean size of the elementary particles is 25 nm, such as the product sold under the trade name "Microtitanium Dioxide USP Grade Hydrophobic" by the company Color Techniques.
  • Uncoated titanium oxide nanopigments are sold, for example, by the company Tayca under the trade names "Microtitanium Dioxide MT 500 B” or “Microtitanium Dioxide MT 600 B", by the company Degussa under the name “P 25”, by the company Wackher under the name “Oxyde de titane transparent PW”, by the company Myoshi Kasei under the name "UFTR”, by the company Tomen under the name "ITS” and by the company Tioxide under the name "Tioveil AQ”.
  • the uncoated zinc oxide nanopigments are, for example:
  • coated zinc oxide nanopigments are, for example:
  • Nanophase Technologies (as a 40% dispersion in Finsolv TN, C12-C15 alkyl benzoate);
  • the uncoated cerium oxide nanopigments are sold under the name "Colloidal Cerium Oxide” by the company Rhone-Poulenc.
  • nanopigments are sold, for example, by the company Arnaud under the names "Nanogard WCD 2002 (FE 45B)", “Nanogard Iron FE 45 BL AQ”, “Nanogard FE 45R AQ” and “Nanogard WCD 2006 (FE 45R)” or by the company Mitsubishi under the name “TY-220”.
  • the coated iron oxide nanopigments are sold, for example, by the company Arnaud under the names "Nanogard WCD 2008 (FE 45B FN)", “Nanogard WCD 2009 (FE 45B 556)", “Nanogard FE 45 BL 345" and “Nanogard FE 45 BL” or by the company BASF under the name "Transparent Iron Oxide”.
  • Mixtures of metal oxides may also be used, especially of titanium dioxide and of cerium dioxide, including the silica-coated equal-weight mixture of titanium dioxide and of cerium dioxide, sold by the company Ikeda under the name "Sunveil A", and also the alumina, silica and silicone-coated mixture of titanium dioxide and of zinc dioxide, such as the product "M 261” sold by the company Kemira, or the alumina, silica and glycerol-coated mixture of titanium dioxide and of zinc dioxide, such as the product "M 21 1" sold by the company Kemira.
  • compositions according to the instant disclosure may be prepared according to techniques that are well known to those skilled in the art, in particular those intended for the preparation of emulsions of oil-in-water or water-in-oil type. They may be in particular in the form of a simple or complex emulsion (O/W, W/O, O/W/O or W/O/W emulsion) such as a cream or a milk, in the form of a gel or a cream-gel, or in the form of a lotion.
  • a simple or complex emulsion such as a cream or a milk
  • a gel or a cream-gel such as a cream or a cream-gel
  • a lotion such as a lotion.
  • Samples comprising different amounts of UV filters were prepared by dissolving the UV filters in ethanol and solvent as illustrated in the table below.
  • Example 1 has a ratio of about 1.0 :0 0.4 : 0.4 : 0.7 : 1.2 :0.1 and Example 2 has a ratio of about 1.0 :0.5 :0.3 :0.6 1.1 : 0.1 (butyl methoxydibenzoylmethane: ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene : terephthalylidene dicamphor sulfonic acid).
  • Phase B ingredients in another beaker and heat to 85°C. 3) Add Phase B into Phase A and homogenized for 20 minutes. Maintain the temperature at 90°C.
  • Samples comprising different amounts of UV filters were prepared by dissolving the UV filters in ethanol and solvent as illustrated in the table below.
  • Dermacryl 79 is an acrylate/octylacrylamide
  • Copolymner film-former
  • PMMA polymethyl methacrylate
  • the in vitro SPF was measured using a Labsphere 2000. Each measurement was made 6 times (6 times on each plate) times on 3 plates for each composition. The amount of UV filters included in each sample and the resulting in vitro SPF is reported in the table below.
  • Example 1 has a ratio of about 1 .0 : 1.0 : 0.3 : 0.2 : 0.9 : 1.2 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene :
  • Example 2 has a ratio of about 1 .0 : 0.9 : 0.3 : 0.5 : 0.9 : 1.3 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene :
  • Samples comprising different amounts of UV filters were prepared by dissolving the UV filters in ethanol and solvent as illustrated in the table below.
  • Dermacryl 79 (Akzo Nobel) is an acrylate/octylacrylamide
  • each UV filter corresponds to the table above (TABLE 10) but lists each UV filter as a ratio relative to butyl methoxydibenzoylmethane.
  • Example 1 has a ratio of about 1 .0 : 0.9 : 0.4 : 0.7 : 0.5 : 1.1 : 0.1 (butyl methoxydibenzoylmethane : ethylhexyl triazone : drometrizole trisiloxane : homosalate : ethylhexyl salicylate : octocrylene :

Abstract

La présente invention concerne des compositions de filtre solaire ayant une combinaison synergétique d'agents de filtration de lumière ultraviolette (UV), qui permettent d'obtenir un facteur de protection solaire (FPS) élevé. Des compositions selon la présente invention ont des valeurs FPS élevées sans nécessiter de quantités totales élevées d'agents de filtration UV. En outre, l'invention concerne des procédés d'utilisation des compositions décrites pour protéger des substances kératiniques telles que la peau et les cheveux contre le rayonnement UV.
PCT/US2016/037761 2015-06-25 2016-06-16 Compositions de filtre solaire ayant une combinaison synergétique de filtres uv WO2016209695A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14/750,299 2015-06-25
US14/750,299 US9572759B2 (en) 2015-06-25 2015-06-25 Sunscreen compositions having synergistic combination of UV filters
US14/750,420 US9539195B1 (en) 2015-06-25 2015-06-25 Sunscreen compositions having synergistic combination of UV filters
US14/750,420 2015-06-25
US14/750,152 US9539194B1 (en) 2015-06-25 2015-06-25 Sunscreen compositions having synergistic combination of UV filters
US14/750,152 2015-06-25

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112603854A (zh) * 2019-10-04 2021-04-06 强生消费者公司 可喷雾的防晒组合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050013781A1 (en) * 2003-05-29 2005-01-20 Playtex Products, Inc. Sunscreen composition
US20080112904A1 (en) * 2005-03-08 2008-05-15 Daniel Henry Traynor Sunscreen Compositions And Methods Of Use
US20100239677A1 (en) * 2002-11-21 2010-09-23 L'oreal Nonaerosol/aerosol dispensing of sunscreen sprays comprising silica microparticles
US20140170192A1 (en) * 2012-12-19 2014-06-19 L'oreal Sunscreen compositions
US9308155B2 (en) * 2005-07-13 2016-04-12 L'oreal Photoprotective composition and screening agents for said composition

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100239677A1 (en) * 2002-11-21 2010-09-23 L'oreal Nonaerosol/aerosol dispensing of sunscreen sprays comprising silica microparticles
US20050013781A1 (en) * 2003-05-29 2005-01-20 Playtex Products, Inc. Sunscreen composition
US20080112904A1 (en) * 2005-03-08 2008-05-15 Daniel Henry Traynor Sunscreen Compositions And Methods Of Use
US9308155B2 (en) * 2005-07-13 2016-04-12 L'oreal Photoprotective composition and screening agents for said composition
US20140170192A1 (en) * 2012-12-19 2014-06-19 L'oreal Sunscreen compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112603854A (zh) * 2019-10-04 2021-04-06 强生消费者公司 可喷雾的防晒组合物

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