WO2016209036A3 - Method for screening inhibitor against immunosuppression by hopq1 using interaction of type iii effector hopq1 and lim domain kinase 1 (limk1) and composition therefor - Google Patents

Method for screening inhibitor against immunosuppression by hopq1 using interaction of type iii effector hopq1 and lim domain kinase 1 (limk1) and composition therefor Download PDF

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Publication number
WO2016209036A3
WO2016209036A3 PCT/KR2016/006791 KR2016006791W WO2016209036A3 WO 2016209036 A3 WO2016209036 A3 WO 2016209036A3 KR 2016006791 W KR2016006791 W KR 2016006791W WO 2016209036 A3 WO2016209036 A3 WO 2016209036A3
Authority
WO
WIPO (PCT)
Prior art keywords
hopq1
limk1
interaction
type iii
inhibitor against
Prior art date
Application number
PCT/KR2016/006791
Other languages
French (fr)
Korean (ko)
Other versions
WO2016209036A2 (en
Inventor
박영준
류충민
윤성진
Original Assignee
한국생명공학연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국생명공학연구원 filed Critical 한국생명공학연구원
Publication of WO2016209036A2 publication Critical patent/WO2016209036A2/en
Publication of WO2016209036A3 publication Critical patent/WO2016209036A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase

Abstract

The present invention relates to a method for screening an inhibitor against immunosuppression by HopQ1 using an interaction of type III effector HopQ1 and LIM domain kinase (LIMK1) and a composition therefor. The inhibitor against the interaction of HopQ1, which is the type III effector protein, and LIMK1, which is a binding partner thereof, can be used as a material for controlling intracellular toxin causing shock by regulating the inhibition of phagocytosis by HopQ1.
PCT/KR2016/006791 2015-06-26 2016-06-24 Method for screening inhibitor against immunosuppression by hopq1 using interaction of type iii effector hopq1 and lim domain kinase 1 (limk1) and composition therefor WO2016209036A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0090939 2015-06-26
KR20150090939 2015-06-26

Publications (2)

Publication Number Publication Date
WO2016209036A2 WO2016209036A2 (en) 2016-12-29
WO2016209036A3 true WO2016209036A3 (en) 2017-02-16

Family

ID=57586045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/006791 WO2016209036A2 (en) 2015-06-26 2016-06-24 Method for screening inhibitor against immunosuppression by hopq1 using interaction of type iii effector hopq1 and lim domain kinase 1 (limk1) and composition therefor

Country Status (2)

Country Link
KR (1) KR101852148B1 (en)
WO (1) WO2016209036A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109164260A (en) * 2018-08-20 2019-01-08 广州伯信生物科技有限公司 A kind of co-immunoprecipitation method that can exclude antibody signal interference
CN111411115B (en) * 2020-03-03 2022-05-27 中山大学 Gene and method for improving rhizobia

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291483B1 (en) * 1996-02-14 2001-09-18 National Institute Of Immunology Methods for prevention and treatment of septic shock

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163474B2 (en) 2008-03-15 2012-04-24 Arbor Vita Corporation NS1-NP diagnostics of influenza virus infection

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291483B1 (en) * 1996-02-14 2001-09-18 National Institute Of Immunology Methods for prevention and treatment of septic shock

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE NCBI 15 March 2015 (2015-03-15), Database accession no. NP_002305.1 *
DATABASE NCBI 30 April 2014 (2014-04-30), Database accession no. KCU995111.1 *
LI, W. ET AL.: "The Pseudomonas Syringae Effector HopQl Promotes Bacterial Virulence and Interacts with Tomato 14-3-3 Proteins in a Phosphorylation-dependent Manner", PLANT PHYSIOLOGY, vol. 161, 2013, pages 2062 - 2074 *
MATSUI, S. ET AL.: "LIM Kinase 1 Modulates Opsonized Zymosan-triggered Activation of Macrophage-like U937 Cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 1, 2002, pages 554 - 549 *
OH, C. -S. ET AL.: "Tomato 14-3-3 Protein 7 Positively Regulates Immunity-associated Programmed Cell Death by Enhancing Protein Abundance and Signaling Ability of MAPKKKa", THE PLANT CELL, vol. 22, 2010, pages 260 - 272 *
YOON, SEONG JIN: "Txnip and Limkl of Mouse Macrophage Regulate Inflammatory Response and Phagocytosis in Bacteria Infection", KOREA UNIVERSITY OF SCIENCE AND TECHNOLOGY DOCTORATE THESIS, February 2015 (2015-02-01), pages I - XII, 1-117 *

Also Published As

Publication number Publication date
WO2016209036A2 (en) 2016-12-29
KR20170001646A (en) 2017-01-04
KR101852148B1 (en) 2018-04-25

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