WO2016200099A3 - 인간 타액 특이적 당사슬을 이용한 인간 타액 검증방법 - Google Patents

인간 타액 특이적 당사슬을 이용한 인간 타액 검증방법 Download PDF

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Publication number
WO2016200099A3
WO2016200099A3 PCT/KR2016/005907 KR2016005907W WO2016200099A3 WO 2016200099 A3 WO2016200099 A3 WO 2016200099A3 KR 2016005907 W KR2016005907 W KR 2016005907W WO 2016200099 A3 WO2016200099 A3 WO 2016200099A3
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WO
WIPO (PCT)
Prior art keywords
human saliva
saliva
human
sugar chains
examining
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Application number
PCT/KR2016/005907
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English (en)
French (fr)
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WO2016200099A2 (ko
Inventor
안현주
김재한
김범진
최종순
이동기
권요셉
Original Assignee
충남대학교산학협력단
한국기초과학지원연구원
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Application filed by 충남대학교산학협력단, 한국기초과학지원연구원 filed Critical 충남대학교산학협력단
Publication of WO2016200099A2 publication Critical patent/WO2016200099A2/ko
Publication of WO2016200099A3 publication Critical patent/WO2016200099A3/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)

Abstract

본 발명은 인간 타액 특이적 당사슬을 이용하여 인간 타액을 검증하는 방법에 관한 것이다. 인간 타액을 비롯한 인간 체액들과 쥐 타액 등을 대상으로 N-당사슬을 분리 및 정제하여 질량분석을 수행한 결과, 인간 타액에는 네 개 이상의 퓨코스를 포함하는 고퓨코실화 N-당사슬이 50% 이상 함유되어 다른 인간 체액이나 다른 동물의 타액과 구별되는 특징이 있어, 법의학 분야 등에 응용할 수 있다.
PCT/KR2016/005907 2015-06-11 2016-06-03 인간 타액 특이적 당사슬을 이용한 인간 타액 검증방법 WO2016200099A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0082601 2015-06-11
KR1020150082601A KR101672717B1 (ko) 2015-06-11 2015-06-11 인간 타액 특이적 당사슬을 이용한 인간 타액 검증방법

Publications (2)

Publication Number Publication Date
WO2016200099A2 WO2016200099A2 (ko) 2016-12-15
WO2016200099A3 true WO2016200099A3 (ko) 2017-02-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/005907 WO2016200099A2 (ko) 2015-06-11 2016-06-03 인간 타액 특이적 당사슬을 이용한 인간 타액 검증방법

Country Status (2)

Country Link
KR (1) KR101672717B1 (ko)
WO (1) WO2016200099A2 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101864161B1 (ko) * 2017-10-31 2018-06-04 충남대학교산학협력단 인간 타액을 확인하는 방법
CN111157661A (zh) * 2020-01-10 2020-05-15 广州医科大学附属第一医院 利用TiO2-PGC芯片质谱法全面分析树鼩呼吸道组织糖链谱的方法
GB202015772D0 (en) 2020-10-05 2020-11-18 Univ Newcastle Pngase enzymes
CN113960232B (zh) * 2021-10-28 2024-02-20 苏州大学 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120066597A (ko) * 2010-12-14 2012-06-22 퍼팩트코리아(주) 타액을 이용한 생리활성 진단 방법
KR20120124767A (ko) * 2011-05-04 2012-11-14 한국기초과학지원연구원 당 동정을 위한 새로운 생물정보처리 분석 방법
KR101484969B1 (ko) * 2014-03-26 2015-01-22 충남대학교산학협력단 Ｎ-당쇄화된 당펩타이드를 이용한 암 진단방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120066597A (ko) * 2010-12-14 2012-06-22 퍼팩트코리아(주) 타액을 이용한 생리활성 진단 방법
KR20120124767A (ko) * 2011-05-04 2012-11-14 한국기초과학지원연구원 당 동정을 위한 새로운 생물정보처리 분석 방법
KR101484969B1 (ko) * 2014-03-26 2015-01-22 충남대학교산학협력단 Ｎ-당쇄화된 당펩타이드를 이용한 암 진단방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HIRTZ, CHRISTOPHE ET AL.: "MS Characterization of Multiple Forms of Alpha-amylase in Human Saliva", PROTEOMICS, vol. 5, no. 17, November 2005 (2005-11-01), pages 4597 - 4607, XP055349654 *
VIEIRA. ANA CAROLINA ET AL.: "Glycomic Analysis of Tear and Saliva in Ocular Rosacea Patients: The Search for a Biomarker", THE OCULAR SURFACE, vol. 10, no. 3, July 2012 (2012-07-01), pages 184 - 192, XP055349653 *

Also Published As

Publication number Publication date
WO2016200099A2 (ko) 2016-12-15
KR101672717B1 (ko) 2016-11-17

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