WO2016194884A1 - Procédé d'inactivation de micro-organismes aériens - Google Patents

Procédé d'inactivation de micro-organismes aériens Download PDF

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Publication number
WO2016194884A1
WO2016194884A1 PCT/JP2016/065949 JP2016065949W WO2016194884A1 WO 2016194884 A1 WO2016194884 A1 WO 2016194884A1 JP 2016065949 W JP2016065949 W JP 2016065949W WO 2016194884 A1 WO2016194884 A1 WO 2016194884A1
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WO
WIPO (PCT)
Prior art keywords
chlorine dioxide
chlorite
light
present
concentration
Prior art date
Application number
PCT/JP2016/065949
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English (en)
Japanese (ja)
Inventor
博文 森野
朋子 小泉
甲子郎 曾川
Original Assignee
大幸薬品株式会社
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Filing date
Publication date
Application filed by 大幸薬品株式会社 filed Critical 大幸薬品株式会社
Priority to CN201680028104.0A priority Critical patent/CN107530464A/zh
Priority to JP2017521944A priority patent/JP6725153B2/ja
Priority to KR1020177033260A priority patent/KR102534711B1/ko
Publication of WO2016194884A1 publication Critical patent/WO2016194884A1/fr
Priority to HK18105303.1A priority patent/HK1245683A1/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20Gaseous substances, e.g. vapours
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/26Accessories or devices or components used for biocidal treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00Disinfection, sterilisation or deodorisation of air
    • A61L9/01Deodorant compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00Disinfection, sterilisation or deodorisation of air
    • A61L9/015Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J21/00Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
    • B01J21/16Clays or other mineral silicates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00Catalysts, in general, characterised by their form or physical properties
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00Catalysts, in general, characterised by their form or physical properties
    • B01J35/30Catalysts, in general, characterised by their form or physical properties characterised by their physical properties
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B11/00Oxides or oxyacids of halogens; Salts thereof
    • C01B11/02Oxides of chlorine
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B11/00Oxides or oxyacids of halogens; Salts thereof
    • C01B11/02Oxides of chlorine
    • C01B11/022Chlorine dioxide (ClO2)
    • C01B11/023Preparation from chlorites or chlorates
    • C01B11/024Preparation from chlorites or chlorates from chlorites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10Apparatus features
    • A61L2202/11Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20Targets to be treated
    • A61L2202/25Rooms in buildings, passenger compartments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2209/00Aspects relating to disinfection, sterilisation or deodorisation of air
    • A61L2209/20Method-related aspects
    • A61L2209/21Use of chemical compounds for treating air or the like

Definitions

  • the present invention relates to a method for inactivating suspended microorganisms in a space using low concentration chlorine dioxide gas.
  • Chlorine dioxide gas is a safe gas for animal organisms at low concentrations (for example, 0.3 ppm or less), but even at such low concentrations, it has a deactivating effect on microorganisms such as bacteria, fungi, and viruses, It is known to have a deodorizing action and the like. Because of these characteristics, chlorine dioxide gas has attracted particular attention in applications such as deodorization, sterilization, virus removal, antifungal and antiseptic during environmental purification and food transportation.
  • chlorine dioxide gas is safe for animal bodies at low concentrations and can be used for various purposes.
  • a method for inactivating respiratory viruses and the like using low-concentration chlorine dioxide gas has been proposed (for example, Patent Document 1).
  • Patent Document 1 a method for inactivating respiratory viruses and the like using low-concentration chlorine dioxide gas.
  • Patent Document 1 since chlorine dioxide gas can be harmful to the animal's body at high concentrations and there is a danger of explosion, development of a method for stably generating chlorine dioxide gas has been studied for practical use. .
  • Patent Document 2 a method of generating chlorine dioxide by irradiating a gel composition comprising chlorite and a water-absorbing resin with ultraviolet rays (for example, Patent Document 2), or a porous carrier containing chlorite and an alkali agent.
  • Patent Document 3 A method of generating chlorine dioxide by using the stabilized chlorine dioxide impregnated and dried and bringing the stabilized chlorine dioxide agent into contact with air has been proposed (for example, Patent Document 3).
  • the method of the present invention in one embodiment, is a method for inactivating suspended microorganisms in space, (1): (A) preparing a solid drug containing a porous material supporting chlorite and (B) a metal catalyst or a metal oxide catalyst; Here, the mass ratio of the chlorite and the metal catalyst or metal oxide catalyst in the solid drug is 1: 0.04 to 0.8; (2): irradiating the solid drug with visible light; and (3): A method comprising: supplying chlorine dioxide gas generated from the solid drug to a space where airborne microorganisms exist.
  • the chlorine dioxide gas concentration in the space is 0.1 ppm to 0.3 ppm in the step (3)
  • the chlorine dioxide gas is supplied into the space.
  • the time is 0.5 minutes to 480 minutes.
  • the method of the present invention is characterized in that the metal catalyst or metal oxide catalyst is selected from the group consisting of palladium, rubidium, nickel, titanium, and titanium dioxide.
  • the porous material is selected from the group consisting of sepiolite, palygorskite, montmorillonite, silica gel, diatomaceous earth, zeolite, and pearlite, and the chlorite is chlorite. It is characterized by being selected from the group consisting of sodium acid, potassium chlorite, lithium chlorite, calcium chlorite, and barium chlorite.
  • the “porous material carrying a chlorite and an alkali agent” is the same as that described above, wherein the chlorite and the alkali agent are simultaneously or sequentially converted into a porous material. It is obtained by impregnating and drying.
  • the agent containing the solid chlorite is (A) a porous material supporting chlorite, and (B) a metal catalyst or metal oxidation. It is a chemical
  • the chlorine dioxide generator used for the method of the present invention in one embodiment, at least one of the openings of the medicine container is present on a side surface of the medicine container, and is sent from the blower. The air is sent to the medicine at least partially through an opening existing on a side surface of the medicine storage section.
  • the chlorine dioxide generator used in the method of the present invention is such that the relative humidity in the medicine container is maintained at 30 to 80% RH by the air sent from the blower.
  • FIG. 13 shows a case where light is emitted from only two light sources (one side) when light is emitted from two light sources (both sides) in the chlorine dioxide generating unit according to an embodiment of the present invention. It is the figure explaining that light can be efficiently delivered to the chemical
  • FIG. 14 shows a change in the amount of chlorine dioxide generated when the relative humidity in the medicine container is changed in the chlorine dioxide generation unit according to the embodiment of the present invention. In addition, in FIG. 14, the data at the time of irradiating light from only one light source part (one side) are shown.
  • FIG. 15 shows changes over time in the amount of chlorine dioxide generated when the relative humidity in the medicine container is changed in the chlorine dioxide generation unit according to the embodiment of the present invention.
  • FIG. 17 shows a schematic diagram of an experiment for inactivating suspended microorganisms in the space using the method of the present invention.
  • the content of the metal catalyst or metal oxide catalyst exceeds 1 times the content of chlorite and when the content of metal catalyst or metal oxide catalyst is 0% of the content of chlorite In any case of less than .04 times, the amount of chlorine dioxide generated when irradiated with visible light can be reduced.
  • the fact that the wavelength of light generated from the light source is substantially included in the range of the specific wavelength region can be confirmed by measuring the wavelength and energy of the light generated from the light source with a known measuring device.
  • the relative humidity in the medicine container is 30 to 80% RH (preferably 40 to 70% RH, more preferably 40 by the air sent from the blower. To 60% RH).
  • the amount of chlorine dioxide generated can be increased by adjusting the relative humidity in the medicine container within the above range.
  • the ozone concentration decreased to about 43% from the ultraviolet region to the visible region.
  • the chlorine dioxide concentration increased to about 213% from the ultraviolet region to the visible region.
  • the amount of chlorine dioxide generated when the test drug is irradiated with visible light is such that the mass ratio of titanium dioxide to chlorite in the drug is 0 to about 0.001. It was shown that it increased as it increased to 3, and gradually decreased when the mass ratio of titanium dioxide to chlorite exceeded about 0.3. Furthermore, it was shown that when the mass ratio of titanium dioxide to chlorite in the composition exceeds about 1.0, the amount of chlorine dioxide generated is lower than when titanium dioxide is not mixed.
  • FIG. 10 is a diagram showing the internal structure of the chlorine dioxide generator 40, which is an embodiment of the present invention.
  • the chlorine dioxide generator 40 of this invention is equipped with the unit for a chlorine dioxide generation (LED chip mounting substrate 41 and chemical
  • the chlorine dioxide generator further includes a blower fan 44 inside, and supplies air into the chlorine dioxide generation unit by driving the blower fan 44. By adjusting the driving of the blower fan 44, the relative humidity in the medicine container in the chlorine dioxide generating unit can be adjusted.
  • Example 5 Examination of the relative humidity of the medicine container Using the chlorine dioxide generating unit shown in FIG. 9 and the chlorine dioxide generator shown in FIG. 10, chlorine dioxide is generated by the relative humidity in the medicine container. Changes in the amount were examined.
  • Example 4 The same conditions as in Example 4 were used for measuring the drug stored in the drug storage unit, the visible light irradiation method, and the chlorine dioxide concentration.
  • the relative humidity in the medicine container was adjusted by controlling the amount of air supplied to the medicine container (that is, the amount of water vapor supplied to the medicine) by driving the blower fan.
  • 14 and 15 show the relationship between the relative humidity in the medicine container and the chlorine dioxide concentration in the chamber.
  • FIG. 14 shows the average value of the chlorine dioxide concentration measured several times during the light irradiation of 0.5 to 2 hours and its standard deviation
  • FIG. 15 shows the change over time of the chlorine dioxide concentration in the chamber. Show.
  • Example 6 Examination of usefulness of intermittent irradiation Using the unit for generating chlorine dioxide shown in FIG. 9, the usefulness of intermittent irradiation of visible light in the present invention was examined.
  • Chlorine dioxide gas concentration of 1 m 3 chamber was monitored by chlorine dioxide gas sensor.
  • the concentration value of the chlorine dioxide gas sensor was corrected in comparison with the gas concentration value obtained by ion chromatography.
  • the viable cell count was 4.1 ⁇ 10 3 CFU / 10L air in 90 minutes.
  • the chlorine dioxide gas concentration in the chamber was an average of 0.05 ppmv, and the viable cell count was 3.4 ⁇ 10 2 CFU / at an exposure time of 90 minutes. It became 10L air, and was reduced by 1 log 10 or more (90% or more) with respect to the control (FIG. 25).

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
  • Catalysts (AREA)

Abstract

La présente invention vise à fournir un procédé pour inactiver des micro-organismes aériens en fournissant une quantité suffisante de dioxyde de chlore gazeux dans l'air. À cet effet, l'invention concerne un procédé pour inactiver des micro-organismes aériens, qui comprend : (1) une étape dans laquelle un agent chimique solide est préparé, ledit agent chimique solide contenant (A) un matériau poreux portant un chlorite et (B) un catalyseur métallique ou un catalyseur d'oxyde métallique de telle sorte que, dans l'agent chimique solide, le rapport en masse de chlorite/catalyseur métallique ou catalyseur d'oxyde métallique est de 1:0,04 à 0,8 ; (2) une étape dans laquelle l'agent chimique solide est exposé à la lumière visible ; et (3) une étape dans laquelle le dioxyde de chlore gazeux produit à partir de l'agent chimique solide est fourni dans l'air contenant des micro-organismes aériens.
PCT/JP2016/065949 2015-06-03 2016-05-31 Procédé d'inactivation de micro-organismes aériens WO2016194884A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201680028104.0A CN107530464A (zh) 2015-06-03 2016-05-31 使空间中的漂浮微生物失活的方法
JP2017521944A JP6725153B2 (ja) 2015-06-03 2016-05-31 空間中の浮遊微生物を失活させる方法
KR1020177033260A KR102534711B1 (ko) 2015-06-03 2016-05-31 공간 중의 부유 미생물을 실활시키는 방법
HK18105303.1A HK1245683A1 (zh) 2015-06-03 2018-04-24 使空間中的漂浮微生物失活的方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015113290 2015-06-03
JP2015-113290 2015-06-03

Publications (1)

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WO2016194884A1 true WO2016194884A1 (fr) 2016-12-08

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PCT/JP2016/065949 WO2016194884A1 (fr) 2015-06-03 2016-05-31 Procédé d'inactivation de micro-organismes aériens

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JP (1) JP6725153B2 (fr)
KR (1) KR102534711B1 (fr)
CN (1) CN107530464A (fr)
HK (1) HK1245683A1 (fr)
TW (1) TWI754614B (fr)
WO (1) WO2016194884A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021224673A1 (fr) * 2020-05-05 2021-11-11 CO2Apps S.R.L. Substance et méthode pour empêcher la transmission de virus dans le système respiratoire
JP2022121489A (ja) * 2018-11-13 2022-08-19 シーエスピー テクノロジーズ,インコーポレイティド 抗微生物性ガス放出剤、並びにその使用のためのシステム及び方法
JP7464463B2 (ja) 2019-06-28 2024-04-09 日揮触媒化成株式会社 塩素化合物吸着剤

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109701053B (zh) * 2018-12-26 2020-12-04 宁波大学 消毒方法
US20220339596A1 (en) * 2019-10-01 2022-10-27 Acenet Inc. Method for producing radicals, method for sterilizing spores, and cancer treatment drug

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JP2002543977A (ja) * 1999-05-18 2002-12-24 サウスウエスト・リサーチ・インスティチュート 制御された気体徐放のためのエネルギー活性化組成物
WO2007061092A1 (fr) * 2005-11-28 2007-05-31 Taiko Pharmaceutical Co., Ltd. Mesure défensive contre une infection à virus flottant
JP2011067285A (ja) * 2009-09-24 2011-04-07 Wada Kinzoku Kogyo Kk 殺菌性ガス供給装置
WO2011118447A1 (fr) * 2010-03-26 2011-09-29 大幸薬品株式会社 Dispositif de génération de dioxyde de chlore
JP2015077268A (ja) * 2013-10-17 2015-04-23 シャープ株式会社 脱臭方法
WO2015098731A1 (fr) * 2013-12-27 2015-07-02 大幸薬品株式会社 Composition génératrice de dioxyde de chlore par irradiation avec de la lumière visible

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JP2005224386A (ja) 2004-02-12 2005-08-25 Daiichi Seidenki Kk 二酸化塩素ガス消毒装置
JP5605744B2 (ja) 2010-02-25 2014-10-15 ダイソー株式会社 安定化二酸化塩素剤および二酸化塩素の安定した発生方法
CN102847181B (zh) * 2012-09-26 2014-05-28 深圳万和制药有限公司 延缓二氧化氯产生和释放的制品及其制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002543977A (ja) * 1999-05-18 2002-12-24 サウスウエスト・リサーチ・インスティチュート 制御された気体徐放のためのエネルギー活性化組成物
WO2007061092A1 (fr) * 2005-11-28 2007-05-31 Taiko Pharmaceutical Co., Ltd. Mesure défensive contre une infection à virus flottant
JP2011067285A (ja) * 2009-09-24 2011-04-07 Wada Kinzoku Kogyo Kk 殺菌性ガス供給装置
WO2011118447A1 (fr) * 2010-03-26 2011-09-29 大幸薬品株式会社 Dispositif de génération de dioxyde de chlore
JP2015077268A (ja) * 2013-10-17 2015-04-23 シャープ株式会社 脱臭方法
WO2015098731A1 (fr) * 2013-12-27 2015-07-02 大幸薬品株式会社 Composition génératrice de dioxyde de chlore par irradiation avec de la lumière visible

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022121489A (ja) * 2018-11-13 2022-08-19 シーエスピー テクノロジーズ,インコーポレイティド 抗微生物性ガス放出剤、並びにその使用のためのシステム及び方法
JP7497391B2 (ja) 2018-11-13 2024-06-10 シーエスピー テクノロジーズ,インコーポレイティド 抗微生物性ガス放出剤、並びにその使用のためのシステム及び方法
JP7464463B2 (ja) 2019-06-28 2024-04-09 日揮触媒化成株式会社 塩素化合物吸着剤
WO2021224673A1 (fr) * 2020-05-05 2021-11-11 CO2Apps S.R.L. Substance et méthode pour empêcher la transmission de virus dans le système respiratoire

Also Published As

Publication number Publication date
JPWO2016194884A1 (ja) 2018-04-05
KR20180015624A (ko) 2018-02-13
TW201701906A (zh) 2017-01-16
CN107530464A (zh) 2018-01-02
TWI754614B (zh) 2022-02-11
KR102534711B1 (ko) 2023-05-19
JP6725153B2 (ja) 2020-07-15
HK1245683A1 (zh) 2018-08-31

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