WO2016187847A1 - Procédé et système d'acquisition de signal - Google Patents

Procédé et système d'acquisition de signal Download PDF

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Publication number
WO2016187847A1
WO2016187847A1 PCT/CN2015/079956 CN2015079956W WO2016187847A1 WO 2016187847 A1 WO2016187847 A1 WO 2016187847A1 CN 2015079956 W CN2015079956 W CN 2015079956W WO 2016187847 A1 WO2016187847 A1 WO 2016187847A1
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WIPO (PCT)
Prior art keywords
signal
living body
path signal
module
signals
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PCT/CN2015/079956
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English (en)
Chinese (zh)
Inventor
王智勇
李梁
喻娇
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深圳市长桑技术有限公司
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Application filed by 深圳市长桑技术有限公司 filed Critical 深圳市长桑技术有限公司
Priority to PCT/CN2015/079956 priority Critical patent/WO2016187847A1/fr
Priority to US15/576,846 priority patent/US11039747B2/en
Priority to CN201580080088.5A priority patent/CN107613856A/zh
Publication of WO2016187847A1 publication Critical patent/WO2016187847A1/fr
Priority to US17/322,937 priority patent/US20210267452A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0017—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system transmitting optical signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0051—Detecting, measuring or recording by applying mechanical forces or stimuli by applying vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7246—Details of waveform analysis using correlation, e.g. template matching or determination of similarity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0223—Magnetic field sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0271—Thermal or temperature sensors
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Definitions

  • the invention relates to a signal acquisition method and system, in particular to a signal acquisition method and system for a living body or an object in a motion/vibration state.
  • Signal detection, signal control, signal calibration and signal processing are very common and important in all areas of medical, industrial control, automation, aerospace, automotive transportation, mobile communications, and home appliances. Especially for the accurate extraction and processing of low-frequency small-amplitude signals, it is directly or indirectly related to the trouble-free operation of various industrial processes.
  • Physiological signals can be summarized into two broad categories: chemical information (the composition of the chemical components that make up the living body and the information related to its changes) and physical information (the shape, position, relative relationship of the organs of the living body, the forces generated by the movement, heat, Sound, light and other related information).
  • chemical information the composition of the chemical components that make up the living body and the information related to its changes
  • physical information the shape, position, relative relationship of the organs of the living body, the forces generated by the movement, heat, Sound, light and other related information.
  • a large number of physiological signals have a direct or indirect relationship with the vital signs of the living body, and the physiological signals can directly or indirectly reflect the vital signs of the living body.
  • the vibration or motion of the light source or the collected object may cause large interference or noise to the acquisition result, resulting in signal distortion or flooding.
  • Photoplethysmograph It is a method for non-invasive detection of blood volume changes in living tissue using photoelectric means.
  • the vital signs such as blood pressure of the living body can be calculated by measuring the PPG signal.
  • the photoelectric pulse wave ie, the PPG signal
  • the photoelectric pulse wave belongs to the low frequency physiological signal
  • most of the motion/vibration frequency caused by the motion of the living body is also in this frequency range. Due to the similarity between the two frequencies, conventional hardware filtering or software filtering does not achieve a good denoising effect. Therefore, a better method and system for removing motion noise is needed.
  • a method comprising the steps of: emitting a beam of light to an object; acquiring a first path signal reflected by the object; acquiring a second path signal reflected by the object, wherein the second path signal is The first path signal is different; calculating and extracting relationship information between the first path signal and the second path signal; and using the relationship information to calculate and acquire a feature of the object.
  • the spectrum of the light beam is at least one of a visible light spectrum, an infrared spectrum, and a far infrared spectrum.
  • the object is a living body
  • the first road signal includes the living body PPG signal and the living body motion/vibration signal.
  • the object is a living body
  • the second path signal includes the living body motion/vibration signal.
  • normalization processing when calculating relationship information between the first path signal and the second path signal, normalization processing should be performed.
  • a correlation coefficient when calculating relationship information between the first path signal and the second path signal, a correlation coefficient should be set.
  • the object is a living body
  • the relationship information includes the living body PPG signal.
  • Also disclosed herein is a system comprising: a transmitting end for transmitting a light beam to an object; a first receiving end for receiving a first path signal reflected by the object; and a second receiving end for receiving a second road signal reflected by the object, the second road signal is different from the first road signal; an analysis module, configured to calculate a relationship between the first road signal and the second road signal And a calculation module, configured to calculate and acquire a feature of the object according to the relationship information.
  • the spectrum of the light beam is at least one of a visible light spectrum, an infrared spectrum, and a far infrared spectrum.
  • the second receiving end is different from at least one of a resistance, a current, a voltage, and a light intensity sensitivity of the first receiving end.
  • the object is a living body
  • the first road signal includes the living body PPG signal and the living body motion/vibration signal.
  • the object is a living body
  • the second path signal includes the living body motion/vibration signal.
  • the analysis module has a normalization processing function, and normalizes two signals when calculating relationship information.
  • the analysis module has an association coefficient selection function, and when the relationship information is calculated, a corresponding correlation coefficient may be selected.
  • the object is a living body
  • the relationship information includes the living body PPG signal.
  • the system further includes an output module, the output module including a display device.
  • Figure 1 is a schematic diagram of the system
  • Figure 2 is a schematic view of the method
  • 3 is a schematic diagram of an acquisition module
  • FIG. 4 is a schematic diagram of an application example of an acquisition module
  • Figure 5 is a schematic diagram of a process of collecting two signals using one light source
  • FIG. 6 is a schematic diagram of a process of collecting two signals using two light sources
  • Figure 7 is a schematic diagram of an analysis module
  • Figure 8 is a schematic diagram of an application embodiment of an analysis module
  • Figure 10 is a graph showing the experimental results of the two acquired signals and the noise-treated signals.
  • the signal acquisition method and system involved in the present specification can be applied to various fields, including but not limited to medical fields, industrial control fields, automation fields, aerospace fields, automobile transportation fields, mobile communication fields, and home appliance control fields.
  • the system can be applied to the medical field as a vital sign acquisition system.
  • the invention can be applied to signal detection, signal control, signal calibration and signal processing in the above various fields, and can realize accurate detection, control and extraction of signals. Especially for the detection and extraction of low-frequency small amplitude signals, the accuracy is high and the calculation amount is small.
  • it can be used for acquisition of physiological signals of living bodies and/or acquisition of vital signs, and the like.
  • This article will describe the vital sign acquisition system in the medical field as an example, but the whole method and process are equally applicable to other fields.
  • the invention can be applied to a variety of situations when used as a vital sign acquisition system, including but not limited to monitoring (including but not limited to elderly guardianship, middle-aged guardianship, youth monitoring and child care, etc.), medical diagnosis (including but not Limited to ECG diagnosis, pulse diagnosis, blood pressure diagnosis, blood oxygen diagnosis, etc.), sports monitoring (including but not limited to long-distance running, medium and short running, sprinting, cycling, rowing, archery, horse riding, swimming, climbing, etc.), hospital care ( Including but not limited to intensive patient monitoring, genetic disease patient monitoring, emergency patient monitoring, etc., pet care (critical care pet care, newborn pet care, home pet care, etc.).
  • monitoring including but not limited to elderly guardianship, middle-aged guardianship, youth monitoring and child care, etc.
  • medical diagnosis including but not Limited to ECG diagnosis, pulse diagnosis, blood pressure diagnosis, blood oxygen diagnosis, etc.
  • sports monitoring including but not limited to long-distance running, medium and short running, sprinting, cycling, rowing, archery, horse riding,
  • the vital sign acquisition system can collect and acquire one or more vital signs from a living body, such as electrocardiogram, pulse, blood pressure, blood oxygen, heart rate, body temperature, HRV, BPV, brain wave, human body Physical and chemical information such as ultra-low frequency radio waves, respiration, musculoskeletal status, blood sugar, blood lipids, blood concentration, platelet content, height, and weight.
  • the vital sign acquisition system may include an acquisition module, an analysis module, a calculation module, an output module, and the like.
  • the acquisition module can be used to acquire two or more signals related to living organisms.
  • the analysis module can be used to analyze the characteristics of two or more signals and extract the relationship information between the signals.
  • At least one of the two or more signals related to the living body collected may be It is a physiological signal containing noise, and at least one signal may mainly contain a noise signal.
  • the system eg, an analysis module in the system
  • the relationship information may be a corrected physiological signal.
  • the computing module can calculate the vital signs by using the relationship information.
  • An output module can be used to output the vital signs.
  • the system can better remove the noise interference signal in the vital body signal, and the calculation amount is small and the result is accurate. For example, the system can better remove motion/vibration noise interference signals in the living body PPG signal.
  • the system monitors vital signs of living organisms. The monitoring can be continuous and the monitoring can also be discontinuous.
  • the monitoring can be periodic or triggered by an instruction or signal.
  • This command or signal can be an input from a user (such as a patient, medical staff, etc.).
  • This command or signal can also be a signal, for example, a signal associated with the monitored living being.
  • the monitored vital body signal is a PPG signal whose monitoring can be triggered by an associated signal (such as a heartbeat) exceeding a threshold.
  • the monitoring can be real-time or non-real-time. For example, one or more physiological signals of the living body in a certain period of time may be temporarily stored, and the calculation module calculates the average or near-average vital signs of the living body during the time period.
  • the vital sign acquisition system can output the vital signs of the monitored living body in real time (or non-real time), such as ECG, pulse, blood pressure, blood oxygen concentration, heart rate variability, blood concentration, blood lipids and the like.
  • the system can transmit the results of the monitoring to external devices including, but not limited to, storage devices, display devices, or servers.
  • the system can remotely provide these vital signs to relevant third parties, such as hospitals, nursing homes or affiliates. All of the transmissions related to signals or vital signs described above can be wired or wireless.
  • FIG. 1 shows a schematic diagram of a system that can obtain vital signs.
  • This system may include, but is not limited to, one or more engines 100, one or more external devices 150, one or more power sources 160, and/or servers 170, and the like.
  • the engine 100 may include, but is not limited to, an acquisition module 110, an analysis module 120, a calculation module 130, an output module 140, and the like.
  • the acquisition module 110 is configured to acquire, receive, and acquire one or more signals.
  • the module can collect signals through photoelectric induction, temperature sensing, humidity change, pressure change, body surface potential change, voltage change, current change or magnetic field change, or it can be connected to other external devices to obtain signals by manual input.
  • the acquisition module can obtain various kinds of signals such as acoustic, optical, magnetic, thermal, and mechanical.
  • the types of signals collected include, but are not limited to, pulse wave, ECG, heart rate, blood pressure, blood oxygen, breathing, height, weight, body temperature, musculoskeletal status, brain wave, fat content, blood glucose concentration, blood concentration, blood flow and other physiology.
  • the acquisition module 110 can acquire not only static signals but also dynamic signals.
  • the acquisition module 110 can obtain the PPG signal of the living body by means of photoelectric sensing, and can also obtain the PPG signal and the motion/vibration signal of the living body when the living body is in motion or vibration.
  • the acquisition module 110 can acquire two or more signals at the same time or in time.
  • the module can have one or more signal acquisition units.
  • the module can have one or more light source emitters, one or more photosensor receivers.
  • the plurality of light source emitting ends can emit multiple light beams of different characteristics, such as, but not limited to, infrared and green light, red light and green light, infrared light, and red light.
  • the multiple beams can be in phase or different phases. It can be different wavelengths or the same wavelength. It can be different frequency bands or the same frequency band. It can be the same strength or it can be different strength.
  • the multiple beams may also be obtained by adding one or more original beams/signals by adding the same or different carrier signals.
  • the spectrum of the original beam/signal can be moved to an arbitrary spectral range by frequency modulation, phase modulation, amplitude modulation, etc., thereby facilitating beam/signal transmission.
  • multiple sensor receivers can receive multiple signals simultaneously. You can also receive multiple channels by time-sharing by setting a sampling frequency. No., and you can set the sampling period for cyclic sampling.
  • the transmitting end and the receiving end are not necessarily included in the collecting module 110.
  • the transmitting end and the receiving end can also be separately present in other modules. It is also possible for both to exist in other modules at the same time. It is also possible that one of them is in the acquisition module and the other is in the other module.
  • the light source emitting end and the photoelectric sensor receiving end may be arranged in any combination to collect two or more signals of the same or different signals.
  • the acquisition module 110 can take advantage of the various devices that are now available and that may occur in the future. It may be a blood pressure measuring device such as a watch type sphygmomanometer, a wrist sphygmomanometer, or an upper arm type sphygmomanometer. It can also be an ECG monitoring device such as a medical ECG monitoring system or an ECG monitor. It may also be a pulse wave detector, a brain wave monitor, a respiratory detector, a blood measuring device, or the like. The device used by the acquisition module 110 can be local or remote.
  • the above instrument or device may be part of the acquisition module 110 or may exist independently as a separate module in the system. It can also be independent of the system, as an external device, the acquisition module can read signals from these external devices. These instruments or devices are not required for the implementation of system functions.
  • the acquisition module 110 can integrate a calibration unit or a compensation unit (not shown), or the engine 100 can be provided with a separate calibration unit or compensation unit (not shown) for collecting two or more signals. Make adjustments, optimizations, calibrations, or remove uncorrelated error interference.
  • Signal acquisition can be affected by a variety of factors. These factors can affect one or more of the signal's waveform, peak, trough, peak amplitude, peak point spacing, phase, frequency, period, and more.
  • the physiological signals of the same living body may differ at different times of the day.
  • the physiological signals of the same living body may be different under different psychological or physiological conditions.
  • different living organisms have different physiological signals at the same time or psychological/physiological state.
  • the acquisition module 110 can integrate a corresponding calibration unit (not shown) or a compensation unit (not shown). Or the engine 100 is provided with a corresponding separate calibration unit (not shown) or a compensation unit (not shown) for adjusting, optimizing, calibrating or removing the above-mentioned error interference to improve the accuracy of the acquired physiological signals of the living body. Sex.
  • the acquisition module 110 can integrate corresponding self-adaptation Should be the unit (not shown in the figure). This adaptive unit can adjust different parameter states for different living bodies.
  • the adaptive unit may store the physiological signals collected, received, and acquired from the same living body into the server 170 (for example, a cloud server), so that the collecting module 110 has an adaptive function.
  • the acquisition module 110 stores each collected data into a server 170 (eg, a cloud server) and tags corresponding data for different living entities accordingly.
  • the module can start the machine learning process according to the data of the same living body at different times or different states, and adjust the collected signals or data according to different characteristics of different living bodies.
  • the adaptive function enables the server 170 to form a database of individual physiological signals of the same living body, thereby making the collected physiological signals of the living body more accurate.
  • photoelectric sensors are affected by factors such as light intensity, skin color, skin roughness, skin temperature, skin moisture, ambient temperature, and environmental humidity.
  • the acquisition module 110 can integrate a corresponding environment adaptation unit (not shown in the figure). Or an environment adaptation unit (not shown) in the engine 100 is connected to the acquisition module 110.
  • a correction or compensation unit corresponding to environmental influence factors is used to compensate, correct, cancel or remove the influence or interference of environmental factors on the physiological signal characteristics of the living body.
  • the analysis module 120 can be used to perform various operations such as analysis, calculation, processing, and the like on the acquired signals.
  • the analysis module 120 can be centralized or distributed.
  • the analysis module 120 can perform operations such as analysis, calculation, processing, and the like on the signal. These processes can be real-time or non-real-time.
  • Analysis, calculation or processing procedures include, but are not limited to, various common feature analysis, statistical analysis, mathematical calculations, data processing, and the like.
  • the analysis, calculation or processing can be a direct mathematical operation or a software-based programming analysis.
  • the data or analysis results, calculation results, and processing results involved in the analysis, calculation, or processing may be displayed in a waveform form or in digital form, but the display is not required.
  • a caching step may be added between any two processes for storing real-time or non-real-time data involved in the operation of the analysis module 120.
  • the calculation module 130 calculates the vital signs of the living body according to the physiological signals collected by the collection module 110 or analyzed by the analysis module 120.
  • the calculation process can be real-time or non-real-time.
  • the types of vital signs that the calculation module 130 can calculate include, but are not limited to, blood pressure, pulse rate value, blood oxygen saturation, heart rate variability, heart murmur, bowel sound, pH value, creatinine content, transferase content, body temperature. And one or more of vital signs such as carcinoembryonic antigen content.
  • Calculation methods include, but are not limited to, various common mathematical calculations, statistical analysis, data processing, and the like. The calculation process can also take into account the influence of the environment and other factors, adding relevant calibration coefficients.
  • the type of data or signal involved in the calculation process may include, but is not limited to, the determination of one or more physiological parameters of the living being.
  • the data involved in the calculation process may be not only the physiological signals collected by the acquisition module 110 or the physiological signals analyzed and processed by the analysis module 120.
  • Other physiological signals of the living body stored in the server 170 can also be called. Can also call this life
  • the physical signs acquire other physiological signals of the living body stored in the storage device of the system. It is also possible to intersperse a plurality of physiological signals by using the above-mentioned several calling routes. None of the various calculation methods or calculation processes in the calculation module 130 described above are necessary.
  • Various modifications and changes in form and detail may be made to the module without departing from the principles of the invention. Changes are still within the scope of the claims of the present invention.
  • the vital sign value can also be used as initial or intermediate data in the calculation process of other vital sign values.
  • the final result of the module can be a vital sign or multiple vital signs.
  • the output module 140 can be used to output physiological signals analyzed, calculated, and/or processed by the analysis module 120, and can also output vital signs calculated by the calculation module 130.
  • the process by which the output module 140 outputs data may be wired or wireless. It can be output to local or mobile terminals such as desktop computers, laptops, mobile phones, and tablets, or it can be output to a remote server or a cloud server. It can also be output to other external devices connected to the vital sign acquisition system.
  • the display form of the output data includes but is not limited to LED (light emitting diode), LCD (liquid crystal display) and other electronic display and resistance technology touch screen, capacitive technology touch screen, plasma touch screen, vector pressure sensing technology touch screen, infrared technology touch screen, etc. touch screen.
  • the output signal can be in the form of a digital form, a waveform form, an analog waveform form, a symbol form, a code form, a voice form, a video form, and an image form.
  • the types of output signals include, but are not limited to, blood pressure, pulse rate, blood oxygen saturation, heart rate variability, heart murmur, bowel sounds, pH, creatinine content, transferase content, body temperature, and carcinoembryonic antigen content.
  • the output process can be real-time or non-real-time. It can be executed directly by the system or by the connected external device.
  • External device 150 generally refers to various devices that are directly or indirectly related to one or more modules of the vital sign acquisition system. It can be local or remote. It can be wired or wireless.
  • the external device 150 can be used to display physiological signals.
  • LED light emitting diode
  • LCD liquid crystal display
  • It may be a storage device for storing a physiological signal, such as a mobile hard disk, a floppy disk, an optical disk, a RAM (random access memory), a ROM (read-only memory), a cloud disk, or the like, or a desktop computer or a notebook computer that can implement the above functions.
  • the power supply 160 refers to all devices that can provide power, either wired or wireless. It can be an external household or industrial AC power source, or it can be a battery such as a lithium ion battery.
  • the server 170 is configured to store all data involved in the operation of the vital sign acquisition system, and can provide data call support for each module in the system in real time or non-real time. Server 170 can also serve as a database for the system.
  • the server 170 can be a local server or a cloud server and can serve as a cloud database of the system.
  • the engine 100 may add a corresponding storage module (not shown in the figure), or each module in the engine 100 may also integrate a corresponding storage unit (not shown) to implement various real-time or non-generation generated by the running process of the system. Real-time data, or cached data generated by various steps in the system's operation.
  • the storage module or the storage unit may be various storage devices such as a mobile hard disk, a floppy disk, an optical disk, a RAM (random access memory), and a ROM (read-only memory) cloud disk. It should be noted that the storage module or the storage unit is not required, and the storage function may also be implemented by the external device 150 or the server 170. For example, it can be implemented by means of cloud storage.
  • the implementation of cloud storage is mainly to connect one or more groups of remote servers through the Internet to realize real-time or non-real-time storage and processing of data.
  • the engine 100 or the data generated during the operation of the system and the corresponding analysis results, calculation results, processing results, calculated vital signs, etc. can be stored in the personal cloud. Access to the personal cloud here requires identification. Similarly, it can also be stored in a public cloud, and access to the public cloud requires or does not require identification.
  • connection manner between the collection module 110, the analysis module 120, the calculation module 130, and the output module 140 may be wired or wireless.
  • Each module can be connected to a different power source, or shared by two, three or three, or four sharing the same power supply.
  • the acquisition module 110, the analysis module 120, the calculation module 130, and the output module 140 can respectively connect different externalities.
  • Devices can also be connected to the same external device together, or they can be connected to the same or different external devices in any combination.
  • the external device 150 can be connected to one or more modules, and the connection manner can be wired or wireless.
  • the connection between the engine 100 and the server 170 may be wired or wireless. Server 170 can be local or remote.
  • the acquisition module 110 and the output module 140 can be integrated into a single module that combines the functions of acquiring signals and outputting signals.
  • the module can be connected to the analysis module 120 and the computing module 130, either wired or wirelessly.
  • Each module can integrate a corresponding storage unit for short-term buffering of information data during system execution or for long-term preservation of information data.
  • the engine 100 can also add corresponding independent storage modules for storing acquired and/or analyzed and processed physiological signals, and/or calculated vital signs.
  • the connections between modules, modules and external devices in the system for obtaining vital signs, and the connections between the systems and the storage devices or servers are not limited to the above description.
  • the above connection method can be used singly or in combination with a plurality of connection methods in the acquisition system.
  • Individual modules can also be integrated to implement the functionality of more than one module from the same device.
  • External devices can also be integrated on the implementation device of one or more modules, and single or multiple modules can also be integrated on a single or multiple external devices.
  • the connections between the modules and the external devices in the system, and the connections between the system and the storage devices or servers can be wired or wirelessly connected.
  • the wired connection includes but is not limited to a wired connection method such as a wire or an optical fiber
  • the wireless connection includes, but is not limited to, a wireless connection manner such as Bluetooth, infrared, and the like.
  • Engine 100 can include one or more processors.
  • the various modules or units of engine 100 may be on one or more processors.
  • acquisition module 110, analysis module 120, calculation module 130, and output module 140 can be on one or more processors.
  • One or more processes The device can be in communication with a storage device (not shown), an external device 150, or a server 170.
  • the processor can read signals or calculate program instructions from a storage device (not shown), external device 150 or server 170, and perform the analysis or calculation or processing of the read signals as described elsewhere herein to obtain an OR.
  • the processor can be connected wirelessly or by wire to other devices that may be directly or indirectly related to the system, such as a smartphone app, a medical facility monitoring device, a local or remote computer client, and the like. And can share information with these devices.
  • FIG. 2 is a schematic diagram of a method for obtaining vital signs by the system.
  • This method may include the operation of acquiring a physiological or non-physiological signal of the living body at step 210.
  • Types of physiological signals may include, but are not limited to, pulse waves, electrocardiogram, heart rate, blood pressure, blood oxygen, breathing, height, weight, body temperature, musculoskeletal status, brain waves, fat content, blood glucose concentration, blood concentration, blood fluidity, etc.
  • Non-physiological signals may include, but are not limited to, vital body motion/vibration signals and the like.
  • Acquisition of physiological or non-physiological signals can be performed by acquisition module 110.
  • the system can perform an analysis calculation step 220 on these signals. This step 220 enables feature analysis of the acquired signals.
  • Feature results include, but are not limited to, one or more of waveforms, peaks, troughs, peak amplitudes, peak point spacing, phase, frequency, period, and the like.
  • Analytical calculations can be performed by analysis module 120. The analytical calculation process can be real-time or non-real-time.
  • step 230 After the step 220 completes analyzing various features of the received signal, it is determined by step 230 whether there is noise in the received physiological signal. If the result of the determination is that there is no noise in the physiological signal, step 260 may be directly executed to output the physiological signal. The output of the physiological signal can be performed by the output module 140. At this point, you can also return to step 210 to continue collecting new signals, starting a new process.
  • step 250 can also be performed to calculate one or a set of vital signs using the physiological signal. Vital signs can be calculated by the calculation module 130. If the result of the determination in step 230 is that there is noise in the physiological signal, step 240 is performed to perform noise processing on the collected physiological signal. Noise processing can be performed by analysis module 120. The physiological signal after the noise processing can be transmitted to the storage step (not shown) and stored in the corresponding storage device.
  • the storage device may be the external device 150 mentioned above, or may be a storage unit integrated by the collection module 110 (not shown). Can also be a separate storage module of the engine 100 (in the figure) Not reflected).
  • the server 170 can also be the server 170. It may also be a storage unit integrated with each module of the engine 100 (not shown in the figure).
  • the physiological signal after the noise processing in step 240 can be output at step 260.
  • the physiological signal after the noise processing can also be transmitted to step 250, and the vital signs are calculated by using the physiological signal after the noise treatment.
  • the calculated vital signs can be output at step 260.
  • the methods and steps described herein can occur in any suitable order, where appropriate, or at the same time.
  • individual steps may be eliminated from any one method without departing from the spirit and scope of the subject matter described herein. Aspects of any of the examples described above can be combined with aspects of any of the other examples described to form further examples without losing the effect sought.
  • a pre-processing step may be added between step 210 and step 220, which is used to perform preliminary coarse smoothing processing or remove significant interference processing on the collected two or more signals.
  • Processing methods include, but are not limited to, low pass filtering, band pass filtering, wavelet transform filtering, median filtering, morphological filtering, and curve fitting.
  • other selection or processing conditions can be added between the acquisition signal step 210 and the analysis calculation step 220.
  • two or more signals collected can be stored and backed up.
  • this storage backup step can be added between any two steps in the flowchart.
  • step 230 is not necessary, and the noise processing step may be skipped directly to perform the next noise processing.
  • the noise processing step 240 may invoke one or more processing methods, and the processing methods may be independent of each other or may be associated with each other.
  • the data generated during the processing may be supported as data of other processing methods. Similarly, data generated by other processing methods can also be called.
  • FIG. 3 is a schematic illustration of an acquisition module.
  • Acquisition module 110 includes one or more signal detection units, as shown 310-1, 310-2, ... 310-N.
  • One or more signal detection units can be used to detect physiological signals of a living being, such as a living body PPG signal.
  • the physiological signals of the living body detectable here can be detected from the same position of the living body, or can be detected from different positions of the living body.
  • One or more signal detection units can be used to detect other non-physiological signals of the living being, such as motion/vibration signals.
  • One or more signal detection units may be used to detect or store the reference signal, such as a signal received directly by the receiving end after the transmitting end transmits.
  • Each signal detecting unit may exist independently of each other, may be associated with each other, or may be integrated in the same signal detecting unit.
  • One signal detection unit can use one or more signals Detection method.
  • each signal detecting unit may also adopt the same signal detecting method or different signal detecting methods.
  • Each signal detecting unit may include a respective A/D sampling unit (Analog/Digital) (not shown), or may be shared by two, three or three, or all of the same A/D sampling unit ( Not shown in the figure).
  • Each signal detecting unit may share the same light source transmitting end (not shown in the figure), or may use different light source transmitting ends (not shown in the figure).
  • Each signal detecting unit can share the same sensor receiving end (not shown in the figure), or can use different sensor receiving ends (not shown in the figure). Similarly, the light source emitting end (not shown) and the sensor receiving end (not shown) can be combined in any form to achieve better signal detection.
  • the pre-processing unit 320 can be used to perform preliminary pre-processing on the acquired signals. Pre-processing can achieve the effect of smoothing the signal or removing significant interference.
  • the preprocessing method may include, but is not limited to, one or more of low pass filtering, band pass filtering, wavelet transform filtering, median filtering, morphological filtering, and curve fitting.
  • the acquisition module 110 is connected to other modules or devices 330 wirelessly or by wire, enabling real-time or non-real-time data transmission.
  • the acquisition module 110 is merely a specific example and should not be considered as the only feasible implementation.
  • Each of the above modules or units may be implemented by one or more components, and the function of each module or unit is not limited thereto.
  • various modifications and forms and details of the specific implementation manners and steps of the acquisition module may be performed without departing from this principle. change. It is also possible to make a number of simple deductions or substitutions, with some adjustments or combinations of the order of the modules or units without any inventive effort, but such modifications and changes are still within the scope of the above description.
  • a corresponding smoothing processing unit or a pre-processing unit may be added to each signal detecting unit for performing simple smoothing processing or coarse filtering processing on the collected signals to achieve smooth processing signals or Remove the effects of significant interference.
  • the pre-processing unit 320 can also be integrated in one or more of the signal detection units.
  • the pre-processing unit 320 is not required and may be implemented by an external device to which the acquisition module 110 is connected.
  • the A/D sampling unit included or used by each of the signal detecting units is not essential.
  • the acquisition module 110 can not only realize the collection of digital signals, but also realize the collection of analog signals. The type of signal collected does not affect the steps after the acquisition of the signal. Implementation of the functionality of other modules or devices other than the line or acquisition module.
  • the acquisition module 110 can utilize the collected physiological signals or non-physiological signals and reference signals to calculate signals absorbed or lost by the living body in different processes.
  • FIG. 4 shows a schematic diagram of four specific embodiments of the acquisition module 110.
  • the A scheme includes one transmitter and two receivers.
  • the B scheme includes a transmitting end and a receiving end.
  • the C scheme includes two transmitting ends and two receiving ends.
  • the D scheme includes two transmitting ends and one receiving end.
  • the four cases listed in the figure represent only possible implementations of the acquisition module 110, and do not indicate that the specific embodiment of the acquisition module 110 is limited to the above cases. Take the A scheme as an example, including one transmitter and two receivers.
  • the transmitting end may be a light source of different frequency bands of different types and different wavelengths, and the light source may belong to different frequency bands, including but not limited to visible light spectrum, infrared spectrum, far infrared spectrum, etc., and the types of light beams are specifically, for example, but not limited to, red light, green light, Infrared, blue, violet, yellow, orange, and glaucom.
  • the receiving end may be a different type of sensor, which may include, but is not limited to, a photoelectric sensor, a displacement sensor, an acceleration sensor, a vibration sensor, a mechanical sensor, a temperature sensor, a gas sensor, and the like.
  • the types of photoelectric sensors include, but are not limited to, diffuse reflection type photoelectric sensors, through-beam type photoelectric sensors, distance type photoelectric sensors, slot-shaped photoelectric sensors, fiber optic photoelectric sensors, and the like.
  • the transmitting end is placed near the skin of the living body to be detected, and the transmitting end can simultaneously emit two beams of the same type, or two light beams of the same type can be simultaneously distributed.
  • the two beams reach the skin of the living body at the same time or in a time-sharing manner, and penetrate the skin to reach the blood vessels deep in the skin of the living body. After the two beams are reflected by the living body, they are respectively received by the two receiving ends.
  • the parameter states of the two receivers can be different.
  • the two receiving ends can be adjusted to different parameter states by adjusting parameters not limited to resistance, current, voltage, light intensity sensitivity, and the like. Since the parameter states of the two receivers are different, the sensitivity to the strength of the signal is different.
  • the PPG signal of the living body belongs to the low frequency physiological signal, and the signal intensity is relatively weak. If the sensitivity of the receiving end is low, the PPG signal of the living body is not received/detected. Therefore, in this embodiment, the signal received by the first receiving end is a physiological signal of the living body, and may include a PPG signal of the living body and a motion/vibration signal of the living body, and the signal received by the second receiving end may include The motion/vibration signal of the living body.
  • the B scheme includes a transmitting end and a receiving end.
  • the transmitter can send time-sharing Two channels of the same type are emitted.
  • the first light beam reaches the skin of the living body, penetrates the skin and reaches the blood vessel at the depth of the skin. After being reflected by the living body, it is received by the receiving end.
  • the receiving end is in the first parameter state, and the received first signal is a physiological signal of the living body, including the PPG signal of the living body and the motion/vibration signal of the living body.
  • the transmitting end emits a second beam, and the second beam reaches the skin of the living body. Similarly, after being reflected by the living body, it is received by the receiving end.
  • the receiving end has been adjusted to the second parameter state. Similar to the foregoing A scheme, after the parameter state of the receiving end is changed, the sensitivity is lowered, and the PPG signal of the living body is not received/detected. Therefore, in this embodiment, the received second path signal includes a living body motion/vibration signal, and the difference between the second parameter state and the first parameter state may be, but is not limited to, resistance, current, voltage, One or more of the parameters such as light intensity sensitivity.
  • the C scheme of the acquisition module 110 includes two transmitters and two receivers.
  • the two transmitting ends can emit two beams of different characteristics, such as but not limited to infrared and green, red and green, infrared and red. These two beams can be in phase or different phases. It can be different wavelengths or the same wavelength. It can be different frequency bands or the same frequency band. It can be the same strength or it can be different strength.
  • the two beams can also be obtained by adding one or more original beams/signals by adding the same or different carrier signals. For example, the spectrum of the original beam/signal can be moved to an arbitrary spectral range by frequency modulation, phase modulation, amplitude modulation, etc., thereby facilitating beam/signal transmission.
  • Two different beams are emitted to the skin of the living body. Because the penetration ability of the two beams is different, the first beam penetrates the surface of the skin to reach the blood vessels deep in the skin, and the second beam is reflected directly on the skin surface. . At this time, the parameter status, resistance, current, voltage, and light intensity sensitivity of the two receiving ends are the same, and the two receiving ends receive two different signals.
  • the light beam that penetrates the surface of the skin and reaches the depth of the skin is reflected by the living body and is received by the first receiving end.
  • the first signal received by the first receiving end is the physiological signal of the living body, including the living body PPG signal and the living body. Motion/vibration signal.
  • the light beam reflected directly by the living body on the surface of the skin is received by the second receiving end, and the second signal received by the second receiving end includes the living body motion/vibration signal.
  • the D scheme includes two transmitting ends and one receiving end.
  • Two emitters can emit two beams of different characteristics, such as but not limited to infrared and green, red and green, infrared And red light, etc. These two beams can be in phase or different phases. It can be different wavelengths or the same wavelength. It can be different frequency bands or the same frequency band. It can be the same strength or it can be different strength.
  • the two beams can also be obtained by adding one or more original beams/signals by adding the same or different carrier signals. For example, the spectrum of the original beam/signal can be moved to an arbitrary spectral range by frequency modulation, phase modulation, amplitude modulation, etc., thereby facilitating beam/signal transmission.
  • Two different beams are emitted to the skin of the living body in a time-sharing manner. Due to the different penetrating power of the two beams, the first beam penetrates the surface of the skin to reach the blood vessels deep in the skin, and the second beam directly hits the skin. The surface is reflected. Subsequently, the two beams are reflected by the living body and then received by the receiving end in a time-sharing manner, wherein the first beam penetrates the surface of the skin and reaches the blood vessel at the depth of the skin, and the reflected signal after the reflection of the living body is the physiology of the living body. Signals, including vital body PPG signals and motion/vibration signals. The second beam is directly reflected by the living body on the surface of the skin, and the reflected signal received by the receiving end includes a living body motion/vibration signal.
  • the acquisition module 110 can include one or more transmitting ends, and one or more receiving ends.
  • the transmitting end and the receiving end can be arranged in any combination to achieve better signal acquisition.
  • the transmitting end and the receiving end can be integrated in the same photoelectric sensor, or can be separately present in different photoelectric sensors or other devices.
  • the function of collecting two signals described above can also be realized by using one transmitting end and one receiving end. By adjusting the intensity of the exciting current of the transmitting end, the transmitting end emits two beams of different intensities. Two different beam penetration capabilities Different, so the effect described above can also be achieved after reflection by the living body.
  • FIG. 5 is a schematic diagram of the acquisition module collecting two signals.
  • the scheme A in FIG. 4 is taken as an example, and an example of collecting two signals is given. It does not mean that the manner and form of acquiring two signals are limited to those shown in the figure.
  • the transmitter can simultaneously emit two beams of the same type, or two channels of the same type can be emitted in time.
  • the transmission paths of the two beams are the same, penetrate the surface of the skin of the living body and reach the deep skin.
  • At the blood vessel of the blood vessel it is received by the receiving end after being reflected by the living body.
  • At least one of the parameters of the resistance, current, voltage and light intensity sensitivity of the two receiving ends is different.
  • the PPG signal of the living body belongs to the low frequency physiological signal, the signal strength is relatively weak, and if the sensitivity of the receiving end is low, The PPG signal of the living body is not received/detected.
  • a receiver with two different parameter states can receive two different signals.
  • the first signal received by the first receiving end is a physiological signal of the living body, including the PPG signal of the living body and the motion/vibration signal of the living body, and the second signal received by the second receiving end includes the motion/vibration of the living body. signal.
  • FIG. 6 is another schematic diagram of the acquisition module collecting two signals.
  • the scheme C in FIG. 4 is taken as an example, and the process of acquiring signals by two transmitting ends and two receiving ends is given.
  • the two transmitters can transmit two different types of beams of different wavelengths and different wavelengths, such as but not limited to red and infrared, red and green, green and infrared.
  • the first light beam penetrates the surface layer of the living body skin until the blood is deep in the blood vessel. After being reflected by the living body, it is received by the first receiving end, and the received signal is the first signal, that is, the physiological signal of the living body, including life.
  • Body PPG signal and vital body motion/vibration signal The second beam of light is directly reflected by the living body on the surface of the skin and does not penetrate into the blood of the blood vessel.
  • the second signal received by the second receiving end includes a living body motion/vibration signal.
  • the light source transmitting end splits two light beams of the same frequency band of the same type and the same frequency band, and after being reflected by the living body,
  • the receiving end adjusts and changes at least one of a resistance, a current, a voltage, and a light sensitivity to receive two signals in a time division manner.
  • the case shown in FIG. 6 can also use the same receiving end with the same resistance state, current, voltage, light intensity sensitivity and the like, that is, as shown in the scheme D in FIG. 4, one receiving end can be divided. Receive two signals that are reflected by the living body.
  • FIG. 7 is a schematic diagram of the analysis module 120.
  • the analysis module 120 can include a processing unit 710, a computing unit 720, and a noise processing unit 730.
  • the processing unit 710 is configured to perform feature analysis on the received first to Nth road signals.
  • the analysis methods used may include, but are not limited to, sampling analysis, grid analysis, feature point extraction, regression analysis, Gaussian process regression analysis, analysis of variance, mean analysis, cluster analysis, linear discriminant algorithm, multiple linear principal component analysis, Factor analysis, discriminant analysis, comparative analysis, simulation analysis, simulation analysis, threshold method, Gaussian function decomposition method, wavelet transform, Fourier transform, Chebyshev polynomial fitting, QRS wave detection algorithm, peak detection algorithm, HTT method, Quadratic Discriminant Analysis, Maximum Entropy Classifier, Decision Tree, Decision Table, Kernel Estimation, Nearest Neighbor, Naive Bayes Classifier, Neural Network, Visual Controller, Gene Expression Programming, Markov Random Field, Kalman Filters, particle filters, independent component analysis, principal component analysis, conditional random domains, hidden Markov models, maximum entropy Markov models, recurrent neural networks, associative rules, inductive logic programming, similarity metric learning, depth One of a neural network, a deep belief network, a convolutional neural
  • the calculating unit 720 can directly calculate the received first to Nth road signals, and can also calculate the signal after the feature analysis.
  • Calculation methods may include, but are not limited to, minimum-maximum normalization, Z-score normalization, scaling by decimal scale, linear function method, logarithmic function method, inverse cotangent function method, norm method, historical threshold iteration, modeling method, Least squares method, elimination method, reduction method, substitution method, image method, comparison method, scaling method, vector method, induction method, counter-evidence method, exhaustive method, matching method, undetermined coefficient method, changing element method, dismantling One or more of the item method, the complement method, the factorization method, the parallel movement method, the function approximation method, the interpolation method, the curve fitting method, the integral method, the differential method, the disturbance method, and the like.
  • the manner of adjustment processing may include, but is not limited to, angle modulation, phase modulation, frequency modulation, amplitude modulation, double sideband modulation, single sideband modulation, vestigial sideband modulation, amplitude offset modulation, phase offset modulation, quadrature amplitude modulation, One or more of frequency offset modulation, continuous phase modulation, orthogonal frequency division multiplexing, pulse code modulation, pulse width modulation, pulse amplitude modulation, pulse position modulation, pulse density modulation, and triangular integral modulation.
  • the calculating unit 710 can also perform demodulation processing on the received first to Nth signals to decompose the modulated original signal.
  • the noise processing unit 730 can be used to perform noise processing on the signals.
  • the noise processing method may include, but is not limited to, a reference signal removal method, a compensation method, a high-pass filtering method, a FIR filtering method, a curve fitting method, a wavelet filtering method, an adaptive filtering method, a median filtering method, a morphological filtering method, and the like.
  • one or more of the subtraction or addition operations may be performed on two or more signals.
  • the processing unit 710, the computing unit 720, and the noise processing unit 730 can transmit data between two or two or between the three in real time or in non-real time.
  • Analysis module 120 can be connected wirelessly or by wire to other modules or devices 740.
  • the analysis module 120 can be wirelessly or wiredly connected to one or more of the computing module 130, the output module 140, and the external device 150, etc., and can implement real-time or non-real-time data transmission.
  • the above description of the analysis module 120 is merely a specific example and should not be considered as the only feasible implementation.
  • Each of the above modules or units may be implemented by one or more components, and the function of each module or unit is not limited thereto.
  • the processing unit 710 and the computing unit 720 can be integrated in the same unit, and have the functions of signal analysis and calculation; similarly, the processing unit 710, the computing unit 720, and the noise processing unit 730 can be integrated in two or three A unit that combines the functions of each unit.
  • the analysis module 120 can add a corresponding storage unit (not shown in the figure) to implement real-time generated or involved in the operation of the module or units. Or non-real time data.
  • FIG. 8 is a schematic diagram of one embodiment of an analysis module 120.
  • the analysis module 120 can include a feature analysis unit 810, a normalization unit 820, and a noise processing unit 830.
  • Feature analysis unit 810 can be used to perform feature analysis on the received signals.
  • the feature analysis can include, but is not limited to, one or more of a waveform, a peak, a trough, a peak amplitude, a peak point interval, a phase, a frequency, a period, and the like.
  • the analyzed feature results can be displayed in waveform form or in digital form, but the display is not required.
  • the normalization unit 820 can be used to normalize the analyzed feature results.
  • the normalization method may include, but is not limited to, one or more of minimum-maximum normalization, Z-score normalization, decimal scaling normalization, linear function method, logarithmic function method, inverse cotangent function method, norm method, and the like.
  • the noise processing unit 830 can be used to perform noise processing on physiological signals.
  • the first signal is a physiological signal of a living body
  • the second path is a non-physiological signal such as a living body motion/vibration signal.
  • the second signal is used as a reference signal to remove noise from the first signal, that is, the physiological signal of the living body.
  • correlation coefficient units may be integrated in the noise processing unit 830 or may exist in the analysis module 120 alone. It can also be integrated in other units or it can be implemented by the external device 150.
  • the analysis module 120 can be connected to other modules or devices (not shown) wired or wirelessly, and can realize real-time or non-real-time data transmission. The above description of the analysis module 120 is merely a specific example and should not be considered as the only feasible implementation.
  • each of the above modules or units may be implemented by one or more components, and the function of each module or unit is not limited thereto.
  • the normalization unit 820 in the analysis module 120 is not required, normalized processing
  • the process can be implemented by the external device 150.
  • any unit can be integrated into other units and not necessarily separately.
  • the analysis module 120 can integrate corresponding storage units (not shown) for storing real-time or non-real-time data generated during the analysis process.
  • a phase adjustment unit (not shown) may be added to the analysis module 120, or the phase adjustment unit (not shown) may be integrated in the normalization unit 820 or the noise processing unit 830, or integrated in other modules. Or in the external device 150.
  • the phase adjustment unit (not shown) realizes phase adjustment of the two signals, and the adjustment methods include, but are not limited to, left and right translation of the two signal waveforms, peak wave trough feature point correspondence, etc., and the two signals are adjusted to have substantially the same phase. Any subsequent calculations, analysis or processing can be performed directly.
  • steps 910 and 920 are performed to respectively read the first path signal and the second path signal, wherein the first path signal is a physiological signal of the living body.
  • Step 910 and step 920 may be performed simultaneously or in a time-sharing manner.
  • step 930 is performed, which performs feature analysis on the two signals, including but not limited to one of waveform, peak, trough, peak amplitude, peak point interval, phase, frequency, period, and the like. Or a variety.
  • a decision step 940 is performed. According to the characteristics of the two signals analyzed in step 930, it is determined whether there is noise in the first path signal.
  • step 950 is directly executed to output the first path signal.
  • step 960 is performed to normalize the first signal or the second signal, and the normalization method includes but is not limited to minimum-maximum normalization, Z-score normalization, and scaling by decimal One or more of normalization, linear function method, logarithmic function method, inverse cotangent function method, norm method, and the like.
  • the normalization step 960 can be performed by the normalization unit 820. After the normalization process, the magnifications of the two signal waveforms are adjusted to be consistent, that is, the original signals are standardized, are of the same order of magnitude and are comparable, and can be further processed.
  • the noise processing step 970 is performed, at which time the second channel signal is used as a noise reference to remove the noise in the first channel signal.
  • the first signal is a physiological signal of a living body containing a noise signal
  • the second signal mainly includes a noise signal. Therefore, the second signal can be used as a reference for the noise signal, and the reference signal can be used to perform correction, correction, calculation, and the like on the first signal to achieve the purpose of removing the noise signal in the first signal.
  • the noise processing method used in the noise processing step 970 may include but not Limited to simple filtering, algorithm filtering, etc., specific algorithms such as, but not limited to, various simple mathematical operations such as addition, subtraction, multiplication, division, square root, etc., primary function, quadratic function, cubic function, quadratic function, fifth-order function, power function , compound functions, program functions, transcendental functions, complex functions, and other functions, physical simulation, mathematical simulation, semi-physical simulation, continuous simulation, discrete simulation, simulation, digital simulation, hybrid simulation, real-time simulation, ultra-real time One or more of various simulation calculations such as simulation and sub-real-time simulation.
  • the correlation coefficient unit (not shown) can be selected to read and apply the corresponding association. coefficient.
  • the correlation coefficient can be applied to any one or more algorithm steps, can be used as initial data, and can also be used for correction and optimization of terminal data.
  • step 980 is executed by the output module 140 to output the noise-processed signal.
  • the first path signal and the second path signal may be adjusted, for example, but not limited to, one or more of adjusting amplitude, phase, frequency, intensity, and the like.
  • Methods of adjustment processing include, but are not limited to, angle modulation, phase modulation, frequency modulation, amplitude modulation, double sideband modulation, single sideband modulation, vestigial sideband modulation, amplitude offset modulation, phase offset modulation, quadrature amplitude modulation, frequency
  • offset modulation continuous phase modulation, orthogonal frequency division multiplexing, pulse code modulation, pulse width modulation, pulse amplitude modulation, pulse position modulation, pulse density modulation, and triangular integral modulation.
  • the first path signal and the second path signal may be demodulated to decompose the modulated original signal.
  • a corresponding cache or store step can be added between step 930 and step 940.
  • the signal features obtained by the analysis of step 930 are stored, and the subsequent determining step can read the cache or store the data in a non-real time.
  • similar caching or storage steps can be added between any two steps.
  • a phase adjustment step can be added between the normalization step 960 and the noise processing step 970.
  • the two signals are adjusted to have the same phase, and the subsequent calculation and noise processing steps can be performed more accurately.
  • the determining step 940 is not essential, and after the feature analysis, the subsequent analysis processing can be directly performed.
  • Fig. 10 is a graph showing experimental results of the first path signal, the second path signal, and the noise-processed signal.
  • the waveform diagrams shown in the figures are for illustrative purposes only and are not intended to represent a particular embodiment of the invention.
  • the acquisition module 110 collects two signals and transmits them to the analysis module 120.
  • the analysis module 120 performs feature analysis on the two signals, including but not limited to one or more of waveform, peak, trough, peak amplitude, peak point interval, phase, frequency, period, and the like.
  • the characteristic results are shown in the figure.
  • the first signal is the physiological signal of the living body, including the living body PPG signal and the living body motion/vibration signal
  • the second signal includes the living body motion/vibration signal.
  • the waveforms, peak positions, trough positions, peak point spacing, phase and other characteristics of the first signal and the second signal are basically the same, and the obvious difference between the two is the difference in amplitude.
  • the first path signal can be subjected to noise processing.
  • the second signal is used as the noise reference signal, and the noise processing unit 830 in the analysis module 120 performs a noise processing step to remove the noise in the first signal to obtain the noise-processed signal as shown in the figure.
  • the noise-processed signal is the PPG signal of the living body.
  • the PPG signal can be directly outputted by the output module 140 as an output result, or can be used as initial data or intermediate data of a subsequent vital sign calculation step.
  • the vital sign acquisition system can better remove motion/vibration noise or interference in the physiological signal of the living body, and the calculation amount is small and the calculation result has high accuracy.
  • the light source emitting end of the collecting module 110 is illuminated, and the light emitting end simultaneously emits two light beams of the same wavelength.
  • Beam types include, but are not limited to, red, green, infrared, blue, violet, yellow, orange, cyan, and the like.
  • the two beams reach the skin of the living body, and may be the skin at the same position, or the skin adjacent to the same position in the vicinity.
  • the light beam penetrates the surface of the skin to reach the blood of the blood vessels deep in the skin. After being reflected by the living body, two reflected signals (or reflected light) of the same wavelength are obtained.
  • the acquisition module has two sensor receivers.
  • the two receiving ends are located at the same position or at different positions close to the living body.
  • the two receiving ends respectively receive two reflected signals, and the parameter states of the two receiving ends are different.
  • the two receiving ends can be adjusted to different parameter states by adjusting one or more of parameters not limited to resistance, current, voltage, light intensity sensitivity, and the like.
  • the receivers with different parameter states have different sensitivities to the two signals. Since the PPG signal of the living body belongs to the low frequency physiological signal, the signal intensity is relatively weak. If the sensitivity of the receiving end is low, the PPG signal of the living body cannot be received/detected.
  • the first signal received by the first receiving end is a physiological signal of the living body, including the PPG signal of the living body and the motion/vibration signal of the living body.
  • the second signal received by the second receiving end includes a motion/vibration signal of the living body.
  • the pre-processing unit 320 of the acquisition module 110 is configured to perform preliminary pre-processing on the collected two signals, and the pre-processing can achieve the effect of smoothing the processed signal or removing the significant interference.
  • the pre-processing methods include, but are not limited to, one or more of low-pass filtering, band-pass filtering, wavelet transform filtering, median filtering, morphological filtering, and curve fitting.
  • the preprocessed two signals can be directly transmitted to the analysis module 120 in real time.
  • the storage device may be an external device 150, which may be a separate storage module in the engine 100, or may be integrated in the collection module 110, or may be the server 170, and any other engine, module or unit having a storage function. Then, it is read by the analysis module 120 in non-real time.
  • the analysis module 120 can read two signals at the same time, and can also read two signals separately in a time-sharing manner.
  • the feature analysis unit 810 of the analysis module 120 performs feature analysis on the two signals.
  • Feature analysis includes, but is not limited to, one or more of waveforms, peaks, troughs, peak amplitudes, peak point spacing, phase, frequency, period, and the like. These feature results can be passed in real time and proceed to the next step, or can be cached in the corresponding cache device (not shown), and the subsequent steps are read and executed by other units in non-real time.
  • the noise determination step may be simultaneously performed to determine whether there is noise in the first channel signal.
  • the normalization unit 820 then reads the two signals in real time or in non-real time and performs normalization processing. Normalization methods include, but are not limited to, one or more of minimum-maximum normalization, Z-score normalization, scaling standardization, linear function method, logarithmic function method, inverse cotangent function method, norm method, and the like. .
  • the magnification of the waveform pattern of the multiple signals is adjusted to be consistent, that is, the original signals are subjected to standardization processing, are of the same order of magnitude, and are comparable, and can be further processed.
  • the two signals may be adjusted, for example, but not limited to, one or more of amplitude, phase, frequency, intensity, and the like.
  • the signal may be finely tuned by one or more of modulation, carrier, waveform left and right translation, peak trough feature point correspondence, compression, frequency fine adjustment, Fourier transform, and the like.
  • the two signals can perform the next calculation or noise processing more accurately.
  • the first path signal is then subjected to noise processing by the noise processing unit 830.
  • the second signal in the noise processing process is used as the noise reference signal, and the noise processing methods used include, but are not limited to, simple filtering, algorithm filtering, and the like.
  • the specific algorithm is, for example but not limited to, various simple mathematical operations such as addition, subtraction, multiplication, multiplication, division, square opening, first function, quadratic function, cubic function, quadratic function, Fifth-order functions, power functions, compound functions, program functions, transcendental functions, complex functions, and other functions, physical simulation, mathematical simulation, semi-physical simulation, continuous simulation, discrete simulation, simulation, digital simulation, hybrid simulation One or more of various simulation calculations such as real-time simulation, ultra-real-time simulation, and sub-real-time simulation.
  • correlation coefficient units (not shown in the figure) in the noise processing process.
  • the correlation coefficient unit may be integrated in the noise processing unit 830 or may exist in the analysis module 120 alone. It can also be integrated in other units or it can be implemented by the external device 150.
  • the first path signal and the second path signal may be adjusted, for example, but not limited to, one or more of adjusting amplitude, phase, frequency, intensity, and the like.
  • Methods of adjustment processing include, but are not limited to, angle modulation, phase modulation, frequency modulation, amplitude modulation, double sideband modulation, single sideband modulation, vestigial sideband modulation, amplitude offset modulation, phase offset modulation, quadrature amplitude modulation, frequency
  • offset modulation continuous phase modulation, orthogonal frequency division multiplexing, pulse code modulation, pulse width modulation, pulse amplitude modulation, pulse position modulation, pulse density modulation, and triangular integral modulation.
  • the first path signal and the second path signal may be demodulated to decompose the modulated original signal.
  • the noise-processed first signal may be directly output by the output module 140 or may be stored in a corresponding storage device, and the calculation module 130 may read and perform calculations in real time or non-real time.
  • the types of vital signs that the calculation module 130 can calculate include, but are not limited to, blood pressure, pulse rate values, blood oxygen saturation, heart rate variability, heart murmur, bowel sounds, pH value, creatinine content, transferase content, body temperature, and One or more of vital signs such as carcinoembryonic antigen content.
  • Calculation methods include, but are not limited to, various common mathematical calculations, statistical analysis, data processing, and the like.
  • the data or signal types involved in the calculation process include, but are not limited to, the determination of physiological parameters of the living body, such as, but not limited to, height, weight, vital capacity, heart beat parameters, blood glucose levels, blood viscosity measurement, vasodilation pressure, vasoconstriction pressure.
  • the calculated vital signs of the living body can be output by the output module 140 in real time or non-real time.
  • the two beams of light reach the skin of the living body respectively, and may be the skin at the same position, or the skin adjacent to the same position in the vicinity.
  • the light beam penetrates the surface of the skin to reach the blood of the blood vessels deep in the skin.
  • the acquisition module has a sensor receiving end, and the receiving end adjusts the parameter state to receive two reflected signals in a time-sharing manner, wherein the adjustable parameters include, but are not limited to, one or more of resistance, current, voltage, light intensity sensitivity, and the like.
  • the parameters of the receiving end are different, the sensitivity to the signal is different. Since the PPG signal of the living body belongs to the low frequency physiological signal, the signal intensity is relatively weak. If the sensitivity of the receiving end is low, the PPG signal of the living body cannot be received/detected. Therefore, the receiving end can receive two different signals in a time-sharing manner.
  • the first signal is a physiological signal of the living body, including the PPG signal of the living body and the motion/vibration signal of the living body
  • the second signal includes the motion/vibration of the living body. signal.
  • the pre-processing unit 320 of the acquisition module 110 is configured to perform preliminary pre-processing on the collected two signals, and the pre-processing can achieve the effect of smoothing the processed signal or removing the significant interference.
  • Preprocessing methods include, but are not limited to, low pass filtering, band pass filtering, wavelet transform filtering, median filtering, morphological filtering, and curve fitting.
  • the preprocessed two signals can be directly transmitted to the analysis module 120 in real time, or can be stored in the storage device (the storage device can be the external device 150, can be a separate storage module in the engine 100, or can be integrated in the collection.
  • the storage device can be the external device 150, can be a separate storage module in the engine 100, or can be integrated in the collection.
  • server 170 as well as any other engine, module or unit having storage functionality, may be thereafter read by analysis module 120 in non-real time.
  • the operation process and operation steps of the analysis module 120, the calculation module 130, and the output module 140 are the same as those described in the first embodiment.
  • the light source emitting end of the collecting module 110 is illuminated, and the transmitting end simultaneously emits two light beams of different wavelengths, including but not limited to red light, green light, infrared light, blue light, violet light, yellow light, orange light, and cyan light.
  • the two beams of light reach the skin of the living body respectively, and may be the skin at the same position, or the skin adjacent to the same position in the vicinity.
  • the first beam penetrates the surface layer of the living body to the blood of the blood vessel deep in the skin, and is reflected by the living body to obtain the first path reflection signal (or the first path reflection light). .
  • the second beam has a weak penetrating ability and cannot penetrate the surface of the skin to reach the depth of the skin. Therefore, after the surface of the skin of the living body is reflected, a second reflection signal (or a second reflected light) is obtained.
  • the acquisition module 110 has two sensor receiving ends, the two receiving ends are located at the same position, or at different positions close to the living body. The parameters of resistance, current, voltage, and light sensitivity of the two receiving ends are the same.
  • the two receiving ends respectively receive two reflected signals
  • the first signal received by the first receiving end is a physiological signal of the living body, including a PPG signal of the living body and a motion/vibration signal of the living body.
  • the second signal received by the second receiving end includes a motion/vibration signal of the living body.
  • the pre-processing unit 320 of the acquisition module 110 is configured to perform preliminary pre-processing on the collected two signals, and the pre-processing can achieve the effect of smoothing the processed signal or removing the significant interference.
  • the pre-processing methods include, but are not limited to, one or more of low-pass filtering, band-pass filtering, wavelet transform filtering, median filtering, morphological filtering, and curve fitting.
  • the preprocessed two signals can be directly transmitted to the analysis module 120 in real time, or can be stored in the storage device (the storage device can be the external device 150, can be a separate storage module in the engine 100, or can be integrated in the collection.
  • the storage device can be the external device 150, can be a separate storage module in the engine 100, or can be integrated in the collection.
  • server 170 as well as any other engine, module or unit having storage functionality, may be thereafter read by analysis module 120 in non-real time.
  • the operation process and operation steps of the analysis module 120, the calculation module 130, and the output module 140 are the same as those described in the first embodiment.
  • the light emitting end of the light source in the collecting module 110 is illuminated, and the transmitting end simultaneously emits two light beams of different wavelengths.
  • Beam types include, but are not limited to, red, green, infrared, blue, violet, yellow, orange, cyan, and the like.
  • the two beams of light reach the skin of the living body. It may be the skin at the same location, or it may be adjacent to the skin at the same location.
  • the first beam penetrates the surface layer of the living body to the blood of the blood vessel deep in the skin, and is reflected by the living body to obtain the first path reflection signal (or the first path reflection light). .
  • the second beam has a weak penetrating ability and cannot penetrate the surface of the skin to reach the depth of the skin. Therefore, after the surface of the skin of the living body is reflected, a second reflection signal (or a second reflected light) is obtained.
  • the acquisition module 110 has a sensor receiving end, and the receiving end can receive two reflected signals in a time-sharing manner. The first signal is reflected by deep blood vessels in the skin of the living body, including the PPG signal and the motion/vibration signal of the living body.
  • the second signal is reflected by the surface layer of the living body, including the motion/vibration signal of the living body.
  • the pre-processing unit 320 of the acquisition module 110 is configured to perform preliminary pre-processing on the collected two signals, and the pre-processing can achieve the effect of smoothing the processed signal or removing the significant interference.
  • the pre-processing methods include, but are not limited to, one or more of low-pass filtering, band-pass filtering, wavelet transform filtering, median filtering, morphological filtering, and curve fitting.
  • the preprocessed two signals can be directly transmitted to the analysis module 120 in real time, or can be stored in the storage device (the storage device can be the external device 150, can be a separate storage module in the engine 100, or can be integrated in the collection.
  • server 170 as well as any other engine, module or unit having storage functionality, may be thereafter read by analysis module 120 in non-real time.
  • the operation process and operation steps of the analysis module 120, the calculation module 130, and the output module 140 are the same as those described in the first embodiment.
  • multiple light source emitters can simultaneously emit multiple beams of different characteristics at the same time or in time.
  • This multiple beam can be obtained by adding one or more original beams/signals by adding the same or different carrier signals.
  • the spectral band to which the original beam/signal belongs may include, but is not limited to, visible light spectrum, infrared spectrum, far infrared spectrum, and the like.
  • the multiple beams may be different, may be the same in pairs, or may be combined in any form into two or more sets of identical or different beams.
  • the process of adding a carrier signal for modulation may include angle modulation, phase modulation, frequency modulation, amplitude modulation, double sideband modulation, single sideband modulation, vestigial sideband modulation, amplitude offset modulation, phase offset modulation, quadrature amplitude modulation.
  • the multiple beams are transmitted to the skin of the living body, which may be the same position of the living body, or may be adjacent to the same position in the vicinity, or may be different positions of the living body.
  • the ability of multiple beams to penetrate is different, and the ability to penetrate the surface of the skin of a living body is also different. Therefore, after multiple beams reach the living body and are reflected by the living body, multiple different reflected signals can be obtained. These reflected signals may reflect different physiological or psychological parameters of the living body, such as but not limited to blood flow at different locations, motion/vibration of the skin surface at different locations, organ status, heart beat parameters, pulse beat parameters, skin surface tension One or more of skin elasticity, bone state, muscle state, body fat content, and the like.
  • the acquisition module 110 has a plurality of sensor receiving ends, and the receiving ends can receive multiple reflected signals simultaneously or in time.
  • the pre-processing unit 320 of the acquisition module 110 is configured to perform preliminary pre-processing on the collected multi-path signals, and the pre-processing can achieve the effect of smoothing the processed signals or removing significant interference.
  • the pre-processing methods include, but are not limited to, one or more of low-pass filtering, band-pass filtering, wavelet transform filtering, median filtering, morphological filtering, and curve fitting.
  • the pre-processed multi-path signal can be directly transmitted to the analysis module 120 in real time, or can be stored in the storage device (the storage device can be an external device 150, can be a separate storage module in the engine 100, or can be integrated in the collection.
  • server 170 as well as any other engine, module or unit having storage functionality, may be thereafter read by analysis module 120 in non-real time.
  • the operation process and operation steps of the analysis module 120, the calculation module 130, and the output module 140 are the same as those described in the first embodiment.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
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  • Signal Processing (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Evolutionary Computation (AREA)
  • Fuzzy Systems (AREA)
  • Mathematical Physics (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un procédé et un système d'acquisition de signal, comprenant des fonctions telles que la collecte, l'analyse, le calcul et la sortie de signal. Le système peut être utilisé pour acquérir des signes vitaux ; en collectant au moins deux trajets de signaux physiologiques, des informations de relation entre les au moins deux trajets de signaux physiologiques sont calculées ; les signes vitaux sont obtenus en calculant les informations de relation ; et les signes vitaux obtenus par l'intermédiaire d'un calcul sont délivrés.
PCT/CN2015/079956 2015-05-27 2015-05-27 Procédé et système d'acquisition de signal WO2016187847A1 (fr)

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US15/576,846 US11039747B2 (en) 2015-05-27 2015-05-27 Signal obtaining method and system
CN201580080088.5A CN107613856A (zh) 2015-05-27 2015-05-27 一种信号获取方法与系统
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