WO2016166623A1 - Dispositif de détection de cannabis - Google Patents

Dispositif de détection de cannabis Download PDF

Info

Publication number
WO2016166623A1
WO2016166623A1 PCT/IB2016/051623 IB2016051623W WO2016166623A1 WO 2016166623 A1 WO2016166623 A1 WO 2016166623A1 IB 2016051623 W IB2016051623 W IB 2016051623W WO 2016166623 A1 WO2016166623 A1 WO 2016166623A1
Authority
WO
WIPO (PCT)
Prior art keywords
breath
recited
subject
cannabis
detection system
Prior art date
Application number
PCT/IB2016/051623
Other languages
English (en)
Inventor
Rajpaul Attariwala
Kulwant Malhi
Original Assignee
Cannabix Technologies Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/689,434 external-priority patent/US10888249B2/en
Application filed by Cannabix Technologies Inc. filed Critical Cannabix Technologies Inc.
Publication of WO2016166623A1 publication Critical patent/WO2016166623A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G01N33/4975—Physical analysis of biological material of gaseous biological material, e.g. breath other than oxygen, carbon dioxide or alcohol, e.g. organic vapours

Definitions

  • the present invention is directed to a portable or fixed device for the detection of cannabis, specifically tetrahydrocannabinol (THC), from the exhaled breath of a subject.
  • THC tetrahydrocannabinol
  • Detection of cannabis is commonly performed by urine, blood, or oral specimen sampling. These methods are frequently invasive and require complicated devices for analysis. Alcohol is a simple molecule which can be examined directly by an exhaled breath exam, most commonly by exhaling into an ion spectroscopy chamber. This method has proven reliable and is accepted by legal systems as a noninvasive method to quantify alcohol levels.
  • each individual has the capability to exhale to different pressures, and if, for example, a filter based system is utilized to measure cannabis, an unregulated high pressure provided by a subject can tear apart the filter. Also, as each subject has a different amount of exhaled breath, it is important to be able to quantify the flowrate, or total volumetric flow, that has been breathed into the device.
  • Prior devices designed for exhaled breath do not describe a method of removal of fluid or solid contaminants, such as by way of a spit trap to collect or remove oral fluids, which prevents oral fluid contaminants from reaching a gas material detection chamber.
  • the present invention comprises a system which is designed to measure a subject's breath, remove fluid and/or contaminants, and collect a tetrahydrocannabinol (THC) sample in an entrapment container for detection of cannabis use.
  • THC tetrahydrocannabinol
  • the invention includes a breathing tube with a rebreather valve, and a fluid and solid contaminant removal device.
  • a pressure or volumetric flow measurement and regulating device is placed along the path of the exhaled breath pathway before or after a fixed or removable THC sample collecting chamber.
  • the THC collecting chamber may contain a port for cannabis sample detection, preparation or collection.
  • the described device is designed to permit detection of cannabis use relatively quickly, thus allowing it to be used, for example, by police officers in the field, etc.
  • Figure 1 is a schematic illustration showing an embodiment of the system to collect a cannabis sample from a breathing subject.
  • Figure 2 is a flowchart illustrating a method for collecting a sample of cannabis.
  • Cannabis detection by breath requires many components to separate raw cannabis and its metabolized forms from the psychoactive component tetrahydrocannabinol (THC).
  • THC tetrahydrocannabinol
  • FIG. 1 The embodiment of the invention described in Figure 1 consists of a portable cannabis detection system 20, where the psychoactive component of cannabis, tetrahydrocannabinol, is detected from the breath of a subject 24.
  • Figure 2 is the block diagram illustrating a method 22 for detecting and/or measuring THC in the breath of the subject 24.
  • the method 22 depicted in the block diagram of Figure 2 may be implemented by the portable cannabis detection system 20 of Figure 1 or by any device or system capable of performing at least some combination of the steps described in Figure 1.
  • the example portable cannabis detection system 20 comprises a mouthpiece 30, an intake non-rebreather valve 32, a contaminant trap 34, a THC collection and housing component 36, a pressure measurement and/or regulator component 38, a liquid injection/sampling port 40, and a volumetric flow measuring component 42.
  • the cannabis detection system 20 is comprised of either disposable, or aseptic cleanable reusable components or as a single whole device.
  • the flowchart of Figure 2 outlines the method for detection 22 of THC by outlining the direction materials pass through a device for cannabis detection such as the portable cannabis detection system 20 as generally described above.
  • the detection method 22 depicted in Figure 2 comprises the steps of providing a breathing device at block 50, removing contaminant material at block 52, conditioning the exhaled breath flow at block 54, collecting the THC at the block 60, measuring at least one and typically all of volume, flow, and pressure at block 62, and collecting or preparing a sample at block 64.
  • the components and materials used by the steps in the flowchart of Figure 2 are designed to provide to a THC collection device such as the THC collection component 36 of the example portable cannabis detection system 20 described above, at block 60, an appropriate sample of exhaled breath from which THC content may be detected and/or measured.
  • the example cannabis detection system 20 is coupled to the subject 24 via the mouthpiece 30.
  • This mouthpiece 30 is directly connected to a non- rebreather valve 32 which allows the subject 24 to both inhale and exhale through the mouthpiece 30 without the subject 24 removing his lips from the mouthpiece 30 to inhale and without requiring the subject 24 to breathe through his nose to inhale.
  • the air exchange step performed by the example mouthpiece 30 and non-rebreather valve 32 is described at the block 50 in the flowchart of Figure 2.
  • Arrows A and B in Figures 1 and 2 show air entering and exiting the system, respectively, thereby allowing the subject 24 to inhale and exhale through the mouthpiece 30, with the exhaled breath being redirected into the contaminant trap 34.
  • the example contaminant trap 34 consists of a device that allows interfering materials, such as vapor, fluid, and/or solids, to be removed from the exhaled breath from the subject 24 and allows exhaled THC-containing breath to pass through unrestricted.
  • the example trap 34 thus removes contaminants from the exhaled breath as performed by the removing contaminant material step shown at block 52 in Figure 2.
  • the containment trap 34 can be removed to access liquid contaminants which may include metabolized or unmetabolized components of cannabis or to remove components of exhaled breath that would interfere with the detection of THC in the collection device 36.
  • the example containment trap 34 may be a contaminant removal component comprising a flap valve covering holes that allows oral fluid to pass out of the device or to be collected in another chamber.
  • the degree of effort of exhalation by subjects such as the subject 24 is variable, which results in the exhaled breath occurring at various pressures.
  • a pressure regulator and or measuring device 38 is placed in line with the exhaled breath.
  • the example THC collection component 36 prepares the exhaled breath to be appropriately collected as shown at the step corresponding to block 54 in the flowchart of Figure 2.
  • the pressure measuring and/or regulating component 38 can be placed anywhere beyond the mouthpiece to control pressure input into or from the device.
  • a wide variety of pressure regulating or measuring devices can be utilized, and an example may consist of a balloon which expands with high pressure exhaled breath, and collapses to deliver exhaled breath to the detection component of the device at a controlled pressure.
  • the THC collection component 36 may consist of a vacuum, gas and/or liquid filled chamber with a filter or sensor that is capable of collecting or detecting THC.
  • the example THC collection device 36 may be directly accessed by a sampling port 40 for either sampling or filling with gas or liquid materials as shown by block 64 in Figure 2.
  • the THC collection component 36 in whole or in part may be removed from the cannabis detection system 20.
  • An embodiment of the THC collection component 36 would be a filter or cartridge that can be removed for sampling via high performance liquid chromatography and/or mass spectrometry.
  • Other potential embodiments include an ion or magnetic resonance chamber, color detection, light spectroscopy, and/or nanoparticie filter.
  • the THC collection component 36 may consist of a chemical that forms an appearance change material which reacts with THC. This would result in a reaction or change in chemical or physical properties of such chemical so that the alteration would be detectable. For example, a chemical coming into contact with THC could result in a changing of color of the chemical. This color change can then be visualized by detection/looking through the access port 40.
  • the port 40 can be used to prepare the filtered sample for any of these methods.
  • a volumetric flow measuring device 42 is placed to quantify the amount of exhaled breath provided by the subject 24.
  • the location of this measurement device 62 as shown in the flowchart of Figure 2 can be placed anywhere along the pathway of the exhaled breath, or may be coupled with the step of conditioning the exhaled breath flow shown by block 54 and/or the pressure measurement or regulator device 38.
  • the purpose for recording the volume of breath passing through the device is to enable a way to measure how much exhaled breath has been input into the system 20. Each individual, based on their lung capacity and/or effort, can exhale different volumes.
  • a volumetric flow rate measurement device incorporated into the system for cannabis detection provides a means to quantify this amount per breath, and/or as a total sum during use of the device. This ensures that sufficient exhaled breath is delivered to the THC collection component 36 to allow detection of cannabis or THC use.
  • a variety of different flow meters can be used as the volumetric flow measuring device 42.
  • One example is a rotating blade which spins with exhaled breath and records the volume of flow that is exhaled.
  • a second example would be a diaphragm that detects air pressure and converts air pressure to flow volume.
  • the device can provide results of THC detection in seconds or minutes based on how the cannabis detection device 20 and/or THC collection analysis method 22 are implemented.
  • the device can be implemented or equipped to correlate a measured or detected THC sample to a specific subject.
  • a DNA fingerprint method can be added to the contaminant trap 34, or elsewhere inline, to detect and/or monitor who is utilizing the device (e.g., through use of the subject's saliva or other DNA sample).
  • the THC sample measurement and the DNA sample are stored together and/or cross- reference in a way that ensures that a particular THC sample measurement and DNA sample are positively associated with each other for evidentiary purposes if necessary.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Cette invention concerne un système pour la collecte du cannabis et de son composant psychoactif, le tétrahydrocannabinol à partir d'un échantillon d'air expiré. Une seule ou plusieurs expirations sont conditionnées par élimination des contaminants, et régulation du débit et/ou de la pression pour recueillir un échantillon de tétrahydrocannabinol pour une analyse opportunément locale ou à distance. Le système de détection de cannabis comprend un piège de confinement pour éliminer les substances interférentes contenues dans l'haleine du sujet et un composant de collecte pour échantillonner les composants d'haleine introduits dans le système par l'intermédiaire du piège de confinement à des fins d'analyse visant à déterminer la présence de THC dans l'haleine.
PCT/IB2016/051623 2015-04-17 2016-03-22 Dispositif de détection de cannabis WO2016166623A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/689,434 2015-04-17
US14/689,434 US10888249B2 (en) 2014-04-18 2015-04-17 Cannabis drug detection device

Publications (1)

Publication Number Publication Date
WO2016166623A1 true WO2016166623A1 (fr) 2016-10-20

Family

ID=57127954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2016/051623 WO2016166623A1 (fr) 2015-04-17 2016-03-22 Dispositif de détection de cannabis

Country Status (1)

Country Link
WO (1) WO2016166623A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202018106075U1 (de) * 2018-10-24 2020-01-27 Securetec Detektions-Systeme Ag Probenanalyseeinrichtung sowie Entnahmeelement für eine Probenanalyseeinrichtung

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6383736B1 (en) * 2000-02-29 2002-05-07 Ted Titmas Personal drug use indicator
WO2011029889A1 (fr) * 2009-09-09 2011-03-17 Sensa Bues Ab Détection de drogue dans l'air expiré
US8251123B2 (en) * 2010-12-30 2012-08-28 United Technologies Corporation Casting core assembly methods
WO2012120140A1 (fr) * 2011-03-09 2012-09-13 Sensa Bues Ab Dispositif d'échantillonnage portable et procédé d'échantillonnage de substances médicamenteuses à partir de l'haleine expirée
US20140288454A1 (en) * 2013-03-14 2014-09-25 Pulmonary Analytics Method For Using Exhaled Breath to Determine the Presence of Drug
CA2887841A1 (fr) * 2014-04-18 2015-10-18 Cannabix Breathalyzer Inc. Dispositif de detection de cannabis

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6383736B1 (en) * 2000-02-29 2002-05-07 Ted Titmas Personal drug use indicator
WO2011029889A1 (fr) * 2009-09-09 2011-03-17 Sensa Bues Ab Détection de drogue dans l'air expiré
US8251123B2 (en) * 2010-12-30 2012-08-28 United Technologies Corporation Casting core assembly methods
WO2012120140A1 (fr) * 2011-03-09 2012-09-13 Sensa Bues Ab Dispositif d'échantillonnage portable et procédé d'échantillonnage de substances médicamenteuses à partir de l'haleine expirée
US20140288454A1 (en) * 2013-03-14 2014-09-25 Pulmonary Analytics Method For Using Exhaled Breath to Determine the Presence of Drug
CA2887841A1 (fr) * 2014-04-18 2015-10-18 Cannabix Breathalyzer Inc. Dispositif de detection de cannabis
CA2850998A1 (fr) * 2014-04-18 2015-10-18 Thc Breathalyzer, Inc. Dispositif de detection de cannabis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STUBBS: "The breath of a drunken driver", NEW SCIENTIST, vol. 21, no. 373, 9 January 1964 (1964-01-09), pages 75 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202018106075U1 (de) * 2018-10-24 2020-01-27 Securetec Detektions-Systeme Ag Probenanalyseeinrichtung sowie Entnahmeelement für eine Probenanalyseeinrichtung

Similar Documents

Publication Publication Date Title
US20210085213A1 (en) Cannabis drug detection device
US20190307396A1 (en) Device and method for detection of cannabis and other controlled substances using faims
JP6332597B2 (ja) 呼気から薬物物質をサンプリングするための携帯用サンプリングデバイス及び方法
US10359417B2 (en) Portable sampling device and method for detection of biomarkers in exhaled breath
JP6861270B2 (ja) 呼気サンプルを捕捉するためのシステムおよびデバイス
ES2484515T3 (es) Detección de drogas en aliento exhalado
JP7491590B2 (ja) 呼吸サンプル採取器
JP2018105874A5 (fr)
KR20160047565A (ko) 범용 호흡 분석 샘플링 장치
US20110009762A1 (en) Portable pneumotachograph for measuring components of an expiration volume and method therefor
JP2013504074A5 (fr)
CA2892870A1 (fr) Appareil de collecte de respiration alveolaire
TWI642936B (zh) 口臭偵測用之分析呼吸氣體混合物之裝置及方法
WO2016166623A1 (fr) Dispositif de détection de cannabis
DE102007012210A1 (de) Transportabler Pneumotachograph zur Messung von Bestandteilen des Exspirationsvolumens sowie ein Verfahren hierzu
WO2020148030A1 (fr) Dispositif pour le prélèvement d'un échantillon d'haleine sous forme gazeuse d'une personne testée

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16779675

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16779675

Country of ref document: EP

Kind code of ref document: A1