WO2016166418A3 - Modèle in vitro d'une inflammation chronique - Google Patents
Modèle in vitro d'une inflammation chronique Download PDFInfo
- Publication number
- WO2016166418A3 WO2016166418A3 PCT/FI2016/050245 FI2016050245W WO2016166418A3 WO 2016166418 A3 WO2016166418 A3 WO 2016166418A3 FI 2016050245 W FI2016050245 W FI 2016050245W WO 2016166418 A3 WO2016166418 A3 WO 2016166418A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chronic inflammation
- vitro model
- studies
- model
- vitro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1157—Monocytes, macrophages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1305—Adipocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/1382—Adipose-derived stem cells [ADSC], adipose stromal stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/04—Screening or testing on artificial tissues
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne un modèle in vitro d'une inflammation chronique destiné à être utilisé par exemple dans des études pharmacologiques et toxicologiques et dans des études sur le développement du diabète de type 2 à inflammation chronique, et en tant que modèle général en recherche fondamentale et appliquée.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20155270 | 2015-04-13 | ||
FI20155270 | 2015-04-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016166418A2 WO2016166418A2 (fr) | 2016-10-20 |
WO2016166418A3 true WO2016166418A3 (fr) | 2017-01-12 |
Family
ID=55808619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FI2016/050245 WO2016166418A2 (fr) | 2015-04-13 | 2016-04-13 | Modèle in vitro d'une inflammation chronique |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2016166418A2 (fr) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007044418A2 (fr) * | 2005-10-06 | 2007-04-19 | Moscatello David K | Milieux de culture cellulaire, kits et procédés d’utilisation |
-
2016
- 2016-04-13 WO PCT/FI2016/050245 patent/WO2016166418A2/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007044418A2 (fr) * | 2005-10-06 | 2007-04-19 | Moscatello David K | Milieux de culture cellulaire, kits et procédés d’utilisation |
Non-Patent Citations (11)
Title |
---|
ADRIAN C.H. TING ET AL: "The adipogenic potential of various extracellular matrices under the influence of an angiogenic growth factor combination in a mouse tissue engineering chamber", ACTA BIOMATERIALIA, vol. 10, no. 5, 1 December 2013 (2013-12-01), AMSTERDAM, NL, pages 1907 - 1918, XP055321393, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2013.11.019 * |
ALVI SAIRAH ET AL: "Successful establishment of long-term bone marrow cultures in 103 patients with myelodysplastic syndromes", LEUKEMIA RESEARCH, vol. 25, no. 11, November 2001 (2001-11-01), pages 941 - 954, XP002760392, ISSN: 0145-2126 * |
CHUA K H ET AL: "Effects of serum reduction and VEGF supplementation on angiogenic potential of human adipose stromal cells in vitro", CELL PROLIFERATION, vol. 46, no. 3, June 2013 (2013-06-01), pages 300 - 311, XP002764494 * |
LEQUEUX C ET AL: "Optimization of a culture medium for the differentiation of preadipocytes into adipocytes in a monolayer", BIO-MEDICAL MATERIALS AND ENGINEERING, vol. 19, no. 4-5, 2009, pages 283 - 291, XP009192501 * |
NAKARAI HIDEO ET AL: "Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: Potential link with metabolic complications", INNATE IMMUNITY, SAGE PUBLICATIONS LTD, vol. 18, no. 1, 1 February 2012 (2012-02-01), pages 164 - 170, XP009191118, ISSN: 1753-4259 * |
NISHIO MIWAKO ET AL: "Differentiation of human pluripotent stem cells into highly functional classical brown adipocytes", METHODS IN ENZYMOLOGY, ACADEM. PRESS, USA, vol. 537, 1 January 2014 (2014-01-01), pages 177 - 197, XP009191114, ISSN: 1557-7988, DOI: 10.1016/B978-0-12-411619-1.00010-0 * |
OUTI HUTTALA ET AL: "Human vascular model with defined stimulation medium - a characterization study", ALTEX, 2 March 2015 (2015-03-02), XP055292329, Retrieved from the Internet <URL:http://www.altex.ch/resources/altex_2015_2_125_136_Huttala4f.pdf> [retrieved on 20160729], DOI: 10.14573/altex.1411271 * |
PENG ZHANGSONG ET AL: "Tissue Engineering Chamber Promotes Adipose Tissue Regeneration in Adipose Tissue Engineering Models Through Induced Aseptic Inflammation", TISSUE ENGINEERING PART C-METHODS, vol. 20, no. 11, November 2014 (2014-11-01), pages 875 - 885, XP002760393 * |
SARKANEN JERTTA-RIINA ET AL: "Human adipose tissue extract induces angiogenesis and adipogenesis in vitro.", TISSUE ENGINEERING. PART A JAN 2012, vol. 18, no. 1-2, January 2012 (2012-01-01), pages 17 - 25, XP002760395, ISSN: 1937-335X * |
SPENCER MICHAEL ET AL: "Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation", AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM, vol. 299, no. 6, December 2010 (2010-12-01), pages E1016 - E1027, XP002760391 * |
VUORENPAA HANNA ET AL: "Novel in vitro cardiovascular constructs composed of vascular-like networks and cardiomyocytes", IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY ANIMAL, vol. 50, no. 4, April 2014 (2014-04-01), pages 275 - 286, XP002760394 * |
Also Published As
Publication number | Publication date |
---|---|
WO2016166418A2 (fr) | 2016-10-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2014206561A8 (fr) | Structures d'anticorps | |
MX2015009104A (es) | Composiciones en solución sólida y uso en el tratamiento de enfermedades cardiovasculares. | |
WO2015082046A3 (fr) | Oxépines substituées | |
EP3040195A4 (fr) | Structure en sandwich et article moulé intégré la mettant en oeuvre, ainsi que des procédés de production associés | |
MX366317B (es) | Composiciones y metodos para tratar la inflamacion cronica y las enfermedades inflamatorias. | |
EP3073171A4 (fr) | Film d'isolation thermique et structure de film d'isolation thermique | |
EP2958926A4 (fr) | Composé épidithiodioxopipérazine ou ses dérivés, et leur utilisation | |
EP3725785C0 (fr) | Dérivé de glutarimide, son utilisation, composition pharmaceutique basée sur celui-ci et procédés de production du dérivé de glutarimide | |
WO2015058132A3 (fr) | Anticorps anti-rspo et leurs méthodes d'utilisation | |
EP3083555A4 (fr) | Procédés de diazotisation de 2,5 dichloroanilines | |
EP3113627A4 (fr) | Composition de succédané de sucre à faible teneur en calories et procédés de fabrication de celle-ci | |
EP3344339A4 (fr) | Molécules présentant une utilité en tant que pesticides, et intermédiaires, compositions et procédés associés | |
EP3344599A4 (fr) | Molécules présentant une utilité en tant que pesticide, et leurs intermédiaires, compositions et procédés | |
SG11201600726QA (en) | 1,3-disubstituted cyclopentane derivatives | |
GB2502390B (en) | Novel Ni complex and its derivatives, producing method, and the use thereof as antioxidant | |
EP3344600A4 (fr) | Molécules présentant une utilité en tant que pesticide, et leurs intermédiaires, compositions et procédés | |
EP3347341B8 (fr) | Molécules présentant une utilité en tant que pesticides, ainsi qu'intermédiaires, compositions, et procédés associés | |
MX362070B (es) | Polioles que contienen tanino, su producción y su uso. | |
EP3065726A4 (fr) | Analogues de créatine et leur utilisation | |
EP3078671A4 (fr) | Dérivé de gemcitabine, composition contenant le dérivé et utilisation pharmaceutique du dérivé | |
EP3038631A4 (fr) | Compositions anti-inflammatoires, méthodes et utilisations correspondantes | |
JP2015529327A5 (fr) | ||
EP3344040A4 (fr) | Molécules à usage pesticide, et intermédiaires, compositions et procédés associés | |
HK1215863A1 (zh) | 光交聯的透明質酸衍生物及其製備方法和應用 | |
WO2015044434A3 (fr) | Fluoro-9-méthyl-β-carboline |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 16718385 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 16718385 Country of ref document: EP Kind code of ref document: A2 |