WO2016155068A1 - 糖尿病早期电生理检测方法和系统 - Google Patents

糖尿病早期电生理检测方法和系统 Download PDF

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Publication number
WO2016155068A1
WO2016155068A1 PCT/CN2015/077753 CN2015077753W WO2016155068A1 WO 2016155068 A1 WO2016155068 A1 WO 2016155068A1 CN 2015077753 W CN2015077753 W CN 2015077753W WO 2016155068 A1 WO2016155068 A1 WO 2016155068A1
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Prior art keywords
human body
measurement site
electrodes
electrophysiological
measurement
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PCT/CN2015/077753
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English (en)
French (fr)
Inventor
张贯京
陈兴明
葛新科
张少鹏
方静芳
普拉纽克⋅克里斯基捏
古列莎⋅艾琳娜
波达别特⋅伊万
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Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
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Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
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Publication of WO2016155068A1 publication Critical patent/WO2016155068A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance

Definitions

  • the invention relates to the technical field of medical detection, in particular to an early electrophysiological detection method and system for diabetes.
  • the early detection of diabetes is mainly aimed at the changes of skin tissue resistance and capacitance effect caused by sweat gland sympathetic neuropathy in early diabetic patients, and the change of electrochemical phenomenon of sweat caused by fibrosis of sweat gland tissue.
  • the human body is equivalent to a simple resistance model.
  • the impedance detection method is used to extract the real and imaginary information of the impedance spectrum to reflect the pathological features, or to use the feedback signal of the monitoring current after DC stimulation to judge, but these two
  • the methods are limited by different human body resistance models, which are difficult to establish, and the accuracy is not high. Before the measurement, the measurer needs to do a lot of exercise and sweat, so the measurement efficiency is low.
  • the main object of the present invention is to solve the problem that the electrical detection method is difficult to establish due to limitation of different body resistance models, and the results of early electrophysiological detection of diabetes are not accurate and low in efficiency.
  • the present invention provides an early electrophysiological detection method for diabetes, which comprises the following steps:
  • the present invention also provides an early electrophysiological detection system for diabetes, the early electrophysiological detection system for diabetes comprising:
  • a calibration module for calibrating the measurement site at a location of the human extremity artery and a location adjacent to the pancreas; a setting module, configured to set a plurality of electrodes at the measured measurement portion;
  • the measuring module is configured to measure the resistance value between the electrodes of the measuring portion corresponding to each group of the human body resistance network according to the combination of the preset human body resistance networks by using different frequency measurement signals;
  • the determining and displaying module is configured to determine and display the result of the diabetic electrophysiological test according to the preset detection standard according to the change amount of the resistance value between the electrodes of the measurement part corresponding to the human body resistance network at different frequencies measured.
  • the invention calibrates the corresponding measurement site of the early electrophysiological detection of diabetes, and sets a plurality of electrodes in the measurement site, and uses the measurement signals of different frequencies to measure the measurement parts corresponding to each group of the human body resistance network according to the preset combination of the human body resistance network.
  • the resistance value between the electrodes, and according to the measured change amount of the resistance value between the electrodes of the measurement portion corresponding to the human body resistance network at different frequencies, the result of the electrophysiological detection is determined and displayed according to the preset detection standard. There is no need to establish a human body resistance model, and multiple sets of electrode pairs are used to measure the resistance values of multiple groups of human body resistance networks.
  • the resistance values can be used to measure the possible pathological changes in the early electrophysiological examination of diabetes, and the local body tissues of the human body can be measured in a targeted manner.
  • the disease or health condition makes the results of early electrophysiological examination of diabetes more accurate; and because the measurer does not need to perform a large amount of exercise before the measurement, the measurement efficiency is high.
  • FIG. 1 is a schematic flow chart of a first embodiment of an early electrophysiological detection method for diabetes in the present invention
  • 2 is a schematic flow chart showing the steps of determining and displaying the results of early electrophysiological examination of diabetes in FIG. 1
  • FIG. 3 is a schematic flow chart of the second embodiment of the early electrophysiological detection method for diabetes in the present invention
  • 4 is a schematic structural view of a first embodiment of an early electrophysiological detection system for diabetes in the present invention
  • FIG. 5 is a schematic structural view of a second embodiment of an early electrophysiological detection system for diabetes according to the present invention.
  • FIG. 1 is a schematic flow chart of a first embodiment of an early electrophysiological detection method for diabetes in the present invention.
  • an early electrophysiological test for diabetes includes:
  • Step S10 calibrating the measurement site at a position of the human limb artery and a position close to the pancreas
  • Step S20 providing a plurality of electrodes at the calibrated measurement site
  • a method for measuring the impedance value of the human body is used, and the early detection of diabetes can be measured and screened.
  • the measurement site is first calibrated on the body of the measurer.
  • the measurement site can be calibrated at the position of the extremity of the human body and the position close to the pancreas, and each measurement site corresponds to a calibration value.
  • the infrared light is irradiated to the preset part, since the absorption rate of the infrared light is proportional to the thickness of the human tissue, in the actual application measurement, the position of the measurement point of the user preset part needs to be calibrated in advance to ensure that each In the second measurement, the infrared light is irradiated at the same specific position of the preset measurement site.
  • the infrared light of a certain wavelength may be used to illuminate the measurement site, and the absorption rate E0 of the infrared light of the current wavelength at the measurement site is measured. This value is stored and used as the calibration value of the measured measurement site.
  • a plurality of electrodes are arranged at the calibration measurement site, and one electrode is provided for each measurement site.
  • Step S30 using different frequency measurement signals, according to a preset combination of the human body resistance network, measuring the resistance value between the electrodes of the measurement parts corresponding to each group of human body resistance networks;
  • the measured measurement sites are combined in advance to form a corresponding combination of human body resistance networks.
  • different sets of measurement signals are used to measure each group of human body resistance networks formed.
  • the resistance value between the electrodes of the corresponding measurement portion is obtained as a resistance value at different frequencies.
  • step S40 according to the measured change amount of the resistance value between the electrodes of the measurement part corresponding to the human body resistance network, the result of the diabetes electrophysiological test is determined and displayed according to the preset detection standard.
  • the change of the resistance value between the electrodes of the measurement parts corresponding to each group of human body resistance networks is analyzed.
  • the amount is determined according to the corresponding detection standard preset for the early electrophysiological examination of diabetes, and whether the change amount of the resistance value satisfies the detection standard.
  • the change amount of the resistance value it is determined whether the early electrophysiological test result of the measurer of diabetes is normal, and the result of the electrophysiological test is displayed to the user to prompt the user whether the electrophysiological test result of the measurer is normal or abnormal.
  • the corresponding measurement site of the early electrophysiological detection of diabetes is marked, and a plurality of electrodes are arranged at the measurement site, and the measurement signals of different frequencies are used, and the measurement parts corresponding to each group of human body resistance networks are measured according to the preset combination of the human body resistance network.
  • the resistance value between the electrodes, and according to the measured change amount of the resistance value between the electrodes of the measurement site corresponding to the human body resistance network at different frequencies, the result of the electrophysiological detection is determined and displayed according to the preset detection standard. There is no need to establish a human body resistance model, and multiple sets of electrode pairs are used to measure the resistance values of multiple groups of human body resistance networks.
  • the resistance values can be used to measure the possible pathological changes in the early electrophysiological examination of diabetes, and the local body tissues of the human body can be measured in a targeted manner.
  • the disease or health condition makes the results of early electrophysiological examination of diabetes more accurate; and because the measurer does not need to perform a large amount of exercise before the measurement, the measurement efficiency is high.
  • Fig. 2 is a detailed flow chart showing the steps of determining and displaying the results of early electrophysiological examination of diabetes in Fig. 1.
  • step S40 specifically includes:
  • Step S41 analyzing the amount of change in the resistance value between the electrodes of the measurement portion corresponding to each group of human body resistance networks measured at different frequencies;
  • Step S42 it is determined whether the change of the resistance value between the electrodes of the measurement part corresponding to each group of the human body resistance network satisfies the preset detection standard; if yes, step S43 is performed; if not, step S44 is performed;
  • Step S43 determining that the diabetic electrophysiological test result is normal, and displaying a normal result
  • step S44 an abnormal result and prompt information are displayed.
  • the amount of change in the resistance value between the electrodes of the measurement parts corresponding to each group of the body resistance network is analyzed. Then, according to the preset detection standard of early electrophysiological detection of diabetes, it is judged whether the change of the resistance value between the electrodes of the measurement part corresponding to each group of the human body resistance network satisfies the detection standard, and the detection standard is based on the early electrophysiology of diabetes.
  • the experimental data at the time of the specific measurement and the experimental results are determined.
  • the user when the measured change amount of the resistance value between the electrodes of the measurement part corresponding to each group of the human body resistance network meets the detection standard, it is determined that the result of the electrophysiological detection of the measurer is normal, and the user is displayed at this time. Normal result; if the amount of change in the resistance value between the electrodes of at least one corresponding measurement part in all the human body resistance networks measured does not satisfy the detection standard, it indicates that the result of the electrophysiological detection is abnormal, and at this time, the abnormality is displayed to the user. As a result, the user may be prompted to go to the hospital for review in the form of sending a prompt message, or to prompt the user for a possible disease risk.
  • the resistance value between the electrodes of the measurement portion corresponding to each group of the human body resistance network of the measurer is measured, and the electrophysiological detection is determined according to the analysis of the change amount of the resistance value at different frequencies.
  • the measured data and the results of the electrophysiological detection can be sent to a service platform such as a network hospital through a communication module using WIFI, Bluetooth, and infrared. Through the platform, hospital doctors can further diagnose the measurer based on the received data and results.
  • the measurer is diagnosed, and the diagnosis results and suggestions on daily diet, exercise, and lifestyle are returned to the user through information or other interactive means; or, for the absence of diabetes risk, but other body resistance
  • the amount of change in the measured resistance value under the network does not meet the preset detection standard.
  • the doctor can further analyze other diseases that may exist and diagnose the abnormal data, and then pass the diagnosis result and other precautions through information or other interaction. The way is returned to the user by the platform.
  • FIG. 3 is a schematic flow chart of a second embodiment of an early electrophysiological detection method for diabetes in the present invention.
  • the method before the step S20 is performed, the method further includes:
  • Step S50 using multiple sets of infrared light to illuminate the current measurement site, and comparing the obtained measurement value with the calibration value of the measurement site;
  • step S51 the current measurement site is determined according to the preset error range, so that the determined current measurement site and the measurement site are in the same position.
  • the measurement portion can be positioned once before each measurement of the resistance value between the electrodes of the measurement portion corresponding to the human body resistance network. That is, multiple sets of infrared light are used to illuminate the currently selected measurement part, and the measured value is compared with the calibration value of the corresponding preset measurement part, and the difference between the measured value and the calibration value is within a preset error range. When it is inside, it can be determined that the selected current measurement part is at the same position as the preset measurement part, and the current measurement part can be measured when the measurement is performed.
  • two sets of infrared light of the same wavelength can be selected to illuminate the current measurement site, and infrared light having a wavelength range of 1000 nm to 1200 nm can be selected to illuminate the current measurement site, and infrared light having a wavelength of 1200 nm can penetrate the human body.
  • the skeletal organization is sensitive to location, location is different, and the measured data is different.
  • two sets of infrared light of 1200 nm are preferably irradiated, and the current absorption rates E1 and E2 of the two sets of infrared light are measured at the current measurement site, and the preset error range is set to 5%, that is, when two sets of infrared rays are used.
  • the difference between the measured values E1 and E2 obtained by the light irradiation of the current measurement site and the calibration value E0 is within the range of 5%, it is determined that the current measurement site is the same as the calibration measurement site; if the difference between the measured value and the calibration value If there is a range of less than 5%, the position of the current measurement site is changed until the difference between the measured value and the calibration value is within 5%.
  • the current measurement site is illuminated by multiple sets of infrared light, and the current measurement site is determined according to the comparison result between the measured value and the calibration value of the measurement site, so that the current measurement site and the measurement site are at the same position, and the measurement site is accurately positioned, thereby further ensuring The accuracy of early electrophysiological testing of diabetes.
  • the measured measurement sites are determined as: a position of the left and right sides of the human body close to the wrist artery, and a position of the left and right sides of the human body close to the foot artery, and The front and back sides of the human abdomen are close to the position of the pancreas; and the electrodes are in the form of electrode pairs, and a pair of electrode pairs are arranged on the left and right sides near the wrist artery, and the left and right sides are placed near the foot artery.
  • a pair of electrode pairs are provided with a pair of electrode pairs at positions adjacent to the pancreas on the left and right sides of the front and rear abdomen.
  • the specific human body resistance network combination is as follows:
  • three different frequency measurement signals are used to measure the resistance values between the electrodes of the two measurement sites corresponding to the 24 groups of human body resistance networks, and the resistance values of each group of human body resistance networks at three frequencies are obtained. .
  • the measurement site and the combination of the measurement resistance it is possible to measure all the sites including the lesions that may occur in the early stage of diabetes, especially by setting the corresponding electrodes at different positions on the front and back sides of the human body near the pancreas, and measuring the position and difference of the pancreas. Local resistance values between limbs to facilitate more accurate detection of early lesion location in diabetes.
  • the sinusoidal AC voltage is 3 ⁇ 5.5V at a frequency of 50khz, 100khz, and 150khz.
  • the resistance value of the early diabetic patients is larger than that of the normal person, especially 14), 15) the change of the resistance value is more capable Reflects the lesions of the body of patients with early diabetes, that is, when the body resistance network is combined into the left abdomen (front) to the left abdomen (post), and the right abdomen (front) to the right abdomen (post), the corresponding
  • the amount of change in the electrical resistance between the electrodes of the measurement site can better reflect the lesions of the body of the early diabetic patients, so that the disease state of the patient can be analyzed and determined by the change of the resistance value of the local body part and the magnitude of the difference. (early, intermediate and late).
  • 40 testers of different ages were selected in the clinical trial to verify the feasibility and superiority of the program.
  • the age distribution of 40 testers was 5 for under 30 years old, 30 to 40 years old. 8 people, 12 people from 40 to 50 years old, 10 people from 50 to 60 years old, and 5 people over 60 years old.
  • Test data representing different signs of early, middle and late stages of diabetes:
  • Li 27 years old, normal person; (2) Zhang, 36 years old, early diabetic patients; (3) Zhao, 42 years old, mid-diabetes patients; (4) Tian, 59 years old, with advanced diabetes.
  • Tester representative 14 Rate of change of resistance at 50khz, 100khz 14) Rate of change of resistance at 50khz, 150khz 14) Rate of change of resistance at 100khz, 150khz 15) Rate of change of resistance at 50khz, 100khz 15) Rate of change of resistance at 50khz and 150khz 15) Rate of change of resistance at 100khz, 150khz 1 ) 0.35% 0.38% 0.36% 0.41% 0.45% 0.36% 2 ) 0.59% 0.63% 0.55% 0.60% 0.65% 0.59% 3) 0.73% 0.80% 0.76% 0.78% 0.85% 0.80% 4) 1.03% 1.12% 1.09% 1.13% 1.21% 1.15%
  • the rate of change of the resistance value is less than 0.5%, and the rate of change of the resistance value measured under the other 22 groups of human body resistance networks is also less than 0.5%, and the diabetes of the measurer can be judged.
  • the result of the early detection is normal; if 14), 15) the rate of change of the resistance value exceeds 0.5%, the stage of the measurer is further judged according to the value of the specific change rate, and at this time, the abnormal result is displayed to the user and prompted
  • the user may be in the stage of diabetes, prompting the user to go to the hospital for further diagnosis and examination; such as 14), 15) the change rate of the resistance value is below 0.5%, and the change of the resistance value measured under the other 22 groups of human body resistance networks If there is at least one group exceeding 0.5%, it indicates that the measurer's body may have other abnormal conditions. At this time, the abnormal result is displayed to the user and the user is prompted to go to the hospital for further examination.
  • FIG. 4 is a schematic structural view of a first embodiment of an early electrophysiological detection system for diabetes in accordance with the present invention.
  • the early diabetic electrophysiological detection system comprises:
  • the calibration module 10 is configured to calibrate the measurement site at a position of the human limb artery and a position close to the pancreas;
  • a setting module 20 configured to set a plurality of electrodes at the measured measurement portion
  • the measuring module 30 is configured to measure the resistance value between the electrodes of the measuring portion corresponding to each group of the human body resistance network by using the measurement signals of different frequencies according to a preset combination of the human body resistance network;
  • the determining and displaying module 40 is configured to determine and display the result of the diabetic electrophysiological test according to the preset detection standard according to the measured change amount of the resistance value between the electrodes of the measurement site corresponding to the human body resistance network at different frequencies measured.
  • the calibration module 10 first calibrates the measurement site on the body of the measurer.
  • the measurement site can be calibrated at the position of the human extremity artery and the position close to the pancreas, and each measurement site corresponds to A calibration value; when the infrared light is irradiated to the preset part, since the absorption rate of the infrared light is proportional to the thickness of the human tissue, in the actual application measurement, the position of the measurement point of the preset part of the user needs to be calibrated in advance.
  • the setting module 20 sets a plurality of electrodes at the calibration measurement site, and one electrode is provided for each measurement site.
  • the calibrated measurement sites are combined in advance to form a corresponding combination of human body resistance networks.
  • the measurement module 30 uses different frequency measurement signals to measure each group formed. The resistance value between the electrodes of the measurement part corresponding to the human body resistance network, and the resistance value at different frequencies is obtained.
  • all the sites of possible lesions corresponding to the early electrophysiological detection of diabetes can be measured to facilitate more accurate detection of the early lesion location of the early electrophysiological examination of diabetes.
  • the determination and display module 40 After measuring the resistance of each group of human body resistance networks to obtain the resistance values between the electrodes of the measurement parts corresponding to each group of human body resistance networks at different frequencies, the determination and display module 40 analyzes between the electrodes of the measurement parts corresponding to each group of the body resistance network. The amount of change in the resistance value, and according to the corresponding detection standard preset for the early electrophysiological detection of diabetes, determine whether the amount of change in the resistance value satisfies the detection standard. Finally, according to the change amount of the resistance value, it is determined whether the early electrophysiological test result of the measurer of diabetes is normal, and the result of the electrophysiological test is displayed to the user to prompt the user whether the electrophysiological test result of the measurer is normal or abnormal.
  • the corresponding measurement site of the early electrophysiological detection of diabetes is marked, and a plurality of electrodes are arranged at the measurement site, and the measurement signals of different frequencies are used, and the measurement parts corresponding to each group of human body resistance networks are measured according to the preset combination of the human body resistance network.
  • the resistance value between the electrodes, and according to the measured change amount of the resistance value between the electrodes of the measurement site corresponding to the human body resistance network at different frequencies, the result of the electrophysiological detection is determined and displayed according to the preset detection standard. There is no need to establish a human body resistance model, and multiple sets of electrode pairs are used to measure the resistance values of multiple groups of human body resistance networks.
  • the resistance values can be used to measure the possible pathological changes in the early electrophysiological examination of diabetes, and the local body tissues of the human body can be measured in a targeted manner.
  • the disease or health condition makes the results of early electrophysiological examination of diabetes more accurate; and because the measurer does not need to perform a large amount of exercise before the measurement, the measurement efficiency is high.
  • the determining and displaying module 40 is specifically configured to:
  • the determination and display module 40 After measuring the resistance values between the electrodes of the measurement parts corresponding to the groups of human body resistance networks at different frequencies, the determination and display module 40 respectively change the resistance values between the electrodes of the measurement parts corresponding to each group of the human body resistance network. The amount is analyzed. Then, according to the preset detection standard of early electrophysiological detection of diabetes, it is judged whether the change of the resistance value between the electrodes of the measurement part corresponding to each group of the human body resistance network satisfies the detection standard, and the detection standard is based on the early electrophysiology of diabetes The experimental data at the time of the specific measurement and the experimental results are determined.
  • the user when the measured change amount of the resistance value between the electrodes of the measurement part corresponding to each group of the human body resistance network meets the detection standard, it is determined that the result of the electrophysiological detection of the measurer is normal, and the user is displayed at this time. Normal result; if the amount of change in the resistance value between the electrodes of at least one corresponding measurement part in all the human body resistance networks measured does not satisfy the detection standard, it indicates that the result of the electrophysiological detection is abnormal, and at this time, the abnormality is displayed to the user. As a result, the user may be prompted to go to the hospital for review in the form of sending a prompt message, or to prompt the user for a possible disease risk.
  • the resistance value between the electrodes of the measurement portion corresponding to each group of the human body resistance network of the measurer is measured, and the electrophysiological detection is determined according to the analysis of the change amount of the resistance value at different frequencies.
  • the measured data and the results of the electrophysiological detection can be sent to a service platform such as a network hospital through a communication module using WIFI, Bluetooth, and infrared. Through the platform, hospital doctors can further diagnose the measurer based on the received data and results.
  • the measurer is diagnosed, and the diagnosis results and suggestions on daily diet, exercise, and lifestyle are returned to the user through information or other interactive means; or, for the absence of diabetes risk, but other body resistance
  • the amount of change in the measured resistance value under the network does not meet the preset detection standard.
  • the doctor can further analyze other diseases that may exist and diagnose the abnormal data, and then pass the diagnosis result and other precautions through information or other interaction. The way is returned to the user by the platform.
  • FIG. 5 is a schematic structural view of a second embodiment of an early electrophysiological detection system for diabetes in accordance with the present invention.
  • system further includes a positioning module 50 for:
  • the plurality of sets of infrared light are used to illuminate the current measurement site, and the measured values and the calibration values of the measurement sites are compared;
  • the current measurement site is determined according to the preset error range, so that the determined current measurement site and the measurement site are in the same position.
  • the positioning module 50 can perform positioning on the measurement portion once before measuring the resistance value between the electrodes of the measurement portion corresponding to the human body resistance network. That is, multiple sets of infrared light are used to illuminate the currently selected measurement part, and the measured value is compared with the calibration value of the corresponding preset measurement part, and the difference between the measured value and the calibration value is within a preset error range. When it is inside, it can be determined that the selected current measurement part is at the same position as the preset measurement part, and the current measurement part can be measured when the measurement is performed.
  • two sets of infrared light of the same wavelength can be selected to illuminate the current measurement site, and infrared light having a wavelength range of 1000 nm to 1200 nm can be selected to illuminate the current measurement site, and infrared light having a wavelength of 1200 nm can penetrate the human body.
  • the skeletal organization is sensitive to location, location is different, and the measured data is different.
  • two sets of infrared light of 1200 nm are preferably irradiated, and the current absorption rates E1 and E2 of the two sets of infrared light are measured at the current measurement site, and the preset error range is set to 5%, that is, when two sets of infrared rays are used.
  • the difference between the measured values E1 and E2 obtained by the light irradiation of the current measurement site and the calibration value E0 is within the range of 5%, it is determined that the current measurement site is the same as the calibration measurement site; if the difference between the measured value and the calibration value If there is a range of less than 5%, the position of the current measurement site is changed until the difference between the measured value and the calibration value is within 5%.
  • the current measurement site is illuminated by multiple sets of infrared light, and the current measurement site is determined according to the comparison result between the measured value and the calibration value of the measurement site, so that the current measurement site and the measurement site are at the same position, and the measurement site is accurately positioned, thereby further ensuring The accuracy of early electrophysiological testing of diabetes.
  • the measured measurement sites are determined as: a position of the left and right sides of the human body close to the wrist artery, and a position of the left and right sides of the human body close to the foot artery, and The front and back sides of the human abdomen are close to the position of the pancreas; and the electrodes are in the form of electrode pairs, and a pair of electrode pairs are arranged on the left and right sides near the wrist artery, and the left and right sides are placed near the foot artery.
  • a pair of electrode pairs are provided with a pair of electrode pairs at positions adjacent to the pancreas on the left and right sides of the front and rear abdomen.
  • three different frequency measurement signals are used to measure the resistance values between the electrodes of the two measurement sites corresponding to the 24 groups of human body resistance networks, and the resistance values of each group of human body resistance networks at three frequencies are obtained. .
  • the measurement site and the combination of the measurement resistance it is possible to measure all the sites including the lesions that may occur in the early stage of diabetes, especially by setting the corresponding electrodes at different positions on the front and back sides of the human body near the pancreas, and measuring the position and difference of the pancreas. Local resistance values between limbs to facilitate more accurate detection of early lesion location in diabetes.
  • the sinusoidal AC voltage is 3 ⁇ 5.5V at a frequency of 50khz, 100khz, and 150khz.
  • the resistance value of the early diabetic patients is larger than that of the normal person, especially 14), 15) the change of the resistance value is more capable Reflects the lesions of the body of patients with early diabetes, that is, when the body resistance network is combined into the left abdomen (front) to the left abdomen (post), and the right abdomen (front) to the right abdomen (post), the corresponding
  • the amount of change in the electrical resistance between the electrodes of the measurement site can better reflect the lesions of the body of the early diabetic patients, so that the disease state of the patient can be analyzed and determined by the change of the resistance value of the local body part and the magnitude of the difference. (early, intermediate and late).
  • 40 testers of different ages were selected in the clinical trial to verify the feasibility and superiority of the program.
  • the age distribution of 40 testers was 5 for under 30 years old, 30 to 40 years old. 8 people, 12 people from 40 to 50 years old, 10 people from 50 to 60 years old, and 5 people over 60 years old.
  • Test data representing different signs of early, middle and late stages of diabetes:
  • Li 27 years old, normal person; (2) Zhang, 36 years old, early diabetic patients; (3) Zhao, 42 years old, mid-diabetes patients; (4) Tian, 59 years old, with advanced diabetes.
  • Tester representative 14 Rate of change of impedance at 50khz, 100khz 14) Rate of change of impedance at 50khz, 150khz 14) Rate of change of impedance at 100khz, 150khz 15) Rate of change of impedance at 50khz, 100khz 15) Rate of change of impedance at 50khz, 150khz 15) Rate of change of impedance at 100khz, 150khz 1 ) Rate of change of impedance at 100khz, 150khz 1 ) 0.35% 0.38% 0.36% 0.41% 0.45% 0.36% 2 ) 0.59% 0.63% 0.55% 0.60% 0.65% 0.59% 3) 0.73% 0.80% 0.76% 0.78% 0.85% 0.80% 4) 1.03% 1.12% 1.09% 1.13% 1.21% 1.15%
  • the rate of change of the resistance value is less than 0.5%, and the rate of change of the resistance value measured under the other 22 groups of human body resistance networks is also less than 0.5%, and the diabetes of the measurer can be judged.
  • the result of the early detection is normal; if 14), 15) the rate of change of the resistance value exceeds 0.5%, the stage of the measurer is further judged according to the value of the specific change rate, and at this time, the abnormal result is displayed to the user and prompted
  • the user may be in the stage of diabetes, prompting the user to go to the hospital for further diagnosis and examination; such as 14), 15) the change rate of the resistance value is below 0.5%, and the change of the resistance value measured under the other 22 groups of human body resistance networks If there is at least one group exceeding 0.5%, it indicates that the measurer's body may have other abnormal conditions. At this time, the abnormal result is displayed to the user and the user is prompted to go to the hospital for further examination.

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Abstract

一种糖尿病早期电生理检测方法及糖尿病早期电生理检测系统，糖尿病早期电生理检测方法包括：在人体四肢动脉位置和靠近胰腺的位置标定测量部位；在标定的测量部位设置多个电极；采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值；根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示糖尿病电生理检测的结果。糖尿病早期电生理检测方法及糖尿病早期电生理检测系统，能够针对性地测量人体局部身体组织的病变或健康情况，使得糖尿病早期电生理检测的结果更为准确，且无需测量者在测量前进行大量运动，测量效率较高。

Description

糖尿病早期电生理检测方法和系统
技术领域
本发明涉及医学检测技术领域，尤其涉及一种糖尿病早期电生理检测方法和系统。
背景技术
随着生活水平的提高，全世界范围内的糖尿病患者日益增多，糖尿病的高发及其并发症给患者带来了极大的精神和经济负担。然而，许多处于可逆阶段的糖尿病早期患者，如果能早发现早治疗，是可以阻止其发展到不可逆的临床确诊阶段的。因此，如果能够精确检测到早期亚临床或无症状阶段的糖尿病病人的潜在风险，将会给广大糖尿病潜在患者带来福音。目前，对于糖尿病的早期检测，主要是针对早期糖尿病患者汗腺交感神经病变导致其皮肤组织电阻、电容效应的改变，以及汗腺组织的纤维化造成汗液的电化学现象的改变，采用电检测方法，将人体等效为一个简单的电阻模型，采用阻抗检测方式，提取阻抗谱图的实部和虚部信息来反应病理特征，或者采用直流电刺激后监测电流的反馈信号来进行判断，但是，这两种方法都受限于不同人体电阻模型很难建立，准确度不高，且在测量前需要测量者做大量运动出汗，因而测量效率较低。
发明内容
本发明的主要目的在于解决采用电检测方法由于受限于不同人体电阻模型很难建立，而使得糖尿病早期电生理检测的结果准确度不高、效率低的问题。
为实现上述目的，本发明提供一种糖尿病早期电生理检测方法，所述糖尿病早期电生理检测方法包括以下步骤：
在人体四肢动脉位置和靠近胰腺的位置标定测量部位； 在标定的所述测量部位设置多个电极； 采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值； 根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示糖尿病电生理检测的结果。
此外，为实现上述目的，本发明还提供一种糖尿病早期电生理检测系统，所述糖尿病早期电生理检测系统包括：
标定模块，用于在人体四肢动脉位置和靠近胰腺的位置标定测量部位； 设置模块，用于在标定的所述测量部位设置多个电极； 测量模块，用于采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值； 确定及显示模块，用于根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示糖尿病电生理检测的结果。
本发明标定糖尿病早期电生理检测相应的测量部位，并在测量部位设置多个电极，采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值，并且根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示电生理检测的结果。无需建立人体电阻模型，采用多组电极对测量多组人体电阻网络对应的电阻值，通过电阻值的变换测量糖尿病早期电生理检测所可能存在的身体病变情况，能够针对性的测量人体局部身体组织的病变或健康情况，使糖尿病早期电生理检测的结果更为准确；并且由于无需测量者在测量前进行大量运动，因而测量效率较高。
附图说明
图1为本发明糖尿病早期电生理检测方法第一实施例的流程示意图； 图2为图1中确定并显示糖尿病早期电生理检测的结果的步骤的细化流程示意图； 图3为本发明糖尿病早期电生理检测方法第二实施例的流程示意图； 图4为本发明糖尿病早期电生理检测系统第一实施例的结构示意图； 图5为本发明糖尿病早期电生理检测系统第二实施例的结构示意图。
本发明目的的实现、功能特点及优点将结合实施例，参照附图做进一步说明。
具体实施方式
应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
本发明提供一种糖尿病早期电生理检测方法。 参照图1，图1为本发明糖尿病早期电生理检测方法第一实施例的流程示意图。
在一实施 例中，糖尿病早期电生理检测方法包括：
步骤S10，在人体四肢动脉位置和靠近胰腺的位置标定测量部位；
步骤S20，在标定的测量部位设置多个电极；
本实施例采用测量人体阻抗值的方法，可对糖尿病早期检测进行测量及筛查。在对测量者进行电生理检测时，首先在测量者的身体上标定测量部位，本实施例中，测量部位可标定在人体四肢动脉位置和靠近胰腺的位置，每个测量部位均对应一个标定值；红外光照射预设部位的时候，由于红外光的吸收率随人体组织的厚度成正比例关系，所以在实际的应用测定中，需要预先对用户预设部位的测量点位置进行标定，以保证每次测量时，红外光的照射在预设的测量部位的同一个特定位置，具体标定时，可采用一定波长的红外光照射测量部位，测定测量部位对当前波长的红外光的吸收率E0，将该值存储，并以该值作为所测定的测量部位的标定值。标定了糖尿病早期电生理检测项目的测量部位后，在标定好的测量部位设置多个电极，每个测量部位均设置一个电极。
步骤S30，采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值；
针对不同的糖尿病早期电生理检测，预先将标定的各测量部位进行组合，形成相应的人体电阻网络的组合，在测量时，采用不同频率的测量信号，分别测量所形成的每一组人体电阻网络对应的测量部位的电极之间的电阻值，得到在不同频率下的电阻值。通过测量部位以及测量电阻组合的确定，可以测量糖尿病早期电生理检测对应的可能发生病变的所有部位，以方便更准确的发现糖尿病早期电生理检测的早期病变位置。
步骤S40，根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示糖尿病电生理检测的结果。
对每一组人体电阻网络进行测量得到不同频率下每组人体电阻网络对应的测量部位的电极之间的电阻值后，分析每组人体电阻网络对应的测量部位的电极之间的电阻值的变化量，并按照为糖尿病早期电生理检测所预置的对应的检测标准，判断电阻值的变化量是否满足该检测标准。最终根据电阻值的变化量确定测量者的糖尿病早期电生理检测结果是否正常，并将电生理检测的结果向用户进行显示，以提示用户该测量者的电生理检测结果为正常还是异常。
本实施例标定糖尿病早期电生理检测相应的测量部位，并在测量部位设置多个电极，采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值，并且根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示电生理检测的结果。无需建立人体电阻模型，采用多组电极对测量多组人体电阻网络对应的电阻值，通过电阻值的变换测量糖尿病早期电生理检测所可能存在的身体病变情况，能够针对性的测量人体局部身体组织的病变或健康情况，使糖尿病早期电生理检测的结果更为准确；并且由于无需测量者在测量前进行大量运动，因而测量效率较高。
参照图2，图2为图1中确定并显示糖尿病早期电生理检测的结果的步骤的细化流程示意图。
基于本发明上述实施例，步骤S40具体包括：
步骤S41，分析在不同频率下测得的每组人体电阻网络对应的测量部位的电极之间的电阻值的变化量；
步骤S42，判断每组人体电阻网络对应的测量部位的电极之间的电阻值的变化是否均满足预置的检测标准；若是，执行步骤S43；若否，执行步骤S44；
步骤S43，确定糖尿病电生理检测结果为正常，并显示正常结果；
步骤S44，显示异常结果以及提示信息。
在测得不同频率下各组人体电阻网络对应的测量部位的电极之间的电阻值后，分别对每一组人体电阻网络对应的测量部位的电极之间的电阻值的变化量进行分析。然后，根据预置的糖尿病早期电生理检测的检测标准，判断每组人体电阻网络对应的测量部位的电极之间的电阻值的变化是否均满足该检测标准，该检测标准为根据糖尿病早期电生理检测在具体测量时的实验数据以及实验结果确定。本实施例中当测量的每一组人体电阻网络对应的测量部位的电极之间的电阻值的变化量均满足检测标准时，则确定该测量者电生理检测的结果为正常，此时向用户显示正常结果；如测量的所有人体电阻网络中有至少一组对应的测量部位的电极之间的电阻值的变化量不满足检测标准，则表明电生理检测的结果异常，此时，向用户显示异常结果，并且可以向发送提示信息的形式提示用户可去医院复查，或提示用户可能存在的疾病风险。
进一步地，基于上述实施例，在测量得到测量者的每一组人体电阻网络对应的测量部位的电极之间的电阻值，并根据在不同频率下电阻值的变化量的分析确定了电生理检测的结果后，还可通过通信模块，利用WIFI、蓝牙及红外等方式将测量的数据以及电生理检测的结果发送至网络医院等服务平台。通过该平台，医院医生可根据接收到的数据及结果，对测量者进行进一步诊断。例如，对检测结果为正常的人给出日常饮食、运动及生活方式等方面的建议，通过信息或其他交互方式由平台返回至用户；或者，对于存在糖尿病风险的测量者的数据进行进一步分析，对该测量者进行确诊，并将诊断结果及日常饮食、运动及生活方式等方面的建议，通过信息或其他交互方式由平台返回至用户；或者，对于虽不存在糖尿病风险，但在其他人体电阻网络下所测得的电阻值的变化量不满足预置的检测标准，医生可针对异常的数据，进一步分析其可能存在的其他疾病并诊断，然后将诊断结果及其他注意事项通过信息或其他交互方式由平台返回至用户。
参照图3，图3为本发明糖尿病早期电生理检测方法第二实施例的流程示意图。
在上述本发明糖尿病早期电生理检测方法第一实施例的基础上，第二实施例中，在执行步骤S20之前，该方法还包括：
步骤S50，采用多组红外光照射当前测量部位，比较得到的测量值与测量部位的标定值；
步骤S51，根据预置的误差范围确定当前测量部位，使确定的当前测量部位与测量部位在同一位置。
本实施例中，在每一次测量人体电阻网络对应的测量部位的电极之间的电阻值之前，都可以对测量部位进行一次定位。即采用多组红外光照射当前所选择的测量部位，并根据测量得到的测量值与相应的预置的测量部位的标定值进行比较，当测量值与标定值的差值在预置的误差范围内时，则可确定选择的当前测量部位与预置的测量部位在同一位置，在进行测量时即可对该当前测量部位进行测量。
作为本实施例的优选实施方案，可以选择两组相同波长的红外光照射当前测量部位，具体可选择波长范围为1000nm~1200nm的红外光照射当前测量部位，波长为1200nm的红外光可以穿透人体的骨骼组织，对位置较为敏感，位置不同，测得的数据也不同。本实施例优选两组1200nm的红外光进行照射，测定当前测量部位对所述两组红外光的当前吸收率E1、E2，并且，将预置的误差范围设置为5%，即当两组红外光照射当前测量部位所得到的测量值E1、E2与标定值E0的差值均在5%的范围内时，则判定当前测量部位与标定的测量部位相同；如测量值与标定值的差值有一个不在5%的范围内，则改变当前测量部位的位置，直至测得的测量值与标定值的差值均在5%的范围内。
采用多组红外光照射当前测量部位，根据测量值与测量部位的标定值的比较结果，确定当前测量部位，使当前测量部位与测量部位在同一位置，对测量部位进行精准定位，从而进一步保证了糖尿病早期电生理检测的准确性。
作为本发明优选实施例，根据多次实验以及经验值，确定标定的测量部位分别为：人体左、右两侧靠近腕部动脉的位置，人体左、右两侧靠近脚部动脉的位置，以及人体腹部前、后侧靠近胰腺的位置；而电极以电极对的形式，在左、右两侧靠近腕部动脉的位置设置一对电极对，在左、右两侧靠近脚部动脉的位置设置一对电极对，在前、后腹部左、右两侧靠近胰腺的位置各设置一对电极对。通过上述测量部位的设置，可测量包括了糖尿病早期可能发生病变的所有部位，尤其是通过在人体腹部前、后侧两边靠近胰腺的不同位置设置相应的电极，测量胰腺位置与不同肢体之间的局部电阻值，以方便更准确地发现糖尿病早期病变位置。
为了更准确地测量糖尿病早期患者的身体病变情况，根据设置的4组电极对确定人体电阻网络的组合，确定24组人体电阻网络，具体人体电阻网络的组合方式如下：
1）左侧腕部对左侧脚部，测量左侧靠近腕部动脉的电极和左侧靠近脚部动脉的位置的电极之间的电阻；
2）左侧腕部对右侧腕部，测量左侧靠近腕部动脉的电极和右侧靠近脚部动脉的位置的电极之间的电阻；
3）左侧腕部对右侧腕部，测量左侧靠近腕部动脉的电极和右侧靠近腕部动脉的位置的电极之间的电阻；
4）左侧腕部对左侧腹部（前），测量左侧靠近腕部动脉的电极和腹部前方左边靠近胰腺的位置的电极之间的电阻；
5）左侧腕部对左侧腹部（后），测量左侧靠近腕部动脉的电极和腹部后方左边靠近胰腺的位置的电极之间的电阻；
6）左侧腕部对右侧腹部（前），测量左侧靠近腕部动脉的电极和腹部前方右边靠近胰腺的位置的电极之间的电阻；
7）左侧腕部对右侧腹部（后），测量左侧靠近腕部动脉的电极和腹部后方右边靠近胰腺的位置的电极之间的电阻；
8）右侧腕部对左侧脚部，测量右侧靠近腕部动脉的电极和左侧脚部动脉的位置的电极之间的电阻；
9）右侧腕部对右侧脚部，测量右侧靠近腕部动脉的电极和右侧脚部动脉的位置的电极之间的电阻；
10）右侧腕部对左侧腹部（前），测量右侧靠近腕部动脉的电极和腹部前方左边靠近胰腺的位置的电极之间的电阻；
11）右侧腕部对左侧腹部（后），测量右侧靠近腕部动脉的电极和腹部后方左边靠近胰腺的位置的电极之间的电阻；
12）右侧腕部对右侧腹部（前），测量右侧靠近腕部动脉的电极和腹部前方右边靠近胰腺的位置的电极之间的电阻；
13）右侧腕部对右侧腹部（后），测量右侧靠近腕部动脉的电极和腹部后方右边靠近胰腺的位置的电极之间的电阻；
14）左侧腹部（前）对左侧腹部（后），测量腹部前方左边靠近胰腺的位置的电极和腹部后方左边靠近胰腺的位置的电极之间的电阻；
15）右侧腹部（前）对右侧腹部（后），测量腹部前方右边靠近胰腺的位置的电极和腹部后方右边靠近胰腺的位置的电极之间的电阻；
16）左侧脚部对左侧腹部（前），测量左侧脚部动脉的位置的电极和腹部前方左边靠近胰腺的位置的电极之间的电阻；
17）左侧脚部对左侧腹部（后），测量左侧脚部动脉的位置的电极和腹部后方左边靠近胰腺的位置的电极之间的电阻；
18）左侧脚部对右侧腹部（前），测量左侧脚部动脉的位置的电极和腹部前方右边靠近胰腺的位置的电极之间的电阻；
19）左侧脚部对右侧腹部（后），测量左侧脚部动脉的位置的电极和腹部后方右边靠近胰腺的位置的电极之间的电阻；
20）右侧脚部对左侧腹部（前），测量右侧脚部动脉的位置的电极和腹部前方左边靠近胰腺的位置的电极之间的电阻；
21）右侧脚部对左侧腹部（后），测量右侧脚部动脉的位置的电极和腹部后方左边靠近胰腺的位置的电极之间的电阻；
22）右侧脚部对右侧腹部（前），测量右侧脚部动脉的位置的电极和腹部前方右边靠近胰腺的位置的电极之间的电阻；
23）右侧脚部对右侧腹部（后），测量右侧脚部动脉的位置的电极和腹部后方右边靠近胰腺的位置的电极之间的电阻；
24）左侧脚部对右侧脚部，测量左侧脚部动脉的位置的电极和右侧脚部动脉的位置的电极之间的电阻。
在测量时，采用三种不同频率的测量信号，分别测量上述24组人体电阻网络所对应的两个测量部位的电极之间的电阻值，得到每组人体电阻网络在三种频率下的电阻值。通过上述测量部位以及测量电阻组合的确定，可以测量包括了糖尿病早期可能发生病变的所有部位，尤其是通过在人体腹部前、后侧两边靠近胰腺的不同位置设置相应的电极，测量胰腺位置与不同肢体之间的局部电阻值，以方便更准确地发现糖尿病早期病变位置。
本实施例中，优选采用频率为50khz、100khz、150khz的3~5.5V正弦波交流电压进行测量，通过临床试验得出，在频率为50khz、100khz、150khz的3~5.5V正弦波交流电压下，对每一组人体电阻网络对应的测量部位的电极之间的电阻值进行比较，糖尿病早期患者的电阻值的变化量较正常人要大，尤其是14）、15）电阻值的变化更能反映糖尿病早期患者身体的病变，即当人体电阻网络组合为左侧腹部（前）对左侧腹部（后），以及右侧腹部（前）对右侧腹部（后）时，所得到的对应的测量部位的电极之间的电阻值的变化量更能反映糖尿病早期患者身体的病变，这样便可通过局部身体部位的电阻值的变化及变化差异量的大小，来分析判断患者所处的疾病状况（早期、中期及晚期）。
本实施例在临床试验时选取了40位不同年龄段的试验者来验证本方案的可行性以及优越性，40位试验者的年龄分布：为30岁以下为5人，30岁~40岁为8人，40岁~50岁为12人，50岁~60岁为10人，60岁以上为5人。通过上述方法，对所有试验者在上述三种频率下的24组人体局部电阻值的变化进行了分析，选取了4个人在14）、15）人体电阻网络下所测得的电阻值的变化的测试数据，分别代表糖尿病早期、中期、晚期的不同体征信息：
（1）李某，27岁，正常人； （2）张某，36岁，糖尿病早期患者； （3）赵某，42岁，糖尿病中期患者； （4）田某，59岁，糖尿病晚期患者。
下表为通过50khz、100khz、150khz的3~5.5V正弦波交流电压对以上4个人在14）、15）人体电阻网络下所测得的电阻值的变化量：
试验者代表 14 ）电阻值 在 50khz 、 100khz 下的变化率 14 ）电阻值在 在 50khz 、 150khz 下的变化率 14 ）电阻值在 在 100khz 、 150khz 下的变化率 15 ）电阻值 在 50khz 、 100khz 下的变化率 15 ）电阻值 在 50khz 、 150khz 下的变化率 15 ）电阻值 在 100khz 、 150khz 下的变化率
1 ） 0.35% 0.38% 0.36% 0.41% 0.45% 0.36%
2 ） 0.59% 0.63% 0.55% 0.60% 0.65% 0.59%
3 ） 0.73% 0.80% 0.76% 0.78% 0.85% 0.80%
4 ） 1.03% 1.12% 1.09% 1.13% 1.21% 1.15%
上述数据仅体现了从40位试验者之中所选取的4种不同人群的人体阻抗变化率的情况，通过对40位不同年龄段以及不同身体状况的试验者按照本方案中提供的测试方法进行测试，得到以下规律：
1、正常人：在50khz、100khz、150khz不同频率下，14）、15）阻抗值的变化率在0.5%以下；
2、糖尿病早期患者：在50khz、100khz、150khz不同频率下，14）、15）阻抗值的变化率在0.5%~0.7%；
3、糖尿病中期患者：在50khz、100khz、150khz不同频率下，14）、15）阻抗值的变化率在0.65%~1.0%；
4、糖尿病晚期患者：在50khz、100khz、150khz不同频率下，14）、15）阻抗值的变化率在1.0%以上。
也就是说，除了14）、15）电阻值的变化率在0.5%以下，其他22组人体电阻网络下所测得的电阻值的变化率也在0.5%以下，才可以判断该测量者的糖尿病早期检测的结果为正常；如14）、15）电阻值的变化率超过0.5%，则根据具体的变化率的值进一步判断该测量者所处的阶段，此时，向用户显示异常结果并提示用户有可能处于糖尿病的哪个阶段，提示用户去医院进行进一步确诊检查；如14）、15）电阻值的变化率在0.5%以下，而其他22组人体电阻网络下所测得的电阻值的变化率有至少一组超过0.5%，则表明该测量者的身体有可能出现其他异常情况，此时，向用户显示该异常结果并提示用户其可以去医院进行进一步检查。
本发明还提供一种糖尿病早期电生理检测系统。 参照图4，图4为本发明糖尿病早期电生理检测系统第一实施例的结构示意图。
在一实施例中，糖尿病早期电生理检测系统包括：
标定模块10，用于在人体四肢动脉位置和靠近胰腺的位置标定测量部位；
设置模块20，用于在标定的所述测量部位设置多个电极；
测量模块30，用于采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值；
确定及显示模块40，用于根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示糖尿病电生理检测的结果。
本实施例采用测量人体阻抗值的方法，可对糖尿病早期检测进行测量及筛查。在对测量者进行电生理检测时，标定模块10首先在测量者的身体上标定测量部位，本实施例中，测量部位可标定在人体四肢动脉位置和靠近胰腺的位置，每个测量部位均对应一个标定值；红外光照射预设部位的时候，由于红外光的吸收率随人体组织的厚度成正比例关系，所以在实际的应用测定中，需要预先对用户预设部位的测量点位置进行标定，以保证每次测量时，红外光的照射在预设的测量部位的同一个特定位置，具体标定时，可采用一定波长的红外光照射测量部位，测定测量部位对当前波长的红外光的吸收率E0，将该值存储，并以该值作为所测定的测量部位的标定值。标定了糖尿病早期电生理检测项目的测量部位后，设置模块20在标定好的测量部位设置多个电极，每个测量部位均设置一个电极。
针对不同的糖尿病早期电生理检测，预先将标定的各测量部位进行组合，形成相应的人体电阻网络的组合，在测量时，测量模块30采用不同频率的测量信号，分别测量所形成的每一组人体电阻网络对应的测量部位的电极之间的电阻值，得到在不同频率下的电阻值。通过测量部位以及测量电阻组合的确定，可以测量糖尿病早期电生理检测对应的可能发生病变的所有部位，以方便更准确的发现糖尿病早期电生理检测的早期病变位置。
对每一组人体电阻网络进行测量得到不同频率下每组人体电阻网络对应的测量部位的电极之间的电阻值后，确定及显示模块40分析每组人体电阻网络对应的测量部位的电极之间的电阻值的变化量，并按照为糖尿病早期电生理检测所预置的对应的检测标准，判断电阻值的变化量是否满足该检测标准。最终根据电阻值的变化量确定测量者的糖尿病早期电生理检测结果是否正常，并将电生理检测的结果向用户进行显示，以提示用户该测量者的电生理检测结果为正常还是异常。
本实施例标定糖尿病早期电生理检测相应的测量部位，并在测量部位设置多个电极，采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值，并且根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示电生理检测的结果。无需建立人体电阻模型，采用多组电极对测量多组人体电阻网络对应的电阻值，通过电阻值的变换测量糖尿病早期电生理检测所可能存在的身体病变情况，能够针对性的测量人体局部身体组织的病变或健康情况，使糖尿病早期电生理检测的结果更为准确；并且由于无需测量者在测量前进行大量运动，因而测量效率较高。
在上述实施例中，确定及显示模块40具体用于：
分析在不同频率下测得的每组人体电阻网络对应的测量部位的电极之间的电阻值的变化量；
判断每组人体电阻网络对应的测量部位的电极之间的电阻值的变化是否均满足预置的检测标准；若是，确定糖尿病电生理检测结果为正常，并显示正常结果；若否，显示异常结果以及提示信息。
在测得不同频率下各组人体电阻网络对应的测量部位的电极之间的电阻值后，确定及显示模块40分别对每一组人体电阻网络对应的测量部位的电极之间的电阻值的变化量进行分析。然后，根据预置的糖尿病早期电生理检测的检测标准，判断每组人体电阻网络对应的测量部位的电极之间的电阻值的变化是否均满足该检测标准，该检测标准为根据糖尿病早期电生理检测在具体测量时的实验数据以及实验结果确定。本实施例中当测量的每一组人体电阻网络对应的测量部位的电极之间的电阻值的变化量均满足检测标准时，则确定该测量者电生理检测的结果为正常，此时向用户显示正常结果；如测量的所有人体电阻网络中有至少一组对应的测量部位的电极之间的电阻值的变化量不满足检测标准，则表明电生理检测的结果异常，此时，向用户显示异常结果，并且可以向发送提示信息的形式提示用户可去医院复查，或提示用户可能存在的疾病风险。
进一步地，基于上述实施例，在测量得到测量者的每一组人体电阻网络对应的测量部位的电极之间的电阻值，并根据在不同频率下电阻值的变化量的分析确定了电生理检测的结果后，还可通过通信模块，利用WIFI、蓝牙及红外等方式将测量的数据以及电生理检测的结果发送至网络医院等服务平台。通过该平台，医院医生可根据接收到的数据及结果，对测量者进行进一步诊断。例如，对检测结果为正常的人给出日常饮食、运动及生活方式等方面的建议，通过信息或其他交互方式由平台返回至用户；或者，对于存在糖尿病风险的测量者的数据进行进一步分析，对该测量者进行确诊，并将诊断结果及日常饮食、运动及生活方式等方面的建议，通过信息或其他交互方式由平台返回至用户；或者，对于虽不存在糖尿病风险，但在其他人体电阻网络下所测得的电阻值的变化量不满足预置的检测标准，医生可针对异常的数据，进一步分析其可能存在的其他疾病并诊断，然后将诊断结果及其他注意事项通过信息或其他交互方式由平台返回至用户。
参照图5，图5为本发明糖尿病早期电生理检测系统第二实施例的结构示意图。
基于上述本发明糖尿病早期电生理检测系统第一实施例，第二实施例中，该系统还包括定位模块50，该定位模块50用于：
采用多组红外光照射当前测量部位，比较得到的测量值与测量部位的标定值；
根据预置的误差范围确定当前测量部位，使确定的当前测量部位与测量部位在同一位置。
本实施例中，在每一次测量人体电阻网络对应的测量部位的电极之间的电阻值之前，定位模块50都可以对测量部位进行一次定位。即采用多组红外光照射当前所选择的测量部位，并根据测量得到的测量值与相应的预置的测量部位的标定值进行比较，当测量值与标定值的差值在预置的误差范围内时，则可确定选择的当前测量部位与预置的测量部位在同一位置，在进行测量时即可对该当前测量部位进行测量。
作为本实施例的优选实施方案，可以选择两组相同波长的红外光照射当前测量部位，具体可选择波长范围为1000nm~1200nm的红外光照射当前测量部位，波长为1200nm的红外光可以穿透人体的骨骼组织，对位置较为敏感，位置不同，测得的数据也不同。本实施例优选两组1200nm的红外光进行照射，测定当前测量部位对所述两组红外光的当前吸收率E1、E2，并且，将预置的误差范围设置为5%，即当两组红外光照射当前测量部位所得到的测量值E1、E2与标定值E0的差值均在5%的范围内时，则判定当前测量部位与标定的测量部位相同；如测量值与标定值的差值有一个不在5%的范围内，则改变当前测量部位的位置，直至测得的测量值与标定值的差值均在5%的范围内。
采用多组红外光照射当前测量部位，根据测量值与测量部位的标定值的比较结果，确定当前测量部位，使当前测量部位与测量部位在同一位置，对测量部位进行精准定位，从而进一步保证了糖尿病早期电生理检测的准确性。
作为本发明优选实施例，根据多次实验以及经验值，确定标定的测量部位分别为：人体左、右两侧靠近腕部动脉的位置，人体左、右两侧靠近脚部动脉的位置，以及人体腹部前、后侧靠近胰腺的位置；而电极以电极对的形式，在左、右两侧靠近腕部动脉的位置设置一对电极对，在左、右两侧靠近脚部动脉的位置设置一对电极对，在前、后腹部左、右两侧靠近胰腺的位置各设置一对电极对。通过上述测量部位的设置，可测量包括了糖尿病早期可能发生病变的所有部位，尤其是通过在人体腹部前、后侧两边靠近胰腺的不同位置设置相应的电极，测量胰腺位置与不同肢体之间的局部电阻值，以方便更准确地发现糖尿病早期病变位置。
在测量时，采用三种不同频率的测量信号，分别测量上述24组人体电阻网络所对应的两个测量部位的电极之间的电阻值，得到每组人体电阻网络在三种频率下的电阻值。通过上述测量部位以及测量电阻组合的确定，可以测量包括了糖尿病早期可能发生病变的所有部位，尤其是通过在人体腹部前、后侧两边靠近胰腺的不同位置设置相应的电极，测量胰腺位置与不同肢体之间的局部电阻值，以方便更准确地发现糖尿病早期病变位置。
本实施例中，优选采用频率为50khz、100khz、150khz的3~5.5V正弦波交流电压进行测量，通过临床试验得出，在频率为50khz、100khz、150khz的3~5.5V正弦波交流电压下，对每一组人体电阻网络对应的测量部位的电极之间的电阻值进行比较，糖尿病早期患者的电阻值的变化量较正常人要大，尤其是14）、15）电阻值的变化更能反映糖尿病早期患者身体的病变，即当人体电阻网络组合为左侧腹部（前）对左侧腹部（后），以及右侧腹部（前）对右侧腹部（后）时，所得到的对应的测量部位的电极之间的电阻值的变化量更能反映糖尿病早期患者身体的病变，这样便可通过局部身体部位的电阻值的变化及变化差异量的大小，来分析判断患者所处的疾病状况（早期、中期及晚期）。
本实施例在临床试验时选取了40位不同年龄段的试验者来验证本方案的可行性以及优越性，40位试验者的年龄分布：为30岁以下为5人，30岁~40岁为8人，40岁~50岁为12人，50岁~60岁为10人，60岁以上为5人。通过上述方法，对所有试验者在上述三种频率下的24组人体局部电阻值的变化进行了分析，选取了4个人在14）、15）人体电阻网络下所测得的电阻值的变化的测试数据，分别代表糖尿病早期、中期、晚期的不同体征信息：
（1）李某，27岁，正常人； （2）张某，36岁，糖尿病早期患者； （3）赵某，42岁，糖尿病中期患者； （4）田某，59岁，糖尿病晚期患者。
下表为通过50khz、100khz、150khz的3~5.5V正弦波交流电压对以上4个人在14）、15）人体电阻网络下所测得的电阻值的变化量：
试验者代表 14 ）阻抗值在 50khz 、 100khz 下的变化率 14 ）阻抗值在 50khz 、 150khz 下的变化率 14 ）阻抗值在 100khz 、 150khz 下的变化率 15 ）阻抗值 在 50khz 、 100khz 下的变化率 15 ）阻抗值 在 50khz 、 150khz 下的变化率 15 ）阻抗值 在 100khz 、 150khz 下的变化率
1 ） 0.35% 0.38% 0.36% 0.41% 0.45% 0.36%
2 ） 0.59% 0.63% 0.55% 0.60% 0.65% 0.59%
3 ） 0.73% 0.80% 0.76% 0.78% 0.85% 0.80%
4 ） 1.03% 1.12% 1.09% 1.13% 1.21% 1.15%
上述数据仅体现了从40位试验者之中所选取的4种不同人群的人体阻抗变化率的情况，通过对40位不同年龄段以及不同身体状况的试验者按照本方案中提供的测试方法进行测试，得到以下规律：
1、正常人：在50khz、100khz、150khz不同频率下，14）、15）阻抗值的变化率在0.5%以下；
2、糖尿病早期患者：在50khz、100khz、150khz不同频率下，14）、15）阻抗值的变化率在0.5%~0.7%；
3、糖尿病中期患者：在50khz、100khz、150khz不同频率下，14）、15）阻抗值的变化率在0.65%~1.0%；
4、糖尿病晚期患者：在50khz、100khz、150khz不同频率下，14）、15）阻抗值的变化率在1.0%以上。
也就是说，除了14）、15）电阻值的变化率在0.5%以下，其他22组人体电阻网络下所测得的电阻值的变化率也在0.5%以下，才可以判断该测量者的糖尿病早期检测的结果为正常；如14）、15）电阻值的变化率超过0.5%，则根据具体的变化率的值进一步判断该测量者所处的阶段，此时，向用户显示异常结果并提示用户有可能处于糖尿病的哪个阶段，提示用户去医院进行进一步确诊检查；如14）、15）电阻值的变化率在0.5%以下，而其他22组人体电阻网络下所测得的电阻值的变化率有至少一组超过0.5%，则表明该测量者的身体有可能出现其他异常情况，此时，向用户显示该异常结果并提示用户其可以去医院进行进一步检查。
以上仅为本发明的优选实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书及附图内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。

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  1. 一种糖尿病早期电生理检测方法，其特征在于，所述糖尿病早期电生理检测方法包括以下步骤：
    在人体四肢动脉位置和靠近胰腺的位置标定测量部位； 在标定的所述测量部位设置多个电极； 采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值； 根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示糖尿病电生理检测的结果。
  2. 如权利要求1所述的糖尿病早期电生理检测方法，其特征在于，所述采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值的步骤之前，所述糖尿病早期电生理检测方法还包括步骤： 采用多组红外光照射当前测量部位，比较得到的测量值与所述测量部位的标定值； 根据预置的误差范围确定当前测量部位，使确定的当前测量部位与所述测量部位在同一位置。
  3. 如权利要求1所述的糖尿病早期电生理检测方法，其特征在于，所述根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示糖尿病电生理检测的结果的步骤包括： 分析在不同频率下测得的每组人体电阻网络对应的测量部位的电极之间的电阻值的变化量； 判断每组人体电阻网络对应的测量部位的电极之间的电阻值的变化是否均满足预置的检测标准；若是，确定糖尿病电生理检测结果为正常，并显示正常结果；若否，显示异常结果以及提示信息。
  4. 如权利要求3所述的糖尿病早期电生理检测方法，其特征在于，所述采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值的步骤之前，所述糖尿病早期电生理检测方法还包括步骤： 采用多组红外光照射当前测量部位，比较得到的测量值与所述测量部位的标定值； 根据预置的误差范围确定当前测量部位，使确定的当前测量部位与所述测量部位在同一位置。
  5. 如权利要求1所述的糖尿病早期电生理检测方法，其特征在于，所述测量部位包括：人体左、右两侧靠近腕部动脉的位置，人体左、右两侧靠近脚部动脉的位置，以及人体前、后腹部左、右两侧靠近胰腺的位置。
  6. 如权利要求5所述的糖尿病早期电生理检测方法，其特征在于，所述在标定的所述测量部位设置多个电极包括： 在人体左、右两侧靠近腕部动脉的位置各设置一个电极； 在人体左、右两侧靠近脚部动脉的位置各设置一个电极； 在人体前、后腹部左、右两侧靠近胰腺的位置各设置两个电极。
  7. 一种糖尿病早期电生理检测系统，其特征在于，所述糖尿病早期电生理检测系统包括： 标定模块，用于在人体四肢动脉位置和靠近胰腺的位置标定测量部位； 设置模块，用于在标定的所述测量部位设置多个电极； 测量模块，用于采用不同频率的测量信号，按照预置的人体电阻网络的组合，测量每组人体电阻网络对应的测量部位的电极之间的电阻值； 确定及显示模块，用于根据测量的不同频率下人体电阻网络对应的测量部位的电极之间的电阻值的变化量，按照预置的检测标准，确定并显示糖尿病电生理检测的结果。
  8. 如权利要求7所述的糖尿病早期电生理检测系统，其特征在于，所述糖尿病早期电生理检测系统还包括定位模块，该定位模块用于： 采用多组红外光照射当前测量部位，比较得到的测量值与所述测量部位的标定值； 根据预置的误差范围确定当前测量部位，使确定的当前测量部位与所述测量部位在同一位置。
  9. 如权利要求7所述的糖尿病早期电生理检测系统，其特征在于，所述确定及显示模块具体用于：
    分析在不同频率下测得的每组人体电阻网络对应的测量部位的电极之间的电阻值的变化量； 判断每组人体电阻网络对应的测量部位的电极之间的电阻值的变化是否均满足预置的检测标准；若是，确定糖尿病电生理检测结果为正常，并显示正常结果；若否，显示异常结果以及提示信息。
  10. 如权利要求9所述的糖尿病早期电生理检测系统，其特征在于，所述糖尿病早期电生理检测系统还包括定位模块，该定位模块用于： 采用多组红外光照射当前测量部位，比较得到的测量值与所述测量部位的标定值； 根据预置的误差范围确定当前测量部位，使确定的当前测量部位与所述测量部位在同一位置。
  11. 如权利要求7所述的糖尿病早期电生理检测系统，其特征在于，所述标定模块标定的测量部位包括：人体左、右两侧靠近腕部动脉的位置，人体左、右两侧靠近脚部动脉的位置，以及人体前、后腹部左、右两侧靠近胰腺的位置。
  12. 如权利要求11所述的糖尿病早期电生理检测系统，其特征在于，所述设置模块具体用于： 在人体左、右两侧靠近腕部动脉的位置各设置一个电极； 在人体左、右两侧靠近脚部动脉的位置各设置一个电极； 在人体前、后腹部左、右两侧靠近胰腺的位置各设置两个电极。
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