WO2016149885A1 - Utilisations d'eau potable microcinétique multipolaire dans la préparation de boissons, de produits de santé ou de médicaments permettant de réduire le taux d'urée dans le sang - Google Patents

Utilisations d'eau potable microcinétique multipolaire dans la préparation de boissons, de produits de santé ou de médicaments permettant de réduire le taux d'urée dans le sang Download PDF

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WO2016149885A1
WO2016149885A1 PCT/CN2015/074764 CN2015074764W WO2016149885A1 WO 2016149885 A1 WO2016149885 A1 WO 2016149885A1 CN 2015074764 W CN2015074764 W CN 2015074764W WO 2016149885 A1 WO2016149885 A1 WO 2016149885A1
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frequency electromagnetic
electromagnetic wave
water
drinking water
kinetic energy
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PCT/CN2015/074764
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English (en)
Chinese (zh)
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王卫星
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欢乐海（北京）水业科技有限公司
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Priority to PCT/CN2015/074764 priority Critical patent/WO2016149885A1/fr
Priority to AU2015387925A priority patent/AU2015387925A1/en
Publication of WO2016149885A1 publication Critical patent/WO2016149885A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/48—Treatment of water, waste water, or sewage with magnetic or electric fields

Definitions

  • the invention belongs to the technical field of water treatment, and particularly relates to the use of multi-pole micro-kinetic energy drinking water in preparing beverages, health care products or medicines for reducing blood uric acid.
  • Water is an inorganic substance composed of two elements of hydrogen and oxygen, and is a colorless and odorless transparent liquid under normal temperature and normal pressure. Water is one of the most common substances, an important resource for all life, including human beings, and the most important component of living things. Water plays an important role in the evolution of life. Humans have long begun to understand water, and water is regarded as a basic component in the ancient and simple material view of the East and West.
  • the water molecule itself has its special structural shape, it is composed of two hydrogen and one oxygen ion combined at an angle of 104.5. It is an ionization system with an electronic "magnetic polarity". Water molecules exhibit solid crystals below zero and below zero, which we call ice. However, water is not completely liquid at a temperature of from zero to 60 ° C, but exists in the form of a liquid crystal. However, if the temperature is higher than 60 ° C, the liquid crystal molecules will be destroyed.
  • the form of the diluted solute molecules can be contained in its liquid crystals, which is a generally understood dissolution process.
  • the new discovery is that when a solute molecule is separated from a water molecule by some means (eg, through multiple dilutions and oscillations), the water molecule can still maintain a "shape" memory of the solute molecule. When the body cells are exposed to such water molecules, the "shape" memory of the solute molecule is treated as a true solute molecule, which is the cornerstone of homeopathic therapy with more than 200 years of history.
  • Water is composed of two elements of hydrogen and oxygen, but does not exist in nature as a single water molecule, but a group of many water molecules that aggregate into water molecules (H 2 O) n exists in nature (ie, the above liquid Crystallization), the group of water molecules may be chain, ring, agglomerate or grape-like, with at least five water molecules, and more than a dozen, tens to hundreds.
  • Electromagnetic waves have been used to treat water molecules to increase the energy level of water molecules or to disinfect or prevent and remove dirt.
  • these treatment methods do not control the effect of the treatment well, and the effect of the treated water is mostly limited to drinking, and there is no other additional advantageous effect.
  • the present invention provides a multi-pole micro-kinetic energy drinking water obtained by electromagnetic wave non-contact treatment, a preparation method thereof and use thereof.
  • the present invention provides a multi-pole micro-kinetic energy drinking water prepared by non-contact treatment of drinking water raw water by electromagnetic waves, and the ultraviolet absorption peak is short-waved compared with the raw water of drinking water.
  • the direction shift is 25 nm to 40 nm, preferably 28 nm to 30 nm in the short-wave direction, and most preferably 30 nm or 28 nm in the short-wave direction.
  • the spectral intensity of the fluorescent radiation of the multi-pole micro-kinetic energy drinking water of the invention is greatly improved in the spectrum of 300 nm to 400 nm, and repeated experiments on the same sample show that the experiment has good repeatability. .
  • the drinking water raw water is ordinary tap water or various kinds of mineral water or pure water, such as Evian natural mineral water, Cambodia glacier mineral water, Nongfu Spring, Wahaha, and the like.
  • the multi-pole micro-kinetic energy drinking water of the present invention is best consumed or used within 72 hours after preparation.
  • the present invention provides a method for preparing the above-mentioned multi-pole micro-kinetic energy drinking water, which comprises non-contact treatment of drinking water raw water by using electromagnetic waves of low, medium and high frequencies, wherein the frequency of low-frequency electromagnetic waves
  • the range is 30-100 kHz
  • the frequency range of the intermediate frequency electromagnetic wave is 550-720 kHz
  • the frequency range of the high frequency electromagnetic wave is 300-725 MHz.
  • the drinking water raw water is ordinary tap water or various kinds of mineral water or pure water, such as Evian natural mineral water, Cambodia glacier mineral water, Nongfu Spring, Wahaha, and the like.
  • the low frequency electromagnetic wave has a frequency in the range of 45-75 kHz.
  • the intermediate frequency electromagnetic wave has a frequency range of 600-720 kHz.
  • the high frequency electromagnetic wave has a frequency in the range of 300-425 MHz.
  • the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave are a sine wave, a square wave, a sharp wave, a sawtooth wave or a trapezoidal wave.
  • the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave waveform may be the same or different, preferably the same.
  • the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave propagate in the same direction.
  • the high frequency electromagnetic wave is a triangular wave and is perpendicular to a propagation direction of the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave.
  • the low-frequency electromagnetic wave and the high-frequency electromagnetic wave are simultaneously processed by the electromagnetic wave non-contact treatment of the drinking water raw water treatment by using three different frequencies of low, medium and high frequencies, and then the intermediate frequency electromagnetic wave and the high frequency electromagnetic wave are simultaneously processed.
  • the time for simultaneous treatment using the low frequency electromagnetic wave and the high frequency electromagnetic wave is 10-30 minutes, preferably 10-20 minutes; the time for simultaneous treatment using the intermediate frequency electromagnetic wave and the high frequency electromagnetic wave is 10-30 minutes, preferably 10-20 minutes. .
  • the prepared ultraviolet light absorption peak of the multi-pole micro-kinetic energy drinking water is shifted to the short-wave direction by 25 nm to 40 nm, preferably to the short-wave direction by 28 nm to 30 nm, and most preferably to the short-wave direction. 30 nm or 28 nm.
  • the spectral intensity of the fluorescent radiation of the multi-pole micro-kinetic energy drinking water of the invention is greatly improved in the spectrum of 300 nm to 400 nm, and repeated experiments on the same sample show that the experiment has good repeatability. .
  • a method and apparatus for generating electromagnetic waves are conventional techniques in the art.
  • the present invention provides the use of the above-described multi-pole micro-kinetic energy drinking water in the preparation of various mineral water, purified water, beverages, health care products or medicines.
  • the beverage is a functional beverage and can be used for anti-fatigue, weight loss, laxative, blood pressure lowering, blood sugar lowering, blood uric acid and blood urea.
  • the health care product or drug can be used for anti-fatigue, weight loss, laxative, blood pressure lowering, blood sugar lowering, blood uric acid and blood urea.
  • the invention adopts electromagnetic wave non-contact type treatment water, without adding any additives, is simple to manufacture, has high production efficiency and low cost.
  • the multi-pole micro-kinetic energy drinking water of the present invention is more than the drinking water before treatment.
  • the original water produced a significant shift in the ultraviolet absorption peak to the short-wave direction.
  • the spectral intensity of the fluorescent radiation was greatly improved in the 300-400 nm spectrum, and more extranuclear electrons were in the high-energy non-radiative energy level.
  • Animal experiments have been shown to have anti-fatigue, weight loss, laxative, blood pressure lowering, blood sugar lowering, blood uric acid and blood urea.
  • FIG 1 shows the effect of water in different treatment groups on peroxide-induced DNA damage
  • FIG. 1 shows the effect of differently treated media on cells
  • 3 is an absorption spectrum distribution of the ordinary drinking water raw water and the multi-pole micro kinetic energy of the present invention obtained by using the ordinary drinking water raw water;
  • Figure 6 is a fluorescence steady state transient test result of ordinary drinking water (raw water) and its multi-pole micro-kinetic energy drinking water;
  • Figure 7 is a fluorescence steady state transient test result of Evian natural mineral water (raw water) and multi-pole micro-kinetic energy drinking water made therewith;
  • Figure 8 shows the fluorescence steady-state transient test results of Vietnamese glacial mineral water (raw water) and multi-pole micro-kinetic energy drinking water made therewith;
  • Figure 9 shows the results of repeatability test of three samples of multi-pole micro-kinetic energy drinking water made from raw water of Georgia glacial mineral water;
  • Figure 10 shows the effect of kinetic energy on uric acid (UA) in hyperuricemia rats
  • Figure 11 shows the effect of kinetic energy on urea (UREA) in hyperuricemia rats
  • Figure 12 shows the effect of kinetic energy on creatinine (CREA) in hyperuricemia rats.
  • Embodiment 1 Method for preparing multi-pole micro-kinetic energy drinking water of the present invention
  • electromagnetic waves of three different frequencies of low, medium and high are applied in a non-contact manner, wherein the frequency of the low frequency electromagnetic wave is 30 kHz, the frequency range of the intermediate frequency electromagnetic wave is 550 kHz, and the frequency range of the high frequency electromagnetic wave is 300 MHz. .
  • the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave are both sinusoidal waves, and the electromagnetic wave propagation directions of the two are the same.
  • the high frequency electromagnetic wave is a triangular wave and is perpendicular to a propagation direction of the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave.
  • non-contact electromagnetic waves of low, medium and high frequencies are applied, wherein the frequency of the low frequency electromagnetic waves is 100 kHz, the frequency range of the intermediate frequency electromagnetic waves is 720 kHz, and the frequency range of the high frequency electromagnetic waves is 725 MHz. .
  • the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave are both square waves, and the electromagnetic wave propagation directions of the two are the same.
  • the high frequency electromagnetic wave is a triangular wave and is perpendicular to a propagation direction of the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave.
  • electromagnetic waves of low, medium and high frequencies are applied non-contactly, wherein the frequency of the low frequency electromagnetic waves is 45 kHz, the frequency range of the intermediate frequency electromagnetic waves is 600 kHz, and the frequency range of the high frequency electromagnetic waves is 300 MHz. .
  • the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave are both square waves, and the electromagnetic wave propagation directions of the two are the same.
  • the high frequency electromagnetic wave is a triangular wave and is perpendicular to a propagation direction of the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave.
  • Embodiment 4 Method for preparing multi-pole micro-kinetic energy drinking water of the present invention
  • non-contact electromagnetic waves of low, medium and high frequencies are applied, wherein the frequency of the low frequency electromagnetic waves is 75 kHz, the frequency range of the intermediate frequency electromagnetic waves is 720 kHz, and the frequency range of the high frequency electromagnetic waves is 425 MHz. .
  • the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave are sharp waves, and the electromagnetic wave propagation directions of the two are the same.
  • the high frequency electromagnetic wave is a triangular wave and is perpendicular to a propagation direction of the low frequency electromagnetic wave and the intermediate frequency electromagnetic wave.
  • the multi-pole micro-kinetic energy drinking water prepared in Examples 1-4 was tested according to the Standard Test Method for Drinking Water (GB/T 5750-2006), and the test results were basically the same. The results are shown in Table 1.
  • the indicators of the micro-kinetic energy drinking water of the present invention all meet the requirements of the Sanitary Standard for Drinking Water (GB5749-2006).
  • Test substance Micro-kinetic energy drinking water prepared in Example 3
  • Animals Kunming species of white mice were provided by the Laboratory Animal Resources Research Institute of China Food and Drug Control Research Institute (Qualification No.: SCXK (Beijing) 2009-0017), SPF Grade, body weight 18.0 ⁇ 22.0g, before the test, the animals fasted overnight, free to drink water.
  • Dosage grouping The test substance is set at a dose of 20,000 mg/kg body weight, and each of the female and male animals is 10. Grouped by sex. The dose was calculated by oral gavage at 0.1 ml/10 g body weight.
  • the oral LD 50 of the test article for both female and male mice is greater than 10000 mg/kg body weight, which is an actual non-toxic grade.
  • Plasmid DNA pET28a plasmid was amplified and extracted in DH5a E. coli (plasmid extraction kit was purchased from Promega);
  • EDTA is provided by Sinopharm Chemical Reagent Co., Ltd.;
  • Electrophoresis Instrument Liuyi Instrument Factory
  • Test substance Micro-kinetic energy drinking water prepared in Examples 3 and 4
  • Group I untreated group, adding untreated sterile water to the reaction system;
  • Group II the kinetic energy drinking water prepared in Example 3;
  • Group III The kinetic energy drinking water prepared in Example 4.
  • reaction materials were added in the following order, and the final volume of the reaction system was 10 ⁇ L:
  • reaction was terminated by adding 1 ⁇ L of 5 mM EDTA and 2.2 ⁇ L of loading buffer at 0.5 hour and 1 hour, respectively.
  • the redox reaction between vitamin C and divalent copper ions is accompanied by the formation of peroxide, which causes damage to the plasmid DNA, which is reflected in the weakening of the electrophoresis band.
  • the results of this experiment are shown in Figure 1.
  • the experiments were divided into three groups. The grouping method is described in the scheme. The two time points of each group were: 0.5 hours and 1 hour, and the brightness of DNA represented the DNA content.
  • the rate of degradation of plasmid DNA by redox reaction was basically the same in group II and group III compared with untreated group I, and there was no effect of preventing or accelerating DNA damage and cleavage due to water treatment.
  • the redox reaction between vitamin C and divalent copper ions is accompanied by the formation of peroxide, which causes damage to the plasmid DNA, which is reflected in the weakening of the electrophoresis band.
  • the results of this experiment showed that the rate of degradation of plasmid DNA by redox reaction was basically the same in group II and group III compared with untreated group I, and there was no industrial effect of preventing or accelerating DNA damage and cleavage due to water treatment. It is indicated that the multipolar micro kinetic energy of the present invention has no effect on peroxide-induced DNA damage.
  • L.1 human liver cancer cells HepG2;
  • FAM-aptamer purchased from Shanghai Shenggong Bioengineering Co., Ltd.;
  • the cell culture medium adherently cultured in a 96-well plate was changed to medium A and medium B containing FAM-C6-8 aptamer, cultured at 37 ° C for 30 min, washed once with PBS, and observed under a fluorescence microscope.
  • Fig. 2 There is no difference in cell morphology between the treated group and the untreated group.
  • the cells are white-fluorescent, the cell membrane is intact, and no obvious FAM-labeled C6-8 aptamer green fluorescence is observed in the cells.
  • the FAM-labeled C6-8 aptamer can enter the cell and bind to the protein in the cell, and emit green fluorescence after excitation at 530 wavelength.
  • the results in the figure show that there is no difference between the cells in the treated group and the untreated group, all of which are autofluorescence, indicating that the cell membrane is intact, and the multipolar microkinetic energy technology of the present invention has no effect on cell morphology and cell membrane integrity.
  • Glacier Mineral Water Purchase at Carrefour supermarket;
  • ultrapure water made by the German Sartorius ultrapure water preparation system
  • Example 3 The ordinary drinking water raw water used in Example 3 and the micro-kinetic energy drinking water prepared in Example 3 were placed in an experimental vessel, and the absorption of the spectral light spectrum of the standard light source of the sample of 200 nm to 800 nm was scanned, and the experimental results were recorded.
  • Example 3 The micro-kinetic energy prepared in Example 3 is placed in an ultraviolet intensity detecting system, the ultraviolet light source illuminates the water to be tested, and the photodetector Thorlab DET10A/M is read by an oscilloscope MS04104 to read ultraviolet rays that have not passed the water to be tested. Intensity value, read the UV passing through the water to be tested Line strength value, continuous uninterrupted test for 72 hours, the amount of change in UV intensity during recording.
  • Example 3 The drinking water made from the Vietnamese glacial mineral water in the same manner as in Example 3 is placed in the ultraviolet intensity detecting system, and the step (2) is repeated to record the amount of change in the ultraviolet intensity during the recording.
  • Multi-pole micro-kinetic energy drinking water made from ordinary water
  • Multi-pole micro-kinetic energy drinking water made from Evian natural mineral water
  • Multi-pole micro-kinetic energy drinking water made from Vietnamese glacial mineral water
  • the absorption spectrum absorption peak of the multi-pole micro-kinetic energy drinking water of the present invention is shifted to a short wave by about 30 nm;
  • Glacier Mineral Water Purchase at Carrefour supermarket;
  • ultrapure water made by the German Sartorius ultrapure water preparation system
  • Test environment temperature 22 ° C, humidity 37%.
  • Example 3 The micro-kinetic energy prepared in Example 3 is placed in a sample cell of a fiber optic spectrometer, and an excitation pulse is given to the sample by a 266 nm pulsed ultraviolet laser, and the spectral spectrum of the sample is used to measure the emission spectrum of the sample. Fluorescence emission spectrum of the sample.
  • Example 3 The ordinary drinking water raw water used in Example 3 was placed in the fiber optic spectrometer sample cell, and step 2 was repeated to record the experimental data.
  • the fluorescence steady-state transient test results of ordinary drinking water and multi-pole micro-kinetic drinking water made by it are shown in Fig. 6.
  • the fluorescence steady-state transient test results of Evian natural mineral water and its multi-pole micro-kinetic drinking water are shown in Figure 7.
  • the fluorescence steady-state transient test results of Vietnamese glacial mineral water and multi-pole micro-kinetic drinking water made by it are shown in Fig. 8.
  • the glacial mineral water in Moscow was tested for repeatability by taking three samples of multi-polar micro-kinetic energy drinking water made of raw water. The results are shown in Figure 9.
  • Example 9 Multi-polar micro-kinetic energy drinking water of the present invention is high in potassium oxonate hyperuricemia SD Mouse influence
  • the multi-pole micro-kinetic energy drinking water (kinetic energy water) prepared in Example 3 is a colorless and odorless transparent aqueous liquid, which is stored at room temperature and used within 72 hours after preparation;
  • Feeding conditions Experimental animal facilities continue to maintain barrier environmental standards.
  • the control range of the main environmental indicators room temperature 20 ⁇ 26 ° C, the daily temperature difference ⁇ 4 ° C.
  • the relative humidity is 40 to 70%.
  • Minimum air exchange times 15 times / hour, light illumination: dark 12h: 12h.
  • the animals are housed in a polypropylene rat group box.
  • the cage specifications are: 545*395*200mm 3 , 5 per box, and the feeding space meets the minimum space required for experimental animals in the national standard GB14925-2010 of the People's Republic of China. Provisions. All animals are managed by trained personnel. Replace the litter and cage once a week. Rat-specific feed is added daily for animal consumption, and the animal's diet is kept free during the whole feeding process.
  • Baoding appliances should be of reasonable structure, appropriate specifications, sturdy and durable, environmentally friendly and easy to operate. The mandatory restrictions on the animal's body should be reduced to a minimum without affecting the experiment.
  • Sample collection The operation of collecting samples for experimental animals in a safe and humane manner (minimizing the tension and discomfort caused to animals).
  • Test indicators animal general observation, weight, growth status, blood uric acid, urea, creatinine.
  • Animal grouping and dose design Animals were quarantined for 2 weeks after receiving. At the end of quarantine, 70 animals were randomly divided into groups according to the results of blood uric acid determination, which were divided into 6 groups, 10 in each group. Ten animals were selected as the normal control group, and 50 animals were orally administered with 0.70 g/kg potassium oxonate (0.10 g/ml) per day to prepare a hyperuricemia model.
  • the blank control group drank normal drinking water daily; the model control group drank normal drinking water daily; the kinetic energy low dose group drank kinetic energy daily (drinking bottle filling kinetic energy, supplemented once a day); kinetic energy high dose group
  • the kinetic energy was administered once a day at a dose of 1.5 mL/100 g.
  • the positive drug was administered once daily at a dose of 10 mg/kg and the dose was 1.5 mL.
  • the first day of administration (D15), the 34th day of administration (D34), and the 43rd day of administration (D43), blood uric acid, serum creatinine, and urea were measured four times. The first 3 times were collected by eyelids, and the last time the blood was collected from the abdominal aorta.
  • the weight results were processed using SPSS statistical software and compared between the drug-administered group and the control group. According to the following method: Kolmogorov-Smirnov method should be used for normal test, Levene median method for homogeneity test of variance, if P>0.05, one-way ANOVA method, if normal and variance The homogeneity test failed (P ⁇ 0.05), then a non-parametric Mann-Whitney test was required.
  • the uric acid value of the model group was higher than that of the blank control group or the benzbromarone group.
  • the serum uric acid was significantly lower than the model control group, and the difference was significant, indicating that the model of hyperuricemia model was successful.
  • the uric acid in the kinetic energy group was significantly lower than that of the model control group, and the difference was significant, indicating that the kinetic energy had uric acid lowering. If the uric acid value of the phenyl bromide kinetic energy group is lower than that of the phenyl bromide group, it can be judged that the kinetic energy has the effect of increasing the uric acid function of the benzbromarone tablets, and simultaneously determining the urea and creatinine levels.
  • the effect criteria of the drug group are the same as above.

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Abstract

La présente invention concerne des utilisations d'une eau potable microcinétique multipolaire dans la préparation de boissons, de produits de santé ou de médicaments permettant de réduire le taux d'urée dans le sang. Ladite eau potable microcinétique multipolaire est préparée à partir d'une eau potable brute qui est passée à travers une onde électromagnétique sans contact. Par comparaison avec l'eau potable brute, le pic d'absorption dans l'ultraviolet est décalé de 25 nm à 40 nm, le décalage préféré étant de 28 nm à 30 nm, et le décalage optimal étant soit de 30 nm, soit de 28 nm.
PCT/CN2015/074764 2015-03-20 2015-03-20 Utilisations d'eau potable microcinétique multipolaire dans la préparation de boissons, de produits de santé ou de médicaments permettant de réduire le taux d'urée dans le sang WO2016149885A1 (fr)

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PCT/CN2015/074764 WO2016149885A1 (fr) 2015-03-20 2015-03-20 Utilisations d'eau potable microcinétique multipolaire dans la préparation de boissons, de produits de santé ou de médicaments permettant de réduire le taux d'urée dans le sang
AU2015387925A AU2015387925A1 (en) 2015-03-20 2015-03-20 Uses of multipolar microkinetic drinking water in preparing drink, healthcare product or medicament for reducing blood urea

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