WO2016148455A3 - 몬테루카스트의 생체이용률을 개선시키기 위한 방법 - Google Patents

몬테루카스트의 생체이용률을 개선시키기 위한 방법 Download PDF

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Publication number
WO2016148455A3
WO2016148455A3 PCT/KR2016/002487 KR2016002487W WO2016148455A3 WO 2016148455 A3 WO2016148455 A3 WO 2016148455A3 KR 2016002487 W KR2016002487 W KR 2016002487W WO 2016148455 A3 WO2016148455 A3 WO 2016148455A3
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WO
WIPO (PCT)
Prior art keywords
montelukast
bioavailability
improving
increasing
present
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PCT/KR2016/002487
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English (en)
French (fr)
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WO2016148455A2 (ko
Inventor
이영주
오주희
Original Assignee
경희대학교 산학협력단
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Publication of WO2016148455A2 publication Critical patent/WO2016148455A2/ko
Publication of WO2016148455A3 publication Critical patent/WO2016148455A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

본 발명은 몬테루카스트의 생체이용률을 증가시키기 위한 방법에 관한 것으로, 본 발명에 따른 내인성 계면활성제(담즙산), 고분자 계면활성제 등의 가용화제를 몬테루카스트 염과 병용투여하는 방법은, 몬테루카스트 또는 이의 약학적으로 허용 가능한 염을 단독으로 투여하였을 경우 발생하는 몬테루카스트의 재침전이 효과적으로 방지되므로 생체 내 몬테루카스트의 흡수율이 증가하고 흡수속도가 빨라져, 우수한 생체이용률을 나타내는 효과가 있다.
PCT/KR2016/002487 2015-03-13 2016-03-11 몬테루카스트의 생체이용률을 개선시키기 위한 방법 WO2016148455A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150035272 2015-03-13
KR10-2015-0035272 2015-03-13

Publications (2)

Publication Number Publication Date
WO2016148455A2 WO2016148455A2 (ko) 2016-09-22
WO2016148455A3 true WO2016148455A3 (ko) 2016-11-10

Family

ID=56919144

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/002487 WO2016148455A2 (ko) 2015-03-13 2016-03-11 몬테루카스트의 생체이용률을 개선시키기 위한 방법

Country Status (2)

Country Link
KR (1) KR101892340B1 (ko)
WO (1) WO2016148455A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113491696A (zh) * 2017-07-05 2021-10-12 江阴优培尔康药业有限公司 包含孟鲁司特与贻贝粘附蛋白的组合的局部制剂
KR102111346B1 (ko) * 2019-08-20 2020-05-22 아영창 침전으로부터 안정한 소듐디옥시콜레이트를 포함하는 수용액상 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040047961A (ko) * 2001-10-26 2004-06-05 머크 프로스트 캐나다 앤드 캄파니 몬테루카스트 과립 제형
US20080200533A1 (en) * 2005-07-04 2008-08-21 Ramu Krishnan Drug or Pharmaceutical Compounds and a Preparation Thereof
KR100910848B1 (ko) * 2007-09-13 2009-08-06 재단법인서울대학교산학협력재단 알러지성 비염 치료약물을 유효성분으로 함유하는 비강분무용 마이크로스피어 및 이의 제조방법
KR20100093428A (ko) * 2009-02-16 2010-08-25 서울대학교산학협력단 항알러지성 약물을 활성성분으로 함유하는 비강투여용 액상제제
KR20150002304A (ko) * 2013-06-28 2015-01-07 한미약품 주식회사 몬테루카스트 및 그의 약제학적으로 허용 가능한 염을 포함하는 안정성이 개선된 시럽 제제 및 그의 제조 방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040047961A (ko) * 2001-10-26 2004-06-05 머크 프로스트 캐나다 앤드 캄파니 몬테루카스트 과립 제형
US20080200533A1 (en) * 2005-07-04 2008-08-21 Ramu Krishnan Drug or Pharmaceutical Compounds and a Preparation Thereof
KR100910848B1 (ko) * 2007-09-13 2009-08-06 재단법인서울대학교산학협력재단 알러지성 비염 치료약물을 유효성분으로 함유하는 비강분무용 마이크로스피어 및 이의 제조방법
KR20100093428A (ko) * 2009-02-16 2010-08-25 서울대학교산학협력단 항알러지성 약물을 활성성분으로 함유하는 비강투여용 액상제제
KR20150002304A (ko) * 2013-06-28 2015-01-07 한미약품 주식회사 몬테루카스트 및 그의 약제학적으로 허용 가능한 염을 포함하는 안정성이 개선된 시럽 제제 및 그의 제조 방법

Also Published As

Publication number Publication date
KR20160110245A (ko) 2016-09-21
WO2016148455A2 (ko) 2016-09-22
KR101892340B1 (ko) 2018-08-27

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