WO2016148336A1

WO2016148336A1 - Apparatus for measuring biomaterial in vivo

Info

Publication number: WO2016148336A1
Application number: PCT/KR2015/004379
Authority: WO
Inventors: 변영재; 알카알카; 나경민; 장희돈; 송주협
Original assignee: 울산과학기술원
Priority date: 2015-03-16
Filing date: 2015-04-30
Publication date: 2016-09-22
Also published as: KR20160111063A

Abstract

The present invention relates to an apparatus for measuring a biomaterial in vivo, which comprises: a structure arranged in a blood vessel; a light source arranged on the structure so as to irradiate light in a set wavelength band to blood; a light receiving element for receiving a part of the light irradiated from the light source, which is not absorbed into a predetermined biomaterial in the blood and is reflected therefrom; and a transmission unit for transmitting a detection signal according to the quantity of light output from the light receiving element, the transmission unit being arranged on the structure.

Description

In vivo biomaterial measuring device

The present invention relates to an apparatus for measuring biomaterials in vivo, and more particularly, to an apparatus for irradiating light having a wavelength absorbed by a set biomaterial in a blood vessel and measuring the concentration of the set biomaterial through reflected light. It relates to a biomaterial measuring device.

Recently, there is an increasing number of patients suffering from diabetes or coronary artery disease. In particular, after the diagnosis of diabetes, long-term management is required to prevent complications, and coronary artery disease is a disease directly connected to the heart, which is the most important organ in the human body, and prevention and prior management are important.

For the long-term management of diabetes, it is most effective to obtain blood glucose data of patients, and recently, blood glucose measurement devices have been used through blood collection. Blood glucose can be determined by measuring the concentration of glucose in the blood (glucose). However, since the blood glucose measurement method through blood collection is a means of pain, a method of measuring glucose concentration by irradiating light without blood collection has recently been developed, but such a method has a high frequency to improve the accuracy to reduce the epidermal effect. The need for a light source capable of irradiating light causes a problem of increased cost.

The determination of protein concentrations is not as reliable as the non-generalized methods that apply only to individual proteins, or because they are not based on data measured at the single molecule level for a particular protein. There is no problem.

An object of the present invention is to provide an in vivo biomaterial measuring apparatus capable of irradiating light of a wavelength absorbed by a set biomaterial in a blood vessel and measuring the concentration of the set biomaterial through reflected light.

The present invention, a structure disposed in the blood vessel; A light source disposed on the structure to irradiate light of a predetermined wavelength band with blood; A light receiving element receiving light reflected from the light source irradiated by the light source without being absorbed by the biomaterial set in the blood; And a transmitter disposed on the structure, the transmitter configured to transmit a detection signal according to the amount of light output from the light receiving element.

According to another aspect of the invention, the invention, the structure of the stent structure disposed in the blood vessel; An LED type light source disposed on the structure to irradiate blood with light in a wavelength band having high absorption rate of glucose or protein; A light receiving element that receives light reflected from the light source without being absorbed by the blood; A wireless power supply unit receiving induction power from the outside and providing the light source to the light source in a magnetic resonance manner and having a plurality of coil members installed in the structure; And an in vivo biomaterial measuring apparatus disposed on the structure and including a transmitter for transmitting a detection signal according to the amount of light output from the light receiving element or analysis information analyzing the detection signal to the outside.

In vivo biomaterial measuring apparatus according to the present invention has the following effects.

First, there is an advantage in that the concentration of the set biomaterial can be accurately measured without interfering elements because it irradiates light directly in the blood vessel, in particular the light of the wavelength absorbed only in the set biomaterial.

Second, the display means can visually confirm the measured concentration of the set biomaterial through the display means, and can be confirmed by measuring in real time when the user wants to measure the concentration of the set biomaterial regardless of time and place. have.

Third, the biomaterial measuring device once placed in the blood vessel can be used semi-permanently because it is provided with a wireless power supply unit and can receive power from an external induction power.

1 is a conceptual diagram showing an in vivo biomaterial measuring apparatus according to an embodiment of the present invention.

FIG. 2 is a block diagram showing the configuration of the in vivo biomaterial measuring apparatus according to FIG. 1.

1 and 2 are shown for the in vivo biomaterial measuring apparatus according to the present invention.

In vivo biomaterial measuring apparatus 100 (hereinafter, referred to as a biomaterial measuring apparatus) according to an embodiment of the present invention, referring to FIGS. 1 and 2, the structure 110, the light source 130, the light receiving device 150, The transmitter 170 and the display means 190 is included. The structure 110 is disposed in the blood vessel 1 of the user. The structure 110 is formed in the form of a mesh extending in the longitudinal direction of the blood vessel 1 using a metal material, for example, a stent, which is a medical device, may be applied. For example, the metal material may be stainless steel or an alloy of stainless steel and another metal material, but the metal material may be formed of various materials. The structure 110 is inserted into the vessel 1 of the user (patient) is disposed.

The light source 130 is disposed on the structure 110 and irradiates light with blood flowing in the blood vessel 1. The light of the set wavelength band is irradiated from the light source 130. The set wavelength band of the light is determined according to the set biomaterial 3 to be measured by the biomaterial measuring apparatus 100.

More specifically, the set biomaterial 3 is set to the wavelength of light having the highest absorption rate. The set biomaterial 3 to be measured by the biomaterial measuring apparatus 100 according to the present invention is either glucose or protein. When the set biomaterial 3 is glucose, the set wavelength band of the light irradiated from the light source 130 is 600 nm to 1500 nm to irradiate light in a visible light region close to infrared rays. When the light irradiated from the light source 130 is light of the set wavelength band, the absorption in the glucose is the best.

However, when the set biomaterial is a protein, the light source 130 irradiates light in an ultraviolet region having a set wavelength band of 100 nm to 400 nm, or emits light in a near infrared region having a set wavelength band of 780 nm to 15 μm. In particular, when irradiating light in the ultraviolet region, light having a set wavelength band of 280 nm is irradiated.

As such, the light source 130 may be selectively changed according to the set biomaterial 3 to be measured by the set biomaterial measuring apparatus 100. In the present embodiment, the light source 130 is exemplarily applied as an LED, but is not limited thereto and may be applied in various embodiments.

The light receiving element 150 is disposed on the structure 110 similarly to the light source 130. When the light is irradiated to the blood from the light source 130, the light receiving element 150 receives light that is reflected without being absorbed by the set biomaterial 3. Since the light irradiated from the light source 130 irradiates the set biomaterial 3 with light having a high absorption rate to the set biomaterial 3 as described above, when the light comes into contact with the set biomaterial 3, the set biomaterial 3 is exposed. ) Is absorbed.

However, since the light irradiated from the light source 130 is not all absorbed by the set biomaterial 3, the light that is not absorbed by the set biomaterial 3 is reflected. The light receiving element 150 receives light reflected without being absorbed by the set biomaterial 3, and converts the received light amount (amount of light) into a detection signal and outputs the detected signal. For example, a photodiode is applied to the light receiving device 150, but is not limited thereto and may be applied in various embodiments.

The transmitter 170 is disposed on the structure 110 and transmits the detection signal output from the light receiving element 150 to the display means 190 to be described later. That is, the detection signal output from the light receiving element 150 is converted into electromagnetic waves and transmitted to the display means 190. The transmitter 170 is applied to the microstrip antenna by way of example. The transmitter 170 uses a resonant frequency of 400 to 405 MHz band used for medical communication.

The display means 190 calculates the concentration of the set biomaterial 3 in the blood from the detection signal received from the transmitter 170 and displays the image for visual confirmation by the user. The display means 190 may be applied in the form of an electronic device having a display panel, for example, a computer, or in the form of a smart device such as a smartphone, a tablet PC, or the like.

The display means 190 includes a receiver 191 receiving the detection signal transmitted from the transmitter 170 and a calculator 193 for calculating the concentration of the set biomaterial 3 from the detection signal. .

When the receiver 191 receives the detection signal transmitted from the transmitter 170, the receiver 191 supplies the detected signal to the calculator 193. Since the calculation unit 193 stores a light quantity and a database of the set biomaterial 3, the detection signal output from the light receiving element 150 is stored in the set biomaterial 3 based on the database. The concentration can be calculated.

Since the transmitter 170 and the receiver 191 are connected by wireless communication, the smart device applied as the display means 190 can measure the set biomaterial 3 regardless of time and place. There is an advantage.

On the other hand, the biomaterial measuring device 100 further includes a wireless power supply unit 120. The wireless power supply unit 120 is for supplying power to the light source 130, is disposed on the structure (110). The wireless power supply unit 120 receives power from the outside and supplies power to the light source 130 in a magnetic resonance manner.

In more detail, the wireless power supply unit 120 includes an Rx coil unit 121 and a load coil unit 123. The Rx coil unit 121 is a receiving coil, and receives induction power by an electromagnetic field generated by a charger (not shown) as described below. The wireless power supply unit 120 is operated by the magnetic resonance wireless power transmission. As described above, the wireless power supply unit 120 disposed on the structure 110 includes the Rx coil unit 121 and the load coil unit 123, and transmits induced power to the wireless power unit 120. The charger (not shown) includes a source coil (not shown) and a Tx coil (transmission resonance coil, not shown).

When power is applied to the source coil (not shown), a magnetic field vibrating at the resonance frequency of the Tx coil (not shown) is generated in the Tx coil (not shown), which receives energy from the source coil, to generate the same resonance frequency. The Rx coil unit 121 is designed to deliver energy, that is, induction power, intensively. In this way, the induced power delivered to the Rx coil unit 121 supplies power to the light source 130 from the load coil 123.

The Rx coil unit 121 is disposed to surround any one of the inner circumferential surface or the outer circumferential surface of the structure 110 to receive the induced power from the outside in a magnetic resonance manner. In the present embodiment, as shown in FIG. 1, the Rx coil part 121 is illustrated to surround the inner circumferential surface of the structure 110, but the present invention is not limited thereto. The Rx coil part 121 is formed by winding at least two times a conductive wire (for example, a copper wire).

The load coil unit 123 is disposed to surround any one of the inner circumferential surface or the outer circumferential surface of the structure 110, like the Rx coil unit 121, and is connected to the light source 130 to thereby When the induced power is transmitted to the Rx coil unit 121, the load coil unit 123 supplies power to the light source 130. In the present embodiment, the load coil unit 123 is also disposed while surrounding the inner circumferential surface of the structure 110. The load coil unit 123 is disposed spaced apart from the Rx coil unit 121 by a predetermined interval. Unlike the Rx coil part 121, the load coil part 123 is formed by winding a conductive wire once.

The charger (not shown) that transmits induction power to the wireless power supply unit 120 includes a separate measurement of the bio material when the user wants to measure the concentration of the set biomaterial 3 while carrying it separately. When placed close to the device 100, the wireless power supply unit 120 receives induced power from the charger (not shown) in a magnetic resonance manner, and supplies power to the light source 130 so that the light source 130 emits light. I will investigate.

Since the wireless power supply unit 120 uses a frequency band of 1 to 5 GHz, even if power is supplied to the light source 130 in the blood vessel 1, the wireless power supply unit 120 does not affect the human body and has a specific Absorption Rate (SAR). ) Is also very low. As in the present embodiment, since the method of transmitting power in a magnetic resonance method is a known technology through Korean Patent No. 10-1470815 (Low Voltage Magnetic Resonance Wireless Power Transmitter), the wireless power supply unit 120 The configuration is not limited to the above-described embodiment, and the magnetic resonance method of the various embodiments can be applied.

Looking at the method of using the biomaterial measuring device 100 as described above, as follows. Since the biomaterial measuring apparatus 100 is disposed in the blood family, the biomaterial measuring apparatus 100 may be disposed in the blood vessel 1 of the user through a procedure or surgery. When the user wants to measure the concentration of the set biomaterial 3 using the biomaterial measuring apparatus 100, the user places the charger (not shown) close to the position where the biomaterial measuring apparatus 100 is disposed.

The Rx coil unit 121 of the wireless power supply unit 120 that receives the induced power generated by the electromagnetic field generated by the charger (not shown) receives the induced power in a magnetic resonance method so that the load coil unit 123 receives the Power is supplied to the light source 130. When the light source 130 is supplied with power, the light is irradiated, but the light emitted from the light source 110 has a high absorption rate for the set biomaterial 3 to be measured through the biomaterial measuring apparatus 100. Light having a wavelength is irradiated.

If the set biomaterial 3 is glucose, the light source 130 irradiates the glucose with light having a high absorption rate. On the other hand, if the set biomaterial 3 is a protein, the light source 130 irradiates light having a high absorption rate with respect to the protein.

When light is irradiated from the light source 130, the light is absorbed by the set biomaterial 3 included in blood, but all of the light emitted from the light source 130 is absorbed by the set biomaterial 3. Therefore, light that is not absorbed by the set biomaterial 3 is reflected. Light that is not absorbed by the set biomaterial 3 and is reflected is received by the light receiving element 150 disposed in the structure 110. The light receiving element 150 converts the received light amount (amount of light) into a detection signal and outputs the detected signal. The transmitter 170 transmits the detection signal to the display means 190.

The receiving unit 191 of the display unit 190 receives the detection signal transmitted from the transmitting unit 170 and supplies it to the calculating unit 193. The calculation unit 193 calculates the concentration of the set biomaterial 3 in the blood by using the detection signal transmitted from the light receiving element 150.

Since the calculation unit 160 stores a database for calculating the concentration of the set biomaterial, the concentration of the set biomaterial is calculated based on the detection signal transmitted from the light receiving element 150 based on the database. . The concentration of the calculated biomaterial 3 is output to the display means 190 so that the user can visually confirm the concentration.

Since the biomaterial measuring apparatus 100 according to the present invention is disposed in a blood vessel of a user, when the user wants to measure the concentration of the set biomaterial, the biomaterial measuring apparatus 100 may measure in real time regardless of time and place. In particular, since the power for driving the light source can be supplied in a magnetic resonance method using a wireless power transmission technology, the biomaterial measuring device disposed in the blood vessel of the user can be used semi-permanently and continuously.

Although the present invention has been described with reference to the embodiments shown in the drawings, this is merely exemplary, and it will be understood by those skilled in the art that various modifications and equivalent other embodiments are possible. Therefore, the true technical protection scope of the present invention will be defined by the technical spirit of the appended claims.

By using the biomaterial measuring apparatus in vivo according to the present invention, it is possible to measure the biomaterials such as protein and glucose directly in the blood vessel in real time, so that the measuring apparatus can more accurately diagnose and manage diabetes and heart disease. Development can be actively carried out.

Claims

A structure disposed within the vessel;

A light source disposed on the structure to irradiate light of a predetermined wavelength band with blood;

A light receiving element receiving light reflected from the light source irradiated by the light source without being absorbed by the biomaterial set in the blood; And

In vivo biomaterial measuring apparatus disposed on the structure comprising a transmitter for transmitting a detection signal according to the amount of light output from the light receiving element.
The method according to claim 1,

And a display means for calculating and displaying a concentration of the set biomaterial in the blood through the detection signal received from the transmitter.
The method according to claim 1,

The structure is in vivo biomaterial measuring apparatus formed of a metal material.
The method according to claim 1,

The structure, extending in the longitudinal direction of the blood vessel, in vivo biomaterial measuring apparatus is formed in the form of a net.
The method according to claim 4,

The structure is a stent (stent) in vivo biomaterial measuring apparatus.
The method according to claim 1,

The set biomaterial is any one of glucose or protein in vivo biomaterial measuring apparatus.
The method according to claim 1,

The transmitter in vivo biomaterial measuring apparatus comprising a micro strip antenna.
The method according to claim 2,

The display means,

A receiver receiving the detection signal transmitted from the transmitter; And

And a calculation unit configured to receive the detection signal through the receiver and calculate a concentration of the set biomaterial based on a stored database.
The method according to claim 1,

In vivo biomaterial measuring apparatus disposed on the structure, further comprising a wireless power supply for supplying power to the light source.
The method according to claim 9,

In vivo biomaterial measuring apparatus for supplying power to the light source by receiving the induction power from the outside in a magnetic resonance method.
The method according to claim 9,

The wireless power supply unit,

An Rx coil part disposed surrounding one of an inner circumferential surface and an outer circumferential surface of the structure and receiving inductive power in the magnetic resonance method; And

It is arranged to surround any one of the inner circumferential surface or the outer circumferential surface of the structure and is connected to the light source, and supplies power to the light source using the induced power delivered to the Rx coil part spaced apart from the Rx coil part by a predetermined interval In vivo biomaterial measuring apparatus including a load coil unit.
The method according to claim 11,

The Rx coil unit is a biological material measuring apparatus in vivo formed in which the wire is wound spirally at least twice.
The method according to claim 11,

The load coil unit is a biomaterial measuring apparatus in vivo formed by winding the wire once.
The method according to claim 6,

When the biomaterial is glucose, the set wavelength band of the light source is 600nm to 1500nm in vivo biomaterial measuring apparatus.
The method according to claim 6,

When the biomaterial is a protein, the light source is in vivo biomaterial measuring apparatus for irradiating light in the ultraviolet region of the set wavelength band of 100nm to 400nm.
The method according to claim 6,

When the biomaterial is a protein, the light source is an in vivo biomaterial measuring apparatus for irradiating light from the near infrared to the far infrared region having a set wavelength band of 780nm to 15um.
A stent structure disposed within the vessel;

An LED type light source disposed on the structure to irradiate blood with light in a wavelength band having high absorption rate of glucose or protein;

A light receiving element that receives light reflected from the light source without being absorbed by the blood;

A wireless power supply unit receiving induction power from a magnetic resonance method from the outside and providing the inductive power to the light source and having a plurality of coil members installed in the structure; And

In vivo biomaterial measuring apparatus disposed on the structure comprising a transmitting unit for transmitting the detection signal according to the amount of light output from the light receiving element or the analysis information analyzing the detection signal to the outside.