WO2016130460A3 - Phthalazinone pyrazole derivatives for treating retinal degenerative disease - Google Patents
Phthalazinone pyrazole derivatives for treating retinal degenerative disease Download PDFInfo
- Publication number
- WO2016130460A3 WO2016130460A3 PCT/US2016/016957 US2016016957W WO2016130460A3 WO 2016130460 A3 WO2016130460 A3 WO 2016130460A3 US 2016016957 W US2016016957 W US 2016016957W WO 2016130460 A3 WO2016130460 A3 WO 2016130460A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- degenerative disease
- pyrazole derivatives
- retinal degenerative
- treating retinal
- phthalazinone
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds, compositions, kits and methods for treating conditions related to Retinal degenerations, and related diseases, including retinitis pigmentosa and atrophic age-related macular degeneration, are disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562113705P | 2015-02-09 | 2015-02-09 | |
US62/113,705 | 2015-02-09 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2016130460A2 WO2016130460A2 (en) | 2016-08-18 |
WO2016130460A9 WO2016130460A9 (en) | 2016-09-15 |
WO2016130460A3 true WO2016130460A3 (en) | 2016-11-03 |
Family
ID=56614641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2016/016957 WO2016130460A2 (en) | 2015-02-09 | 2016-02-08 | Phthalazinone pyrazole derivatives for treating retinal degenerative disease |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2016130460A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102015562B1 (en) * | 2017-12-04 | 2019-08-28 | 한국화학연구원 | Composition for inducing differentiation of hepatocyte-like cells having polarity and differentiation method of hepatocyte-like cells using the same |
EP4188383A1 (en) * | 2020-07-28 | 2023-06-07 | Mirati Therapeutics, Inc. | Sos1 inhibitors |
WO2023116902A1 (en) * | 2021-12-23 | 2023-06-29 | 北京望实智慧科技有限公司 | Sos1 inhibitor |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020016367A1 (en) * | 1997-01-15 | 2002-02-07 | Richard Sportsman | Nonpeptide insulin receptor agonists |
US20060089359A1 (en) * | 2004-09-24 | 2006-04-27 | Edward Boyd | Phthalazinone derivatives |
US20070219195A1 (en) * | 2006-03-20 | 2007-09-20 | Roche Palo Alto Llc | Methods of inhibiting BTK and SYK protein kinases |
WO2007107298A1 (en) * | 2006-03-20 | 2007-09-27 | F. Hoffmann-La Roche Ag | Phthalazinone pyrazole derivatives, their manufacture and use as pharmaceutical agents |
-
2016
- 2016-02-08 WO PCT/US2016/016957 patent/WO2016130460A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020016367A1 (en) * | 1997-01-15 | 2002-02-07 | Richard Sportsman | Nonpeptide insulin receptor agonists |
US20060089359A1 (en) * | 2004-09-24 | 2006-04-27 | Edward Boyd | Phthalazinone derivatives |
US20070219195A1 (en) * | 2006-03-20 | 2007-09-20 | Roche Palo Alto Llc | Methods of inhibiting BTK and SYK protein kinases |
WO2007107298A1 (en) * | 2006-03-20 | 2007-09-27 | F. Hoffmann-La Roche Ag | Phthalazinone pyrazole derivatives, their manufacture and use as pharmaceutical agents |
Non-Patent Citations (1)
Title |
---|
KUGLSTATTER, A. ET AL.: "Insights into the conformational flexibility of Br uton's tyrosine kinase from multiple ligand complex structures", PROTEIN SCI., vol. 20, no. 2, 2011, pages 428 - 436, XP055005936, [retrieved on 20101217] * |
Also Published As
Publication number | Publication date |
---|---|
WO2016130460A2 (en) | 2016-08-18 |
WO2016130460A9 (en) | 2016-09-15 |
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