WO2016123836A1 - 基于螺旋电阻器的生物标志物浓度测量装置和方法 - Google Patents

基于螺旋电阻器的生物标志物浓度测量装置和方法 Download PDF

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Publication number
WO2016123836A1
WO2016123836A1 PCT/CN2015/073832 CN2015073832W WO2016123836A1 WO 2016123836 A1 WO2016123836 A1 WO 2016123836A1 CN 2015073832 W CN2015073832 W CN 2015073832W WO 2016123836 A1 WO2016123836 A1 WO 2016123836A1
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WIPO (PCT)
Prior art keywords
resistor
module
spiral
concentration
resistance
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Ceased
Application number
PCT/CN2015/073832
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English (en)
French (fr)
Inventor
张贯京
张俊然
普拉纽克⋅克里斯基捏
古列莎⋅艾琳娜
穆桑特⋅卢卡
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Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
Original Assignee
Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
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Publication of WO2016123836A1 publication Critical patent/WO2016123836A1/zh
Anticipated expiration legal-status Critical
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance

Definitions

  • the invention relates to the field of life health technology, and in particular to a spiral resistor based biomarker concentration measuring device and method.
  • variable resistors have been widely used, such as changing the characteristics of a signal generator, dimming a light, starting a motor, or controlling its rotational speed.
  • the existing variable resistors are difficult to meet the accuracy requirements; and for the measurement of the concentration of biomarkers, the commonly used method is photometric method, by the body fluid of the human body in vitro.
  • the component of the specimen is mixed with one or more test reagents to determine the concentration of the analyte a plurality of times, thereby initiating a biochemical reaction, which causes a measurable change in the optical properties of the analyte, and photometric detection and utilization of light Attenuation of the flow through a light-absorbing and/or astigmatic medium, however, this measurement method is susceptible to system errors during measurement due to the type of sample itself and the interfering substances it may contain. The measurement of the concentration of the biomarker is not accurate enough.
  • a primary object of the present invention is to provide a spiral resistor-based biomarker concentration measuring apparatus and method capable of improving the accuracy of concentration measurement of a biomarker.
  • the present invention provides a concentration measuring device for a biomarker based on a spiral resistor, wherein the concentration measuring device for a biomarker based on a spiral resistor includes a biosensor module, a spectrum receiving module, and a control module. , drive module and spiral track resistance:
  • the biosensor module includes a light receiving unit and a sensing unit; the light receiving unit is configured to receive and reflect a characteristic spectral signal, and the sensing unit is configured to combine an antigen in the biomarker;
  • the spectrum receiving module is connected to the control module and the driving module, and configured to receive a characteristic spectrum signal reflected by the light receiving unit, and send the characteristic spectrum signal to the control module;
  • the control module is electrically connected to the driving module, and configured to generate a control signal according to the characteristic spectral signal to control the driving module to drive the spiral track resistance and the spectrum receiving module to move; and, according to the spiral An output resistance value of the track resistance determines a displacement offset of the characteristic spectrum, and determines a concentration of the biomarker according to the displacement offset;
  • the spiral track resistance is electrically connected to the driving module and is driven by the driving module to change an output resistance value of the spiral track resistance.
  • the spiral track resistance comprises a resistor body, a resistor complex and a resistance pointer:
  • the surface of the resistor body is provided with a first thread; the resistor mating body is sleeved on the resistor body, and the resistor mating body is provided with a second thread adapted to the first thread; The first end is fixed on the resistance matching body, and the second end of the resistance pointer is in contact with the surface of the first thread;
  • the resistor body is connected to the driving module, and the resistor body is driven to move under the driving of the driving module, and the resistor matching body drives the resistor pointer to move along the surface of the first thread to change The output resistance value of the spiral track resistance;
  • the spectral receiving module is coupled to the resistor mating body, and the resistor body drives the resistive body to move under the driving of the driving module to drive the spectrum receiving module to move.
  • the sensing unit includes a metal film layer disposed on the light receiving unit, and an antibody layer disposed on the metal film layer for binding an antigen in the biomarker.
  • the spiral track resistance comprises a resistor body, a resistor complex and a resistance pointer:
  • the surface of the resistor body is provided with a first thread; the resistor mating body is sleeved on the resistor body, and the resistor mating body is provided with a second thread adapted to the first thread; The first end is fixed on the resistance matching body, and the second end of the resistance pointer is in contact with the surface of the first thread;
  • the resistor body is connected to the driving module, and the resistor body is driven to move under the driving of the driving module, and the resistor matching body drives the resistor pointer to move along the surface of the first thread to change The output resistance value of the spiral track resistance;
  • the spectral receiving module is coupled to the resistor mating body, and the resistor body drives the resistive body to move under the driving of the driving module to drive the spectrum receiving module to move.
  • control module is specifically configured to:
  • the concentration of the biomarker is determined according to a correspondence relationship between the displacement shift amount of the characteristic spectrum and the biomarker concentration.
  • the spiral track resistance comprises a resistor body, a resistor complex and a resistance pointer:
  • the surface of the resistor body is provided with a first thread; the resistor mating body is sleeved on the resistor body, and the resistor mating body is provided with a second thread adapted to the first thread; The first end is fixed on the resistance matching body, and the second end of the resistance pointer is in contact with the surface of the first thread;
  • the resistor body is connected to the driving module, and the resistor body is driven to move under the driving of the driving module, and the resistor matching body drives the resistor pointer to move along the surface of the first thread to change The output resistance value of the spiral track resistance;
  • the spectral receiving module is coupled to the resistor mating body, and the resistor body drives the resistive body to move under the driving of the driving module to drive the spectrum receiving module to move.
  • the concentration measuring device for the spiral resistor-based biomarker further comprises a concentrating module disposed at a front end of the spectral receiving module for collecting the characteristic spectral signal.
  • the spiral track resistance comprises a resistor body, a resistor complex and a resistance pointer:
  • the surface of the resistor body is provided with a first thread; the resistor mating body is sleeved on the resistor body, and the resistor mating body is provided with a second thread adapted to the first thread; The first end is fixed on the resistance matching body, and the second end of the resistance pointer is in contact with the surface of the first thread;
  • the resistor body is connected to the driving module, and the resistor body is driven to move under the driving of the driving module, and the resistor matching body drives the resistor pointer to move along the surface of the first thread to change The output resistance value of the spiral track resistance;
  • the spectral receiving module is coupled to the resistor mating body, and the resistor body drives the resistive body to move under the driving of the driving module to drive the spectrum receiving module to move.
  • the concentration measuring device of the spiral resistor-based biomarker further comprises a deceleration module connected to the driving module, the deceleration module is configured to reduce the rotation speed of the driving module.
  • the spiral resistor-based biomarker concentration measuring device further comprises a signal processing module, an output end of the spiral track resistance is electrically connected to an input end of the signal processing module, and an output of the signal processing module
  • the terminal is electrically connected to the control module, and the signal processing module is configured to perform signal conversion, signal amplification and A/D conversion on the output resistance value.
  • the present invention also provides a concentration measuring method of a concentration measuring device for a biomarker based on a spiral resistor, the concentration measuring method comprising the following steps:
  • the light receiving unit of the biosensor module receives the characteristic spectral signal emitted by the light source, and reflects the characteristic spectral signal after the antibody layer of the sensing unit and the antigen in the biomarker are combined to the spectrum receiving module;
  • the spectral receiving module receives the characteristic spectral signal and transmits the characteristic spectral signal to a control module;
  • the control module controls the driving module to drive the spectrum receiving module and the spiral track resistance motion according to the characteristic spectral signal
  • the control module determines a displacement offset of the characteristic spectrum according to an output resistance value of the spiral track resistance, and determines a concentration of the biomarker according to the displacement offset.
  • the method for measuring the concentration of the spiral resistor-based biomarker further comprises the steps of:
  • the signal conversion module performs signal conversion, signal amplification, and A/D conversion on the output resistance value of the spiral track resistance.
  • the control module determines a displacement offset of the characteristic spectrum according to an output resistance value of the spiral track resistance, and determines a concentration of the biomarker according to the displacement offset
  • the steps include:
  • the control module acquires an initial position value of the characteristic spectrum and a corresponding initial resistance value, and determines a current position value of the characteristic spectrum according to a correspondence relationship between an output resistance value of the spiral track resistance and a position value of the characteristic spectrum;
  • the control module determines a displacement offset of the characteristic spectrum according to a current position value of the characteristic spectrum and an initial position value of the characteristic spectrum;
  • the control module determines the concentration of the biomarker according to the correspondence between the displacement offset of the characteristic spectrum and the biomarker concentration.
  • the method for measuring the concentration of the spiral resistor-based biomarker further comprises the steps of:
  • the signal conversion module performs signal conversion, signal amplification, and A/D conversion on the output resistance value of the spiral track resistance.
  • the invention receives incident light through the light receiving unit of the biosensor module, the sensing unit combines the antigen in the biomarker, and the light receiving unit reflects the reflected light to the spectrum receiving module, and under the control of the control module, the driving module drives the spectrum receiving The module moves to determine the final position of the characteristic spectrum, and drives the spiral track resistance motion to change the output resistance; after determining the final position of the characteristic spectrum, the control module determines the displacement offset of the characteristic spectrum according to the output resistance value of the spiral track resistance, The concentration of the biomarker is determined based on the displacement offset.
  • the concentration of the biomarker is determined, and the influence of the type of the biomarker itself and the interfering substance is avoided, thereby improving the concentration measurement of the biomarker. Accuracy.
  • FIG. 1 is a schematic structural view of a first embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention
  • FIG. 2 is a schematic structural view of the biosensor module of FIG. 1;
  • Figure 3 is a schematic structural view of the spiral track resistance of Figure 1;
  • FIG. 4 is a schematic structural view of a preferred embodiment of the resistor body and the resistor mating body of the spiral track resistor of FIG. 3;
  • FIG. 5 is a schematic structural view of a preferred embodiment of a first embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention
  • FIG. 6 is a schematic structural view of a second embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention.
  • FIG. 7 is a schematic structural view of a third embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention.
  • FIG. 8 is a schematic structural view of a fourth embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention.
  • FIG. 9 is a schematic flow chart of a first embodiment of a method for measuring a concentration of a biomarker based on a spiral resistor according to the present invention.
  • FIG. 10 is a schematic diagram showing the refinement flow of S40 in FIG. 9;
  • FIG. 11 is a schematic flow chart of a second embodiment of a method for measuring a concentration of a biomarker based on a spiral resistor according to the present invention.
  • the invention provides a concentration measuring device for a biomarker based on a spiral resistor, the output resistance value of the spiral track resistance, the correspondence relationship between the output resistance value and the position of the characteristic spectral signal, and the displacement offset of the characteristic spectrum and the biological
  • concentration measuring device for a biomarker based on a spiral resistor, the output resistance value of the spiral track resistance, the correspondence relationship between the output resistance value and the position of the characteristic spectral signal, and the displacement offset of the characteristic spectrum and the biological
  • FIG. 1 is a schematic structural view of a first embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention.
  • the concentration measuring device of the spiral resistor-based biomarker includes a biosensor module 10, a spectrum receiving module 20, a control module 30, a driving module 40, and a spiral track resistance 50, wherein :
  • the bio-sensing module 10 includes a light receiving unit 101 and a sensing unit 102; the light receiving unit 101 is configured to receive and reflect a characteristic spectral signal, and the sensing unit 102 is configured to combine an antigen in the biomarker;
  • the spectral receiving module 20 is connected to the control module 30 and the driving module 40 for receiving the characteristic spectral signal reflected by the light receiving unit 101, and transmitting the characteristic spectral signal to the control module 30;
  • the control module 30 is electrically connected to the driving module 40 for generating a control signal according to the characteristic spectral signal to control the driving module 40 to drive the spiral track resistance 50 and the spectrum receiving module 20 to move; and determining the characteristic according to the output resistance value of the spiral track resistance 50.
  • the spiral track resistance 50 is electrically coupled to the drive module 40 and is driven by the drive module 40 to vary the output resistance value of the spiral track resistance 50.
  • FIG. 2 is a schematic structural diagram of the biosensor module of FIG. 1.
  • the biosensor module 10 adopts SPR (Surface Plasmon). Resonance, surface plasmon resonance technology) biosensor, as shown in FIG. 2, the biosensor module 10 includes a light receiving unit 101 and a sensing unit 102, and receives light of a specific wavelength from the light source through the light receiving unit 101, the light receiving The unit 101 is a prism; the sensing unit 102 is configured to combine the antigen in the biomarker, and the incident light is received by the light receiving unit 101 and then passed through the sensing unit 102. After being absorbed by the sensing unit 102, a certain degree of attenuation occurs after attenuation.
  • SPR Surface Plasmon
  • the sensing unit 102 includes a metal film layer 1021 disposed on the light receiving unit 101, and an antibody layer 1022 disposed on the metal film layer 1021 for binding the antigen in the biomarker, the metal film
  • the layer 1021 typically employs a silver film or a gold film
  • the antibody layer 1022 is an antibody capable of binding to various types of antigens in the biomarker, and when the biomarker in the liquid flows through the antibody layer 1022, it binds to the corresponding antibody thereon. A biochemical reaction takes place.
  • the spectral receiving module 20 is configured as a photodiode capable of receiving the characteristic spectral signal reflected by the bio-sensing module 10 and converting it into an electrical signal, and transmitting the converted electrical signal to the control module 30; in an initial state, The spectral receiving module 20 is disposed at an initial position of the characteristic spectrum, that is, a position where the reflected light is located when the antigen in the biomarker is not combined, and preferably, the center position of the spectral receiving module 20 and the center position of the initial position of the characteristic spectrum. Coincident, just received all the characteristic spectral signals.
  • the spectral receiving signal received by the spectral receiving module 20 is the smallest.
  • the entrance aperture of the intermediate unit of the spectrum receiving module 20 is on the order of nanometers.
  • the position of the characteristic spectrum is considered to be at an odd center point; if the lowest value of the infrared light received by the intermediate unit of the spectrum receiving module 20 at a certain point is an even number of positions, the position of the characteristic spectrum is considered to be at an even number of positions.
  • the spectrum receiving module 20 is connected to the driving module 40, and can receive the characteristic spectrum dynamically under the driving of the driving module 40.
  • the driving module 40 is configured to drive the spiral track resistance 50 to move.
  • the driving module 40 can be selected as a motor.
  • the stepping motor is preferred. The smaller the step size of the stepping motor, the higher the measurement accuracy. The design measurement accuracy should be considered comprehensively.
  • the stepping motor can be selected to have a step size of 0.5 or 0.75 to ensure accurate measurement of the size of a small object to be measured.
  • the output resistance value of the corresponding spiral track resistance 50 is also the initial resistance value.
  • the control module 30 determines that the size of the characteristic spectrum signal exceeds the preset range, the corresponding control is generated.
  • the signal is controlled to drive the spectral receiving module 20 to move until the size of the characteristic spectral signal received by the spectral receiving module 20 is within a preset range, that is, the characteristic spectral signal is detected to move to a final position, which is a characteristic spectral signal.
  • the current position value At the same time, the driving module 40 drives the spiral track resistance 50 to change the output resistance value of the spiral track resistance 50.
  • the spiral track resistance 50 stops moving, and the current output resistance of the spiral track resistance 50 at this time. The value corresponds to the current position value of the characteristic spectral signal.
  • the control module 30 determines the current position value of the characteristic spectral signal according to the output resistance value of the spiral track resistance 50 and the correspondence relationship between the output resistance value and the position of the characteristic spectral signal, and further determines the displacement offset of the characteristic spectrum, and then according to the feature.
  • the correspondence between the displacement shift of the spectrum and the concentration of the biomarker determines the concentration of the biomarker.
  • the control module 30 acquires the initial position value of the characteristic spectrum and the corresponding initial resistance value, according to the correspondence relationship between the output resistance value of the spiral track resistance 50 and the position value of the characteristic spectrum.
  • the correspondence relationship is a linear relationship. Since the current output resistance value of the spiral track resistance 50 is known, the current position value of the characteristic spectrum can be determined, according to the current position value of the characteristic spectrum and the initial position value of the characteristic spectrum. The distance between the two can determine the displacement of the characteristic spectrum; then, according to the correspondence between the displacement of the characteristic spectrum and the concentration of the biomarker, the correspondence is also a linear relationship, thereby determining the biomarker concentration.
  • the incident light is received by the light receiving unit 101 of the biosensor module 10, the sensing unit 102 combines the antigen in the biomarker, and the light receiving unit 101 reflects the reflected light to the spectrum receiving module 20, and is controlled by the control module 30.
  • the driving module 40 drives the spectrum receiving module 20 to determine the final position of the characteristic spectrum, and drives the spiral track resistance 50 to change the output resistance; after determining the final position of the characteristic spectrum, the control module 30 is based on the spiral track resistance 50.
  • the output resistance value determines the displacement offset of the characteristic spectrum and determines the concentration of the biomarker based on the displacement offset.
  • the concentration of the biomarker is determined according to the correspondence between the output resistance value of the spiral track resistance 50 and the concentration of the biomarker, thereby avoiding the type of the biomarker itself and the influence of the interfering substance, thereby improving the concentration measurement of the biomarker.
  • the accuracy is determined according to the correspondence between the output resistance value of the spiral track resistance 50 and the concentration of the biomarker, thereby avoiding the type of the biomarker itself and the influence of the interfering substance, thereby improving the concentration measurement of the biomarker. The accuracy.
  • FIG. 3 is a schematic structural view of the spiral track resistance of FIG. 1;
  • FIG. 4 is a schematic structural view of a preferred embodiment of the resistance body of the spiral track resistance of FIG.
  • the spiral track resistance 50 includes a resistor body 501, a resistor mating body 502, and a resistance pointer 503, wherein:
  • the surface of the resistor body 501 is provided with a first thread 5011; the resistor mating body 502 is sleeved on the resistor body 501, and the resistor mating body 502 is provided with a second thread 5021 adapted to the first thread 5011; the first end 5031 of the resistor pointer 503 Fixed to the resistor mating body 502, the second end 5032 of the resistive pointer 503 is in contact with the surface of the first thread 5011.
  • the resistor body 501 and the resistor body 502 are coupled to each other.
  • the resistor body 502 is sleeved on the resistor body 501.
  • the resistor body 501 is configured as a screw structure.
  • the surface of the resistor body 501 is provided with a first thread 5011.
  • the resistor body 502 is configured as a nut.
  • the inner surface of the resistor mating body 502 is provided with a second thread 5021 adapted to the first thread 5011.
  • the first thread 5011 is engaged with the second thread 5021.
  • the first end 5031 of the resistor pointer 503 and the first end of the resistor body 501 The surface of the thread 5011 is in contact with the second end 5032 of the resistor pointer 503, and is specifically fixed to the second thread 5021.
  • FIG. 5 is a schematic structural view of a preferred embodiment of a first embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention.
  • the resistor body 501 is connected to the driving module 40.
  • the driving module 40 drives the resistor body 501 to rotate.
  • the rotation of the resistor body 501 can drive the resistor matching body 502 to move in the horizontal direction.
  • the resistance pointer 503 is moved along the surface of the first thread 5011 to change the output resistance value of the spiral track resistance 50.
  • the resistor mating body 502 can be connected to the driving module 40.
  • the driving module 40 directly drives the resistor mating body 502 to rotate and move in the horizontal direction to drive the resistor body.
  • the rotation of 501 causes the resistance pointer 503 to move along the surface of the first thread 5011 to change the output resistance value of the spiral track resistance 50.
  • the spectrum receiving module 20 is disposed on the resistor matching body 502, the resistor body 501 of the spiral track resistor 50 is mechanically coupled to the driving module 40, and the driving module 40 drives the resistor body 501 to move.
  • the resistor body 501 drives the resistor mating body 502 to move in the horizontal direction, thereby driving the spectrum receiving module 20 to move.
  • a first thread 5011 and a second thread 5021 are provided on the resistor body 501 and the resistor mating body 502 of the spiral track resistor 50, so that the resistor partner 502 drives the resistor pointer 503 to move along the surface of the first thread 5011.
  • the embodiment of the present invention improves the accuracy of the output resistance value of the spiral track resistance 50, further satisfying the precision control and The requirements for system accuracy in the field of precision measurement.
  • FIG. 6 is a schematic structural view of a second embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention.
  • the concentration measuring device for the biomarker based on the spiral resistor further includes:
  • the concentrating module 60 is disposed at the front end of the spectrum receiving module 20 for collecting characteristic spectral signals.
  • the concentrating module 60 aggregates the characteristic spectral signals, so that the scattered characteristic spectral signals are gathered to overcome the problem of light scattering and interference of the characteristic spectral signals, so that the measured characteristic spectral signals are received by the spectral receiving module 20 at a maximum amount, thereby improving the measurement.
  • the concentrating module 60 can use a concentrating device such as a condensing mirror, a lenticular lens, and an LED lamp cup.
  • the concentrating module 60 is integrated with the spectrum receiving module 20, and is coupled to the spectrum receiving module 20 at the driving module 40. The driving is driven to improve the absorption rate of the characteristic spectral signal by the spectrum receiving module 20 in the whole process, thereby improving the measurement precision.
  • FIG. 7 is a schematic structural view of a third embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention.
  • the concentration measuring device for the biomarker based on the spiral resistor further includes:
  • the deceleration module 70 is connected to the driving module 40 for reducing the rotation speed of the rotation of the driving module 40.
  • the deceleration module 70 can be disposed at the output end of the driving module 40, and can be a one-stage or multi-stage speed reducer; when the driving module 40 is in operation, the speed of the driving module 40 is reduced by the deceleration module 70, thereby reducing the driving.
  • the torque of the module 40 increases the measurement accuracy, thereby meeting the measurement requirements of a measurement system that requires higher measurement accuracy.
  • FIG. 8 is a schematic structural view of a fourth embodiment of a concentration measuring device for a biomarker based on a spiral resistor according to the present invention.
  • the concentration measuring device for the biomarker based on the spiral resistor further includes:
  • the signal processing module 80, the output end of the spiral track resistance 50 is electrically connected to the input end of the signal processing module 80, the output end of the signal processing module 80 is electrically connected to the control module 30, and the signal processing module 80 is used for outputting the spiral track resistance 50.
  • the resistance value is used for signal conversion, signal amplification, and A/D conversion.
  • the signal processing module 80 specifically includes a resistance voltage signal conversion unit, a signal amplification unit, and an A/D conversion unit: the resistance voltage signal conversion unit is configured to convert the output resistance value of the spiral track resistance 50 into a corresponding voltage value;
  • the signal amplifying unit is used for amplifying the converted voltage value, and the amplification factor determines the accuracy of the whole system, and the amplification factor of the amplifier in the signal amplifying unit is more than 500 times, designed as multi-stage filtering and amplification, which is used in the embodiment.
  • the linear range of the amplifier is 0.7v ⁇ 3.6v; the A/D conversion unit uses a digital-to-analog converter for analog-to-digital conversion of the amplified voltage value.
  • the invention also provides a method for measuring the concentration of a biomarker based on a spiral resistor.
  • FIG. 9 is a schematic flow chart of a first embodiment of a method for measuring a concentration of a biomarker based on a spiral resistor according to the present invention.
  • the method for measuring the concentration of a biomarker based on a spiral resistor includes:
  • Step S10 the light receiving unit of the biosensor module receives the characteristic spectrum signal emitted by the light source, and reflects the characteristic spectrum signal after the antibody layer of the sensing unit and the antigen in the biomarker are combined to the spectrum receiving module;
  • Step S20 the spectrum receiving module receives the characteristic spectrum signal, and sends the characteristic spectrum signal to the control module;
  • Step S30 the control module controls the driving module to drive the spectrum receiving module and the spiral track resistance motion according to the characteristic spectral signal;
  • Step S40 when the driving module is stopped, the control module determines the displacement offset of the characteristic spectrum according to the output resistance value of the spiral track resistance, and determines the concentration of the biomarker according to the displacement offset.
  • the biosensor module adopts SPR (Surface Plasmon) Resonance, surface plasmon resonance technology) biosensor
  • the biosensor module comprises a light receiving unit and a sensing unit, and receives light of a specific wavelength from a light source through a light receiving unit, the light receiving unit is a prism;
  • the sensing unit is used for combining The antigen in the biomarker, the incident light is received by the light receiving unit and then passes through the sensing unit, and after absorption by the sensing unit, a certain degree of attenuation occurs, and the attenuated incident light is reflected, such as the antigen in the biomarker.
  • the sensing unit When the sensing unit is combined, it will cause the surface material to change in quality and the reflected light will shift.
  • the sensing unit includes a metal film layer disposed on the light receiving unit, and an antibody layer disposed on the metal film layer, the antibody layer is used to bind the antigen in the biomarker, and the metal film layer is usually a silver film or The gold membrane, the antibody layer is an antibody capable of binding to various types of antigens in the biomarker, and when the biomarker in the liquid flows through the antibody layer, a biochemical reaction occurs in combination with the corresponding antibody thereon.
  • the output resistance value of the corresponding spiral track resistance is also the initial resistance value.
  • the control module determines that the size of the characteristic spectral signal exceeds a preset range, a corresponding control signal is generated.
  • the control driving module drives the spectral receiving module to move until the size of the characteristic spectral signal received by the spectral receiving module is within a preset range, that is, the characteristic spectral signal is detected to move to a final position, which is the current position value of the characteristic spectral signal.
  • the driving module drives the spiral track resistance movement to change the output resistance value of the spiral track resistance.
  • the characteristic spectral signal moves to the final position, the spiral track resistance stops moving, and the current output resistance value of the spiral track resistance corresponds to the characteristic spectrum. The current position value of the signal.
  • the control module determines the current position value of the characteristic spectral signal according to the output resistance value of the spiral track resistance and the correspondence relationship between the output resistance value and the position of the characteristic spectral signal, and further determines the displacement offset of the characteristic spectrum, and then according to the characteristic spectrum
  • the correspondence between the displacement offset and the concentration of the biomarker determines the concentration of the biomarker.
  • the light receiving unit of the biosensor module receives the incident light
  • the sensing unit combines the antigen in the biomarker
  • the light receiving unit reflects the reflected light to the spectrum receiving module.
  • the driving module drives the spectrum.
  • Receiving module motion to determine a final position of the characteristic spectrum, and driving the spiral track resistance motion to change the output resistance; after determining the final position of the characteristic spectrum, the control module determines the displacement offset of the characteristic spectrum according to the output resistance value of the spiral track resistance And determining the concentration of the biomarker based on the displacement offset.
  • the concentration of the biomarker is determined, and the influence of the type of the biomarker itself and the interfering substance is avoided, thereby improving the concentration measurement of the biomarker. Accuracy.
  • FIG. 10 is a schematic diagram of the refinement flow of S40 in FIG.
  • step S40 specifically includes:
  • Step S401 the control module acquires an initial position value of the characteristic spectrum and a corresponding initial resistance value, and determines a current position value of the characteristic spectrum according to a correspondence relationship between an output resistance value of the spiral track resistance and a position value of the characteristic spectrum;
  • Step S402 the control module determines the displacement offset of the characteristic spectrum according to the current position value of the characteristic spectrum and the initial position value of the characteristic spectrum;
  • Step S403 the control module determines the concentration of the biomarker according to the correspondence between the displacement offset of the characteristic spectrum and the concentration of the biomarker.
  • the control module When detecting that the characteristic spectral signal moves to the final position, acquires the initial position value of the characteristic spectrum and the corresponding initial resistance value, and according to the correspondence relationship between the output resistance value of the spiral track resistance and the position value of the characteristic spectrum, the corresponding relationship is A linear relationship, since the current output resistance value of the spiral track resistance is known, the current position value of the characteristic spectrum can be determined, and the distance between the current position value of the characteristic spectrum and the initial position value of the characteristic spectrum can be determined.
  • the displacement offset of the characteristic spectrum then, according to the corresponding relationship between the displacement offset of the characteristic spectrum and the biomarker concentration, the correspondence relationship is also a linear relationship, thereby determining the concentration of the biomarker.
  • FIG. 11 is a schematic flow chart of a second embodiment of a method for measuring a concentration of a biomarker based on a spiral resistor according to the present invention.
  • the method further includes:
  • step S50 the signal conversion module performs signal conversion, signal amplification, and A/D conversion on the output resistance value of the spiral track resistance.
  • the signal processing module specifically includes a resistance voltage signal conversion unit, a signal amplification unit, and an A/D conversion unit. After the spiral track resistance outputs its output resistance value, the signal processing module converts the output resistance value into a corresponding voltage value through its resistance voltage signal conversion unit, and then amplifies the converted voltage value through the signal amplification unit, and the amplification factor is determined.
  • the accuracy of the whole system, the amplification factor of the amplifier in the signal amplification unit is more than 500 times, designed for multi-stage filtering and amplification.
  • the linear range of the amplifier used in this embodiment is 0.7v ⁇ 3.6v; the amplified voltage value is A.
  • the /D conversion unit performs analog-to-digital conversion, and the A/D conversion unit adopts a digital-to-analog converter.
  • a 24-bit digital-to-analog converter is selected, and the digital signal corresponding to the converted output resistance value can be further determined by the control module. The current position value of the object.

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Abstract

一种基于螺旋电阻器的生物标志物的浓度测量装置，包括：生物传感模块（10），用于接收和反射特征光谱信号，以及结合生物标志物中的抗原；光谱接收模块（20），用于接收光接收单元（101）反射的特征光谱信号，并将特征光谱信号发送至控制模块（30）；控制模块（30），用于根据特征光谱信号控制驱动模块（40）带动螺旋轨道电阻（50）和光谱接收模块（20）运动；以及，根据螺旋轨道电阻（50）的输出电阻值确定特征光谱的位移偏移量，并根据位移偏移量确定生物标志物的浓度；螺旋轨道电阻（50），在驱动模块（40）的驱动下运动以改变螺旋轨道电阻（50）的输出电阻值。还公开了一种相应的测量方法，避免了生物标志物本身的类型和干扰性物质的影响，从而提高了对生物标志物的浓度测量的精确度。

Description

基于螺旋电阻器的生物标志物浓度测量装置和方法
技术领域
本发明涉及生命健康技术领域，尤其涉及一种基于螺旋电阻器的生物标志物浓度测量装置和方法。
背景技术
目前，可变电阻器的应用已经非常广泛，例如可以改变信号发生器的特性、使灯光变暗、启动电动机或控制它的转速等。在精密控制和精密测量领域，现有的可变电阻器很难满足其精度的需求；而对于生物标志物的浓度的测量，通常所采用的方法是光度测量法，通过在体外将人体的体液标本的分量与一种或多种检验试剂混合，多次确定被分析物的浓度，由此引发生物化学反应，这使得被测物的光学特性发生可测的变化，光度测量法检查并利用光流穿过吸光性的和/或散光性的媒介时的发生的减弱，然而，这种测量方法由于受样本本身的类型和其可能包含的干扰性物质的影响，导致在测量时易发生系统错误，使得对生物标志物的浓度的测量结果不够准确。
发明内容
本发明的主要目的在于提供一种基于螺旋电阻器的生物标志物浓度测量装置和方法，能够提高对生物标志物的浓度测量的精确度。
为实现上述目的，本发明提供了一种基于螺旋电阻器的生物标志物的浓度测量装置，所述基于螺旋电阻器的生物标志物的浓度测量装置包括生物传感模块、光谱接收模块、控制模块、驱动模块和螺旋轨道电阻：
所述生物传感模块包括光接收单元和传感单元；所述光接收单元用于接收和反射特征光谱信号，所述传感单元用于结合生物标志物中的抗原；
所述光谱接收模块，与所述控制模块和驱动模块连接，用于接收所述光接收单元反射的特征光谱信号，并将所述特征光谱信号发送至所述控制模块；
所述控制模块，与所述驱动模块电连接，用于根据所述特征光谱信号生成控制信号以控制所述驱动模块带动所述螺旋轨道电阻和所述光谱接收模块运动；以及，根据所述螺旋轨道电阻的输出电阻值确定所述特征光谱的位移偏移量，并根据所述位移偏移量确定所述生物标志物的浓度；
所述螺旋轨道电阻，与所述驱动模块电连接，在所述驱动模块的驱动下运动以改变所述螺旋轨道电阻的输出电阻值。
优选地，所述螺旋轨道电阻包括电阻本体、电阻配合体和电阻指针：
所述电阻本体表面设置有第一螺纹；所述电阻配合体套设在所述电阻本体上，所述电阻配合体设置有与所述第一螺纹适配的第二螺纹；所述电阻指针的第一端固定于所述电阻配合体上，所述电阻指针的第二端与所述第一螺纹的表面接触；
所述电阻本体与所述驱动模块连接，在所述驱动模块的驱动下带动所述电阻配合体运动，所述电阻配合体带动所述电阻指针沿所述第一螺纹的表面移动，以改变所述螺旋轨道电阻的输出电阻值；
所述光谱接收模块与所述电阻配合体连接，所述电阻本体在所述驱动模块的驱动下带动所述电阻配合体运动，以带动所述光谱接收模块运动。
优选地，所述传感单元包括设置在所述光接收单元上的金属膜层，以及设置在所述金属膜层上的抗体层，该抗体层用于结合生物标志物中的抗原。
优选地，所述螺旋轨道电阻包括电阻本体、电阻配合体和电阻指针：
所述电阻本体表面设置有第一螺纹；所述电阻配合体套设在所述电阻本体上，所述电阻配合体设置有与所述第一螺纹适配的第二螺纹；所述电阻指针的第一端固定于所述电阻配合体上，所述电阻指针的第二端与所述第一螺纹的表面接触；
所述电阻本体与所述驱动模块连接，在所述驱动模块的驱动下带动所述电阻配合体运动，所述电阻配合体带动所述电阻指针沿所述第一螺纹的表面移动，以改变所述螺旋轨道电阻的输出电阻值；
所述光谱接收模块与所述电阻配合体连接，所述电阻本体在所述驱动模块的驱动下带动所述电阻配合体运动，以带动所述光谱接收模块运动。
优选地，所述控制模块具体用于：
获取所述特征光谱的初始位置值及对应的初始电阻值，根据螺旋轨道电阻的输出电阻值与特征光谱的位置值的对应关系，确定所述特征光谱的当前位置值；
根据所述特征光谱的当前位置值以及特征光谱的初始位置值，确定所述特征光谱的位移偏移量；
根据所述特征光谱的位移偏移量与生物标志物浓度的对应关系，确定所述生物标志物的浓度。
优选地，所述螺旋轨道电阻包括电阻本体、电阻配合体和电阻指针：
所述电阻本体表面设置有第一螺纹；所述电阻配合体套设在所述电阻本体上，所述电阻配合体设置有与所述第一螺纹适配的第二螺纹；所述电阻指针的第一端固定于所述电阻配合体上，所述电阻指针的第二端与所述第一螺纹的表面接触；
所述电阻本体与所述驱动模块连接，在所述驱动模块的驱动下带动所述电阻配合体运动，所述电阻配合体带动所述电阻指针沿所述第一螺纹的表面移动，以改变所述螺旋轨道电阻的输出电阻值；
所述光谱接收模块与所述电阻配合体连接，所述电阻本体在所述驱动模块的驱动下带动所述电阻配合体运动，以带动所述光谱接收模块运动。
优选地，所述基于螺旋电阻器的生物标志物的浓度测量装置还包括聚光模块，所述聚光模块设置于所述光谱接收模块的前端，用于聚集所述特征光谱信号。
优选地，所述螺旋轨道电阻包括电阻本体、电阻配合体和电阻指针：
所述电阻本体表面设置有第一螺纹；所述电阻配合体套设在所述电阻本体上，所述电阻配合体设置有与所述第一螺纹适配的第二螺纹；所述电阻指针的第一端固定于所述电阻配合体上，所述电阻指针的第二端与所述第一螺纹的表面接触；
所述电阻本体与所述驱动模块连接，在所述驱动模块的驱动下带动所述电阻配合体运动，所述电阻配合体带动所述电阻指针沿所述第一螺纹的表面移动，以改变所述螺旋轨道电阻的输出电阻值；
所述光谱接收模块与所述电阻配合体连接，所述电阻本体在所述驱动模块的驱动下带动所述电阻配合体运动，以带动所述光谱接收模块运动。
优选地，所述基于螺旋电阻器的生物标志物的浓度测量装置还包括与所述驱动模块连接的减速模块，所述减速模块用于减小所述驱动模块转动的转速。
优选地，所述基于螺旋电阻器的生物标志物的浓度测量装置还包括信号处理模块，所述螺旋轨道电阻的输出端与所述信号处理模块的输入端电连接，所述信号处理模块的输出端与所述控制模块电连接，所述信号处理模块用于对所述输出电阻值进行信号转换、信号放大和A/D转换。
此外，为实现上述目的，本发明还提供一种基于螺旋电阻器的生物标志物的浓度测量装置的浓度测量方法，所述浓度测量方法包括如下步骤：
生物传感模块的光接收单元接收光源发射的特征光谱信号，并将经传感单元的抗体层与生物标志物中的抗原结合后的所述特征光谱信号反射至光谱接收模块；
光谱接收模块接收所述特征光谱信号，并将所述特征光谱信号发送至控制模块；
控制模块根据所述特征光谱信号控制驱动模块带动光谱接收模块和螺旋轨道电阻运动；
在驱动模块停止时，控制模块根据所述螺旋轨道电阻的输出电阻值确定所述特征光谱的位移偏移量，并根据所述位移偏移量确定所述生物标志物的浓度。
优选地，所述基于螺旋电阻器的生物标志物的浓度测量方法还包括步骤：
信号转换模块对螺旋轨道电阻的输出电阻值进行信号转换、信号放大和A/D转换。
优选地，所述在驱动模块停止时，控制模块根据所述螺旋轨道电阻的输出电阻值确定所述特征光谱的位移偏移量，并根据所述位移偏移量确定所述生物标志物的浓度的步骤包括：
控制模块获取所述特征光谱的初始位置值及对应的初始电阻值，根据螺旋轨道电阻的输出电阻值与特征光谱的位置值的对应关系，确定所述特征光谱的当前位置值；
控制模块根据所述特征光谱的当前位置值以及特征光谱的初始位置值，确定所述特征光谱的位移偏移量；
控制模块根据所述特征光谱的位移偏移量与生物标志物浓度的对应关系，确定所述生物标志物的浓度。
优选地，所述基于螺旋电阻器的生物标志物的浓度测量方法还包括步骤：
信号转换模块对螺旋轨道电阻的输出电阻值进行信号转换、信号放大和A/D转换。
本发明通过生物传感模块的光接收单元接收入射光，传感单元结合生物标志物中的抗原，光接收单元将反射光反射至光谱接收模块，在控制模块的控制下，驱动模块驱动光谱接收模块运动以确定特征光谱的最终位置，以及驱动螺旋轨道电阻运动以改变输出电阻；在确定了特征光谱的最终位置后，控制模块根据螺旋轨道电阻的输出电阻值确定特征光谱的位移偏移量，并根据位移偏移量确定生物标志物的浓度。根据螺旋轨道电阻的输出电阻值与生物标志物的浓度的对应关系确定生物标志物的浓度，避免了生物标志物本身的类型和干扰性物质的影响，从而提高了对生物标志物的浓度测量的精确度。
附图说明
图1为本发明基于螺旋电阻器的生物标志物的浓度测量装置第一实施例的结构示意图；
图2为图1中生物传感模块的结构示意图；
图3为图1中螺旋轨道电阻的结构示意图；
图4为图3中螺旋轨道电阻的电阻本体和电阻配合体配合的优选实施方式的结构示意图；
图5为本发明基于螺旋电阻器的生物标志物的浓度测量装置第一实施例的优选实施方式的结构示意图；
图6为本发明基于螺旋电阻器的生物标志物的浓度测量装置第二实施例的结构示意图；
图7为本发明基于螺旋电阻器的生物标志物的浓度测量装置第三实施例的结构示意图；
图8为本发明基于螺旋电阻器的生物标志物的浓度测量装置第四实施例的结构示意图；
图9为本发明基于螺旋电阻器的生物标志物的浓度测量方法第一实施例的流程示意图；
图10为图9中S40的细化流程示意图；
图11为本发明基于螺旋电阻器的生物标志物的浓度测量方法第二实施例的流程示意图。
本发明目的的实现、功能特点及优点将结合实施例，参照附图做进一步说明。
具体实施方式
应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
本发明提供一种基于螺旋电阻器的生物标志物的浓度测量装置，通过螺旋轨道电阻的输出电阻值、输出电阻值与特征光谱信号的位置的对应关系，以及特征光谱的位移偏移量与生物标志物的浓度的对应关系，确定生物标志物的浓度，以提高对生物标志物的浓度测量的精确度。
参照图1，图1为本发明基于螺旋电阻器的生物标志物的浓度测量装置第一实施例的结构示意图。
在一实施例中，如图1所示，基于螺旋电阻器的生物标志物的浓度测量装置包括生物传感模块10、光谱接收模块20、控制模块30、驱动模块40和螺旋轨道电阻50，其中：
生物传感模块10包括光接收单元101和传感单元102；光接收单元101用于接收和反射特征光谱信号，传感单元102用于结合生物标志物中的抗原；
光谱接收模块20，与控制模块30和驱动模块40连接，用于接收光接收单元101反射的特征光谱信号，并将特征光谱信号发送至控制模块30；
控制模块30，与驱动模块40电连接，用于根据特征光谱信号生成控制信号以控制驱动模块40带动螺旋轨道电阻50和光谱接收模块20运动；以及，根据螺旋轨道电阻50的输出电阻值确定特征光谱的位移偏移量，并根据位移偏移量确定生物标志物的浓度；
螺旋轨道电阻50，与驱动模块40电连接，在驱动模块40的驱动下运动以改变螺旋轨道电阻50的输出电阻值。
进一步参照图2，图2为图1中生物传感模块的结构示意图。本实施例中，生物传感模块10采用SPR（Surface Plasmon Resonance，表面等离子共振技术）生物传感器，如图2所示，生物传感模块10包括光接收单元101和传感单元102，通过光接收单元101接收来自光源的特定波长的入射光，该光接收单元101为棱镜；传感单元102用于结合生物标志物中的抗原，入射光经光接收单元101接收后经过传感单元102，经传感单元102吸收后会发生一定程度的衰减，衰减后的入射光会反射出去，如生物标志物中的抗原与传感单元102结合，则会引起表面物质质量改变，反射光会发生偏移。具体地，传感单元102包括设置在光接收单元101上的金属膜层1021，以及设置在金属膜层1021上的抗体层1022，该抗体层1022用于结合生物标志物中的抗原，金属膜层1021通常采用银膜或金膜，抗体层1022为能够与生物标志物中的各种类型的抗原结合的抗体，当液体中的生物标志物流经抗体层1022时，会与其上的相应抗体结合发生生物化学反应。
光谱接收模块20设置为光电二极管，该光电二极管能够接收生物传感模块10所反射的特征光谱信号并将其转化为电信号，将转化后的电信号发送至控制模块30；在初始状态下，光谱接收模块20设置于特征光谱的初始位置，即生物标志物中的抗原未结合时反射光所在的位置，且在优选情况下，光谱接收模块20的中心位置与特征光谱的初始位置的中心位置重合，刚好接收到全部的特征光谱信号。在一个实施例中，假设特征光谱信号与周围光谱信号相比为弱信号，则此时，光谱接收模块20接收到的特征光谱信号大小最小。本实施例中，为了提高系统测量的分辨率，光谱接收模块20的中间单元入射孔径为纳米级，如果光谱接收模块20的中间单元在某一点接收的红外光的最低值为奇数个位点，则认为特征光谱的位置在奇数的中心点位置；如果光谱接收模块20的中间单元在某一点接收的红外光的最低值为偶数个位点，则认为特征光谱的位置在位于偶数个位点的中间两个点位置。光谱接收模块20与驱动模块40连接，可在驱动模块40的驱动下，动态的接收特征光谱。
驱动模块40用于驱动螺旋轨道电阻50运动，该驱动模块40可选择为电机，本实施例中优选为步进电机，该步进电机的步长越小，测量精度越高。在设计时应综合考虑系统测量精度的要求。在本实施例中，可选择步进电机的步长为0.5°或0.75°，以保证对微小的被测对象的尺寸的精密测量。
当入射光经过光接收单元101接收，并经传感单元102吸收后反射至光谱接收模块20，当光谱接收模块20位于初始位置时，对应螺旋轨道电阻50的输出电阻值也为初始电阻值。随着特征光谱因待测物的变化而移动，光谱接收模块20接收到的特征光谱信号的大小会发生改变，当控制模块30判断出该特征光谱信号的大小超过预设范围时，生成相应控制信号，以控制驱动模块40驱动光谱接收模块20运动，直到光谱接收模块20接收到的特征光谱信号的大小在预设范围内，即检测到特征光谱信号移动到最终位置，该位置为特征光谱信号的当前位置值。同时，驱动模块40驱动螺旋轨道电阻50运动以改变螺旋轨道电阻50的输出电阻值，当特征光谱信号移动到最终位置时，螺旋轨道电阻50停止运动，此时螺旋轨道电阻50的当前的输出电阻值对应于特征光谱信号的当前位置值。控制模块30根据螺旋轨道电阻50的输出电阻值，以及输出电阻值与特征光谱信号的位置的对应关系，确定特征光谱信号的当前位置值，并进一步确定特征光谱的位移偏移量，然后根据特征光谱的位移偏移量与生物标志物的浓度的对应关系，确定生物标志物的浓度。
具体地，在检测到特征光谱信号移动到最终位置时，控制模块30获取特征光谱的初始位置值及对应的初始电阻值，根据螺旋轨道电阻50的输出电阻值与特征光谱的位置值的对应关系，该对应关系为一线性关系，由于螺旋轨道电阻50的当前的输出电阻值是已知的，因而可确定特征光谱的当前位置值，根据特征光谱的当前位置值以及特征光谱的初始位置值之间的距离，可确定特征光谱的位移偏移量；然后，根据特征光谱的位移偏移量与生物标志物浓度的对应关系，该对应关系也为一线性关系，由此便可确定生物标志物的浓度。
本实施例通过生物传感模块10的光接收单元101接收入射光，传感单元102结合生物标志物中的抗原，光接收单元101将反射光反射至光谱接收模块20，在控制模块30的控制下，驱动模块40驱动光谱接收模块20运动以确定特征光谱的最终位置，以及驱动螺旋轨道电阻50运动以改变输出电阻；在确定了特征光谱的最终位置后，控制模块30根据螺旋轨道电阻50的输出电阻值确定特征光谱的位移偏移量，并根据位移偏移量确定生物标志物的浓度。根据螺旋轨道电阻50的输出电阻值与生物标志物的浓度的对应关系确定生物标志物的浓度，避免了生物标志物本身的类型和干扰性物质的影响，从而提高了对生物标志物的浓度测量的精确度。
参照图3和图4，图3为图1中螺旋轨道电阻的结构示意图；图4为图3中螺旋轨道电阻的电阻本体和电阻配合体配合的优选实施方式的结构示意图。
螺旋轨道电阻50包括电阻本体501、电阻配合体502和电阻指针503，其中：
电阻本体501表面设置有第一螺纹5011；电阻配合体502套设在电阻本体501上，电阻配合体502设置有与第一螺纹5011适配的第二螺纹5021；电阻指针503的第一端5031固定于电阻配合体502上，电阻指针503的第二端5032与第一螺纹5011的表面接触。
电阻本体501和电阻配合体502相互配合，电阻配合体502套设在电阻本体501上，电阻本体501设置为螺杆结构，电阻本体501表面设置有第一螺纹5011，电阻配合体502设置为螺帽结构，电阻配合体502的内表面设置有与第一螺纹5011适配的第二螺纹5021，第一螺纹5011与第二螺纹5021啮合；电阻指针503的第一端5031与电阻本体501的第一螺纹5011的表面接触，电阻指针503的第二端5032固定于电阻配合体502上，具体可设置在第二螺纹5021上。
进一步参照图5，图5为本发明基于螺旋电阻器的生物标志物的浓度测量装置第一实施例的优选实施方式的结构示意图。
在本发明一优选实施例中，电阻本体501与驱动模块40连接，螺旋轨道电阻50工作时，通过驱动模块40驱动电阻本体501转动，电阻本体501的转动可带动电阻配合体502沿水平方向移动，从而带动电阻指针503沿第一螺纹5011的表面移动，以改变螺旋轨道电阻50的输出电阻值。在本发明的其他实施例中，还可将电阻配合体502与驱动模块40连接，螺旋轨道电阻50工作时，通过驱动模块40直接驱动电阻配合体502转动并沿水平方向移动，以带动电阻本体501转动，从而带动电阻指针503沿第一螺纹5011的表面移动，以改变螺旋轨道电阻50的输出电阻值。
如图5所示，在本发明一优选实施例中，光谱接收模块20设置于电阻配合体502上，螺旋轨道电阻50的电阻本体501与驱动模块40机械连接，驱动模块40驱动电阻本体501运动，电阻本体501带动电阻配合体502沿水平方向移动，从而带动光谱接收模块20运动。
在螺旋轨道电阻50的电阻本体501和电阻配合体502上设置相互配合的第一螺纹5011和第二螺纹5021，使电阻配合体502带动电阻指针503在电阻沿第一螺纹5011的表面移动，从而改变螺旋轨道电阻50的输出电阻值，对比于现有技术中的电阻指针沿电阻本体直线方向移动，本发明实施例提高了螺旋轨道电阻50的输出电阻值的精度，进一步满足了在精密控制和精密测量领域对系统精度的要求。
参照图6，图6为本发明基于螺旋电阻器的生物标志物的浓度测量装置第二实施例的结构示意图。
在上述本发明第一实施例的基础上，第二实施例中，基于螺旋电阻器的生物标志物的浓度测量装置还包括：
聚光模块60，该聚光模块60设置于光谱接收模块20的前端，用于聚集特征光谱信号。
聚光模块60对特征光谱信号进行聚集，使得散射的特征光谱信号聚拢，以克服特征光谱信号的光线散射和干涉等问题，使测量的特征光谱信号最大量的被光谱接收模块20接收，提高测量系统的精确度。该聚光模块60可以采用聚光镜、凹凸透镜和LED灯杯等具有聚光作用的装置，优选地，聚光模块60与光谱接收模块20集成于一体，与光谱接收模块20一起在驱动模块40的驱动下运动，提高整个过程中光谱接收模块20对特征光谱信号的吸收率，从而提高测量精度。
参照图7，图7为本发明基于螺旋电阻器的生物标志物的浓度测量装置第三实施例的结构示意图。
在上述本发明第一实施例的基础上，第三实施例中，基于螺旋电阻器的生物标志物的浓度测量装置还包括：
减速模块70，该减速模块70与驱动模块40连接，用于减小驱动模块40转动的转速。
本实施例中，减速模块70可设置在驱动模块40的输出端，可为一级或多级减速器；在驱动模块40工作时，通过减速模块70降低驱动模块40的转速，从而减小驱动模块40的转矩，使得测量精度提高，从而满足对测量精度要求更高的测量系统的测量需求。
参照图8，图8为本发明基于螺旋电阻器的生物标志物的浓度测量装置第四实施例的结构示意图。
在上述本发明第一实施例的基础上，第四实施例中，基于螺旋电阻器的生物标志物的浓度测量装置还包括：
信号处理模块80，螺旋轨道电阻50的输出端与信号处理模块80的输入端电连接，信号处理模块80的输出端与控制模块30电连接，信号处理模块80用于对螺旋轨道电阻50的输出电阻值进行信号转换、信号放大和A/D转换。
本实施例中，信号处理模块80具体包括电阻电压信号转换单元、信号放大单元以及A/D转换单元：电阻电压信号转换单元用于将螺旋轨道电阻50的输出电阻值转换为对应的电压值；信号放大单元用于对转换后的电压值进行放大，放大倍数决定了整个系统的精度，信号放大单元中放大器的放大倍数要500倍以上，设计为多级滤波及放大，本实施例中采用的放大器线性区间为0.7v~3.6v；A/D转换单元采用数模转换器，用于对放大后的电压值进行模数转化，其中数模转换器的位数越高，测量精度越高，本实施例选用24位的数模转换器。具体的电路连接关系，本领域技术人员通过对本部分的描述，再结合所掌握的电路知识即可得出，在此不赘述。
本发明还提供一种基于螺旋电阻器的生物标志物的浓度测量方法。
参照图9，图9为本发明基于螺旋电阻器的生物标志物的浓度测量方法第一实施例的流程示意图。
在一实施例中，基于螺旋电阻器的生物标志物的浓度测量方法包括：
步骤S10，生物传感模块的光接收单元接收光源发射的特征光谱信号，并将经传感单元的抗体层与生物标志物中的抗原结合后的特征光谱信号反射至光谱接收模块；
步骤S20，光谱接收模块接收特征光谱信号，并将特征光谱信号发送至控制模块；
步骤S30，控制模块根据特征光谱信号控制驱动模块带动光谱接收模块和螺旋轨道电阻运动；
步骤S40，在驱动模块停止时，控制模块根据螺旋轨道电阻的输出电阻值确定特征光谱的位移偏移量，并根据位移偏移量确定生物标志物的浓度。
本实施例中，生物传感模块采用SPR（Surface Plasmon Resonance，表面等离子共振技术）生物传感器，生物传感模块包括光接收单元和传感单元，通过光接收单元接收来自光源的特定波长的入射光，该光接收单元为棱镜；传感单元用于结合生物标志物中的抗原，入射光经光接收单元接收后经过传感单元，经传感单元吸收后会发生一定程度的衰减，衰减后的入射光会反射出去，如生物标志物中的抗原与传感单元结合，则会引起表面物质质量改变，反射光会发生偏移。具体地，传感单元包括设置在光接收单元上的金属膜层，以及设置在金属膜层上的抗体层，该抗体层用于结合生物标志物中的抗原，金属膜层通常采用银膜或金膜，抗体层为能够与生物标志物中的各种类型的抗原结合的抗体，当液体中的生物标志物流经抗体层时，会与其上的相应抗体结合发生生物化学反应。
当入射光经过光接收单元接收，并经传感单元吸收后反射至光谱接收模块，当光谱接收模块位于初始位置时，对应螺旋轨道电阻的输出电阻值也为初始电阻值。随着特征光谱因待测物的变化而移动，光谱接收模块接收到的特征光谱信号的大小会发生改变，当控制模块判断出该特征光谱信号的大小超过预设范围时，生成相应控制信号，以控制驱动模块驱动光谱接收模块运动，直到光谱接收模块接收到的特征光谱信号的大小在预设范围内，即检测到特征光谱信号移动到最终位置，该位置为特征光谱信号的当前位置值。同时，驱动模块驱动螺旋轨道电阻运动以改变螺旋轨道电阻的输出电阻值，当特征光谱信号移动到最终位置时，螺旋轨道电阻停止运动，此时螺旋轨道电阻的当前的输出电阻值对应于特征光谱信号的当前位置值。控制模块根据螺旋轨道电阻的输出电阻值，以及输出电阻值与特征光谱信号的位置的对应关系，确定特征光谱信号的当前位置值，并进一步确定特征光谱的位移偏移量，然后根据特征光谱的位移偏移量与生物标志物的浓度的对应关系，确定生物标志物的浓度。
本实施例通过生物传感模块的光接收单元接收入射光，传感单元结合生物标志物中的抗原，光接收单元将反射光反射至光谱接收模块，在控制模块的控制下，驱动模块驱动光谱接收模块运动以确定特征光谱的最终位置，以及驱动螺旋轨道电阻运动以改变输出电阻；在确定了特征光谱的最终位置后，控制模块根据螺旋轨道电阻的输出电阻值确定特征光谱的位移偏移量，并根据位移偏移量确定生物标志物的浓度。根据螺旋轨道电阻的输出电阻值与生物标志物的浓度的对应关系确定生物标志物的浓度，避免了生物标志物本身的类型和干扰性物质的影响，从而提高了对生物标志物的浓度测量的精确度。
参照图10，图10为图9中S40的细化流程示意图。
在上述实施例中，步骤S40具体包括：
步骤S401，控制模块获取特征光谱的初始位置值及对应的初始电阻值，根据螺旋轨道电阻的输出电阻值与特征光谱的位置值的对应关系，确定特征光谱的当前位置值；
步骤S402，控制模块根据特征光谱的当前位置值以及特征光谱的初始位置值，确定特征光谱的位移偏移量；
步骤S403，控制模块根据特征光谱的位移偏移量与生物标志物浓度的对应关系，确定生物标志物的浓度。
在检测到特征光谱信号移动到最终位置时，控制模块获取特征光谱的初始位置值及对应的初始电阻值，根据螺旋轨道电阻的输出电阻值与特征光谱的位置值的对应关系，该对应关系为一线性关系，由于螺旋轨道电阻的当前的输出电阻值是已知的，因而可确定特征光谱的当前位置值，根据特征光谱的当前位置值以及特征光谱的初始位置值之间的距离，可确定特征光谱的位移偏移量；然后，根据特征光谱的位移偏移量与生物标志物浓度的对应关系，该对应关系也为一线性关系，由此便可确定生物标志物的浓度。
参照图11，图11为本发明基于螺旋电阻器的生物标志物的浓度测量方法第二实施例的流程示意图。
基于上述本发明基于螺旋电阻器的生物标志物的浓度测量方法第二实施例，第二实施例中，在执行步骤S40之前，该方法还包括：
步骤S50，信号转换模块对螺旋轨道电阻的输出电阻值进行信号转换、信号放大和A/D转换。
本实施例中，信号处理模块具体包括电阻电压信号转换单元、信号放大单元以及A/D转换单元。在螺旋轨道电阻将其输出电阻值输出后，信号处理模块通过其电阻电压信号转换单元将输出电阻值转换为对应的电压值，然后通过信号放大单元对转换后的电压值进行放大，放大倍数决定了整个系统的精度，信号放大单元中放大器的放大倍数要500倍以上，设计为多级滤波及放大，本实施例中采用的放大器线性区间为0.7v~3.6v；放大后的电压值经A/D转换单元进行模数转化，A/D转换单元采用数模转换器，本实施例选用24位的数模转换器，转换后的输出电阻值所对应的数字信号可供控制模块进一步确定被测对象的当前位置值。
以上仅为本发明的优选实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书及附图内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。

Claims (14)

  1. 一种基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述基于螺旋电阻器的生物标志物的浓度测量装置包括生物传感模块、光谱接收模块、控制模块、驱动模块和螺旋轨道电阻：
    所述生物传感模块包括光接收单元和传感单元；所述光接收单元用于接收和反射特征光谱信号，所述传感单元用于结合生物标志物中的抗原；
    所述光谱接收模块，与所述控制模块和驱动模块连接，用于接收所述光接收单元反射的特征光谱信号，并将所述特征光谱信号发送至所述控制模块；
    所述控制模块，与所述驱动模块电连接，用于根据所述特征光谱信号生成控制信号以控制所述驱动模块带动所述螺旋轨道电阻和所述光谱接收模块运动；以及，根据所述螺旋轨道电阻的输出电阻值确定所述特征光谱的位移偏移量，并根据所述位移偏移量确定所述生物标志物的浓度；
    所述螺旋轨道电阻，与所述驱动模块电连接，在所述驱动模块的驱动下运动以改变所述螺旋轨道电阻的输出电阻值。
  2. 如权利要求1所述的基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述螺旋轨道电阻包括电阻本体、电阻配合体和电阻指针：
    所述电阻本体表面设置有第一螺纹；所述电阻配合体套设在所述电阻本体上，所述电阻配合体设置有与所述第一螺纹适配的第二螺纹；所述电阻指针的第一端固定于所述电阻配合体上，所述电阻指针的第二端与所述第一螺纹的表面接触；
    所述电阻本体与所述驱动模块连接，在所述驱动模块的驱动下带动所述电阻配合体运动，所述电阻配合体带动所述电阻指针沿所述第一螺纹的表面移动，以改变所述螺旋轨道电阻的输出电阻值；
    所述光谱接收模块与所述电阻配合体连接，所述电阻本体在所述驱动模块的驱动下带动所述电阻配合体运动，以带动所述光谱接收模块运动。
  3. 如权利要求1所述的基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述传感单元包括设置在所述光接收单元上的金属膜层，以及设置在所述金属膜层上的抗体层，该抗体层用于结合生物标志物中的抗原。
  4. 如权利要求3所述的基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述螺旋轨道电阻包括电阻本体、电阻配合体和电阻指针：
    所述电阻本体表面设置有第一螺纹；所述电阻配合体套设在所述电阻本体上，所述电阻配合体设置有与所述第一螺纹适配的第二螺纹；所述电阻指针的第一端固定于所述电阻配合体上，所述电阻指针的第二端与所述第一螺纹的表面接触；
    所述电阻本体与所述驱动模块连接，在所述驱动模块的驱动下带动所述电阻配合体运动，所述电阻配合体带动所述电阻指针沿所述第一螺纹的表面移动，以改变所述螺旋轨道电阻的输出电阻值；
    所述光谱接收模块与所述电阻配合体连接，所述电阻本体在所述驱动模块的驱动下带动所述电阻配合体运动，以带动所述光谱接收模块运动。
  5. 如权利要求1所述的基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述控制模块具体用于：
    获取所述特征光谱的初始位置值及对应的初始电阻值，根据螺旋轨道电阻的输出电阻值与特征光谱的位置值的对应关系，确定所述特征光谱的当前位置值；
    根据所述特征光谱的当前位置值以及特征光谱的初始位置值，确定所述特征光谱的位移偏移量；
    根据所述特征光谱的位移偏移量与生物标志物浓度的对应关系，确定所述生物标志物的浓度。
  6. 如权利要求5所述的基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述螺旋轨道电阻包括电阻本体、电阻配合体和电阻指针：
    所述电阻本体表面设置有第一螺纹；所述电阻配合体套设在所述电阻本体上，所述电阻配合体设置有与所述第一螺纹适配的第二螺纹；所述电阻指针的第一端固定于所述电阻配合体上，所述电阻指针的第二端与所述第一螺纹的表面接触；
    所述电阻本体与所述驱动模块连接，在所述驱动模块的驱动下带动所述电阻配合体运动，所述电阻配合体带动所述电阻指针沿所述第一螺纹的表面移动，以改变所述螺旋轨道电阻的输出电阻值；
    所述光谱接收模块与所述电阻配合体连接，所述电阻本体在所述驱动模块的驱动下带动所述电阻配合体运动，以带动所述光谱接收模块运动。
  7. 如权利要求1所述的基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述基于螺旋电阻器的生物标志物的浓度测量装置还包括聚光模块，所述聚光模块设置于所述光谱接收模块的前端，用于聚集所述特征光谱信号。
  8. 如权利要求7所述的基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述螺旋轨道电阻包括电阻本体、电阻配合体和电阻指针：
    所述电阻本体表面设置有第一螺纹；所述电阻配合体套设在所述电阻本体上，所述电阻配合体设置有与所述第一螺纹适配的第二螺纹；所述电阻指针的第一端固定于所述电阻配合体上，所述电阻指针的第二端与所述第一螺纹的表面接触；
    所述电阻本体与所述驱动模块连接，在所述驱动模块的驱动下带动所述电阻配合体运动，所述电阻配合体带动所述电阻指针沿所述第一螺纹的表面移动，以改变所述螺旋轨道电阻的输出电阻值；
    所述光谱接收模块与所述电阻配合体连接，所述电阻本体在所述驱动模块的驱动下带动所述电阻配合体运动，以带动所述光谱接收模块运动。
  9. 如权利要求1所述的基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述基于螺旋电阻器的生物标志物的浓度测量装置还包括与所述驱动模块连接的减速模块，所述减速模块用于减小所述驱动模块转动的转速。
  10. 如权利要求1所述的基于螺旋电阻器的生物标志物的浓度测量装置，其特征在于，所述基于螺旋电阻器的生物标志物的浓度测量装置还包括信号处理模块，所述螺旋轨道电阻的输出端与所述信号处理模块的输入端电连接，所述信号处理模块的输出端与所述控制模块电连接，所述信号处理模块用于对所述输出电阻值进行信号转换、信号放大和A/D转换。
  11. 一种使用如权利要求1所述的基于螺旋电阻器的生物标志物的浓度测量装置的浓度测量方法，其特征在于，所述浓度测量方法包括如下步骤：
    生物传感模块的光接收单元接收光源发射的特征光谱信号，并将经传感单元的抗体层与生物标志物中的抗原结合后的所述特征光谱信号反射至光谱接收模块；
    光谱接收模块接收所述特征光谱信号，并将所述特征光谱信号发送至控制模块；
    控制模块根据所述特征光谱信号控制驱动模块带动光谱接收模块和螺旋轨道电阻运动；
    在驱动模块停止时，控制模块根据所述螺旋轨道电阻的输出电阻值确定所述特征光谱的位移偏移量，并根据所述位移偏移量确定所述生物标志物的浓度。
  12. 如权利要求11所述的基于螺旋电阻器的生物标志物的浓度测量方法，其特征在于，所述基于螺旋电阻器的生物标志物的浓度测量方法还包括步骤：
    信号转换模块对螺旋轨道电阻的输出电阻值进行信号转换、信号放大和A/D转换。
  13. 如权利要求11所述的基于螺旋电阻器的生物标志物的浓度测量方法，其特征在于，所述在驱动模块停止时，控制模块根据所述螺旋轨道电阻的输出电阻值确定所述特征光谱的位移偏移量，并根据所述位移偏移量确定所述生物标志物的浓度的步骤包括：
    控制模块获取所述特征光谱的初始位置值及对应的初始电阻值，根据螺旋轨道电阻的输出电阻值与特征光谱的位置值的对应关系，确定所述特征光谱的当前位置值；
    控制模块根据所述特征光谱的当前位置值以及特征光谱的初始位置值，确定所述特征光谱的位移偏移量；
    控制模块根据所述特征光谱的位移偏移量与生物标志物浓度的对应关系，确定所述生物标志物的浓度。
  14. 如权利要求13所述的基于螺旋电阻器的生物标志物的浓度测量方法，其特征在于，所述基于螺旋电阻器的生物标志物的浓度测量方法还包括步骤：
    信号转换模块对螺旋轨道电阻的输出电阻值进行信号转换、信号放大和A/D转换。
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000304505A (ja) * 1999-04-23 2000-11-02 Tatsumo Kk ポテンショメータ
CN101819136A (zh) * 2010-04-23 2010-09-01 天津大学 基于光纤表面等离子共振的人体葡萄糖浓度连续监测装置
CN103115883A (zh) * 2013-01-24 2013-05-22 重庆大学 微型生化检测仪样品检测系统
CN103604775A (zh) * 2013-07-04 2014-02-26 丹阳聚辰光电科技有限公司 基于微流体芯片的微生物检测仪器及其spr检测方法
CN204374070U (zh) * 2015-02-06 2015-06-03 深圳市易特科信息技术有限公司 高精度生物标志物的浓度测量装置

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
CN1198134C (zh) * 2003-06-04 2005-04-20 苏向东 胶体金免疫层析定量检测装置及定量检测方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000304505A (ja) * 1999-04-23 2000-11-02 Tatsumo Kk ポテンショメータ
CN101819136A (zh) * 2010-04-23 2010-09-01 天津大学 基于光纤表面等离子共振的人体葡萄糖浓度连续监测装置
CN103115883A (zh) * 2013-01-24 2013-05-22 重庆大学 微型生化检测仪样品检测系统
CN103604775A (zh) * 2013-07-04 2014-02-26 丹阳聚辰光电科技有限公司 基于微流体芯片的微生物检测仪器及其spr检测方法
CN204374070U (zh) * 2015-02-06 2015-06-03 深圳市易特科信息技术有限公司 高精度生物标志物的浓度测量装置

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