WO2016122752A1 - Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair - Google Patents
Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair Download PDFInfo
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- WO2016122752A1 WO2016122752A1 PCT/US2015/060893 US2015060893W WO2016122752A1 WO 2016122752 A1 WO2016122752 A1 WO 2016122752A1 US 2015060893 W US2015060893 W US 2015060893W WO 2016122752 A1 WO2016122752 A1 WO 2016122752A1
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Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
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EP15880628.1A EP3250139A4 (en) | 2015-01-28 | 2015-11-16 | Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair |
CA2972416A CA2972416C (en) | 2015-01-28 | 2015-11-16 | Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair |
BR112017016288-1A BR112017016288A2 (en) | 2015-01-28 | 2015-11-16 | method for stimulating activation of heat shock protein in tissue |
JP2017533207A JP6480588B2 (en) | 2015-01-28 | 2015-11-16 | Pulsed electromagnetic therapy and ultrasound therapy for stimulating targeted heat shock proteins and promoting protein repair |
AU2015380411A AU2015380411B2 (en) | 2015-01-28 | 2015-11-16 | Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair |
SG11201705677WA SG11201705677WA (en) | 2015-01-28 | 2015-11-16 | Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair |
CN201580074189.1A CN107205768B (en) | 2015-01-28 | 2015-11-16 | Pulsed electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and promoting protein repair |
Applications Claiming Priority (6)
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US14/607,959 | 2015-01-28 | ||
US14/607,959 US9168174B2 (en) | 2012-05-25 | 2015-01-28 | Process for restoring responsiveness to medication in tissue of living organisms |
US201562153616P | 2015-04-28 | 2015-04-28 | |
US62/153,616 | 2015-04-28 | ||
US14/922,885 | 2015-10-26 | ||
US14/922,885 US9427602B2 (en) | 2012-05-25 | 2015-10-26 | Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair |
Publications (1)
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WO2016122752A1 true WO2016122752A1 (en) | 2016-08-04 |
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PCT/US2015/060893 WO2016122752A1 (en) | 2015-01-28 | 2015-11-16 | Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair |
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EP (1) | EP3250139A4 (en) |
JP (2) | JP6480588B2 (en) |
CN (1) | CN107205768B (en) |
AU (1) | AU2015380411B2 (en) |
BR (1) | BR112017016288A2 (en) |
CA (2) | CA2972416C (en) |
SG (1) | SG11201705677WA (en) |
WO (1) | WO2016122752A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3496810A4 (en) * | 2016-08-09 | 2019-10-16 | Ojai Retinal Technology, LLC | Process for providing protective therapy for biological tissues or fluids |
CN110582238A (en) * | 2017-05-01 | 2019-12-17 | 奥哈伊视网膜技术有限责任公司 | System and method for treating myopia |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111343936B (en) * | 2017-11-15 | 2024-03-22 | 奥哈伊视网膜技术有限责任公司 | Method and system for treating biological tissue using energy |
US20210077190A1 (en) * | 2018-04-24 | 2021-03-18 | Centre National De La Recherche Scientifique | Generator and method for affecting biological tissue and cells using microwave-induced heat profiles |
CN112494135A (en) * | 2020-11-20 | 2021-03-16 | 毕勇 | Laser thermoforming treatment device for bronchial asthma |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5348002A (en) * | 1992-04-23 | 1994-09-20 | Sirraya, Inc. | Method and apparatus for material analysis |
US20100049180A1 (en) * | 2007-10-19 | 2010-02-25 | Lockheed Martin Corporation | System and method for conditioning animal tissue using laser light |
US20100092424A1 (en) * | 2007-11-21 | 2010-04-15 | Sanghvi Narendra T | Method of diagnosis and treatment of tumors using high intensity focused ultrasound |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US6640139B1 (en) * | 1998-10-20 | 2003-10-28 | Dornier Medtech Holding International Gmbh | Thermal therapy with tissue protection |
JP2001104334A (en) * | 1999-10-08 | 2001-04-17 | Olympus Optical Co Ltd | Medical system |
GB0422525D0 (en) * | 2004-10-11 | 2004-11-10 | Luebcke Peter | Dermatological compositions and methods |
JP2008109954A (en) * | 2006-10-27 | 2008-05-15 | Matsushita Electric Works Ltd | Capsule type imaging apparatus |
US8141557B2 (en) * | 2008-10-22 | 2012-03-27 | Peyman Gholam A | Method of oscillatory thermotherapy of biological tissue |
US10219947B2 (en) * | 2012-05-25 | 2019-03-05 | Ojai Retinal Technology, Llc | System and process for retina phototherapy |
CN110251839A (en) * | 2012-09-10 | 2019-09-20 | 真皮光子公司 | The medical device of dermatology |
US9333371B2 (en) * | 2012-11-01 | 2016-05-10 | Seminex Corporation | Variable intensity laser treatments of the skin |
-
2015
- 2015-11-16 CN CN201580074189.1A patent/CN107205768B/en active Active
- 2015-11-16 JP JP2017533207A patent/JP6480588B2/en active Active
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-
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5348002A (en) * | 1992-04-23 | 1994-09-20 | Sirraya, Inc. | Method and apparatus for material analysis |
US20100049180A1 (en) * | 2007-10-19 | 2010-02-25 | Lockheed Martin Corporation | System and method for conditioning animal tissue using laser light |
US20100092424A1 (en) * | 2007-11-21 | 2010-04-15 | Sanghvi Narendra T | Method of diagnosis and treatment of tumors using high intensity focused ultrasound |
Non-Patent Citations (1)
Title |
---|
See also references of EP3250139A4 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3496810A4 (en) * | 2016-08-09 | 2019-10-16 | Ojai Retinal Technology, LLC | Process for providing protective therapy for biological tissues or fluids |
CN110582238A (en) * | 2017-05-01 | 2019-12-17 | 奥哈伊视网膜技术有限责任公司 | System and method for treating myopia |
JP2020518317A (en) * | 2017-05-01 | 2020-06-25 | オーハイ レチナル テクノロジー,エルエルシー | Systems and processes for treatment of myopia |
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AU2015380411B2 (en) | 2019-03-14 |
SG11201705677WA (en) | 2017-08-30 |
CN107205768B (en) | 2020-06-16 |
JP6778772B2 (en) | 2020-11-04 |
CA3063889C (en) | 2023-03-14 |
EP3250139A1 (en) | 2017-12-06 |
JP2019108334A (en) | 2019-07-04 |
CA2972416C (en) | 2020-01-14 |
AU2015380411A1 (en) | 2017-07-20 |
BR112017016288A2 (en) | 2018-03-27 |
CN107205768A (en) | 2017-09-26 |
CA3063889A1 (en) | 2016-08-04 |
EP3250139A4 (en) | 2018-06-27 |
JP2018503434A (en) | 2018-02-08 |
JP6480588B2 (en) | 2019-03-13 |
CA2972416A1 (en) | 2016-08-04 |
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