WO2016117462A1

WO2016117462A1 - Tracheal tube

Info

Publication number: WO2016117462A1
Application number: PCT/JP2016/051102
Authority: WO
Inventors: 秀彬柴田; 祐亮百貫
Original assignee: テルモ株式会社
Priority date: 2015-01-22
Filing date: 2016-01-15
Publication date: 2016-07-28
Also published as: JP6598801B2; JPWO2016117462A1

Abstract

Provided is a tracheal tube that includes a leading end part provided on the lung side within the trachea, a base end part provided on the side opposite the leading end part, and a tube body having a respiratory pathway that passes from the base end part through to the leading end part. A micro structure region is provided at least at a part of the inner surface that forms the respiratory pathway of the tube body, and the micro structure region has a micro structure surface on which a plurality of micro characteristic parts are disposed, thereby making it difficult for sputum to adhere thereto.

Description

Tracheal tube

The present invention relates to a tracheal tube. More particularly, the present invention relates to a tracheal tube such as a tracheostomy tube or an endotracheal tube.

As a method for securing the airway of a patient who needs to secure the airway, tracheal intubation, which is a method of inserting a tracheal tube called an endotracheal tube into the trachea from the mouth or nose through the pharynx to the trachea, Tracheostomy (surgical trachea) is a method in which tracheostomy tubes called tracheostomy tubes are inserted into the trachea from the incision through the skin of the trachea and the upper part of the trachea when the intubation is prolonged or when tracheal intubation is impossible Incision) If the airway is urgently needed, annular thyroid incision is a method of inserting the tracheal cannula by incising the annular thyroid (annular thyroid ligament), and inserting the tracheal cannula by puncturing the annular thyroid An example is a ring-shaped thyroid puncture.

However, since the trachea is stimulated by inserting the tracheal tube into the trachea, the amount of sputum and other secretions increases, causing constriction / occlusion of the tracheal tube and causing dyspnea / suffocation There is a fear. Although wrinkles are normally discharged by ciliary movement of the trachea, wrinkles are likely to adhere because the tracheal tube has no cilia. Therefore, the sputum in the tracheal tube must be periodically sucked to prevent the tracheal tube from becoming constricted and not blocked. The salmon is mainly composed of water and glycoprotein (mucin), and the viscosity is as wide as several hundred to several hundred thousand cP. The higher the viscosity, the easier it will adhere to the tracheal tube, Residue is likely to appear. The soot left behind in the tracheal tube may dry out and become more likely to adhere. The removal of sputum from the tracheal tube must be performed frequently and must be carefully aspirated so that it is left as little as possible, so the burden on the nurse / caregiver is great.
Therefore, there is a demand for a tracheal tube that does not easily adhere soot.

For example, Patent Document 1 discloses that a coating film, which is composed of a mixture of a methyl vinyl ether maleic anhydride copolymer and a fluorine-containing / acrylic / urethane / silicone resin, that exhibits surface lubricity when wet is formed on the inner surface of the tube. Describes a tracheostomy tube in which foreign substances such as sputum are less likely to accumulate. Further, Patent Document 2 discloses that one or more layers of metal oxide particles or the like are deposited on the inner surface (lumen) surface of the airway tube to roughen the surface, and a low surface energy material such as a fluorocarbon polymer (that is, a fluorocarbon polymer) The formation of a superhydrophobic surface region by applying a coating consisting essentially of hydrophobic).

International Publication No. 2006/037626 International Publication No. 2006/135755

However, as far as the present inventors have studied, the tracheal (airway) tubes described in

Patent Documents

1 and 2 have not achieved soot adhesion suppression at the level required recently, and there is room for improvement. It was found that it was left.
Then, this invention makes it a subject to provide the tube for tracheas to which a soot does not adhere easily.

As a result of intensive studies to solve the above-mentioned problems, the present inventors have provided a microstructure region on at least a part of the inner surface forming the respiratory path of the tube body in the tracheal tube, It has been found that having a microstructure surface on which a plurality of micro features are arranged can provide a tube for trachea to which wrinkles are difficult to adhere, and the present invention has been completed.
That is, it has been found that the above problem can be solved by the following configuration.

(1) A trachea comprising a distal end portion provided on the lung side in the trachea, a proximal end portion provided on the opposite side of the distal end portion, and a tube body having a breathing path penetrating from the proximal end portion to the distal end portion. In the tube,
A microstructure region is provided on at least a part of the inner surface forming the breathing path of the tube body,
The microstructure region is a tracheal tube having a microstructure surface on which a plurality of micro features are disposed.
(2) The microstructure region consists of extrusion molding, injection molding, cutting, laser processing, surface processing using a core rod, particle coating, nanoimprinting, solvent treatment, plasma sputtering, nanowire array deposition, and combinations thereof. The tracheal tube according to (1), wherein micro features formed using a method selected from the group are arranged.
(3) The microstructure region is a flexible substrate having at least a portion bent, curved, compressed, stretched, expanded, and / or distorted, and has a plurality of micro features disposed therein. The tracheal tube according to (1), wherein a substrate having a surface is disposed on an inner surface forming a respiratory path of the tube body so that the microstructure surface is exposed to the respiratory path.
(4) The tracheal tube according to any one of (1) to (3), wherein the microstructure surface is a repellent surface.
(5) The tracheal tube according to any one of (1) to (4), wherein the dimension of the micro feature is selected from a range of 10 nm to 1000 μm.
(6) The tracheal tube according to any one of (1) to (5), wherein the pitch between the micro features is selected from a range of 10 nm to 1000 μm.
(7) a plurality of microfeatures comprising a first set of microfeatures having a first set of dimensions and a second set of microfeatures having a second set of dimensions; The tracheal tube according to any one of (1) to (6), which is different from the two sets of dimensions.
(8) The tracheal tube according to (7), wherein the first set of dimensions is selected from a range of 10 nm to 1 μm, and the second set of dimensions is selected from a range of 1 μm to 100 μm.
(9) The tracheal tube according to any one of (1) to (8), further comprising a coating on the plurality of micro features.
(10) The tracheal tube according to (9), wherein the coating contains particles having a size selected from the range of 1 to 100 nm.
(11) The tracheal tube according to any one of (1) to (10), wherein the tube body has a curved portion between a distal end portion and a proximal end portion.
(12) The tracheal tube according to (11), which is a tracheostomy tube.
(13) The tracheal tube according to (11), which is an endotracheal tube.
(14) The tracheal tube according to (11), which is a double-tube tracheotomy tube.
(15) The tracheal tube according to (11), which is an inner tube of a double-tube tracheotomy tube.
(16) The tracheal tube according to (11), which is a tracheal cannula that can be inserted into the trachea through a puncture hole or an incision hole in a ring-shaped thyroid membrane.
(17) The tracheal tube according to (16), which is a tracheal cannula that can puncture the annular thyroid membrane.
(18) The tracheal tube according to (16) or (17), which is a small tracheostomy tube.
(19) The angle between the central axis of the distal end portion and the central axis of the proximal end portion of the curved portion can be changed within a range of ± 45 °, according to any one of (11) to (18) Tube for trachea.
(20) In a cross-sectional view orthogonal to the central axis of the tube body, a plane passing through the center of the tube body at each of the base end portion, the distal end portion, and the bending portion is a plane P, and the plane P is outside the curve of the bending portion of the tube body The intersection point intersecting the inner surface of the tube wall located at the intersection point B is the intersection point B, the reference line perpendicular to the plane P at the intersection point B is the reference line S, the tangent line in contact with the inner peripheral surface of the tube body 102 is the tangent line T, The film according to any one of (11) to (19), wherein the coating is disposed at a position on the inner peripheral surface of the tube body where the angle φ is 30 ° or more when the angle formed with S is the angle φ. Tube for trachea. However, the angle φ is an acute angle or a right angle formed by the reference line S and the tangent line T.

ADVANTAGE OF THE INVENTION According to this invention, the tube for tracheas which a wrinkle cannot adhere easily can be provided.
In addition, by using the tracheal tube of the present invention, it is possible to reduce the frequency of sucking and removing wrinkles adhering to the tracheal tube, so that the burden on the patient and caregiver can be reduced.

FIG. 1 is a diagram illustrating an exemplary microstructured surface comprising a substrate and a plurality of microfeatures. FIG. 2 is a flow diagram of an exemplary method embodiment for creating a repellent surface. FIG. 3 is a view showing a state in which the tracheostomy tube according to the first embodiment of the present invention is attached to a patient. FIG. 4A is a cross-sectional view showing a main part of the tracheostomy tube according to the first embodiment of the present invention shown in FIG. FIG. 4B is a cross-sectional view taken along the line AA shown in FIG. FIG. 4C is a partially enlarged cross-sectional view of the microstructure region. FIG. 4 (D) is a cross-sectional view showing a state in which wrinkles adhering to the inside of the tracheostomy tube according to the first embodiment of the present invention are sucked. FIG. 4E is a partially enlarged cross-sectional view of another embodiment of the microstructure region. FIG. 5A is a cross-sectional view showing a modified example of the tracheostomy tube according to the first embodiment of the present invention. 5B and 5C are cross-sectional views taken along the line BB shown in FIG. 5A. FIG. 6A is a cross-sectional view showing the main part of a tracheostomy tube according to the second embodiment of the present invention. FIG. 6B is a cross-sectional view taken along the line CC shown in FIG. FIG. 6C is a cross-sectional view showing a modified example of the tracheostomy tube according to the second embodiment. FIG. 7A is a cross-sectional view showing the main part of a tracheostomy tube according to the third embodiment of the present invention. FIG. 7B is a cross-sectional view taken along the line DD shown in FIG. FIG. 7C is a cross-sectional view showing a modification of the tracheostomy tube according to the third embodiment. FIG. 8A is a cross-sectional view showing the main part of a tracheostomy tube according to the fourth embodiment of the present invention. FIG. 8B is a cross-sectional view taken along line EE shown in FIG. FIG. 9 is a view showing a state in which an endotracheal tube according to a fifth embodiment of the present invention is attached to a patient. FIG. 10A is a perspective view showing a configuration example of an endotracheal tube according to the fifth embodiment of the present invention. FIG. 10B is a cross-sectional view taken along the line FF shown in FIG. FIG. 11 is a view showing a state in which a tracheal cannula according to a sixth embodiment of the present invention is attached to a patient. FIG. 12 is a view showing a state in which a tracheal cannula according to a seventh embodiment of the present invention is attached to a patient. FIG. 13 is a scanning electron microscope image of the surface of a lotus leaf (Barthlott, W. and Neinhuism, C., April 1997, “The purity of sacred lotus or escape from contamination in biological surfaces”, Planta, 202, No. 1, p. 1-8, doi: 10.1007 / s004250050096W.). FIG. 14 shows a surface roughened by micromachining techniques, showing the change in contact angle of a droplet on the surface. FIG. 14A shows the contact angle θ of the surface before rough surface finishing, and FIG. 14B shows the contact angle θ ^* of the surface after rough surface finishing. FIG. 15 shows a droplet on the surface in Wenzel or Cassie-Baxter state. FIG. 15A represents a droplet on the surface in the Wenzel state, and FIG. 15B represents a droplet on the surface in the Cassie-Baxter state. FIG. 16 shows a convexly curved microstructure surface and droplets on the convexly curved microstructure surface. FIG. 16 (A) represents a convexly curved microstructure surface, and FIG. 16 (B) represents a convexly curved microstructure surface and a droplet thereon. FIG. 17 is a diagram illustrating a concavely curved microstructure surface and a droplet on a concavely curved microstructure surface. FIG. 17A represents a concavely curved microstructure surface, and FIG. 17B represents a concavely curved microstructure surface and a droplet thereon. FIG. 18 shows droplets on the non-microstructure surface and on the microstructure surface. FIG. 18A shows a droplet on a non-microstructure surface, and the contact angle of the surface with respect to the droplet is θ. FIG. 18B is a diagram illustrating a droplet on a microstructure surface in a Wenzel state, and the contact angle of the surface with respect to the droplet is θ _W ^* . FIG. 18C shows a droplet on the microstructure surface in the Cassie-Baxter state, and the contact angle of the surface with respect to the droplet is θ _CB ^* . FIG. 19 is a diagram showing the change in pitch of the micro features for convex and concave surfaces. FIG. 19A shows the case where the surface of the microstructure is curved with a positive curvature, and shows that the interval (pitch) between the micro features is widened. FIG. 19B shows a case where the surface of the microstructure is curved with a negative curvature, and the interval (pitch) between the micro features is narrowed. FIG. 20 is a diagram showing a change in pitch of the silicone micro pillar. FIG. 20A represents a flat polydimethylsiloxane (PDMS) surface and PDMS micropillars disposed on it with a pitch of 24.4 μm. FIG. 20B shows a PDMS surface that is curved with a curvature of + 0.11 / mm and PDMS micro-pillars arranged on the surface with a pitch of 26.2 μm in the bending direction. The pitch in the bending direction increased from 24.4 μm to 26.2 μm (prediction = 25.5 μm). FIG. 20 (C) shows a PDMS surface curved with a curvature of −0.22 / mm and PDMS micro-pillars arranged thereon with a pitch of 20.7 μm in the bending direction. The pitch in the bending direction was narrowed from 24.4 μm to 20.7 μm (prediction = 22.1 μm). FIG. 21 presents a model that shows the pitch versus critical curvature of Cassy-Baxter droplets on the surface for various microfeature heights. FIG. 22 shows the curvature of a curved repellency / superhydrophobic surface (Curvature, 1 / mm) and water droplets (Water) or droplets of a 40/60 glycerin / water mixture by weight (Glyc / wat). It is the graph which plotted the relationship with the predicted value (Predicted) or measured value (Expt) of the contact angle (Contact Angle, degree) of a repellent and superhydrophobic surface. FIG. 23 presents data indicating the angle of inclination (Slide Angle, degrees) that causes slip on a microstructured PDMS surface with various microstructure heights as a function of curvature (Curvature, 1 / mm). It is a figure to do. FIG. 23A is a graph relating to water (Water), and FIG. 23B is a graph relating to a 40/60 glycerin / water mixture (40/60 Glycerol / Water) by weight. FIG. 24 is a graph showing modeling results for a column having a diameter of 5 μm and a pitch of 8 μm in the case of a droplet having an original contact angle θ of 100 °. FIG. 25 is a graph showing modeling results for the transition between the Cassie-Baxter state and the Wenzel state.

[Definition of terms]
The terms and phrases used herein have their art-recognized meanings and can be understood by reference to standard documents, journal references, and contexts known to those skilled in the art. In order to clarify certain uses in the context of the present invention, the following definitions are presented.
“Kashi” is a type of mucus and is a viscous fluid that is secreted from mucous membranes such as the trachea and has a slimy nature. ) And viscoelasticity (such as rubber, it stretches when it is grabbed and lifted, returns to its original shape when released, and breaks when stretched more than a certain amount). Examples of the main components of koji include water and glycoproteins such as mucin.
The “repellency” refers to the property of repelling wrinkles. As a result of repelling wrinkles, wrinkles are less likely to adhere to the inside of the tracheal tube (the inner peripheral surface of the tube body). Moreover, the stringing property of the cocoon can be suppressed. The repellency surface is a surface on which the wrinkle moves when an inclination angle is set to 30 ° and 100 μL of the wrinkle is dropped on the surface.
“Superhydrophobic” refers to a material property in which a liquid, eg, water, does not wet the surface of the material too much. In certain embodiments, superhydrophobicity refers to a material property having a liquid contact angle of greater than 120 °, such as greater than 130 °, greater than 140 °, greater than 150 °, greater than 160 °, or greater than 170 °. .
“Stand-alone” refers to an article that is not attached to another article, eg, a surface or substrate. In certain embodiments, a stand-alone film includes multiple layers, such as a flexible polymer layer and an adhesive layer.
“Single unit”, “single member” and “monolithic” refer to an article or element consisting of a single member of the same material.
“Microfeatures” and “microstructures” are features on an article surface that have an average width, depth, length and / or thickness selected from 100 μm or less, or from 10 nm to 100 μm. Point to.
“Preselected pattern” refers to the organization, design, or composition of the designed article. For example, a preselected pattern of microstructures can refer to an ordered array of micro features. In one embodiment, the preselected pattern is not a random and / or statistical pattern.
“Pitch” refers to the spacing between articles. Pitch refers to the average spacing between multiple articles, the spacing between the center and / or edge of the article, and / or the spacing between specific parts of the article, for example, the tip, point, and / or end of the article. Can point.
“Wettability” refers to the affinity of a surface for a liquid. “Hydrophilic” refers to the degree of attractiveness of a surface to a liquid. “Hydrophobic” refers to the degree of repulsion of a surface against a liquid. In some embodiments, surface wettability, hydrophilicity, and / or hydrophobicity are referred to relative to the liquid contact angle on the surface. The terms “wetting”, “hydrophilic”, and “liquid affinity” are used interchangeably herein to refer to a liquid-surface contact angle of less than 90 °. The terms “non-wetting”, “hydrophobic” and “liquid non-affinity” are used interchangeably herein to refer to a contact angle between a liquid and a surface of greater than 90 °. In some embodiments, the affinity of the surface is different for different liquids, and in these embodiments, the surface is simultaneously made liquid non-affinity and liquid affinity, depending on the reference liquid. Can do.
“Contact angle” refers to the angle at which the interface between the liquid and the gas contacts the solid.
“Flexible” refers to the ability of an article to reversibly deform when deformed, for example, so that the article does not suffer damage characterized by breakage, breakage, or inelastic deformation.

[Tracheal tube]
The tracheal tube of the present invention is made of a material having a distal end portion provided on the lung side in the trachea, a proximal end portion provided on the opposite side of the distal end portion, and a respiratory path penetrating from the proximal end portion to the distal end portion. In the tracheal tube including the tube body, a micro structure region is provided on at least a part of the inner surface forming the breathing path of the tube body, and the micro structure region has a micro structure surface on which a plurality of micro features are arranged. It is characterized by having.

<Microstructure area>
The microstructure region is provided on at least a part of the inner surface forming the respiratory path of the tube body provided in the tracheal tube of the present invention. Further, the microstructure region has a microstructure surface on which a plurality of micro features are disposed.

In the tracheal tube of the present invention, the microstructure region may be provided on at least a part of the inner surface forming the respiratory path of the tube body, but may be provided on any surface of the tracheal tube of the present invention. Good. In particular, the microstructure region is preferably provided on the surface of the tracheal tube of the present invention that is easily in contact with the heel.

In the microstructure region, a plurality of micro features may be directly arranged, or a flexible substrate having a microstructure surface on which the plurality of micro features are arranged. The surface opposite to the microstructure surface may be laminated toward the microstructure region.

<Microstructure surface>
Hereinafter, the microstructure surface and the micro feature will be described in detail.

FIG. 1 illustrates an exemplary embodiment of a microstructure surface. The microstructure surface 10 shown in FIG. 1 has a micro feature 12 disposed on the surface of a substrate (base material) 11. The microfeature 12 of this embodiment has a circular cross-sectional shape with a diameter 13. Also shown is the pitch 14 between the centers of the microfeatures 12 and the height 15 of the microfeatures 12 on the microstructured surface 10 shown in FIG.

At least a portion of the microstructure surface may be curved, bent, compressed, stretched, expanded, distorted, and / or deformed. The radius of curvature of at least a portion of the curved and / or bent microstructure surface is not particularly limited, but is preferably selected from the range of 1 mm to 1,000 m. At least a portion of the compressed microstructured surface is preferably compressed to a level of 1% to 100% of the original size. At least a portion of the stretched or expanded microstructure surface is preferably expanded or stretched to a level of 100% to 500% of the original size. The strain level of at least a portion of the distorted microstructure surface is preferably selected from the range of −99% to 500%.

The microstructured surface may be a curved surface, for example, one that is flexible to match the contour of the article or structure. For example, the surface of the flexible substrate (substrate) on which the microfeatures are arranged may be a curved surface, for example a surface having one or more concave and / or convex regions. Good. Also, for example, the surface located opposite the microfeatures of the substrate (base material) having a flexible microstructured surface and optionally a surface having an adhesive layer may be a curved surface, eg one or more Or a surface having concave and / or convex regions. The flexible substrate (base material) may be substantially flat. Furthermore, the flexible substrate (base material) may include a surface having a combination of a substantially planar region and a curved region. The microstructured surface may include folds, folds, or otherwise inelastically deformed regions that are shaped such that the microstructured surface conforms to a cornered article or is deformed. It is configured so that it can be introduced.

The micro feature and the substrate (base material) may be composed of a single member, for example, a monolithic structure having the micro feature as an integral component of the substrate (base material). For example, a micro-structured surface may be integrally formed as part of the substrate (base material) itself, extending from the surface of the substrate (base material), and optionally having the same composition as the substrate (base material). It may be a flexible film or a flexible substrate having a microstructured surface. The micro feature and the substrate (base material) may be configured as a component integrated with a component of the tracheal tube.

The dimension of the micro feature is preferably selected from the range of 10 nm to 1000 μm. The length, height, diameter, and / or width of the microfeature is preferably selected from the range of 10 nm to 1000 μm, more preferably from the range of 10 nm to 100 μm. The pitch between the micro features is preferably selected from the range of 10 nm to 1000 μm, more preferably selected from the range of 1 μm to 1000 μm, and even more preferably selected from the range of 10 μm to 1000 μm.

The plurality of microfeatures have a physical dimension of a multimodal distribution, for example, a bimodal distribution height, and / or a bimodal distribution diameter, and / or a bimodal distribution microstructure pitch. It may be. For example, the plurality of microfeatures may include a first set of microfeatures having a first set of dimensions and a second set of microfeatures having a second set of dimensions. The first set and the second set may have different dimensions. The first set of dimensions is preferably selected from the range of 10 nm to 10 μm, and the second set of dimensions is preferably selected from the range of 10 μm to 1000 μm.

The microfeature may be any cross-sectional shape, for example, circular, oval, triangular, square, rectangular, polygonal, star, hexagonal, letter shape, number shape, mathematical symbol shape, etc. You may have the cross-sectional shape containing arbitrary combinations of these. Here, the cross-sectional shape refers to the cross-sectional shape of the microstructure in a plane parallel to the plane of the flexible substrate (base material).

The microstructure surface may include micro features having a preselected pattern. The preselected pattern may be a regular array of micro features. The preselected pattern also includes several regions where the microfeatures have a first pitch, and several regions where the microfeatures have a second pitch, eg, a pitch greater than the first pitch. May be included.

A microfeature having a preselected pattern includes a region where the microfeature has a first cross-sectional shape and a region where the microfeature has a second cross-sectional shape, eg, a cross-sectional shape different from the first cross-sectional shape; May be included. The preselected pattern of microfeatures may include regions where the microfeatures have a plurality of cross-sectional shapes and / or sizes. A preselected pattern of microfeatures may refer to microfeatures of two or more cross-sectional shapes and / or sizes in two or more arrays. Two or more arrays can be arranged in parallel, ie, the two arrays do not overlap. In another specific embodiment, two or more arrays can be arranged to overlap, and microfeatures having two or more cross-sectional shapes and / or sizes are interspersed in the overlapping arrays.

The microfeatures of the preselected pattern may include microfeatures of a plurality of dimensions, for example, a bimodal or multimodal distribution of dimensions. For example, a first group of micro features having a dimension selected from 10 nm to 1 μm and a second group of micro features having a dimension selected from 1 μm to 100 μm. May be included. Also, the size, shape, and arrangement of the microfeatures may be preselected with micrometer scale or nanometer scale accuracy and / or precision.

The microfeature may include particles having dimensions selected from the range of 1-100 nm. The surface of the flexible substrate (base material) and / or the microfeature may be provided with a coating, for example a coating comprising particles having a dimension selected from the range of 1 to 100 nm. These particles provide an additional level of roughness on the nanometer scale to the surface of a flexible substrate (substrate), increasing surface repellency, hydrophobicity, and / or changing surface energy. To do.

The micro features of the preselected pattern may be designed to give the surface certain physical properties. For example, an ordered array of microfeatures can impart repellency and superhydrophobicity to the surface of the article. The physical properties that can be adjusted and imparted by the microfeatures of the preselected pattern are not particularly limited, but include, for example, repellency; hydrophobicity; hydrophilicity; self-cleaning ability; fluid resistance coefficient and / or air resistance coefficient; Visual effects such as prism effect, specific color, and direction-dependent color change; haptic effect; gripping force; surface friction coefficient.

The repellency, hydrophobicity, wettability, and / or hydrophilicity of the microstructure surface can be controlled. For example, as the flexible substrate (substrate) is deformed by bending, bending, expanding, or reducing the substrate (substrate), the repellency, hydrophobicity, wettability, and / or hydrophilicity of the surface Sex changes. In another embodiment, the surface repellency, hydrophobicity, wettability, and / or hydrophilicity remain constant when the flexible substrate (substrate) deforms. Furthermore, when the flexible substrate (base material) deforms, the surface repellency, hydrophobicity, wettability, and / or hydrophilicity remain constant for a portion of the surface, The surface wettability may vary for other parts of the surface. The contact angle of water droplets on the surface may change as the flexible substrate (base material) deforms, or may remain constant.

The contact angle of water droplets on the microstructure surface is preferably more than 120 °, more preferably more than 130 °, 140 °, 150 °, 160 ° or 170 °.

The microstructure surface may contain a polymer. The polymer is not particularly limited. For example, PDMS (polydimethylsiloxane), PMMA (polymethyl methacrylate), PTFE (polytetrafluoroethylene), polyurethane, Teflon (registered trademark), polyacrylate, poly Arylate, thermoplastic material, thermoplastic elastomer, fluoropolymer, biodegradable polymer, polycarbonate, polyethylene, polyimide, polystyrene, polyvinyl, polyolefin, silicone, natural rubber, synthetic rubber, and combinations of two or more of these .

The microstructure surface may contain a metal. Metal includes any metal or alloy that is moldable, castable, embossable, and / or stampable. The metal is not particularly limited. For example, aluminum, aluminum alloy, bismuth, bismuth alloy, tin, tin alloy, lead, lead alloy, titanium, titanium alloy, iron, iron alloy, indium, indium alloy Gold, gold alloy, silver, silver alloy, copper, copper alloy, brass, nickel, nickel alloy, platinum, platinum alloy, palladium, palladium alloy, zinc, zinc alloy, cadmium, cadmium alloy and the like.

The microstructured surface may include industrial materials derived from animals and / or plants, such as materials including carbohydrates, cellulose, lignin, sugars, proteins, fibers, biopolymers, and / or starch. Plant and / or animal derived industrial materials include, but are not limited to, for example, paper; cardboard; textiles, such as wool, linen, cotton, or leather; bioplastics; solid biofuels or biomass, such as Sawdust, flour, or charcoal; and construction materials such as wood, fiberboard, linoleum, cork, bamboo, hardwood and the like.

The microstructure surface may include a composite material. For example, the microstructured surface can include two or more different materials, layers, and / or components.

The microstructure surface may comprise a coating covering them on a plurality of micro features. The coating is not particularly limited, and examples thereof include fluorinated polymers, fluorinated hydrocarbons, silanes, thiols, and combinations of two or more thereof. The microstructure surface may be surface treated. The surface treatment method is not particularly limited, and examples thereof include curing, cooking, annealing, chemical treatment, chemical coating, painting, coating, plasma treatment, and combinations of two or more of these.

<Production method of microstructure surface>
FIG. 2 illustrates an exemplary embodiment for creating a microstructured surface.
The flow diagram shown in FIG. 2 begins with a substrate (base material) 21 with a photosensitive polymer or resist 22 sensitive to light or particles on top. By applying light 24 to the resist 22 through the stencil mask 23, the micro feature 25 can be formed in the resist. In other embodiments, other types of electromagnetic waves, energy beams, or particles are used to form these micro-features or nano-features.
At this stage, the resist 22 having the recess 26 of the formed micro feature 25 is used as a mold. The microfeatures 25 can also be modified by processing the substrate (base material) 21 (eg by chemical etching). In some embodiments, the surface is coated with a drug to facilitate or improve subsequent molding steps.
Uncured polymer 27 is molded into microfeatures 25 and cured by heat, time, ultraviolet light, or other curing methods. When the cured polymer 28 is removed from the substrate (base material) -resist mold, features from the mold are transferred to the cured polymer 28.

The micro features on the surface of the microstructure may be made by duplicating from a lithography patterned mold. Microfeatures may be replicated directly from a lithographically patterned mold (first generation duplication) or from a mold that has microfeatures replicated from a lithographically patterned mold Good (second generation replication). Further, the microfeature may be a third or subsequent generation that replicates a lithographically patterned master feature.

An example of a method for producing the microstructure surface on the surface of the article will be described, but the method for producing the microstructure surface on the article surface is not limited to this method, and various methods can be used. The method comprises the steps of providing an article and a microstructured surface comprising a flexible substrate (substrate) having a plurality of microfeatures disposed on the surface and an adhesive layer disposed on the opposite surface And attaching the microstructured surface to the surface of the article. As the substrate (base material) having flexibility, a polymer substrate (base material) is preferable. As the polymer, those described above can be preferably used.

<Control method for repellency, superhydrophobicity, etc. of microstructure surface>
A method for controlling the repellency, superhydrophobicity and / or wettability of a surface including a flexible substrate (base material) provided with a plurality of micro features will be described. The method includes the steps of (i) providing a flexible substrate (base material) provided with a plurality of micro features, and (ii) deforming the flexible substrate (base material), Thereby controlling the repellency, superhydrophobicity and / or wettability of the surface. The step of deforming the flexible substrate (base material) includes bending the flexible substrate (base material), bending the flexible substrate (base material), and bending the flexible substrate (base material). This can be realized by expanding the material), stretching the flexible substrate (base material), and / or compressing the flexible substrate (base material). In one embodiment, the step of deforming the flexible substrate (base material) optionally includes changing the pitch between at least a portion of the microfeatures by a value selected from the range of, for example, 10 nm to 1000 μm. , By selectively increasing or decreasing by a value selected from the range of 100 nm to 100 μm.

A method for controlling the repellency and superhydrophobicity of the microstructure surface will be described. The method includes providing a microstructured surface and deforming the microstructured surface, thereby controlling the repellency and superhydrophobicity of the surface. In this method, the microstructure surface comprises a flexible substrate (base material) provided with a plurality of micro features. The flexible substrate (base material) may include a polymer and / or a metal.
Examples of the polymer include, but are not limited to, PDMS (polydimethylsiloxane), PMMA (polymethyl methacrylate), PTFE (polytetrafluoroethylene), polyurethane, Teflon (registered trademark), polyacrylate, poly Arylate, thermoplastic material, thermoplastic elastomer, fluoropolymer, biodegradable polymer, polycarbonate, polyethylene, polyimide, polystyrene, polyvinyl, polyolefin, silicone, natural rubber, synthetic rubber, and combinations of two or more of these .
The metal is not particularly limited as long as it is any metal or alloy that is moldable, castable, embossable, and / or stampable, for example, aluminum, aluminum alloy, bismuth, bismuth alloy , Tin, tin alloy, lead, lead alloy, titanium, titanium alloy, iron, iron alloy, indium, indium alloy, gold, gold alloy, silver, silver alloy, copper, copper alloy, brass, nickel, nickel alloy, platinum, Examples include platinum alloy, palladium, palladium alloy, zinc, zinc alloy, cadmium, cadmium alloy and the like.

In addition to or in addition to repellency and superhydrophobicity, one or more physical, mechanical, or optical properties can be a flexible substrate with a plurality of microfeatures ( It is set, changed and / or controlled by deforming the substrate. For example, optical characteristics such as reflectance, wavelength distribution of reflected or scattered light, transmittance, wavelength distribution of propagating light, refractive index, or any combination thereof are provided with a plurality of micro features The flexible substrate (base material) can be controlled by bending, bending, expanding, stretching, and / or contracting. In addition, physical properties such as air resistance or fluid resistance can be obtained by bending, bending, expanding, extending, and / or reducing a flexible substrate (base material) provided with a plurality of micro features. Can be controlled. Also, surface tactile properties, such as surface tactile sensation, can be obtained by bending, bending, expanding, stretching, and / or bending a flexible substrate (substrate) provided with a plurality of micro features. It can be controlled by reducing.

The characteristics of the microstructure surface can be selectively adjusted by bending, bending, compressing, stretching, expanding, distorting, and / or deforming the substrate (base material). The characteristics of at least a portion of the microstructured surface can be selectively adjusted by bending, bending, compressing, stretching, expanding, distorting, and / or deforming at least a portion of the substrate (substrate). For example, the air resistance and / or fluid resistance of the surface can be selectively adjusted by bending, bending, compressing, stretching, expanding, distorting, and / or deforming the substrate (substrate). The wettability of the surface can be selectively adjusted by bending, bending, compressing, stretching, expanding, distorting, and / or deforming the substrate (base material). Also, the optical properties of the surface can be selectively adjusted by bending, bending, compressing, stretching, expanding, distorting, and / or deforming the substrate (base material). For example, the surface prism effect, direction dependent reflectivity, direction dependent propagation rate, reflectivity, transmittance, reflected wave wavelength distribution, scattered wave wavelength distribution, propagated wave wavelength distribution, and / or refractive index are: The substrate (base material) can be selectively adjusted by bending, bending, compressing, stretching, expanding, distorting, and / or deforming.

A method for controlling the wettability of the microstructure surface will be described. The method includes providing a microstructured surface and deforming the microstructured surface thereby controlling the wettability of the microstructured surface. In this method, the microstructure surface comprises a flexible substrate (base material) provided with a plurality of micro features. The flexible substrate (base material) may include a polymer.
Examples of the polymer include PDMS (polydimethylsiloxane), PMMA (polymethyl methacrylate), PTFE (polytetrafluoroethylene), polyurethane, Teflon (registered trademark), polyacrylate, polyarylate w, thermoplastic material, heat Plastic elastomer, fluoropolymer, biodegradable polymer, polycarbonate, polyethylene, polyimide, polystyrene, polyvinyl, polyolefin, silicone, natural rubber, synthetic rubber, and combinations of two or more of these.
In this method, since the flexible substrate (base material) is deformed, the pitch between adjacent micro features changes. The method of deforming the flexible substrate (base material) is not particularly limited, but the substrate (base material) is forced to extend or adopt a curved shape. And bending the substrate (base material). The surface wettability may increase, decrease, or not change as the flexible substrate (base material) is deformed.

Hereinafter, embodiments of the tracheal tube of the present invention will be described in detail with reference to the drawings as appropriate.

<First embodiment of tube for trachea>
First, a first embodiment of the tracheal tube of the present invention will be described with reference to FIGS. 3 and 4. The tracheal tube shown in FIGS. 3 and 4 is a so-called tracheostomy tube.
A tracheostomy tube 101 shown in FIG. 3 is an instrument for performing respiratory management of a patient, and is used in a state where it is directly inserted into the trachea 7 through an incision hole formed by incising the trachea. The tracheostomy tube 101 includes a tube body 102 that constitutes a main part of the tracheostomy tube 101, and a fixing portion 127 for fixing the tube body 102 to a patient.

As shown in FIGS. 4 (A) and 4 (B), a microstructure region 150 is provided on the inner surface (inner peripheral surface) forming the respiratory path 102a of the tube body 102, and FIG. 4 (C). As shown in FIG. 4E, the microstructure region 150 has a microstructure surface 151 on which a plurality of micro features are disposed. FIG. 4C shows an aspect in which the micro-structure surface 151 is configured by directly arranging the micro features on the inner surface (inner peripheral surface) forming the breathing path 102a of the tube body 102. In FIG. 4E, a microstructure surface 151 in which micro features are arranged on the inner surface (inner circumferential surface) forming the respiratory path 102a of the tube body 102 via a base material 152 and an adhesive layer 153 is configured. Represents an embodiment. In FIG. 4E, the adhesive layer 153 is shown, but the adhesive layer 153 is not included, and the base material 152 is directly on the inner surface (inner peripheral surface) forming the breathing path 102a of the tube body 102. An attached mode may be used.

The method for causing the microstructure region 150 to have the microstructure surface 151 is not particularly limited. For example, as shown in FIG. 4C, a plurality of micro-structure regions 150 are formed on the inner surface forming the respiratory path 102 a of the tube body 102. A method for forming a microstructure surface 151 by forming a feature, as shown in FIG. 4E, a film 160 having a microstructure surface 151 in which a plurality of micro features are arranged on a base material 152. Examples thereof include a method of adhering to the inner surface forming the respiratory path 102a so that the microstructure surface is exposed to the respiratory path 102a. In FIG. 4E, an adhesive layer 153 is interposed to attach the film 160 to the tube body 102. However, there is a method of attaching the film 160 to the tube body 102 without using the adhesive layer 153 such as welding. Therefore, the adhesive layer 153 is not essential in the present invention. Although not shown, a substrate having a microstructure surface on which a plurality of micro features are arranged is curved on at least a portion of at least one surface so that at least a portion of the microstructure surface is exposed to the respiratory tract. For example, a method of forming a tube body by curving.

The method for forming a plurality of micro features on the inner surface forming the respiratory path, or the method for forming the microstructure on the surface of the base material for forming the tube body is not particularly limited. Examples thereof include injection molding, cutting, laser processing, surface processing using a core rod, particle coating, nanoimprint, solvent treatment, plasma sputtering, nanowire array deposition, and combinations thereof.

A method for attaching a film having a microstructured surface to the inner surface forming the respiratory tract is not particularly limited. For example, adhesive, thermal adhesive, photocuring agent, ultraviolet curing agent, thermal welding, ultrasonic welding, high frequency Examples thereof include a method of attaching to the inner surface using welding, laser welding, and a combination thereof.

Hereinafter, each member constituting the tracheostomy tube 101 will be described in detail.
The tube body 102 is formed in a cylindrical shape that is open at both ends and has a uniform outer diameter and inner diameter along the length direction. Inside the tube body 102, a respiratory path 102a, which is a space through which exhalation passes along the length direction of the tube body 102, is formed.
The tube body 102 includes a distal end portion 122, a proximal end portion 121 disposed on the opposite side of the distal end portion 122, and a curved portion 123 positioned between the proximal end portion 121 and the distal end portion 122. The curved portion 123 is curved so that the central axis of the distal end portion 122 and the central axis of the proximal end portion 121 intersect at an angle θ. In the first embodiment, the tube body 102 is formed in an approximately L shape. The That is, the angle θ is about 90 °.
The tube body 102 has such flexibility that the θ can be changed within a range of 90 ° to ± about 45 ° in accordance with a change in the posture of the patient. Even if the θ changes within this range, the microstructure region 150 does not peel off or drop off from the tube body 102.
Examples of the material of the tube body 102 include synthetic resins such as silicone, polycarbonate, polypropylene, polyethylene, and polyvinyl chloride.

As shown in FIG. 4 (A), a tracheostomy hole formed by incising the wall of the trachea 7 and the skin 5 on the upper part of the trachea 7 in a patient lying on his back (the supine position). The distal end portion 122 of the tube body 102 is inserted into the trachea 7. At this time, the distal end portion 122 of the tube body 102 is directed toward the lung side so as to be spaced apart from the mucous membranes (skin-side tracheal mucosa 7a, inner body tracheal mucosa 7b) constituting the tube wall of the trachea 7 toward the lung side. Placed inside.

The proximal end 121 of the tube body 102 is exposed outside the body through the tracheostomy hole, and a ventilator (not shown) is attached to the proximal end 121. When the ventilator is activated, exhalation passes through the respiratory path 102a. Thereby, the patient's breathing is sustained and respiratory management is performed. As a result, it is possible to prevent the airway, which is a passage for oxygen necessary for breathing, from being blocked, and to manage the patient's breathing.

The fixing portion 127 is attached to the proximal end portion 121 of the tube body 102. The fixing portion 127 fixes the distal end portion 122 at an appropriate position in the trachea 7 by contacting the skin 5 when the tube body 102 is attached to the patient. The fixing portion 128 and the bonding portion 129 are fixed to the fixing portion 127. And have.
The fixed plate 128 is a flat plate member, and a storage hole 131 that penetrates the fixed plate 128 is formed at the center. An adhesive portion 129 is attached to the front surface of the fixing plate 128, and the back surface of the fixing plate 128 is brought into contact with the patient's skin 5.
The bonding portion 129 is for bonding the tube body 102 to the fixing portion 127, and has a ring shape in which a substantially circular through hole 130 is formed at the center. The through hole 130 of the bonding portion 129 communicates with the storage hole 131 of the fixing plate 128, and the size of the through hole 130 is set according to the outer diameter of the tube body 102.
The tube body 102 is passed through the accommodation hole 131 of the fixing plate 128 and the through hole 130 of the bonding portion 129, and is fixed by, for example, an adhesive.

In this embodiment, as an example of fixing the tube body 102 to the bonding portion 129, fixing with an adhesive is given as an example, but various fixing methods such as fixing by welding can be employed.

A case where the eyelid in the tracheostomy tube 101 is sucked using a suction catheter will be described with reference to FIG.
As shown in FIG. 3, since the patient wearing the tracheostomy tube 101 is usually lying on his back, foreign substances such as a heel tend to accumulate on the back side in the direction of gravity. That is, wrinkles easily collect on the lower side in FIG.
Therefore, the suction catheter 601 is inserted into the tube body 102 from the proximal end 121 side of the tube body 102, and the tip of the suction catheter 601 is advanced to the vicinity of the distal end portion 122 along the inner surface of the tube body 102, so that the heel Z is moved. Suction.

<Modification>
In the form of the tracheostomy tube 101 of FIGS. 3 and 4 described above, the microstructure region 150 exists over the entire circumference of the inner peripheral surface of the tube body 102, but is not limited to this form. For example, FIG. As shown in (A) to (C), it may exist only in a part on the inner peripheral surface of the tube body 102.
5A to 5C show a tracheostomy tube 201 according to a modification of the first embodiment, and are different from the tracheostomy tube 101 of the first embodiment shown in FIGS. 3 and 4 described above. Is the position where the microstructure region 150 is present. 5B and 5C are cross-sectional views taken along line BB shown in FIG. 5A.
In the tracheostomy tube 201, in a cross-sectional view orthogonal to the central axis of the tube body 102, the plane P passing through the center J of each tube body 102 at the proximal end portion 121, the distal end portion 122, and the bending portion 123 is curved. An intersection K intersecting the inner surface of the tube wall located outside the curve of the portion 123, an intersection L intersecting the inner surface of the tube wall located at the inside of the curve of the curved portion 123 of the tube body 102, and an intersection K Assuming a reference line S orthogonal to the plane P, a tangent line T in contact with the inner peripheral surface of the tube body 102, and a contact point M between the tangent line T and the inner peripheral surface, the angle formed by the tangent line T and the reference line S The microstructure region 150 exists at a position on the inner peripheral surface of the tube body 102 where φ is 30 ° or more. However, the angle φ is φ = 0 ° when the contact point M coincides with the intersection point L or the intersection point K, that is, when the tangent line T coincides with the reference line S or is parallel, and the contact point M becomes the intersection point K and the intersection point L. In other words, when the reference line S and the tangent line T do not match and are not parallel, an acute angle or a right angle formed by the reference line S and the tangent line T is intended.
When the tracheostomy tube 201 having the microstructure region 150 at the position as described above is inserted into a patient lying on his back as shown in FIG. 3, the wrinkles adhering to the microstructure region 150 have its action (repellency). Due to inertia, the tube body 102 moves to the back side of the patient (lower side in FIGS. 5B and 5C) and tends to accumulate. In general, the distal end portion of the suction catheter described in FIG. 4D easily reaches the lower position in FIGS. 5B and 5C on the inner peripheral surface of the tube body 102. 5B and 5C, it is difficult to reach the left and right side positions (positions where the microstructure region 150 is disposed). Therefore, if the microstructure region 150 is arranged at the position as described above, even if the wrinkle adheres to the microstructure region 150, the wrinkle easily moves to a position where it can be sucked by the suction catheter. As a result, the wrinkle is accumulated inside the tube body. Is suppressed.

<Second embodiment of tube for trachea>
A second embodiment of the tracheal tube of the present invention will be described with reference to FIG. The tracheal tube shown in FIG. 6 is a so-called tracheostomy tube.
The difference between the tracheostomy tube 301 of the second embodiment shown in FIG. 6 and the tracheostomy tube 101 of the first embodiment shown in FIG. 4 described above is mainly that the tracheostomy tube 301 includes the cuff 106 and the cuff. The point which has the adjustment part 108 is mentioned. Therefore, in the following, differences from the tracheostomy tube 101 such as the cuff 106 and the cuff adjusting unit 108 will be mainly described, and portions common to the tracheostomy tube 101 are denoted by the same reference numerals and description thereof is omitted.

A cuff 106 is attached to the distal end portion 122 of the tube body 102. The cuff 106 is fixed so as to cover the outer peripheral surface of the tube body 102 in the vicinity of the distal end portion 122. The cuff 106 is connected to the cuff adjusting unit 108. The cuff adjusting unit 108 includes a pilot balloon 126 and an air injection tube 125 that connects the cuff 106 and the pilot balloon 126.

The pilot balloon 126 is formed to have a substantially flat hexagonal cross section. In this example, the cross-sectional shape of the pilot balloon 126 is described as a hexagon, but the present invention is not limited to this. For example, the cross-sectional shape of the pilot balloon 126 can be formed in a substantially square shape or a circular shape, and may be formed in various other shapes.

An air injection hole 126 a is provided at one end of the pilot balloon 126, and a discharge port 126 b is provided at the other end of the pilot balloon 126. A check valve is attached to the air injection hole 126a. Then, air is sent into the cuff 106 through the pilot balloon 126 and the air injection tube 125 from the air injection hole 126a. The air sent in does not leak from the air injection hole 126a by the check valve. Further, the pressure applied to the cuff 106 can be sensed tactilely by pressing the pilot balloon 126 with a finger.

One end of the air injection tube 125 is connected to the pilot balloon 126, and the other end is connected to the cuff 106. The air injection tube 125 communicates with the internal space of the cuff 106 through the cuff side opening 111 formed once.
A storage hole 231 is formed at the center of the fixed plate 128. The adhesive portion 129 has a substantially circular through hole 130 and a groove formed from the outer periphery toward the through hole 130. The through hole 130 communicates with the storage hole 231. The tube body 102 and the air injection tube 125 pass through the storage hole 231. That is, the air injection tube 125 passes through the groove portion of the bonding portion 129 and the accommodation hole 131 of the fixing plate 128. Then, as shown in FIG. 6B, the air injection tube 125 is disposed along the inside of the curved portion 123 of the tube body 102 and is fixed to the outer peripheral surface 102c of the tube body 102.

When the air sent from the air injection hole 126a through the pilot balloon 126 and the air injection tube 125 enters the cuff 106, the cuff 106 swells and the mucous membrane of the trachea 7 (skin-side tracheal mucosa 7a, body inner tracheal mucosa 7b). ). Thereby, the gap formed between the tube body 102 and the trachea 7 can be closed.
The cuff 106 closes the gap formed between the tube body 102 and the trachea 7, thereby preventing oxygen sent from the ventilator from leaking to the larynx side, and saliva etc. flowing from the larynx side. It can prevent getting into the lung side.

<Modification>
In FIG. 6B, the configuration in which the air injection tube 125 is fixed to the outer peripheral surface 102c of the tube body 102 has been described. However, the present invention is not limited to this configuration. For example, as shown in FIG. Instead of the air injection tube 125, an air injection lumen 125 a may be provided in the tube wall of the tube body 302, and air may be sent from the pilot balloon 126 to the cuff 106.

<Third embodiment of tube for trachea>
A third embodiment of the tracheal tube of the present invention will be described with reference to FIG. The tracheal tube shown in FIG. 7 is a so-called tracheostomy tube.
The difference between the tracheostomy tube 401 of the third embodiment shown in FIG. 7 and the tracheostomy tube 301 of the second embodiment shown in FIG. 6 described above is mainly that the tracheostomy tube 401 is a cuff side suction part. The point which has 138 is mentioned. Therefore, in the following, differences from the tracheostomy tube 301 such as the cuff side suction portion 138 will be mainly described, and the same reference numerals are given to portions common to the tracheostomy tube 301 and description thereof will be omitted.

A cuff side suction part 138 is arranged on the opposite side of the cuff adjusting part 108 with the tube body 102 interposed therebetween. The cuff side suction part 138 includes a cuff side suction connector 139 and a cuff side suction tube 140.
A storage hole 331 is formed at the center of the fixed plate 128. The cuff side suction tube 140 passes through the groove portion of the bonding portion 129 and the accommodation hole 331 of the fixing plate 128, similarly to the air injection tube 125. 7B, the cuff side suction tube 140 is disposed along the outside of the curved portion 123 of the tube body 102 and is fixed to the outer peripheral surface 102c of the tube body 102.

One end of the cuff side suction tube 140 extends to the vicinity of the cuff 106 and opens, and the cuff side suction port 140a is formed by this opening. A cuff side suction connector 139 is attached to the other end of the cuff side suction tube 140. A suction device (not shown) is attached to the cuff side suction connector 139.

Saliva or the like flowing from the larynx side flows through the mucous membrane of the trachea 7 (skin-side tracheal mucosa 7a, internal tracheal mucosa 7b) and flows to the lung side. The saliva or the like is blocked by the cuff 106 in an inflated state, and accumulates in a space formed by the mucous membrane (skin-side tracheal mucosa 7 a and body inner tracheal mucosa 7 b) and the cuff 106. And the saliva etc. which were dammed by the cuff 106 are sucked from the cuff side suction port 140a by the cuff side suction part 138 by operating the suction device.

Note that the microstructure region 150 described above may be disposed on the inner peripheral surface of the cuff side suction tube 140. By arranging the microstructure region 150 including the repellent layer 154 on the inner peripheral surface of the cuff-side suction tube 140, it is possible to prevent wrinkles from adhering to the inner peripheral surface of the cuff-side suction tube 140 and to absorb the cuff-side suction. Occlusion of the tube 140 can be suppressed.
In addition, a suction line and related components may be further added to suck foreign substances such as sputum attached to the lung side of the cuff 106.

<Modification>
In FIG. 7B, the form in which the air injection tube 125 and the cuff side suction tube 140 are fixed to the outer peripheral surface 102c of the tube body 102 has been described. However, the present invention is not limited to this form. As shown in (C), an air injection lumen 125 b is provided in the tube wall of the tube body 402 instead of the air injection tube 125, and a cuff is inserted in the tube wall of the tube body 402 instead of the cuff side suction tube 140. A side suction lumen 140b may be provided.

<Fourth Embodiment of Tracheal Tube>
A fourth embodiment of the present invention will be described with reference to FIG. The tracheostomy tube shown in FIG. 8 is a so-called tracheostomy tube, but is called a double-tube tracheostomy tube or a tracheostomy tube with an inner tube, and the tracheostomy tube body used for the purpose of securing the airway after tracheostomy And the inner cannula used to remove secretions in the tube and increase the patency of the lumen, and the inner cannula (hereinafter sometimes referred to as “inner cylinder”) is the tracheostomy tube body ( Hereinafter, it may be referred to as an “outer cylinder”).
Hereinafter, each member constituting the double-tube tracheostomy tube 701 will be described in detail.

The tube body 102 constituting the inner cylinder 701a is formed in a cylindrical shape that is open at both ends and has a uniform outer diameter and inner diameter along the length direction. Inside the tube body 102, a respiratory path 102a, which is a space through which exhalation passes along the length direction of the tube body 102, is formed.
The tube body 102 includes a distal end portion 122 and a proximal end portion 121 disposed on the opposite side of the distal end portion 122. If desired, the tube body 102 includes a curved portion 123 positioned between the proximal end portion 121 and the distal end portion 122. You may have.
The tube body 102 is preferably made of a flexible material and is preferably deformed along the tube body 702.
When the tube body 102 has the curved portion 123, the tube body 102 is curved so that the central axis of the distal end portion 122 and the central axis of the base end portion 121 intersect at an angle θ, and the tube body 102 is formed in a substantially L shape. Good. In the tube body 102 shown in FIG. 8A, the angle θ is about 90 °.
Examples of the material of the tube body 102 include synthetic resins such as silicone, polycarbonate, polypropylene, polyethylene, and polyvinyl chloride.

The tube body 702 constituting the outer cylinder 701b is formed in a cylindrical shape that is open at both ends and has a uniform outer diameter and inner diameter along the length direction. Inside the tube body 702, an inner cylinder insertion lumen 702a, which is a space for inserting an inner cannula (inner cylinder) along the length direction of the tube body 702, is formed.
The tube body 702 includes a distal end portion 722, a proximal end portion 721 disposed on the opposite side of the distal end portion 722, and a curved portion 723 positioned between the proximal end portion 721 and the distal end portion 722. The curved portion 723 is curved so that the central axis of the distal end portion 722 and the central axis of the proximal end portion 721 intersect at an angle θ, and in this fourth embodiment, the tube body 702 is formed in an approximately L shape. The That is, the angle θ is about 90 °.
The tube body 702 has such a degree of flexibility that the angle θ can be changed within a range of about 90 ° to about ± 45 ° in accordance with a change in the posture of the patient.
Examples of the material of the tube body 702 include synthetic resins such as silicone, polycarbonate, polypropylene, polyethylene, and polyvinyl chloride.
Note that a microstructure region having the same configuration as that of the microstructure region 150 may be disposed on the inner surface of the tube body 702 forming the inner tube insertion lumen.

Also, the proximal end 721 of the tube body 702 is exposed outside the body through the tracheostomy hole, and a ventilator (not shown) is attached to the proximal end 721. When the ventilator is activated, exhaled air passes through the breathing path 102a of the inner cylinder. Thereby, the patient's breathing is sustained and respiratory management is performed. As a result, it is possible to prevent the airway, which is a passage for oxygen necessary for breathing, from being blocked, and to manage the patient's breathing.

The fixing portion 727 is attached to the proximal end portion 721 of the tube body 702. The fixing portion 727 fixes the distal end portion 722 to an appropriate position in the trachea 7 by contacting the skin 5 when the tube body 702 is attached to the patient. The fixing portion 727 and the bonding portion 729 And have.
The fixing plate 728 is a flat plate member, and a storage hole 731 penetrating the fixing plate 728 is formed at the center. An adhesive portion 729 is attached to the front surface of the fixing plate 728, and the back surface of the fixing plate 728 is brought into contact with the patient's skin 5.
The bonding portion 729 is for bonding the tube body 702 to the fixing portion 727, and has a ring shape in which a substantially circular through hole 730 is formed at the center. The through hole 730 of the bonding portion 729 communicates with the storage hole 731 of the fixing plate 728, and the size of the through hole 730 is set according to the outer diameter of the tube body 702.
The tube body 702 is penetrated through the accommodation hole 731 of the fixing plate 728 and the through hole 730 of the bonding portion 729, and is fixed by, for example, an adhesive.

In the present embodiment, as an example of fixing the tube body 702 to the bonding portion 729, fixing with an adhesive is given as an example, but various fixing methods such as fixing by welding can be employed.

The microstructure region 150 installed on the inner surface constituting the respiratory path 102a of the tube body 102 constituting the inner cylinder is as described in the first embodiment of the present invention.

In the above, one embodiment of the multi-tube tracheostomy tube of the present invention has been described. However, like the second embodiment and the third embodiment of the present invention, the cuff and the cuff adjusting unit, the suction line, and related configurations are described. Modifications such as adding can be made.

<Fifth embodiment of tube for trachea>
A fifth embodiment of the tracheal tube of the present invention will be described with reference to FIGS. 9 and 10. The tracheal tube shown in FIGS. 9 and 10 is a so-called endotracheal tube.
An endotracheal tube 501 shown in FIGS. 9 and 10 is an instrument for performing respiratory management of a patient, and is inserted into the trachea 7 from the patient's mouth. The endotracheal tube 501 includes a tube body 202, a cuff 206, and an air injection tube 225.

As shown in FIG. 10B, the above-described microstructure region 150 is arranged on the inner peripheral surface of the tube body 202 over the entire circumference. The form of the microstructure region 150 is as described above, and a description thereof is omitted.

The endotracheal tube 501 includes a tube body 202, an air injection lumen 225 b provided along the longitudinal direction of the tube body 202 and extending to at least the vicinity of the distal end portion 222 of the tube body 202, and the distal end portion of the tube body 202 The cuff 206 is provided in the vicinity so as to surround the outer peripheral surface of the tube body 202 and communicates with one end of the air injecting lumen 225b and communicates with the other end of the air injecting lumen 225b. A pilot balloon 226 for confirming whether or not

The tube body 202 is formed in a cylindrical shape having both ends opened. The tube body 202 includes a distal end portion 222, a proximal end portion 221 provided on the opposite side of the distal end portion 222, and a curved portion 223 positioned between the proximal end portion 221 and the distal end portion 222.
The tube body 202 is made of a flexible material, and has a breathing path 202a that penetrates from the distal end portion 222 to the proximal end portion 221 for introducing anesthetic gas, oxygen gas, and the like. The distal end portion 222 of the tube body 202 is formed in a smooth bevel shape in order to facilitate insertion into the body. Further, a connector 212 for connecting to the breathing circuit is attached to the proximal end portion 221.

On the tube wall forming the tube body 202, as shown in FIG. 10B, an air injecting lumen 225b narrower than the respiratory path 202a is provided along the longitudinal direction of the tube body 202. The air injection lumen 225b is an inflation lumen for sending air into a cuff 206 described later.
The air injection lumen 225 b communicates with the internal space of the cuff 206 via a cuff side opening 225 a formed on the outer surface of the tube wall of the tube body 202 in the cuff 206.

Further, as shown in FIG. 10A, the air injecting lumen 225b is provided at the position near the base end 221 through the notch 207 formed on the outer surface of the tube wall of the tube body 202. Communicated with.

The connection between the air injection tube 225 and the air injection lumen 225b is performed, for example, by inserting a preheated mandrel into the air injection lumen 225b, and simultaneously removing the mandrel, the air injection tube 225 is inserted into the air injection lumen 225b. It is carried out by a method such as inserting in and fixing using a solvent or an adhesive.

In the vicinity of the distal end portion of the tube body 202, a cuff 206 capable of expanding and contracting is provided so as to surround the outer peripheral surface in an annular shape.
The cuff 206 covers the outer periphery of the tube body 202 with a membrane formed in advance in a cylindrical shape having an inner diameter larger than the outer diameter of the tube body 202 so as to cover the cuff side opening 225a of the air injection lumen 225b. The both ends are adhered to the outer peripheral surface of the tube body 202 by an adhesive or a solvent, or are fused and attached by heat, high frequency, or the like, and are attached in an airtight manner.

In addition, an inflatable / deflatable pilot balloon 226 for recognizing the degree of expansion / contraction of the cuff 206 is installed at the rear end of the air injection tube 225 so as to communicate with the air injection tube 225. .

Furthermore, a check valve 226a having a function of preventing gas from flowing into the pilot balloon 226 but preventing gas from flowing into the pilot balloon 226 is installed at the rear end side of the pilot balloon 226. Yes. When a syringe or the like is connected to the check valve 226a and a gas such as air is press-fitted, the gas passes through the pilot balloon 226, the air injection tube 225, the air injection lumen 225b, and the cuff side opening 225a. The cuff 206 is fed into the cuff 206 and the cuff 206 expands.

In the above, one embodiment of the endotracheal tube of the present invention has been described. However, as with the tracheostomy tube of the present invention, modifications such as addition of a suction line and related configurations are possible.

<Sixth Embodiment of Tracheal Tube>
A sixth embodiment of the tracheal tube of the present invention will be described with reference to FIG. The tracheal tube shown in FIG. 11 is also called a small tracheostomy tube, a percutaneous tracheal puncture tube, an annular thyroid puncture tracheal cannula, an annular thyroid incision tracheal cannula, or the like.
A tracheal cannula 801 shown in FIG. 11 is an instrument for performing respiratory management of a patient who needs emergency respiratory management, and is inserted into the trachea 7 by puncturing the patient's annular thyroid membrane. The tracheal cannula 801 includes a tube body 102 and a fixing part 127. The tube body 102 of the tracheal cannula 801 is also called an outer needle because it punctures the annular thyroid membrane in a set with the inserted inner needle.

The tracheal cannula 801 includes a tube body 102 into which an inner needle (not shown) is inserted, and a fixing portion 127 that is provided at the proximal end portion of the tube body and fixes the tube body 102 to the skin. The tube body 102 is made of a synthetic resin, and has a curved portion that is curved at an angle of 15 ° or less with respect to the axial direction of the inner needle at the distal end portion.

On the inner surface (inner peripheral surface) forming the respiratory path of the tube body 102 of the tracheal cannula 801, the above-described microstructure region 150 (not shown) is arranged over the entire periphery. The form of the microstructure region 150 (not shown) is as described above, and a description thereof is omitted.

When the tracheal cannula 801 is used, the annular thyroid membrane (annular thyroid ligament) between the cricoid cartilage and the thyroid cartilage is punctured with a metal inner needle (not shown) inserted into the tube body 102. Next, the inner needle (not shown) is removed, and only the tube body 102 is left in the trachea. Then, the tracheal cannula 801 is fixed by tying a cotton tape or the like (not shown) inserted through a string hole (not shown) provided in the fixing part 127 to the neck.

Although one embodiment of the small tracheostomy tube of the present invention has been described above, various modifications are possible as with the tracheostomy tube of the present invention.

<Seventh Embodiment of Tracheal Tube>
A seventh embodiment of the tracheal tube of the present invention will be described with reference to FIG. The tracheal tube shown in FIG. 12 is also called an annular thyroid puncture tracheal cannula, an annular thyroid incision tracheal cannula, or the like.
A tracheal cannula 901 shown in FIG. 12 is used for the purpose of aspirating and removing secreted fluid stored in the trachea or bronchus. It is an instrument used to secure the emergency airway used to secure the respiratory airway leading from the front of the neck to the inside of the trachea for the purpose of emergency resuscitation at the time, and through the puncture hole or incision hole of the patient's cricoid thyroid 7 is inserted. The tracheal cannula 901 includes a tube body 102 and a fixing portion 127 (in particular, also referred to as a flange portion).

The tracheal cannula 901 includes a tube body 102 into which an introducer (not shown) is inserted, and a fixing portion 127 (flange) that is provided at the base of the tube body and fixes the tube body 102 to the skin. The tube body 102 is made of a synthetic resin, and includes a curved portion that curves from the proximal end portion to the distal end portion.

On the inner surface (inner peripheral surface) forming the respiratory path of the tube body 102 of the annular thyroid puncture tracheal cannula 901, the above-described microstructure region 150 (not shown) is arranged over the entire circumference. The form of the microstructure region 150 (not shown) is as described above, and a description thereof is omitted.

The tracheal cannula 901 expands the puncture hole of the cricoid thyroid membrane by an expansion operation by a dilator (not shown) via a guide wire (not shown) introduced into the trachea 7 using the Seldinger method, for example. The tube body 102 into which an introducer (not shown) is inserted can be inserted into the trachea 7 through the puncture hole expanded in the thyroid membrane, and the introducer can be removed to place the tracheal cannula 901 in the trachea. The thyroid membrane is incised, the tube body 102 into which the introducer is inserted from the incision hole is inserted into the trachea 7, the introducer is removed, and the tracheal cannula 901 may be placed in the trachea. After placement of the tracheal cannula 901, normal tracheal suction using a suction catheter (not shown) and oxygen or air supply can be performed via the tracheal cannula 901.

In the above, one embodiment of the tracheal cannula for thyroid puncture of the present invention has been described, but various modifications are possible as with the tracheostomy tube of the present invention.

The invention can be further understood by the following non-limiting examples.

<Flexible microstructure and nanostructure repellency / superhydrophobic surface>
In this example, a flexible surface provided with repellency and superhydrophobicity by micromachining and nanomachining will be described. The term repellency refers to the property that the surface repels wrinkles, and superhydrophobicity refers to the property that the surface repels water extremely. Some studies show non-curved microstructured repellant / superhydrophobic surfaces, others teach readers how to make rigid curved microstructured repellant / superhydrophobic surfaces However, there has been no research combining flexibility with curvature and micro-repellent / superhydrophobic surfaces.

Depending on the roughness of the surface, the way in which the surface interacts with the liquid changes.
FIG. 13 shows a micrograph image of the surface of a lotus plant that uses microscale and nanoscale roughness to modify the shape and behavior of water droplets on the plant surface (Barthlott, W. and Neinhuism, C., “ The purity of sacred lotus or escape from contamination in biological surfaces, Planta, April 1997, Vol. 202, No. 1, p. 1-8, doi: 10.1007 / s004250050096W). The surface of the lotus leaf changes the shape and behavior of water droplets on the surface due to its microscale and nanoscale roughness. The friction between water and these surfaces is greatly reduced, and water droplets can easily roll off the surfaces. For this reason, the surface of the lotus plant exhibits super-hydrophobicity that water droplets do not wet the surface so much and roll on the surface easily.
FIG. 14 shows that microscale and nanoscale surfaces can be roughened by standard micromachining techniques. The manner in which the surface interacts with the liquid changes depending on the roughness of the surface. Microfabrication tools can roughen microscale and nanoscale surfaces to increase hydrophobicity, as well as lotus plants, and can also increase repellency. A hydrophobic surface is a surface with an original contact angle θ exceeding 90 °. If the surface is hydrophobic, the new contact angle θ ^* of the roughened surface exceeds 90 °. As shown in FIG. 14, the contact angle between the surface 31 before roughing and the droplet 32 is θ (FIG. 14A), but the surface after roughing is roughened by a micromachining tool. The contact angle between 33 and the droplet 34 changes to θ ^* (> θ) (FIG. 14B).
FIG. 15 shows two different possible wet states on the surface of the micro / nanostructure: the Wenzel state (FIG. 15A) and the Cassie-Baxter state (FIG. 15B). Both the Wenzel state (FIG. 15A) and the Cassie-Baxter state (FIG. 15B) are possible for micro / nanostructured surfaces. In the Wenzel state (FIG. 15A), the surface 41 and the liquid 42 are in close contact with both the valley and the peak. In the Cassie-Baxter state (FIG. 15B), the surface 43 and the liquid 44 are in contact only at the peak, and the air pocket 45 remains between the liquid 44 and the valley of the surface 43. The droplets slide on a Cassie-Baxter surface that requires less force than the Wenzel surface.
If the original contact angle θ and surface geometry are known, θ ^* and wet state can be predicted for the surface of the micro / nanostructure.
The following Wenzel equation can be used to predict a new contact angle θ ^* of a droplet on the surface of a microstructure or nanostructure.
cosθ ^* = r · cosθ
Here, r is the ratio of the actual surface area to the projected surface area (r = actual surface area / Toei surface area).
In addition, θ ^* can be predicted using the following Cassie-Baxter equation.
cos θ ^* = φ (cos θ + 1) −1
Here, φ is the fraction of the area where water contacts when the droplet is in the Kathy-Baxter state, that is, the ratio of the point contact area in the contact area (φ <1).

To determine whether the liquid is in the Wenzel state or the Cassie-Baxter state, θ ^* can be calculated by the Wenzel method and then by the Cassie-Baxter method. Two different methods result in two different predicted contact angles. The smallest contact angle among the calculated contact angles is the most promising. If the contact angle is calculated using the Wenzel equation, the droplet is likely to be in the Wenzel state. If the contact angle is calculated using the Kathy-Baxter equation, the droplet is likely to be in the Kathy-Baxter state.

FIG. 16 shows that a flexible microstructured surface can be curved convexly. FIG. 16A shows a microstructured surface 51 that is convexly curved, and FIG. 16B maintains superhydrophobicity when droplets 52 are added to the microstructured surface 51 curved in a convex shape. In addition, it shows that repellency is maintained. The superhydrophobicity of the microstructured surface can change the wet state and θ ^* when curved convexly. The reason is that if the upper part of the microstructure moves away from each other, the effective pitch of the micro feature increases and the effective φ decreases. As the effective φ decreases, θ ^* can be increased, and the possibility of a Wenzel state is higher than when the microstructure surface is not curved.

FIG. 17 shows that a flexible microstructured material can be bent concavely. FIG. 17A shows a concavely curved microstructure surface 53, and FIG. 17B maintains superhydrophobicity when droplets 54 are added to the concavely curved microstructure surface 53. FIG. In addition, it shows that repellency is maintained. The superhydrophobicity of the microstructured surface can change the wet state and θ ^* when curved concavely. The reason is that when the upper part of the microstructure moves close to each other, the effective pitch of the micro feature is reduced and the effective φ is increased. As the effective φ increases, θ ^* can be reduced, and more likely the Cassie-Baxter state is greater than when the microstructure surface is not curved.

<Effects of curvature on repellency and superhydrophobicity of flexible silicone microstructures>
Repellency and superhydrophobicity can suppress corrosion, control fluid flow, and reduce surface resistance. The surface microstructure can control the repellency and hydrophobicity of the surface by adjusting the interaction between the droplet and the surface. Published studies on microstructure repellency / hydrophobic surfaces are limited to almost exclusively flat surfaces, but for many repellency / superhydrophobic applications, microstructures on curved surfaces The ability to make is needed. Polymer microfabrication provides an inexpensive way to create microstructured repellant / superhydrophobic surfaces, and polymer compliance allows curved microstructured repellant / hydrophobic surfaces. This example illustrates a situation where the curvature of a flexible microstructured polymer affects repellency and hydrophobicity.

FIG. 18 shows a state in which a droplet having a contact angle θ can interact with a repellent / hydrophobic surface in a Wenzel state or a Cassie-Baxter state. FIG. 18A shows that the droplet 62 seated on the solid surface 61 and surrounded by the gas 63 forms a unique contact angle θ. FIG. 18B shows that when the solid surface 64 is rough and the droplet 65 surrounded by the gas 63 is in critical contact with the ridge of the solid surface 64, the droplet 65 is in a Wenzel state. Show. The contact angle in this case is θ _W ^* . In FIG. 18C, when the solid surface 66 is a rough surface and the droplet 67 surrounded by the gas 63 is seated on the top of the bulge of the solid surface 66, the droplet 67 and the solid surface 66 are separated. There is an air pocket 68 in between, indicating that the droplet 67 is in the Kathy-Baxter state. The contact angle in this case is θ _CB ^* . It is desirable to achieve the Cassie-Baxter state because the droplets can move significantly. The size, shape, and pitch of the microfeatures on the microstructure surface will affect the state of the droplet on the surface in any state.

Due to the curvature of the polymer, the pitch of the micro features can be changed to affect the repellency and hydrophobicity.
In FIG. 19, by curving the microstructure surface, the geometry of the microstructure surface changes and the interaction between the microstructure surface and the droplet changes. As shown in FIG. 19A, on the microstructure surface 71 curved with a positive curvature, the pitch 73 of the micro features 72 is wider than before the curve, and the droplets interact with fewer micro features. . Also, as shown in FIG. 19B, on the microstructure surface 74 curved with a negative curvature, the pitch 76 of the micro features 75 becomes narrower than before the curve, and the droplets have more micro features. Interacts with part 75. θ _CB ^* is a function of φ, φ is a function of pitch, and pitch is a function of curvature. Therefore, θ _CB ^* is a function of curvature. Other hydrophobic properties such as the required slip force are also a function of curvature. Curvature thus affects the hydrophobic properties, for example droplet slippage.
FIG. 20 shows the change in pitch of PDMS (polydimethylsiloxane) micropillars as a function of curvature. FIG. 20A shows a flat microstructured surface 81 with a PDMS micropillar pitch of 24.4 μm. FIG. 20B shows a curved member 84 having an outer surface curved with a positive curvature (+ 0.11 / mm) and an inner surface curved with a negative curvature (−0.22 / mm) and a micro curved with a positive curvature. A structural surface 82 is shown. In the microstructure surface 82 curved with a positive curvature, the pitch of the PDMS microcolumns was widened from 24.4 μm to 26.2 μm (prediction = 25.5 μm) as compared to the flat microstructure surface 81. FIG. 20C shows a curved member 84 having an outer surface curved with a positive curvature (+ 0.11 / mm) and an inner surface curved with a negative curvature (−0.22 / mm), and a micro curved with a negative curvature. A structural surface 83 is shown. In the microstructure surface 83 curved with a negative curvature, the pitch of the PDMS micro-pillars was narrowed from 24.4 μm to 20.7 μm (prediction = 22.1 μm) compared to the flat microstructure surface 81.

In order for the Cassie-Baxter condition to exist, the following inequality must be satisfied:
cos θ <(φ−1) / (r−φ)
Here, φ is the ratio of the area of the top of the column, and r is the ratio of the true surface area to the projected surface area.
At this time, the critical pitch Pc of the Wenzel / Cathy-Baxter transition is
Pc = [A− {h · b · cos θ / (1 + cos θ)}] / P
It is. Where A is the area of the top of the micro feature, h is the height of the micro feature, b is the outer periphery of the micro feature, and P is the pitch of the micro feature on the flat surface. .

When a film of thickness t is curved toward the neutral axis of the film with a radius of curvature R, the new pitch in the bending direction is P _α = P (R + t / 2 + h) · R ⁻¹
It is. Where P is the pitch of the micro features on the flat surface, h is the height of the micro features, t is the thickness of the film, and R is the radius of curvature.
FIG. 21 shows the microstructure surface with microfeature diameter = 25 μm, film thickness = 0.7 mm, surface contact angle θ = 112 ° for several values of microfeature height (h, μm). The critical surface curvature (1 / R _C , 1 / mm) for a film having a variation with the pitch of micro features (pitch _Old , mm) on a flat surface is shown.

In order to experimentally test the influence of curvature on the repellency / hydrophobicity of the microstructure surface, it has a microstructure surface in which cylindrical micro features having a diameter of 25 μm and a height of 70 μm are arranged at a pitch of 50 μm. A polydimethylsiloxane (PDMS) sheet having a thickness of 0.7 mm was prepared. On the flat PDMS microstructure surface, the contact angles θ of 10 μL of pure water and a glycerin / water mixture mixed at a mass ratio of 40/60 were 102 ° and 112 °, respectively. On the flat PDMS microstructure surface, the θ _CB ^* of 10 μL water and glycerin / water were 147 ° and 152 °, respectively.

FIG. 22 shows that PDMS is highly flexible and can be bent to a positive or negative curvature while maintaining repellency and superhydrophobicity. It also shows that the contact angle varies as a function of curvature.

In FIG. 23, a water droplet having a volume of 10 μL or a droplet of a mixture of glycerin / water mixed at a mass ratio of 40/60 is placed on a PDMS film having a microstructured surface, the PDMS film is inclined, The sliding angle (Slide Angle, θ _SLIDE ) at which the drop causes slipping was measured. The curvature of the curve was changed variously, and for each of them, θ _SLIDE was measured, and the relationship between the curvature of the curve and the slip angle was plotted. FIG. 23A shows the relationship between the curvature of curvature (Curvure, 1 / mm) and the water slide angle (Water Slide Angle, degree), and FIG. 23B shows the curvature of curvature (Curvure, 1 / mm). And 40/60 glycerin / water slip angle (40/60 Glycerol / Water Slide Angle, degree), respectively. θ _SLIDE decreases almost linearly as the curvature becomes more positive. From FIG. 21, the droplet should remain Kathy-Baxter until the curvature reaches + 1.25 / mm, well above the experimental maximum curvature of 0.11 / mm.
In addition, as a PDMS film having a microstructure surface, a thickness t having a microstructure surface in which cylindrical micro features having a height h (μm) and a diameter r (μm) are arranged at a pitch p (μm). (Mm) PDMS film was used.
h = 10 μm, r = 25 μm, p = 50 μm, t = 0.8 mm
h = 40 μm, r = 25 μm, p = 50 μm, t = 1.1 mm
h = 70 μm, r = 25 μm, p = 50 μm, t = 1.2 mm
In FIG. 23, the PDMS film is specified by the height h of the micro feature.

FIG. 24 shows a modeling result regarding a column having a diameter of 5 μm and a pitch of 8 μm in the case of a droplet having an original contact angle of 100 °. In the Wenzel state, the new contact angle θ ^* increases as the column height increases. When the column height reaches 8-9 μm, the droplets transition from the Wenzel state to the Cassie-Baxter state.

FIG. 25 shows the modeling result of the transition between the Cassie-Baxter state and the Wenzel state in the case of a micro pillar having a diameter of 25 μm. As the original contact angle θ increases for pillars with a fixed pitch, the critical height for transition decreases. The critical height for transition increases as the pitch increases when the original contact angle θ is fixed.

The curvature of the curved PDMS microstructure surface changes the number of micropillars that interact with a given volume droplet. To investigate the interaction between the column and the droplet, 25 μL of commercial Cellorow metal with a melting point of 47 ° C. was melted and deposited, and the microcolumn with a height of 70 μm had no curvature, curvature + 0.11 / mm, and curvature It was solidified in a state of −0.22 / mm. The droplets were then examined using a scanning electron microscope (SEM) for an approximate number of impressions from the geometry induced by the columns and curvature. Column impressions were counted along the major and minor axes of the ellipse contact line, and the approximate number of droplet-column interactions was found from the ellipse area formula.

This example shows that the curvature of the microstructure surface made of polymer affects the properties of repellency and hydrophobicity. Using the critical curvature constraints shown here, the microstructure can maintain the Cassie-Baxter state when the curved surface is covered with the microstructure polymer to control the repellency and hydrophobicity of the microstructure surface. Geometric shapes can be designed.

The terms and expressions employed are used as descriptive terms, are not limiting, and use of such terms and expressions does not exclude the features presented and described or some equivalents thereof, It will be appreciated that various modifications are possible within the scope of the claimed invention. Thus, while the invention has been specifically disclosed by preferred embodiments and optional features, modifications and variations of the concepts disclosed herein can be used by those skilled in the art, and such modifications and variations are not It should be understood that it is considered to be encompassed within the scope of the present invention as defined by the appended claims.

5 Skin 7 Trachea 7a Skin side tracheal mucosa 7b Body inner tracheal mucosa 10 Microstructure surface 11 Substrate (base material)
12 Micro features 13 Diameter 14 Pitch 15 Height 21 Substrate (base material)
22 Resist 23 Stencil mask 24 Light 25 Micro feature 26 Recess 27 Uncured polymer 28 Cured polymer 31 Surfaces 32 and 34 before roughing Liquid droplets 33 Surfaces 41 and 43 after roughing Surfaces 42 and 44 Liquid 45 Air pocket 51 Convex-shaped microstructured surface 52, 54 Droplet 53 Convex-shaped microstructured surface 61, 64, 66 Solid surface 62, 65, 67 Droplet 63 Gas 68 Air pocket 71 With positive curvature Curved microstructure surface 72, 75 Micro feature 73, 76 Pitch 74 Microstructure surface 81 curved with negative curvature Flat microstructure surface 82 Microstructure surface 83 curved with positive curvature Microstructure curved with negative curvature Surface 84 Curved member 101, 201, 301, 401, 501 Tracheostomy tube 102 202, 302, 402, 702 Tube body 102a, 202a Breathing path 102c Outer peripheral surface 104a Suction line 104c Air injection line 106, 206 Cuff 108 Cuff adjusting part 121, 221 and 721 Base end part 122, 222, 722 Tip part 123, 223 , 723 Curved portion 125, 225 Air injection tube 111, 225a Cuff side opening 125b, 225b Air injection lumen 126, 226 Pilot balloon 126a Air injection hole 126b Outlet 127, 727 Fixing portion 128, 728 Fixing plate 129, 729 Adhesion part 130,730 Through hole 131,231,331,731 Storage hole 138 Cuff side suction part 139 Cuff side suction connector 140 Cuff side suction tube 140a Cuff side suction port 150 Micro structure area 151 Micro feature part 152 Material 153 Adhesive layer 160 Film 201 Endotracheal tube 207 Notch 212 Connector 226a Check valve 250 Coating 601 Suction catheter 701 Double-tube tracheotomy tube 701a Inner tube 701b Outer tube 702a Inner tube insertion lumen 801 Ring-shaped thyroid membrane puncture trachea Cannula 901 Tracheal cannula Z for insertion of annular thyroid puncture hole

Claims

A trachea comprising a distal end portion provided on the lung side in a trachea, a proximal end portion provided on the opposite side of the distal end portion, and a tube body having a breathing path penetrating from the proximal end portion to the distal end portion. In the tube,
A microstructure region is provided on at least a part of the inner surface forming the respiratory path of the tube body;
The microstructural region is a tracheal tube having a microstructural surface on which a plurality of microfeatures are disposed.
The microstructure region includes a group consisting of extrusion molding, injection molding, cutting, laser processing, surface processing using a core rod, particle coating, nanoimprint, solvent processing, plasma sputtering, deposition of nanowire arrays, and combinations thereof. The tracheal tube according to claim 1, wherein the microfeatures formed using a selected method are disposed.
The microstructure region is a flexible substrate having at least a part that is curved, bent, compressed, stretched, expanded and / or distorted, and has a microstructure surface on which a plurality of micro features are arranged. The tracheal tube according to claim 1, wherein a substrate having the microstructural surface is disposed on an inner surface of the tube body that forms the respiratory path so as to expose the microstructure surface to the respiratory path.
The tracheal tube according to any one of claims 1 to 3, wherein the microstructure surface is a repellent surface.
The tracheal tube according to any one of claims 1 to 4, wherein a dimension of the micro feature is selected from a range of 10 nm to 1000 µm.
The tracheal tube according to any one of claims 1 to 5, wherein a pitch between the micro features is selected from a range of 10 nm to 1000 µm.
The plurality of microfeatures comprises a first set of microfeatures having a first set of dimensions and a second set of microfeatures having a second set of dimensions, wherein the first set of dimensions is the first set of dimensions. The tracheal tube according to any one of claims 1 to 6, which is different from the two sets of dimensions.
The tracheal tube according to claim 7, wherein the first set of dimensions is selected from a range of 10 nm to 1 µm, and the second set of dimensions is selected from a range of 1 µm to 100 µm.
The tracheal tube according to any one of claims 1 to 8, further comprising a coating on the plurality of micro features.
The tracheal tube according to claim 9, wherein the coating includes particles having a size selected from a range of 1 to 100 nm.