WO2016114644A1 - Dispositif pour auto-prélèvement d'échantillons de cellules épithéliales pour la détection du cancer du col de l'utérus - Google Patents

Dispositif pour auto-prélèvement d'échantillons de cellules épithéliales pour la détection du cancer du col de l'utérus Download PDF

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Publication number
WO2016114644A1
WO2016114644A1 PCT/MX2015/000013 MX2015000013W WO2016114644A1 WO 2016114644 A1 WO2016114644 A1 WO 2016114644A1 MX 2015000013 W MX2015000013 W MX 2015000013W WO 2016114644 A1 WO2016114644 A1 WO 2016114644A1
Authority
WO
WIPO (PCT)
Prior art keywords
section
central
diameter
rod
handle
Prior art date
Application number
PCT/MX2015/000013
Other languages
English (en)
Spanish (es)
Inventor
Ramsés GALAZ MENDEZ
Original Assignee
DE HOYOS REYES, Alicia
TORRES FLORES, Adriana
SILLER GONZALEZ, Andrea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DE HOYOS REYES, Alicia, TORRES FLORES, Adriana, SILLER GONZALEZ, Andrea filed Critical DE HOYOS REYES, Alicia
Publication of WO2016114644A1 publication Critical patent/WO2016114644A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0291—Instruments for taking cell samples or for biopsy for uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0208—Biopsy devices with actuators, e.g. with triggered spring mechanisms

Definitions

  • the object of the present invention is to provide a device for the autotora of epithelial cell samples, in order to have a tool that is capable of providing cells that can be used in subsequent analyzes, preferably in analyzes focused on the detection of cancer. cervicouter ino or human papillomavirus. ⁇ BACKGROUND
  • cervical cancer causes about 500,000 deaths a year in the world. In developing countries, its incidence reaches 40 per 100,000 women (Franco EL, Franco ED, Ferenczy A: Cervical cancer: epidemiology, prevention and the role of human papillomavirus infection. CMAJ 2001; 164 (7)). In Chile, an incidence of 30 per 100,000 women is estimated; 1,500 cases are diagnosed annually and around 900 die, the death rate being 9.6 per 100,000 (Suárez E, Prieto M, Rojas I and cois: National Cancer Program cervicouterinc. Rev Chil Cbstet Ginecol 2C01; 66 (6): 480-91. ⁇ .
  • the international application with number O2014179804 details methods and devices comprising a scraping element used to be in circumferentially and longitudinally contact with the surface of the walls of the uterine cavity, providing a wide contact surface, resulting in the achievement of a sufficient volume and obtaining a tissue sample for comprehensive analysis such as an endometrial biopsy or uterine cancer screening.
  • the device allows the user to maximize the amount of tissue or cells that will be sent to the laboratory for analysis.
  • US patent US5092345 describes a device for obtaining samples of uterine endometrial cells used as specimens in cytodiagnostic for uterine cancer, the device includes a slide-shaped handle and inserted into a tube and a scraping portion in the form of a loop flexible to extract a sample of cells.
  • the scraper portion is retractable by means of a sliding handle, and is capable of sampling the cells of entire regions of the endometrium in a safe and reliable manner.
  • the utility model of Chinese origin with number " CN2873104 refers to a treatment device doctor, more particularly to a cervical sampling device used in gynecology.
  • the device is comprised of a mortar rod and a sampling probe, the massaging probe comprises a main pole, and two separate columns;
  • This device helps in the gynecological examination, collects internal and external cells simultaneously from the cervix when it is sampled, makes a soft cloth brush touch the lining of the cervix, sampling with this device is ideal for smears to verify the presence of cervical cancer cells.
  • Another utility model is the one registered with the number CN2046743, which refers to an endometrial collector that belongs to a medical device.
  • the utility model consists of a sampling rod, an outer tube, a scale, a positioning bolt and a sealing body, the utility model not only analyzes the cells, but can also ⁇ inspect pathological sections, reaching a 100 percent diagnostic rate.
  • the utility model is appropriate for the diagnosis of diseases such as ovarian cancer, cervical cancer, endometrial adenocarcinoma and female uterine hemorrhage.
  • the present invention provides an autotome device whose structure is different from them, allowing a better manipulation by the user when taking the sample.
  • Figure 1 Shows a side view ⁇ of the sample autotome device in its retracted position
  • Figure 2 Illustrates an exploded view of the internal and external elements of the device object of the present invention.
  • Figure 3 Shows a sectional view of the autotome device in its retracted position
  • Figure 4 Shows a sectional view of the autotome device in its ejection position.
  • Figure 5 Illustrates a side view of the preferred form of use of the device object of the present invention where it is introduced into the vaginal cavity
  • Figure 6 It shows a side view of the mechanism of use of the present invention, in which the push of the rod towards the cervical area is performed to scrape and obtain the sample
  • the device for autotome of epithelial cell samples for the detection of cervical cancer with human papillomavirus (HPV), as shown in Figure 2, is comprised of a hollow elongated cylindrical structure consisting of two main sections, a first section and a second section, where ' the first section is formed by a clamping handle (1) with a length greater than 60 mm and less than 100 mm allowing it to adapt ergonomically to the female hand; at the free end (15) of said handle (1) it has a cover (14) with a central hole, through said hole it crosses a central rod (5); by the holding handle (1) is where the patient takes the device to be introduced into the vaginal cavity, as shown in figure 5; the second section comprises an insertion tube (2) with a diameter between 10 mm to 18 mm and a length of 90 to 130 mm, between the insertion tube and the clamping handle an anatomical stop (3) is located which is conformed by at least three rings, as detailed in figure 1, each ring has
  • Crossing the entire length of the device is a sliding central rod (5) within the elongated cylindrical structure, said rod (5) has a manifold (8) at its upper end; the central stem (5) is slid using the thumb or index finger once placed inside the vaginal cavity, so that the collector (8) with which the collector (8) with which the distal end of the insertion tube (2) scraping for sampling is performed, the collector (8), the ⁇ which is u> na flexible part preferably silicone rubber or thermoplastic urethane, is attached to the central shaft (6) via a distal insert (7) which adopts a shape similar to the manifold (8) to be assembled therein, said distal insert (7) has a section with smaller diameter than allows its fracture to be separated from the device;
  • the collector (8) has a rough surface thanks to the protuberances that it presents, with which cervical scraping is carried out to obtain the sample after the push of the central stem (9), allowing to contain a greater amount of cells for the sample by effect of increasing the surface tension of the fluid;
  • a second internal structure (16) is located in the lower part of the rod, which is circular and has the same diameter as it.
  • the spring By stopping pressure on the rod (5), the spring returns to its natural state of relaxation, allowing the manifold (8) to return to its initial position inside the insertion tube (2), thus protecting the sample from any contamination while the device is removed from the vaginal cavity.
  • the sample is contained in the collector, it is possible to deposit it in a container with the appropriate liquid medium to be able to keep the sample and transport it to the laboratory for further analysis.
  • the stem is pushed again in the same way as when the scraping was performed, so that the manifold (8) is exposed outside the insertion tube (2) and the sample can be obtained in two ways, either using the wall of the container to support the device and fracture the distal insert by its thinnest part (7) thus depositing the sample inside the container, or simply placing r
  • the collector in the liquid of the container so that the sample is diluted.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Surgical Instruments (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un dispositif pour l'auto-prélèvement d'échantillons de cellules épithéliales, afin de disposer d'un outil qui puisse fournir des cellules qui peuvent être utilisées dans des analyses ultérieures, préférablement dans des analyses focalisées sur la détection du cancer du col de l'utérus ou du virus du papillome humain; ledit dispositif étant constitué d'une structure cylindrique à deux sections principales: un manche de fixation et un tube d'insertion, traversant la structure cylindrique se trouve une tige centrale, laquelle comporte un mécanisme de rétraction et de poussée, lequel permet le prélèvement d'échantillon d'une patiente de manière rapide et efficace.
PCT/MX2015/000013 2015-01-15 2015-01-27 Dispositif pour auto-prélèvement d'échantillons de cellules épithéliales pour la détection du cancer du col de l'utérus WO2016114644A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXMX/A/2015/000698 2015-01-15
MX2015000698A MX2015000698A (es) 2015-01-15 2015-01-15 Dispositivo para autotoma de muestras de células epiteliales para la detección de cáncer cervicouterino.

Publications (1)

Publication Number Publication Date
WO2016114644A1 true WO2016114644A1 (fr) 2016-07-21

Family

ID=56406110

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2015/000013 WO2016114644A1 (fr) 2015-01-15 2015-01-27 Dispositif pour auto-prélèvement d'échantillons de cellules épithéliales pour la détection du cancer du col de l'utérus

Country Status (2)

Country Link
MX (1) MX2015000698A (fr)
WO (1) WO2016114644A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3394699A (en) * 1965-07-22 1968-07-30 Panto Entpr Inc Instrument for obtaining a biopsy specimen
US5031635A (en) * 1982-03-01 1991-07-16 Accu-Med Corporation Plastic molded biological sample collection swab
WO2011024047A1 (fr) * 2009-08-28 2011-03-03 Arx Tech, Llc Dispositif intravaginal pliable et de conception anatomique pour l'auto-échantillonnage et le confinement de cellules épithéliales cervicales
GB2482336A (en) * 2010-07-30 2012-02-01 Colin George Ferrett Device for sampling material from a body cavity
ES1077410U (es) * 2012-06-29 2012-07-17 Medical Corporate 3000, S.L. Dispositivo de toma de muestras citológicas del cuello uterino

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3394699A (en) * 1965-07-22 1968-07-30 Panto Entpr Inc Instrument for obtaining a biopsy specimen
US5031635A (en) * 1982-03-01 1991-07-16 Accu-Med Corporation Plastic molded biological sample collection swab
WO2011024047A1 (fr) * 2009-08-28 2011-03-03 Arx Tech, Llc Dispositif intravaginal pliable et de conception anatomique pour l'auto-échantillonnage et le confinement de cellules épithéliales cervicales
GB2482336A (en) * 2010-07-30 2012-02-01 Colin George Ferrett Device for sampling material from a body cavity
ES1077410U (es) * 2012-06-29 2012-07-17 Medical Corporate 3000, S.L. Dispositivo de toma de muestras citológicas del cuello uterino

Also Published As

Publication number Publication date
MX2015000698A (es) 2016-07-14

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