WO2016112374A3 - Treating cancer using inhibitors of ataxia-telangiectasia mutated and rad3-related (atr) - Google Patents

Treating cancer using inhibitors of ataxia-telangiectasia mutated and rad3-related (atr) Download PDF

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Publication number
WO2016112374A3
WO2016112374A3 PCT/US2016/012797 US2016012797W WO2016112374A3 WO 2016112374 A3 WO2016112374 A3 WO 2016112374A3 US 2016012797 W US2016012797 W US 2016012797W WO 2016112374 A3 WO2016112374 A3 WO 2016112374A3
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Prior art keywords
rad3
atr
ataxia
inhibitors
treating cancer
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PCT/US2016/012797
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French (fr)
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WO2016112374A2 (en
WO2016112374A9 (en
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Lee Zou
Rachel Litman FLYNN
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The General Hospital Corporation
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Publication of WO2016112374A2 publication Critical patent/WO2016112374A2/en
Publication of WO2016112374A3 publication Critical patent/WO2016112374A3/en
Publication of WO2016112374A9 publication Critical patent/WO2016112374A9/en

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods for identifying and treating cancers, e.g., Alternative Lengthening of Telomeres (ALT)-positive cancers or cancers associated with accumulation of ssDNA, using Ataxia-Telangiectasia mutated and Rad3-related (ATR) inhibitors.
PCT/US2016/012797 2015-01-09 2016-01-11 Treating cancer using inhibitors of ataxia-telangiectasia mutated and rad3-related (atr) WO2016112374A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562101415P 2015-01-09 2015-01-09
US62/101,415 2015-01-09

Publications (3)

Publication Number Publication Date
WO2016112374A2 WO2016112374A2 (en) 2016-07-14
WO2016112374A3 true WO2016112374A3 (en) 2016-09-01
WO2016112374A9 WO2016112374A9 (en) 2017-02-23

Family

ID=56356584

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/012797 WO2016112374A2 (en) 2015-01-09 2016-01-11 Treating cancer using inhibitors of ataxia-telangiectasia mutated and rad3-related (atr)

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WO (1) WO2016112374A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106755430B (en) * 2016-12-28 2021-06-29 南开大学 Application of telomere elongation alternative mechanism (ALT) as colorectal cancer stem cell marker
JOP20190197A1 (en) 2017-02-24 2019-08-22 Bayer Pharma AG An inhibitor of atr kinase for use in a method of treating a hyper-proliferative disease
IT202000005527A1 (en) * 2020-03-16 2021-09-16 Univ Degli Studi Di Trento Therapeutic treatment of chromatinopathies

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120329047A1 (en) * 2009-09-22 2012-12-27 Roger Robert Reddel Methods and assays for the detection of alternative lengthening of telomeres (alt) activity in cells
WO2014140644A1 (en) * 2013-03-15 2014-09-18 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii Chemical entities
WO2014188201A2 (en) * 2013-05-22 2014-11-27 Cancer Research Technology Limited Treatment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120329047A1 (en) * 2009-09-22 2012-12-27 Roger Robert Reddel Methods and assays for the detection of alternative lengthening of telomeres (alt) activity in cells
WO2014140644A1 (en) * 2013-03-15 2014-09-18 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii Chemical entities
WO2014188201A2 (en) * 2013-05-22 2014-11-27 Cancer Research Technology Limited Treatment

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FLYNN ET AL.: "Alternative Lengthening of Telomeres Renders Cancer Cells Hypersensitive to ATR Inhibitors.", SCIENCE, vol. 347, no. Issue 6219, 16 January 2015 (2015-01-16), pages 273 - 277 *
NABETANI ET AL.: "Localization of hRad9, hHus1, hRad1, and hRad17 and Caffeine sensitive DNA Replication at the Alternative Lengthening of Telomeres-associated Promyelocytic Leukemia Body.", J BIOL. CHEM., vol. 279, no. 4, 9 April 2004 (2004-04-09), pages 25849 - 25867 *

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WO2016112374A2 (en) 2016-07-14
WO2016112374A9 (en) 2017-02-23

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