WO2016108609A2 - Endoscopic bio-marking solution - Google Patents
Endoscopic bio-marking solution Download PDFInfo
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- WO2016108609A2 WO2016108609A2 PCT/KR2015/014466 KR2015014466W WO2016108609A2 WO 2016108609 A2 WO2016108609 A2 WO 2016108609A2 KR 2015014466 W KR2015014466 W KR 2015014466W WO 2016108609 A2 WO2016108609 A2 WO 2016108609A2
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- It relates to a biological endoscope display liquid.
- Endoscopic diagnostic techniques have been widely applied to the diagnosis of a wide range of diseases.
- There is a method called dye endoscopy in which endoscopy is observed while the surface of the tissue is displayed during these endoscopy.
- an endoscope display liquid containing a pigment is used.
- endoscopy In the endoscopy or treatment, endoscopy is used to identify a lesion or suspected lesion and to mark the site using an injection needle. After marking, it is used to find, remove or treat the marked area through laparoscopy or surgical incision. Previously, carbon black has been widely used as such a pigment.
- Carbon black is hydrophobic and has low affinity with water, which is poor in dispersibility, and contains impurities such as benzopyrene and dibenz (a, h) anthracene and polycyclic aromatic hydrocarbons (PAHs), which are known as carcinogens. There is a problem.
- One embodiment of the present invention is excellent in dispersibility, harmless to the human body, and provides a biological endoscope display solution excellent in biological tissue display ability.
- a pigment in one embodiment, a pigment, a carrier, and water, wherein the pigment provides a biological endoscope display solution comprising one selected from titanium black, black iron oxide and combinations thereof.
- It may comprise 0.2 wt% to 10 wt% of the pigment.
- It may comprise 0.5 wt% to 3 wt% of the pigment.
- the carrier may comprise one selected from glycerin, diglycerine, butylglycerine, propylene glycol, dipropylene glycol, petylene glycol, polyethylene glycol and combinations thereof.
- the biological endoscope display liquid is:
- the endoscope display solution for a living body may further include a thickener.
- the thickener is carbomer, polysaccharide, polyquanternium, acrylate / C10 ⁇ C30 alkyl acrylate crosspolymer, polyacrylate-1 Polyacrylate-1 Crosspolymer, Hydros Aluminum silicate, Lithium magnesium sodium silicate, tetra sodium pyrophosphate, Sodium magnesium fluorosilicate ), Polyvinylpyrrolidone, and combinations thereof.
- the endoscope display solution for a living body may further include an additive including one selected from an emulsifier, an antifoaming agent, a surfactant, and a combination thereof.
- the biological endoscope display liquid is excellent in dispersibility, harmless to the human body, and excellent in biological tissue display ability.
- a pigment in one embodiment, a pigment, a carrier, and water, wherein the pigment provides a biological endoscope display solution comprising one selected from titanium black, black iron oxide and combinations thereof.
- the endoscope display liquid for a living body is, for example, a composition for directly displaying body tissues such as the stomach inner wall using a pigment.
- the injection endoscope may be used to display the biomarker.
- Titanium black or black iron oxide which is the pigment, is a pigment suitable for living bodies, which is harmless to the human body and skin, and has a stable characteristic, so that it is not easily discolored and is excellent in pigmentation.
- the titanium black or black iron oxide has low cohesiveness, uniform particle size distribution, and hydrophilicity, and is excellent in dispersibility.
- the titanium black or black iron oxide has excellent water dispersibility, and thus, the titanium black or black iron oxide may be more dispersed when the biological endoscope display liquid is water-based.
- the titanium black or black iron oxide is not only excellent in corrosion resistance to acids and alkali, but also because of low oil absorption for oil, the biological endoscope display liquid containing it is excellent in chemical and physical stability.
- the titanium black or black iron oxide is suitable for use as a pigment because of its high reflectance and refractive index.
- the titanium black is black particles including titanium, and may be, for example, black particles such as titanium oxide or titanium oxynitride.
- the black iron oxide may be particles having a diameter of about 1 to about 100 nanometers. Since the black iron oxide particles have a diameter in the above range, excellent black tissue display ability can be exhibited.
- the production method of the titanium black or black iron oxide may be prepared according to a known method, and is not limited to a specific method.
- the titanium black may be obtained by heating and reducing white titanium dioxide (TiO 2 ) at a high temperature or by uniformly mixing white titanium dioxide with metal titanium and heating it in a vacuum.
- the endoscope display solution for a living body may include about 0.2 wt% to about 10 wt% of one selected from the pigment titanium black, black iron oxide, and a combination thereof, and specifically, about 0.5 wt% to about 3 wt%. can do. If the biological endoscope display liquid contains the pigment in the amount below the content range, there is a fear that the biodisplay ability is lowered, and if the biological endoscope display liquid contains the pigment in excess of the content range, it becomes excessively colored around the display target area, In laparoscopic or surgical incisions, it may interfere with determining the incision point, or may interfere with removal of the lesion site, for example by staining up to the internal lesion site.
- the carrier may comprise one selected from glycerin, diglycerine, butylglycerine, propylene glycol, dipropylene glycol, petylene glycol, polyethylene glycol and combinations thereof.
- the endoscope display solution for a living body may be composed of the following content ratios.
- Said pigment about 0.2 wt% to about 10 wt%;
- Said carrier about 0.05 wt% to about 30 wt%;
- the endoscope display solution for a living body may further include a thickener.
- the thickening agent is Carbomer (Carbomer), polysaccharides (Polysaccharide), poly Quan teonyum (Polyquanternium), acrylates / C 10 ⁇ C 30 alkyl acrylate cross polymer (Acrylate / C 10 ⁇ 30 Alkyl acrylate Cross polymer), poly Polyacrylate-1 Crosspolymer, Hydros Aluminum silicate, Lithium magnesium sodium silicate, tetra sodium pyrophosphate, sodium magnesium fluorosilicate (Sodium magnesium fluorosilicate), polyvinylpyrrolidone, and combinations thereof.
- the endoscope display solution for a living body may further include an additive including at least one selected from an emulsifier, an antifoaming agent, a surfactant, or a combination thereof.
- the additive may be a known material to be suitable for the purpose of applying the endoscope display solution for a living body.
- the emulsifier may be used, such as polysorbate, methyl alcohol, and can be used in 3 wt% or less of the endoscope display solution for the living body.
- Titanium black (manufacturer: Fuji pigment, trade name: FUJI 544) 1 wt%, glycerin (manufacturer: Wonpoong Pharmaceutical Co., Ltd., PALMERA G909-1) 15 wt%, polysorbate 2 wt%, benzyl alcohol 2 wt% and water The remainder was mixed to prepare an endoscope display solution for a living body.
- Titanium Black (manufacturer: Fuji pigment, trade name: FUJI 544) 2 wt%, glycerin (manufacturer: Wonpoong Pharmaceutical Co., Ltd., PALMERA G909-1) 15 wt%, polysorbate 2 wt%, benzyl alcohol 2 wt% and water The remainder was mixed to prepare an endoscope display solution for a living body.
- Titanium Black (manufacturer: Fuji pigment, trade name: FUJI 544) 2 wt%, glycerin (manufacturer: Wonpoong Pharmaceutical Co., Ltd., PALMERA G909-1) 15 wt%, polysorbate 3 wt%, benzyl alcohol 2 wt% The remainder was mixed to prepare an endoscope display solution for living bodies.
- Example 1-5 Using the endoscope display solution for living body prepared in Example 1-5 was displayed by injection in 1ml each organ organs of the pig. The indicated portion was observed by laparoscopic endoscope and evaluated according to the following criteria, and the evaluation results are shown in Table 1 below.
- the diameter of the display part exceeds 20 mm
- the endoscope display liquid for biological preparation prepared in Example 1-5 exhibited a display ability at an appropriate level, so that the marked area was clearly displayed to clearly find the marked area at the time of laparoscopy or surgical incision after display.
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Abstract
Provided is an endoscopic bio-marking solution containing a pigment, a carrier and water, wherein the pigment comprises one selected from titanium black, black iron oxide and a combination thereof.
Description
생체용 내시경 표시액에 관한 것이다.It relates to a biological endoscope display liquid.
내시경을 이용한 진단 기술은 광범위한 질환의 진단에 넓게 응용되고 있다. 이들 내시경 검사 중 조직 표면을 표시한 상태로 내시경 관찰하는 색소 내시경법으로 불리는 방법이 있다. 상기 색소 내시경법에 의한 검사를 위해 조직 표면을 표시하기 위하여, 안료를 포함하는 내시경 표시액을 사용한다. Endoscopic diagnostic techniques have been widely applied to the diagnosis of a wide range of diseases. There is a method called dye endoscopy in which endoscopy is observed while the surface of the tissue is displayed during these endoscopy. In order to mark the surface of the tissue for examination by the dye endoscopy, an endoscope display liquid containing a pigment is used.
주로 내시경 검사 또는 치료시 내시경을 통하여 병변 또는 병변으로 의심되는 부분을 확인하고 그 부위를 표식할 때 인젝션니들 (Injection Needle)을 사용하여 표시한다. 표시 후에는 복강경 또는 외과적 절개 등을 통하여 표시된 부위를 찾아 제거하거나 치료하는데 이용한다. 종전에는 이러한 안료로서 카본블랙이 널리 사용되어 왔다. In the endoscopy or treatment, endoscopy is used to identify a lesion or suspected lesion and to mark the site using an injection needle. After marking, it is used to find, remove or treat the marked area through laparoscopy or surgical incision. Previously, carbon black has been widely used as such a pigment.
카본블랙은 소수성이어서 물과의 친화력이 낮아 분산성이 좋지 않고, 또한 발암물질로 알려져 있는 벤조피렌과디벤즈(a,h)안트라센 및 다환방향족탄화수소류(PAHs)와 같은 물질을 불순물로서 포함하고 있다는 문제점이 있다.Carbon black is hydrophobic and has low affinity with water, which is poor in dispersibility, and contains impurities such as benzopyrene and dibenz (a, h) anthracene and polycyclic aromatic hydrocarbons (PAHs), which are known as carcinogens. There is a problem.
본 발명의 일 구현예는 분산성이 우수하고, 인체에 무해하며, 생체 조직 표시능이 뛰어난 생체용 내시경 표시액을 제공한다.One embodiment of the present invention is excellent in dispersibility, harmless to the human body, and provides a biological endoscope display solution excellent in biological tissue display ability.
본 발명의 일 구현예에서, 안료, 운반체 및 물을 포함하고, 상기 안료는 티탄블랙, 흑색 산화철 및 이들의 조합으로부터 선택된 하나를 포함하는 생체용 내시경 표시액을 제공한다.In one embodiment of the present invention, a pigment, a carrier, and water, wherein the pigment provides a biological endoscope display solution comprising one selected from titanium black, black iron oxide and combinations thereof.
상기 안료를 0.2 wt% 내지 10 wt% 포함할 수 있다.It may comprise 0.2 wt% to 10 wt% of the pigment.
상기 안료를 0.5 wt% 내지 3 wt% 포함할 수 있다.It may comprise 0.5 wt% to 3 wt% of the pigment.
상기 운반체는 글리세린, 디글리세린, 부틸글리세린, 프로필렌 글리콜, 디프로필렌 글리콜, 페틸렌 글리콜, 폴리에틸렌글리콜 및 이들의 조합으로부터 선택된 하나를 포함할 수 있다.The carrier may comprise one selected from glycerin, diglycerine, butylglycerine, propylene glycol, dipropylene glycol, petylene glycol, polyethylene glycol and combinations thereof.
상기 생체용 내시경 표시액은: The biological endoscope display liquid is:
상기 안료 0.2 wt% 내지 10 wt%;0.2 wt% to 10 wt% of the pigment;
상기 운반체 0.05 wt% 내지 30 wt%; 및0.05 wt% to 30 wt% of the carrier; And
상기 물 잔부;를 포함할 수 있다.It may include a water balance.
상기 생체용 내시경 표시액은 증점제를 더 포함할 수 있다.The endoscope display solution for a living body may further include a thickener.
상기 증점제는 카보머 (Carbomer), 폴리사카라이드(Polysaccharide), 폴리콴터늄(Polyquanternium), 아크릴레이트/C10~C30 알킬 아크릴레이트 크로스 폴리머(Acrylate/C10~30Alkyl acrylate Cross polymer), 폴리아크릴레이트-1 크로스폴리머(Polyacrylate-1 Crosspolymer), 하이드로서 알루미늄 실리케이트(Hydros Aluminum silicate), 리튬망간소듐 실리케이트(Lithium magnesium sodium silicate), 테트라소듐 파이로포스페이트(tetra sodium pyrophosphate), 소듐마그네슘 플루오로실리케이트(Sodium magnesium fluorosilicate), 폴리비닐피롤리돈 및 이들의 조합으로 이루어진 군으로부터 선택된 하나를 포함할 수 있다.The thickener is carbomer, polysaccharide, polyquanternium, acrylate / C10 ~ C30 alkyl acrylate crosspolymer, polyacrylate-1 Polyacrylate-1 Crosspolymer, Hydros Aluminum silicate, Lithium magnesium sodium silicate, tetra sodium pyrophosphate, Sodium magnesium fluorosilicate ), Polyvinylpyrrolidone, and combinations thereof.
상기 생체용 내시경 표시액은 유화제, 소포제, 계면활성제 및 이들의 조합으로부터 선택된 하나를 포함하는 첨가제를 더 포함할 수 있다.The endoscope display solution for a living body may further include an additive including one selected from an emulsifier, an antifoaming agent, a surfactant, and a combination thereof.
상기 생체용 내시경 표시액은 분산성이 우수하고, 인체에 무해하며, 생체 조직 표시능이 뛰어나다.The biological endoscope display liquid is excellent in dispersibility, harmless to the human body, and excellent in biological tissue display ability.
이하, 본 발명의 실시예에 대하여 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 상세히 설명한다. 본 발명은 여러 가지 상이한 형태로 구현될 수 있으며 여기에서 설명하는 실시예에 한정되지 않는다.Hereinafter, exemplary embodiments of the present invention will be described in detail so that those skilled in the art may easily implement the present invention. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention.
본 발명의 일 구현예에서, 안료, 운반체 및 물을 포함하고, 상기 안료는 티탄블랙, 흑색 산화철 및 이들의 조합으로부터 선택된 하나를 포함하는 생체용 내시경 표시액을 제공한다.In one embodiment of the present invention, a pigment, a carrier, and water, wherein the pigment provides a biological endoscope display solution comprising one selected from titanium black, black iron oxide and combinations thereof.
상기 생체용 내시경 표시액은, 예를 들어, 위 내벽 등과 같은 신체 조직을 안료를 이용하여 직접 표시하기 위한 조성물이다. 예를 들어, 내시경 검사 또는 치료시 내시경을 통하여 병변 또는 병변으로 의심되는 부분을 확인하고 그 부위를 표식할 때 인젝션니들 (Injection Needle)을 통해 상기 생체용 내시경 표시액을 사용하여 표시할 수 있다. The endoscope display liquid for a living body is, for example, a composition for directly displaying body tissues such as the stomach inner wall using a pigment. For example, when identifying a lesion or suspected lesion through an endoscope during endoscopy or treatment, and marking the site, the injection endoscope (Injection Needle) may be used to display the biomarker.
상기 안료인, 티탄블랙 또는 흑색 산화철은 생체에 적합한 안료로서 인체 및 피부에 무해하고, 안정적인 특성을 가지고 있어서 변색이 잘 안되며, 착색이 뛰어난 안료이다.Titanium black or black iron oxide, which is the pigment, is a pigment suitable for living bodies, which is harmless to the human body and skin, and has a stable characteristic, so that it is not easily discolored and is excellent in pigmentation.
상기 티탄블랙 또는 흑색 산화철은 응집성이 낮고 입도 분포가 균일하며, 친수성이어서, 분산성이 매우 우수하다. 또한, 상기 티탄블랙 또는 흑색 산화철은 수분산성이 매우 우수하고, 따라서, 상기 생체용 내시경 표시액이 수계인 경우 상기 티탄블랙 또는 흑색 산화철은 더욱 잘 분산될 수 있다. The titanium black or black iron oxide has low cohesiveness, uniform particle size distribution, and hydrophilicity, and is excellent in dispersibility. In addition, the titanium black or black iron oxide has excellent water dispersibility, and thus, the titanium black or black iron oxide may be more dispersed when the biological endoscope display liquid is water-based.
한편, 상기 티탄블랙 또는 흑색 산화철은 산 및 알칼리에 대하여 내부식성이 우수할 뿐만 아니라, 오일에 대한 흡유성이 낮기 때문에 이를 포함하는 생체용 내시경 표시액은 화학적, 물리적 안정성이 우수하다.On the other hand, the titanium black or black iron oxide is not only excellent in corrosion resistance to acids and alkali, but also because of low oil absorption for oil, the biological endoscope display liquid containing it is excellent in chemical and physical stability.
다른 한편, 상기 티탄블랙 또는 흑색 산화철은 반사율 및 굴절률이 높기 때문에 안료로서 사용되기에 적합하다.On the other hand, the titanium black or black iron oxide is suitable for use as a pigment because of its high reflectance and refractive index.
상기 티탄블랙은 티탄을 포함하는 흑색 입자로서, 예를 들어 산화티탄이나 산질화 티탄 등의 흑색 입자일 수 있다. The titanium black is black particles including titanium, and may be, for example, black particles such as titanium oxide or titanium oxynitride.
상기 흑색 산화철은 약 1 내지 약 100 나노미터의 직경을 갖는 입자일 수 있다. 상기 흑색 산화철 입자가 상기 범위의 직경을 가짐으로써, 우수한 생체 조직 표시능을 나타낼 수 있다.The black iron oxide may be particles having a diameter of about 1 to about 100 nanometers. Since the black iron oxide particles have a diameter in the above range, excellent black tissue display ability can be exhibited.
상기 티탄블랙 또는 흑색 산화철의 제법은 공지된 방법에 따라 제조될 수 있고, 특정한 방법으로 제한되지 않는다. 예를 들어, 상기 티탄블랙은 백색이산화티탄(TiO2)을 고온에서 가열환원시키거나, 또는 백색이산화티탄을 금속티탄과 균일하게 배합시킨 뒤 진공상태에서 가열함으로써 얻을 수 있다. The production method of the titanium black or black iron oxide may be prepared according to a known method, and is not limited to a specific method. For example, the titanium black may be obtained by heating and reducing white titanium dioxide (TiO 2 ) at a high temperature or by uniformly mixing white titanium dioxide with metal titanium and heating it in a vacuum.
상기 생체용 내시경 표시액은 상기 안료인 티탄블랙, 흑색 산화철 및 이들의 조합으로부터 선택된 하나를 약 0.2 wt% 내지 약 10 wt% 포함할 수 있고, 구체적으로, 약 0.5 wt% 내지 약 3 wt% 포함할 수 있다. 상기 생체용 내시경 표시액이 상기 함량 범위 미만으로 상기 안료를 포함하면 생체 표시능이 떨어질 우려가 있고, 상기 함량 범위 초과하여 상기 안료를 포함하면 표시 대상 부위의 주변으로 과도하게 넓게 착색되게 되고, 이후, 복강경 또는 외과적 절개시에, 절개 지점을 정하는 데에 방해가 될 수 있고, 또는, 예를 들어, 내부 병변 부위까지 착색됨으로써 병변 부위의 제거에 방해가 될 수 있다. The endoscope display solution for a living body may include about 0.2 wt% to about 10 wt% of one selected from the pigment titanium black, black iron oxide, and a combination thereof, and specifically, about 0.5 wt% to about 3 wt%. can do. If the biological endoscope display liquid contains the pigment in the amount below the content range, there is a fear that the biodisplay ability is lowered, and if the biological endoscope display liquid contains the pigment in excess of the content range, it becomes excessively colored around the display target area, In laparoscopic or surgical incisions, it may interfere with determining the incision point, or may interfere with removal of the lesion site, for example by staining up to the internal lesion site.
상기 운반체는 글리세린, 디글리세린, 부틸글리세린, 프로필렌 글리콜, 디프로필렌 글리콜, 페틸렌 글리콜, 폴리에틸렌글리콜 및 이들의 조합으로부터 선택된 하나를 포함할 수 있다. The carrier may comprise one selected from glycerin, diglycerine, butylglycerine, propylene glycol, dipropylene glycol, petylene glycol, polyethylene glycol and combinations thereof.
상기 생체용 내시경 표시액은 하기 함량비로 조성될 수 있다.The endoscope display solution for a living body may be composed of the following content ratios.
상기 안료: 약 0.2 wt% 내지 약 10 wt%;Said pigment: about 0.2 wt% to about 10 wt%;
상기 운반체: 약 0.05 wt% 내지 약 30 wt%;Said carrier: about 0.05 wt% to about 30 wt%;
상기 물 잔부Water balance
상기 생체용 내시경 표시액은 증점제를 더 포함할 수 있다. 상기 증점제는 카보머 (Carbomer), 폴리사카라이드(Polysaccharide), 폴리콴터늄(Polyquanternium), 아크릴레이트/C10~C30 알킬 아크릴레이트 크로스 폴리머(Acrylate/C10~30Alkyl acrylate Cross polymer), 폴리아크릴레이트-1 크로스폴리머(Polyacrylate-1 Crosspolymer), 하이드로서 알루미늄 실리케이트(Hydros Aluminum silicate), 리튬망간소듐 실리케이트(Lithium magnesium sodium silicate), 테트라소듐 파이로포스페이트(tetra sodium pyrophosphate), 소듐마그네슘 플루오로실리케이트(Sodium magnesium fluorosilicate), 폴리비닐피롤리돈 및 이들의 조합으로 이루어진 군으로부터 선택된 하나를 포함할 수 있다.The endoscope display solution for a living body may further include a thickener. The thickening agent is Carbomer (Carbomer), polysaccharides (Polysaccharide), poly Quan teonyum (Polyquanternium), acrylates / C 10 ~ C 30 alkyl acrylate cross polymer (Acrylate / C 10 ~ 30 Alkyl acrylate Cross polymer), poly Polyacrylate-1 Crosspolymer, Hydros Aluminum silicate, Lithium magnesium sodium silicate, tetra sodium pyrophosphate, sodium magnesium fluorosilicate (Sodium magnesium fluorosilicate), polyvinylpyrrolidone, and combinations thereof.
또한, 상기 생체용 내시경 표시액은 유화제, 소포제, 계면활성제 등 또는 이들의 조합으로부터 선택된 하나 이상을 포함하는 첨가제를 더 포함할 수 있다. In addition, the endoscope display solution for a living body may further include an additive including at least one selected from an emulsifier, an antifoaming agent, a surfactant, or a combination thereof.
상기 첨가제는 생체용 내시경 표시액을 적용하는 목적에 따라 적합하도록 공지된 물질을 사용할 수 있다.The additive may be a known material to be suitable for the purpose of applying the endoscope display solution for a living body.
예를 들어, 상기 유화제는 폴리솔베이트, 메틸알콜 등을 사용할 수 있고, 상기 생체용 내시경 표시액 중 3 wt% 이하로 사용할 수 있다.For example, the emulsifier may be used, such as polysorbate, methyl alcohol, and can be used in 3 wt% or less of the endoscope display solution for the living body.
이하 본 발명의 실시예 및 비교예를 기재한다. 하기 실시예는 본 발명의 일 실시예일뿐 본 발명이 하기 실시예에 한정되는 것은 아니다.Hereinafter, examples and comparative examples of the present invention are described. The following examples are only examples of the present invention, and the present invention is not limited to the following examples.
실시예Example
실시예 1Example 1
티탄블랙 (제조사: 후지안료, 상품명: FUJI 544) 1 wt%, 글리세린 (제조사: ㈜원풍제약, 상품명: PALMERA G909-1) 15 wt%, 폴리솔베이트 2 wt%, 벤질알콜 2 wt% 및 물 잔부를 혼합하여 생체용 내시경 표시액을 제조하였다.Titanium black (manufacturer: Fuji pigment, trade name: FUJI 544) 1 wt%, glycerin (manufacturer: Wonpoong Pharmaceutical Co., Ltd., PALMERA G909-1) 15 wt%, polysorbate 2 wt%, benzyl alcohol 2 wt% and water The remainder was mixed to prepare an endoscope display solution for a living body.
실시예 2Example 2
티탄블랙 (제조사: 후지안료, 상품명: FUJI 544) 2 wt%, 글리세린 (제조사: ㈜원풍제약, 상품명: PALMERA G909-1) 15 wt%, 폴리솔베이트 2 wt%, 벤질알콜 2 wt% 및 물 잔부를 혼합하여 생체용 내시경 표시액을 제조하였다.Titanium Black (manufacturer: Fuji pigment, trade name: FUJI 544) 2 wt%, glycerin (manufacturer: Wonpoong Pharmaceutical Co., Ltd., PALMERA G909-1) 15 wt%, polysorbate 2 wt%, benzyl alcohol 2 wt% and water The remainder was mixed to prepare an endoscope display solution for a living body.
실시예 3Example 3
티탄블랙 (제조사: 후지안료, 상품명: FUJI 544) 2 wt%, 글리세린 (제조사: ㈜원풍제약, 상품명: PALMERA G909-1) 15 wt%, 폴리솔베이트 3 wt%, 벤질알콜 2 wt% 및 물 잔부를 혼합하여 생체용 내시경 표시액을 제조하였다.Titanium Black (manufacturer: Fuji pigment, trade name: FUJI 544) 2 wt%, glycerin (manufacturer: Wonpoong Pharmaceutical Co., Ltd., PALMERA G909-1) 15 wt%, polysorbate 3 wt%, benzyl alcohol 2 wt% The remainder was mixed to prepare an endoscope display solution for living bodies.
실시예 4Example 4
흑색 산화철 1 wt%, 글리세린 (제조사: ㈜원풍제약, 상품명: PALMERA G909-1) 15 wt%, 폴리솔베이트 2 wt%, 벤질알콜 2 wt% 및 물 잔부를 혼합하여 생체용 내시경 표시액을 제조하였다.Black iron oxide 1 wt%, glycerin (manufacturer: Wonpoong Pharmaceutical Co., Ltd., PALMERA G909-1) 15 wt%, polysorbate 2 wt%, benzyl alcohol 2 wt% and the balance of water to prepare a bioscope endoscope display solution It was.
실시예 5Example 5
흑색 산화철 2 wt%, 글리세린 (제조사: ㈜원풍제약, 상품명: PALMERA G909-1) 15 wt%, 폴리솔베이트 2 wt%, 벤질알콜 2 wt% 및 물 잔부를 혼합하여 생체용 내시경 표시액을 제조하였다.Black iron oxide 2 wt%, glycerin (manufacturer: Wonpoong Pharmaceutical Co., Ltd., product name: PALMERA G909-1) 15 wt%, polysorbate 2 wt%, benzyl alcohol 2 wt% and the balance of water to prepare a bioscope endoscope display solution It was.
실험예 1Experimental Example 1
상기 실시예 1-5에서 제조된 생체용 내시경 표시액을 사용하여 돼지의 장기 내막에 1ml씩 주사하여 표시하였다. 상기 표시된 부분을 복강경 내시경으로 관찰하여 하기 기준에 따라 평가한 뒤, 그 평가 결과를 하기 표 1에 기재하였다.Using the endoscope display solution for living body prepared in Example 1-5 was displayed by injection in 1ml each organ organs of the pig. The indicated portion was observed by laparoscopic endoscope and evaluated according to the following criteria, and the evaluation results are shown in Table 1 below.
<평가 기준><Evaluation Criteria>
4: 표시부의 직경이 20 mm 초과4: The diameter of the display part exceeds 20 mm
3: 표시부의 직경이 20 mm 이내로 선명하게 표시됨3: Display diameter is clearly displayed within 20 mm
2: 표시부가 흐려서 주변 다른 부위와 혼동 우려 있음2: The display is blurry and confused with other parts around it
1: 표시부가 구별되지 않음 1: indicator is not distinguished
| 구분division | 실시예 1Example 1 | 실시예 2Example 2 | 실시예 3Example 3 | 실시예 4Example 4 | 실시예 5Example 5 |
| 평가 결과Evaluation results | 33 | 33 | 33 | 33 | 33 |
상기 실시예 1-5에서 제조된 생체용 내시경 표시액은 적정 수준으로 표시능을 발휘함으로써, 표시 후 복강경 또는 외과적 절개 시에 표시된 부위를 명확히 찾을 수 있도록 선명하게 표시되었음을 확인할 수 있었다.The endoscope display liquid for biological preparation prepared in Example 1-5 exhibited a display ability at an appropriate level, so that the marked area was clearly displayed to clearly find the marked area at the time of laparoscopy or surgical incision after display.
이상에서 본 발명의 바람직한 실시예들에 대하여 상세하게 설명하였지만 본 발명의 권리 범위는 이에 한정되는 것은 아니고 다음의 청구 범위에서 정의하고 있는 본 발명의 기본 개념을 이용한 당업자의 여러 변형 및 개량 형태 또한 본 발명의 권리 범위에 속하는 것이다.Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements of those skilled in the art using the basic concepts of the present invention defined in the following claims are also provided. It belongs to the scope of the invention.
Claims (8)
- 안료, 운반체 및 물을 포함하고,Including pigments, carriers and water,상기 안료는 티탄블랙, 흑색 산화철 및 이들의 조합으로부터 선택된 하나를 포함하는 생체용 내시경 표시액.The pigment is a biological endoscope display liquid comprising one selected from titanium black, black iron oxide and a combination thereof.
- 제1항에 있어서,The method of claim 1,상기 안료를 0.2 wt% 내지 10 wt% 포함하는 0.2 wt% to 10 wt% of the pigment생체용 내시경 표시액. Endoscopic indicator solution for living body.
- 제1항에 있어서,The method of claim 1,상기 안료를 0.5 wt% 내지 3 wt% 포함하는 0.5 wt% to 3 wt% of the pigment생체용 내시경 표시액. Endoscopic indicator solution for living body.
- 제1항에 있어서,The method of claim 1,상기 운반체는 글리세린, 디글리세린, 부틸글리세린, 프로필렌 글리콜, 디프로필렌 글리콜, 페틸렌 글리콜, 폴리에틸렌글리콜 및 이들의 조합으로부터 선택된 하나를 포함하는 The carrier comprises one selected from glycerin, diglycerin, butylglycerine, propylene glycol, dipropylene glycol, petylene glycol, polyethylene glycol and combinations thereof생체용 내시경 표시액.Endoscopic indicator solution for living body.
- 제1항에 있어서,The method of claim 1,상기 생체용 내시경 표시액은: The biological endoscope display liquid is:상기 안료 0.2 wt% 내지 10 wt%;0.2 wt% to 10 wt% of the pigment;상기 운반체 0.05 wt% 내지 30 wt%; 및0.05 wt% to 30 wt% of the carrier; And상기 물 잔부;를 포함하는Containing the water balance;생체용 내시경 표시액.Endoscopic indicator solution for living body.
- 제1항에 있어서,The method of claim 1,상기 생체용 내시경 표시액은 증점제를 더 포함하는 The biological endoscope display solution further comprises a thickener생체용 내시경 표시액.Endoscopic indicator solution for living body.
- 제6항에 있어서,The method of claim 6,상기 증점제는 카보머 (Carbomer), 폴리사카라이드(Polysaccharide), 폴리콴터늄(Polyquanternium), 아크릴레이트/C10~C30 알킬 아크릴레이트 크로스 폴리머(Acrylate/C10~30Alkyl acrylate Cross polymer), 폴리아크릴레이트-1 크로스폴리머(Polyacrylate-1 Crosspolymer), 하이드로서 알루미늄 실리케이트(Hydros Aluminum silicate), 리튬망간소듐 실리케이트(Lithium magnesium sodium silicate), 테트라소듐 파이로포스페이트(tetra sodium pyrophosphate), 소듐마그네슘 플루오로실리케이트(Sodium magnesium fluorosilicate), 폴리비닐피롤리돈 및 이들의 조합으로 이루어진 군으로부터 선택된 하나를 포함하는 The thickener is carbomer, polysaccharide, polyquanternium, acrylate / C10 ~ C30 alkyl acrylate crosspolymer, polyacrylate-1 Polyacrylate-1 Crosspolymer, Hydros Aluminum silicate, Lithium magnesium sodium silicate, tetra sodium pyrophosphate, Sodium magnesium fluorosilicate ), Polyvinylpyrrolidone and combinations thereof생체용 내시경 표시액.Endoscopic indicator solution for living body.
- 제1항에 있어서,The method of claim 1,상기 생체용 내시경 표시액은 유화제, 소포제, 계면활성제 및 이들의 조합으로부터 선택된 하나를 포함하는 첨가제를 더 포함하는The endoscope display solution for a living body further includes an additive including one selected from an emulsifier, an antifoaming agent, a surfactant, and a combination thereof.생체용 내시경 표시액.Endoscopic indicator solution for living body.
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| US6725083B1 (en) * | 1999-02-02 | 2004-04-20 | Senorx, Inc. | Tissue site markers for in VIVO imaging |
| US6394965B1 (en) * | 2000-08-15 | 2002-05-28 | Carbon Medical Technologies, Inc. | Tissue marking using biocompatible microparticles |
| US20060079805A1 (en) * | 2004-10-13 | 2006-04-13 | Miller Michael E | Site marker visable under multiple modalities |
| JP4953761B2 (en) * | 2005-12-06 | 2012-06-13 | Ｈｏｙａ株式会社 | Endoscopic tissue stain composition |
| JP2008273900A (en) * | 2007-05-02 | 2008-11-13 | Takamasa Kanbe | Agent for endoscopy |
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