WO2016096054A1 - Procédé et dispositif destinés au mélange de deux flux de gouttelettes - Google Patents

Procédé et dispositif destinés au mélange de deux flux de gouttelettes Download PDF

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Publication number
WO2016096054A1
WO2016096054A1 PCT/EP2014/078881 EP2014078881W WO2016096054A1 WO 2016096054 A1 WO2016096054 A1 WO 2016096054A1 EP 2014078881 W EP2014078881 W EP 2014078881W WO 2016096054 A1 WO2016096054 A1 WO 2016096054A1
Authority
WO
WIPO (PCT)
Prior art keywords
stream
droplets
droplet
dispenser
hydrogel
Prior art date
Application number
PCT/EP2014/078881
Other languages
English (en)
Inventor
Matthias Lutolf
Andrea NEGRO
Yoji TABATA
Original Assignee
Ecole Polytechnique Federale De Lausanne (Epfl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecole Polytechnique Federale De Lausanne (Epfl) filed Critical Ecole Polytechnique Federale De Lausanne (Epfl)
Priority to PCT/EP2014/078881 priority Critical patent/WO2016096054A1/fr
Publication of WO2016096054A1 publication Critical patent/WO2016096054A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/14—Mixing drops, droplets or bodies of liquid which flow together or contact each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/23—Mixing by intersecting jets

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un procédé destiné au mélange d'un premier flux de gouttelettes (1) avec au moins un deuxième flux de gouttelettes (2) pour obtenir un troisième flux de gouttelettes fusionnées (3), par collision et fusion d'au moins une gouttelette du premier flux (1) avec au moins une gouttelette du deuxième flux (2). Le premier flux de gouttelettes (1) et le ou les deuxième(s) flux de gouttelettes (2) est/sont généré(s) d'une manière synchronisée. L'invention concerne également un dispositif destiné à la génération et au mélange d'un premier flux de gouttelettes (1) et d'un ou de plusieurs deuxième(s) flux de gouttelettes (2) pour obtenir un troisième flux de gouttelettes fusionnées (3), à une gouttelette, une pluralité de gouttelettes ou à un échafaudage à deux dimensions ou à trois dimensions produit par ledit procédé. A l'aide du procédé et du dispositif décrits, il est possible d'exploiter les gouttelettes fusionnées ainsi formées pour plusieurs applications différentes telles que la formation de motifs en 3D (a), le tamisage à haut rendement (b) et des études combinatoires (c).
PCT/EP2014/078881 2014-12-19 2014-12-19 Procédé et dispositif destinés au mélange de deux flux de gouttelettes WO2016096054A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2014/078881 WO2016096054A1 (fr) 2014-12-19 2014-12-19 Procédé et dispositif destinés au mélange de deux flux de gouttelettes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2014/078881 WO2016096054A1 (fr) 2014-12-19 2014-12-19 Procédé et dispositif destinés au mélange de deux flux de gouttelettes

Publications (1)

Publication Number Publication Date
WO2016096054A1 true WO2016096054A1 (fr) 2016-06-23

Family

ID=52347294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/078881 WO2016096054A1 (fr) 2014-12-19 2014-12-19 Procédé et dispositif destinés au mélange de deux flux de gouttelettes

Country Status (1)

Country Link
WO (1) WO2016096054A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018153927A (ja) * 2017-03-15 2018-10-04 株式会社リコー 立体造形物を造形する方法、立体造形物を造形する装置
US10576185B2 (en) 2016-12-29 2020-03-03 Tempo Therapeutics, Inc. Systems to promote healing at a site of a medical device
US10912860B2 (en) 2014-07-17 2021-02-09 The Regents Of The University Of California Controllable self-annealing microgel particles for biomedical applications
WO2023187133A1 (fr) 2022-04-01 2023-10-05 Biosistemika D.O.O. Technologie de manipulation de liquide combinatoire
US11850851B2 (en) 2016-03-30 2023-12-26 Iamfluidics Holding B.V. Process and device for in-air production of single droplets, compound droplets, and shape-controlled (compound) particles or fibers
US11931481B2 (en) 2016-02-16 2024-03-19 The Regents Of The University Of California Microporous annealed particle gel system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200013B1 (en) * 1997-12-26 2001-03-13 Ngk Insulators, Ltd. Process for uniformly mixing materials and apparatus therefor
US20030175410A1 (en) * 2002-03-18 2003-09-18 Campbell Phil G. Method and apparatus for preparing biomimetic scaffold
DE10260071A1 (de) * 2002-12-19 2004-07-08 Gkss-Forschungszentrum Geesthacht Gmbh Vorrichtung zur Analyse von in einer Flüssigkeit enthaltenen biologischen Zellen
WO2008056860A1 (fr) * 2006-11-07 2008-05-15 Postech Academy-Industry Foundation Appareil de mélange de gouttelettes et procédé de mélange de gouttelettes
EP2444147A1 (fr) * 2009-06-16 2012-04-25 Sony Corporation Dispositif pour mélanger des substances et procédé de mélange de substances

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200013B1 (en) * 1997-12-26 2001-03-13 Ngk Insulators, Ltd. Process for uniformly mixing materials and apparatus therefor
US20030175410A1 (en) * 2002-03-18 2003-09-18 Campbell Phil G. Method and apparatus for preparing biomimetic scaffold
DE10260071A1 (de) * 2002-12-19 2004-07-08 Gkss-Forschungszentrum Geesthacht Gmbh Vorrichtung zur Analyse von in einer Flüssigkeit enthaltenen biologischen Zellen
WO2008056860A1 (fr) * 2006-11-07 2008-05-15 Postech Academy-Industry Foundation Appareil de mélange de gouttelettes et procédé de mélange de gouttelettes
EP2444147A1 (fr) * 2009-06-16 2012-04-25 Sony Corporation Dispositif pour mélanger des substances et procédé de mélange de substances

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10912860B2 (en) 2014-07-17 2021-02-09 The Regents Of The University Of California Controllable self-annealing microgel particles for biomedical applications
US11464886B2 (en) 2014-07-17 2022-10-11 The Regents Of The University Of California Controllable self-annealing microgel particles for biomedical applications
US11931481B2 (en) 2016-02-16 2024-03-19 The Regents Of The University Of California Microporous annealed particle gel system
US11931480B2 (en) 2016-02-16 2024-03-19 The Regents Of The University Of California Microporous annealed particle gels and methods of use
US11850851B2 (en) 2016-03-30 2023-12-26 Iamfluidics Holding B.V. Process and device for in-air production of single droplets, compound droplets, and shape-controlled (compound) particles or fibers
US11850852B2 (en) 2016-03-30 2023-12-26 Iamfluidics Holding B.V. Process and device for in-air production of single droplets, compound droplets, and shape-controlled (compound) particles or fibers
US10576185B2 (en) 2016-12-29 2020-03-03 Tempo Therapeutics, Inc. Systems to promote healing at a site of a medical device
US10668185B2 (en) 2016-12-29 2020-06-02 Tempo Therapeutics, Inc. Methods of manufacturing injectable microgel scaffolds
JP2018153927A (ja) * 2017-03-15 2018-10-04 株式会社リコー 立体造形物を造形する方法、立体造形物を造形する装置
EP3385075A1 (fr) * 2017-03-15 2018-10-10 Ricoh Company Ltd. Procédé de fabrication d'un objet de fabrication de forme libre solide et dispositif de fabrication d'un objet de fabrication de forme libre solide
WO2023187133A1 (fr) 2022-04-01 2023-10-05 Biosistemika D.O.O. Technologie de manipulation de liquide combinatoire

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