WO2016090247A1 - Compositions cosmétiques - Google Patents

Compositions cosmétiques Download PDF

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Publication number
WO2016090247A1
WO2016090247A1 PCT/US2015/063995 US2015063995W WO2016090247A1 WO 2016090247 A1 WO2016090247 A1 WO 2016090247A1 US 2015063995 W US2015063995 W US 2015063995W WO 2016090247 A1 WO2016090247 A1 WO 2016090247A1
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WO
WIPO (PCT)
Prior art keywords
composition
skin
hair
peg
oil
Prior art date
Application number
PCT/US2015/063995
Other languages
English (en)
Inventor
Mauricio Castro
Bob Walke
Daniel Ramirez
Bob Foley
Original Assignee
Mary Kay Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mary Kay Inc. filed Critical Mary Kay Inc.
Publication of WO2016090247A1 publication Critical patent/WO2016090247A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/738—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/893—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by an alkoxy or aryloxy group, e.g. behenoxy dimethicone or stearoxy dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the present invention relates generally to methods and compositions useful for moisturizing skin or hair, cleansing skin or hair, soothing or treating skin or hair, concealing skin blemishes or color, and/or providing fragrance to the skin, hair, or clothing.
  • Skin and hair cleansing compositions are typically applied to skin or hair and rinsed-off with water (e.g., rinse-off product).
  • Some problems associated with skin and hair cleansing compositions include skin irritation and dry skin and hair.
  • Moisturizers are complex mixtures of chemical agents specially designed to make the external layers of the skin (epidermis) softer and more pliable. They increase the skin's hydration (water content) by reducing evaporation.
  • Naturally occurring skin lipids and sterols, as well as artificial or natural oils, humectants, emollients, lubricants, etc. may be part of the composition of commercial skin moisturizers. They usually are available as commercial products for cosmetic and therapeutic uses, but can also be made at home using common pharmacy ingredients.
  • moisturizers Some problems associated with moisturizers include the product leaving a greasy or oily feel and poor stability.
  • Concealers are typically applied to skin and left on the skin to hide the appearance of unwanted blemishes or colors on the skin.
  • Some problems associated with concealers include skin irritation, stability, lack of adequate effectiveness, and difficulty in applying to skin.
  • Perfumes, colognes, Eau de perfume (EDP), and deodorants are typically applied and remain on skin, hair, or clothing. They are designed to mask odors and provide an pleasant fragrance. They deliver fragrance to the skin, hair, or clothing.
  • perfumes, colognes, EDP, and deodorants include skin irritation, stability, and allergies.
  • the present invention overcomes deficiencies in the art by providing stable cleansing compositions that can also effectively moisturize, protect, and cleanse the skin or hair.
  • Moisturizing compositions are also provided that can effectively moisturize the skin.
  • Concealer compositions are provided that can effectively conceal blemishes or unwanted colors of or on skin.
  • Fragrance compositions are further provided that can effectively provide fragrance for skin, hair, or clothing.
  • composition comprising any one of, any combination of, or all of: cocamidopropyl betaine; phenoxyethanol; sodium chloride; caprylyl glycol; citric acid; hexylene glycol; ethylhexylglycerin; and hydroxypropyl cyclodextrin.
  • the amounts of the ingredients within the composition can vary (e.g., amounts can be as low as 0.000001% to as high as 80% w/w or any range therein).
  • the composition includes 1% to 6%> w/w of cocamidopropyl betaine; 0.1 % to 3% w/w of phenoxyethanol; 0.1 % to 1% w/w of sodium chloride; 0.1% to 1.5% w/w of caprylyl glycol; 0.05% to 1% w/w of citric acid; 0.01% to 0.5% w/w of hexylene glycol; 0.01% to 0.5% w/w of ethylhexylglycerin; and 0.01% to 0.5% w/w of hydroxypropyl cyclodextrin.
  • the composition includes water. In other instances, the composition can include 25% to 80% w/w of water.
  • compositions above can further include a fragrance. That fragrance, in another instance may be 0.5% to 4% w/w of the composition.
  • the compositions above may also be in the form of an emulsion, a lotion, a gel, or ointment.
  • the composition may further comprise one or more ingredients described herein.
  • the composition may comprise one or more additional ingredients selected from one or more conditioning agents, moisturizing agents, pH adjusters, structuring agents, inorganic salts, and preservatives.
  • compositions above is an emulsion.
  • compositions above further includes any one of, any combination of, or all of: tea-lauryl sulfate; PEG- 120 methyl glucose dioleate; PEG- 18 glyceryl oleate/cocoate; PEG- 12 dimethicone; PPG-30 cetyl ether; and methylparaben.
  • the amounts of the ingredients within the composition can vary (e.g., amounts can be as low as 0.000001%> to as high as 80% w/w or any range therein).
  • the compositions above can include 5% to 20% w/w of tea-lauryl sulfate; 1% to 10%> w/w of PEG- 120 methyl glucose dioleate; 1% to 10%> w/w of PEG-18 glyceryl oleate/cocoate; 0.1% to 3% w/w of PEG-12 dimethicone; 0.1% to 3% w/w of PPG-30 cetyl ether; and 0.05% to 1% w/w of methylparaben.
  • the compositions are capable of cleansing skin or hair.
  • the composition disclosed above is a gel.
  • the composition above includes any one of, any combination of, or all of cocamidopropyl betaine; phenoxyethanol; sodium chloride; caprylyl glycol; citric acid; hexylene glycol; ethylhexylglycerin; hydroxypropyl cyclodextrin; sodium laureth sulfate; propanediol; PPG-2 hydroxyethyl coco/isostearamide; acrylates copolymer; glycerin; triethanolamine; and disodium EDTA.
  • the amounts of the ingredients within the composition can vary (e.g., amounts can be as low as 0.000001% to as high as 80% w/w or any range therein).
  • the composition includes: 5% to 20% w/w of sodium laureth sulfate; 1% to 10% w/w of propanediol; 1% to 10% w/w of PPG-2 hydroxyethyl coco/isostearamide; 1% to 10% w/w of acrylates copolymer; 0.5% to 5% w/w of glycerin; 0.5% to 5% w/w of triethanolamine; and 0.01% to 1% w/w of disodium EDTA.
  • the composition further includes Opuntia tuna fruit extract.
  • the composition includes 0.005% to 0.5% Opuntia tuna fruit extract.
  • the composition is capable of cleansing skin or hair.
  • Methods of use for the compositions disclosed herein are also disclosed.
  • the compositions disclosed are capable of cleansing skin or hair.
  • the compositions are applied to skin or hair by applying the composition to skin or hair followed by rinsing the composition from the skin or hair within 10 minutes after application.
  • the compositions above are applied to the skin or hair and then rinsed, removing dirt, sebum, grease, and/or oil from the skin or hair.
  • compositions described herein comprising applying said composition to the skin and hair followed by rinsing said composition from the skin and hair within 10 minutes after application.
  • the composition is applied to the skin and/or hair and remains on the skin and/or hair for at least 5, 10, 15, 30, or more minutes, or 1, 4, 8, 12, 16, 20, or 24 hours after topical application.
  • the composition can be applied to leg skin, arm skin, torso skin, or skin in the pelvic region.
  • the compositions, when formulated as cleansers, body washes, shampoos, etc. are useful for the removal of dirt, sebum, grease, and/or oil from the skin and hair.
  • composition comprising any one of, any combination of, or all of caprylic/capric triglyceride; hydrogenated polydecene; butylene glycol; propylene glycol stearate; PPG-26 oleate; phenoxyethanol; sorbitan stearate; sorbitan laurate; dimethicone; caprylyl glycol; chlorphenesin; xanthan gum; carbomer; and disodium EDTA.
  • the amounts of the ingredients within the composition can vary (e.g., amounts can be as low as 0.000001% to as high as 80% w/w or any range therein).
  • the composition includes: 1% to 15% w/w of caprylic/capric triglyceride; 1% to 15% w/w of hydrogenated polydecene; 1% to 10% w/w of butylene glycol; 0.1% to 5% w/w of propylene glycol stearate; 0.1% to 5% w/w of PPG-26 oleate; 0.1% to 3% w/w of phenoxyethanol; 0.1%) to 3%) w/w of sorbitan stearate; 0.1% to 3% w/w of sorbitan laurate; 0.1% to 1.5% w/w of dimethicone; 0.05% to 1% w/w of caprylyl glycol; 0.05% to 1% w/w of chlorphenesin; 0.05% to 1% w/w of xanthan gum; 0.05% to 1% w/w of carbomer; and 0.01% to 0.5% w/w of disodium EDTA.
  • the composition further includes water.
  • the water may comprises 25% to 80% w/w of the composition.
  • the composition may also include a fragrance.
  • the composition includes 0.5% to 4% w/w of a fragrance.
  • the composition is formulated as an emulsion, a lotion, a gel, or an ointment.
  • the composition is a lotion.
  • the composition further includes: stearic acid; cetearyl alcohol; PEG- 100 stearate; and triethanolamine.
  • the composition may include: 1% to 10% w/w of stearic acid; 0.5% to 5% w/w of cetearyl alcohol; 0.5% to 5% w/w of PEG- 100 stearate; and 0.1% to 3% w/w of triethanolamine.
  • the composition is capable of moisturizing skin or hair.
  • Methods of use for the compositions disclosed herein are also disclosed.
  • a method of applying the composition to skin or hair comprises applying the composition to skin or hair and leaving the composition on the skin or hair.
  • a method of moisturizing skin or hair comprises applying the composition to skin or hair.
  • a fragrance, perfume, cologne, deodorant, Eau de perfume (EDP), etc. is disclosed.
  • a composition includes any one of, any combination of, or all of: denatured alcohol; water; glycerin; and fragrance.
  • the amounts of the ingredients within the composition can vary (e.g., amounts can be as low as 0.000001% to as high as 80% w/w or any range therein).
  • the composition includes: 25% to 90%) w/w of denatured alcohol; 5% to 75% w/w of water; 0.5%> to 10%> w/w of glycerin; and 0.1% to 5% w/w of fragrance.
  • the composition is capable of being sprayed.
  • the composition is capable of being sprayed as a mist.
  • the composition is capable of providing fragrance onto skin, hair, or clothing.
  • Methods of use for the compositions disclosed herein are also disclosed.
  • the composition is applied to skin, hair, or clothing wherein the composition is left on the skin, hair, or clothing.
  • providing fragrance onto the skin, hair, or clothing comprises applying the composition to skin, hair, or clothing.
  • the composition includes a unique combination of any one of, any combination of, or all of: denatured alcohol; water; fragrance; propylene glycol; ethylhexylglycerin; and octenidine HCl.
  • the amounts of the ingredients within the composition can vary (e.g., amounts can be as low as 0.000001% to as high as 80% w/w or any range therein).
  • the composition includes: 25% to 90% w/w of denatured alcohol; 5% to 20% w/w of water; 0.1% to 20% w/w of fragrance; 0.1% to 3% w/w of propylene glycol; 0.01% to 1% w/w of ethylhexylglycerin; and 0.001% to 0.1% w/w of octenidine HCl.
  • the composition is capable of being sprayed.
  • the composition is capable of being sprayed as a mist.
  • the composition is capable of providing fragrance onto skin, hair, or clothing. Methods of use for the compositions disclosed herein are also disclosed. In one instance the composition is applied to skin, hair, or clothing wherein the composition is left on the skin, hair, or clothing.
  • providing fragrance onto the skin, hair, or clothing comprises applying the composition to skin, hair, or clothing.
  • a concealer in yet another instance, includes a unique combination of any one of, any combination of, or all of: PEG-9 polydimethylsiloxyethyl dimethicone; quaternium-90 bentonite; and tocopherol.
  • the amounts of the ingredients within the composition can vary (e.g., amounts can be as low as 0.000001% to as high as 80% w/w or any range therein).
  • the composition includes: 1% to 10% w/w of PEG-9 polydimethylsiloxyethyl dimethicone; 0.1% to 3% w/w of quaternium-90 bentonite; and 0.01% to 1% w/w of tocopherol.
  • the composition further contains water.
  • the water may comprises 5% to 45% w/w of the composition.
  • the composition further contains: titanium dioxide; dimethicone; cyclopentasiloxane; hydrogenated polydecene; propanediol; hydrogenated polycyclopentadiene; methyl trimethicone; iron oxides; methyl methacrylate crosspolymer; and isododecane.
  • the composition may include: 5% to 25% w/w of titanium dioxide; 5% to 15% w/w of dimethicone; 3% to 15% w/w of cyclopentasiloxane; 3% to 15% w/w of hydrogenated polydecene; 1% to 10% w/w of propanediol; 1% to 10% w/w of hydrogenated polycyclopentadiene; 0.5% to 5% w/w of methyl trimethicone; 0.5% to 5% w/w of iron oxides; 0.5% to 5% w/w of methyl methacrylate crosspolymer; and 0.5% to 5% w/w of isododecane.
  • the composition may further include glycerin; acrylates/dimethicone copolymer; bismuth oxychloride; PEG-9 dimethicone; cyclohexasiloxane; magnesium sulfate; iron oxides; phenoxyethanol; hexylene glycol; disodium stearoyl glutamate; caprylyl glycol; chlorphenesin; dipotassium glycyrrhizate; disodium EDTA; and hydroxypropyl cyclodextrin.
  • the composition may include 0.1% to 3% w/w of glycerin; 0.1% to 3% w/w of acrylates/dimethicone copolymer; 0.1% to 3% w/w of bismuth oxychloride; 0.1% to 3% w/w of PEG-9 dimethicone; 0.1% to 3% w/w of cyclohexasiloxane; 0.1% to 3% w/w of magnesium sulfate; 0.1% to 3% w/w of iron oxides; 0.1% to 3% w/w of phenoxyethanol; 0.01%) to 1%) w/w of hexylene glycol; 0.01% to 1% w/w of disodium stearoyl glutamate; 0.01% to 1% w/w of caprylyl glycol; 0.01% to 0.5% w/w of chlorphenesin; 0.01% to 0.5% w/w of dipotassium glycyrrh
  • composition comprising a solvent, sodium lauryl sulfate, sodium laureth sulfate, lauramidopropyl betaine, glycerin, acrylates copolymer, glycereth-2 cocoate, and a dermatologically acceptable vehicle.
  • the composition comprises 50 to 80% by weight of a solvent, 4 to 8% by weight of sodium lauryl sulfate, 4 to 8% by weight of sodium laureth sulfate, 1 to 5% by weight of lauramidopropyl betaine, 1 to 5% by weight of glycerin, 1 to 5% by weight of acrylates copolymer, and 0.01 to 1% by weight of glycereth-2 cocoate.
  • the composition is formulated as an emulsion, a lotion, a gel, a cream, or an ointment.
  • the composition is a gel.
  • the composition comprises a dermatologically acceptable vehicle described herein.
  • the solvent comprises water, alcohol, or both.
  • the composition further comprises one or more additional ingredients selected from one or more pH adjusters, preservatives, thickening agents, fragrances, color ingredients, emulsifiers, chelating agents, film formers, and conditioning agents.
  • the composition further comprises one or more additional cosmetic ingredients described herein.
  • there is a method of cleansing the hair and skin of the body comprising applying a composition described herein to the hair and skin.
  • the method further comprises rinsing the composition from the hair and skin.
  • the composition removes dirt and oils from the body and/or skin.
  • Embodiment one is a composition comprising cocamidopropyl betaine, phenoxyethanol, sodium chloride, caprylyl glycol, citric acid, hexylene glycol, ethylhexylglycerin, and hydroxypropyl cyclodextrin.
  • Embodiment two is the composition of embodiment one, wherein the composition comprises 1% to 6% w/w of cocamidopropyl betaine, 0.1% to 3% w/w of phenoxyethanol, 0.1 % to 1% w/w of sodium chloride, 0.1 % to 1.5% w/w of caprylyl glycol, 0.05% to 1% w/w of citric acid, 0.01% to 0.5% w/w of hexylene glycol, 0.01% to 0.5% w/w of ethylhexylglycerin, and 0.01% to 0.5% w/w of hydroxypropyl cyclodextrin.
  • Embodiment three is the composition of embodiment one or two, further comprising water.
  • Embodiment four is the composition of embodiment three, wherein the composition comprises 25% to 80% w/w of water.
  • Embodiment five is the composition of any one of embodiments one to four, further comprising a fragrance.
  • Embodiment six is the composition of embodiment five, wherein the composition comprises 0.5% to 4% w/w of a fragrance.
  • Embodiment seven is the composition of any one of embodiments one to six, wherein the composition is an emulsion, a lotion, a gel, or an ointment.
  • Embodiment eight is the composition of embodiment seven, wherein the composition is an emulsion.
  • Embodiment nine is the composition of embodiment seven or eight, further comprising tea-lauryl sulfate, PEG- 120 methyl glucose dioleate, PEG- 18 glyceryl oleate/cocoate, PEG-12 dimethicone, PPG-30 cetyl ether, and methylparaben.
  • Embodiment ten is the composition of embodiment nine, wherein the composition comprises 5%> to 20%) w/w of tea-lauryl sulfate, 1% to 10% w/w of PEG- 120 methyl glucose dioleate, 1% to 10% w/w of PEG-18 glyceryl oleate/cocoate, 0.1% to 3% w/w of PEG-12 dimethicone, 0.1% to 3% w/w of PPG-30 cetyl ether, and 0.05% to 1% w/w of methylparaben.
  • Embodiment eleven is the composition of embodiment seven, wherein the composition is a gel.
  • Embodiment twelve is the composition of embodiment seven or eleven, further comprising sodium laureth sulfate, propanediol, PPG-2 hydroxyethyl coco/isostearamide, acrylates copolymer, glycerin, triethanolamine, and disodium EDTA.
  • Embodiment thirteen is the composition of embodiment twelve, wherein the composition comprises 5% to 20% w/w of sodium laureth sulfate, 1% to 10%> w/w of propanediol, 1% to 10%) w/w of PPG-2 hydroxyethyl coco/isostearamide, 1% to 10%> w/w of acrylates copolymer, 0.5%> to 5% w/w of glycerin, 0.5% to 5% w/w of triethanolamine, and 0.01% to 1% w/w of disodium EDTA.
  • Embodiment fourteen is the composition of embodiment twelve or thirteen, further comprising Opuntia tuna fruit extract.
  • Embodiment fifteen is the composition of embodiment fourteen, wherein the composition comprises 0.005% to 0.5% Opuntia tuna fruit extract.
  • Embodiment sixteen is the composition of any one of embodiments one to fifteen, wherein the composition is capable of cleansing skin or hair.
  • Embodiment seventeen is a method of applying the composition of any one of embodiments one to fifteen to skin or hair comprising applying the composition to skin or hair followed by rinsing the composition from the skin or hair within 10 minutes after application.
  • Embodiment eighteen is the method of embodiment seventeen, wherein said composition removes dirt, sebum, grease, and/or oil from the skin or hair.
  • Embodiment nineteen is a composition comprising caprylic/capric triglyceride, hydrogenated polydecene, butylene glycol, propylene glycol stearate, PPG-26 oleate, phenoxyethanol, sorbitan stearate, sorbitan laurate, dimethicone, caprylyl glycol, chlorphenesin, xanthan gum, carbomer, and disodium EDTA.
  • Embodiment twenty is the composition of embodiment nineteen, wherein the composition comprises 1% to 15% w/w of caprylic/capric triglyceride, 1% to 15% w/w of hydrogenated polydecene, 1% to 10% w/w of butylene glycol, 0.1% to 5% w/w of propylene glycol stearate, 0.1% to 5% w/w of PPG-26 oleate, 0.1% to 3% w/w of phenoxyethanol, 0.1% to 3% w/w of sorbitan stearate, 0.1% to 3% w/w of sorbitan laurate, 0.1% to 1.5% w/w of dimethicone, 0.05% to 1% w/w of caprylyl glycol, 0.05% to 1% w/w of chlorphenesin, 0.05% to 1% w/w of xanthan gum, 0.05% to 1% w/w of carbomer, and 0.01% to 0.5%
  • Embodiment twenty-one is the composition of embodiment nineteen, further comprising water.
  • Embodiment twenty-two is the composition of embodiment twenty-one, wherein the composition comprises 25% to nineteen to twenty-two, further comprising a fragrance.
  • Embodiment twenty-four is the composition of embodiment twenty-three, wherein the composition comprises 0.5% to 4% w/w of a fragrance.
  • Embodiment twenty-five is the composition of any one of embodiments nineteen to twenty-four, wherein the composition is formulated as selected from a group consisting of an emulsion, a lotion, a gel, and an ointment.
  • Embodiment twenty-six is the composition of embodiment twenty-five, wherein the composition is formulated as a lotion.
  • Embodiment twenty-seven is the composition of embodiment twenty-five or twenty-six, further comprising stearic acid, cetearyl alcohol, PEG- 100 stearate, and triethanolamine.
  • Embodiment twenty-eight is the composition of embodiment twenty-seven, wherein the composition comprises 1% to 10%> w/w of stearic acid, 0.5%> to 5% w/w of cetearyl alcohol, 0.5% to 5% w/w of PEG- 100 stearate, and 0.1% to 3% w/w of triethanolamine.
  • Embodiment twenty-nine is the composition of any one of embodiments nineteen to twenty-eight, wherein the composition is capable of moisturizing skin or hair.
  • Embodiment thirty is a method of applying the composition of any one of embodiments nineteen to twenty-nine to skin or hair comprising applying the composition to skin or hair and leaving the composition on the skin or hair.
  • Embodiment thirty-one is a method of moisturizing skin or hair comprising applying the composition of any one of embodiments nineteen to twenty-nine to skin or hair.
  • Embodiment thirty-two is a composition comprising denatured alcohol, water, glycerin, and fragrance.
  • Embodiment thirty-three is the composition of embodiment thirty- two, wherein the composition comprises 25% to 90%> w/w of denatured alcohol, 5% to 75% w/w of water, 0.5% to 10% w/w of glycerin, and 0.1% to 5% w/w of fragrance.
  • Embodiment thirty-four is a composition comprising denatured alcohol, water, fragrance, propylene glycol, ethylhexylglycerin, and octenidine HC1.
  • Embodiment thirty-five is the composition of embodiment thirty-four, wherein the composition comprises 25% to 90% w/w of denatured alcohol, 5% to 20% w/w of water, 0.1% to 20% w/w of fragrance, 0.1% to 3% w/w of propylene glycol, 0.01% to 1% w/w of ethylhexylglycerin, and 0.001% to 0.1% w/w of octenidine HC1.
  • Embodiment thirty-six is the composition of any one of embodiments thirty- two to thirty-five, wherein the composition is formulated as a composition capable of being sprayed.
  • Embodiment thirty-seven is the composition of embodiment thirty-six, wherein the composition is formulated as a composition capable of being sprayed as a mist.
  • Embodiment thirty-eight is the composition of any one of embodiments thirty-two to thirty-seven, wherein the composition is capable of providing fragrance onto skin, hair, or clothing.
  • Embodiment thirty-nine is a method of applying the composition of any one of embodiments thirty-two to thirty-eight to skin, hair, or clothing comprising applying the composition to skin, hair, or clothing and leaving the composition on the skin, hair, or clothing.
  • Embodiment forty is a method of providing fragrance onto skin, hair, or clothing comprising applying the composition of any one of embodiments thirty-two to thirty-eight to skin, hair, or clothing.
  • Embodiment forty-one is a composition comprising PEG-9 polydimethylsiloxyethyl dimethicone, quaternium-90 bentonite, and tocopherol.
  • Embodiment forty-two is the composition of embodiment forty-one, wherein the composition comprises 1% to 10% w/w of PEG-9 polydimethylsiloxyethyl dimethicone, 0.1 % to 3% w/w of quaternium-90 bentonite, and 0.01% to 1% w/w of tocopherol.
  • Embodiment forty-three is the composition of embodiment forty-one or forty-two, further comprising water.
  • Embodiment forty-four is the composition of embodiment forty-three, wherein the composition comprises 5% to 45% w/w of water.
  • Embodiment forty-five is the composition of any one of embodiments forty-one to forty-four, further comprising titanium dioxide, dimethicone, cyclopentasiloxane, hydrogenated polydecene, propanediol, hydrogenated polycyclopentadiene, methyl trimethicone, iron oxides, methyl methacrylate crosspolymer, and isododecane.
  • Embodiment forty-six is the composition of embodiment forty-five, wherein the composition comprises 5% to 25% w/w of titanium dioxide, 5% to 15% w/w of dimethicone, 3% to 15% w/w of cyclopentasiloxane, 3% to 15% w/w of hydrogenated polydecene, 1% to 10% w/w of propanediol, 1% to 10% w/w of hydrogenated polycyclopentadiene, 0.5% to 5% w/w of methyl trimethicone, 0.5% to 5% w/w of iron oxides, 0.5%) to 5% w/w of methyl methacrylate crosspolymer, and 0.5% to 5% w/w of isododecane.
  • Embodiment forty-seven is the composition of any one of embodiments forty- one to forty- six, further comprising glycerin, acrylates/dimethicone copolymer, bismuth oxychloride, PEG-9 dimethicone, cyclohexasiloxane, magnesium sulfate, iron oxides, phenoxyethanol, hexylene glycol, disodium stearoyl glutamate, caprylyl glycol, chlorphenesin, dipotassium glycyrrhizate, disodium EDTA, and hydroxypropyl cyclodextrin.
  • Embodiment forty-eight is the composition of embodiment forty-seven, wherein the composition comprises 0.1% to 3% w/w of glycerin, 0.1% to 3% w/w of acrylates/dimethicone copolymer, 0.1% to 3% w/w of bismuth oxychloride, 0.1% to 3% w/w of PEG-9 dimethicone, 0.1% to 3% w/w of cyclohexasiloxane, 0.1% to 3% w/w of magnesium sulfate, 0.1% to 3% w/w of iron oxides, 0.1% to 3% w/w of phenoxyethanol, 0.01% to 1% w/w of hexylene glycol, 0.01% to 1% w/w of disodium stearoyl glutamate, 0.01% to 1% 1% w/w of caprylyl glycol, 0.01% to 0.5% w/w of chlorphenesin, 0.01% to 0.5%
  • Embodiment forty-nine is the composition of any one of embodiments forty-one to forty-eight, wherein the composition is capable of concealing unwanted color or blemishes of skin.
  • Embodiment fifty is a method of applying the composition of any one of embodiments forty-one to forty-nine to skin comprising applying the composition to skin and leaving the composition on the skin.
  • Embodiment fifty-one is a composition comprising a solvent, sodium lauryl sulfate, sodium laureth sulfate, lauramidopropyl betaine, glycerin, acrylates copolymer, glycereth-2 cocoate, and a dermatologically acceptable vehicle.
  • Embodiment fifty-two is the composition of embodiment fifty-one, wherein the composition comprises 50 to 80% by weight of a solvent, 4 to 8% by weight of sodium lauryl sulfate, 4 to 8% by weight of sodium laureth sulfate, 1 to 5% by weight of lauramidopropyl betaine, 1 to 5% by weight of glycerin, 1 to 5% by weight of acrylates copolymer, and 0.01 to 1% by weight of glycereth-2 cocoate.
  • Embodiment fifty-three is the composition of embodiment fifty-one or fifty-two, wherein the composition is an emulsion, a lotion, a gel, a cream, or an ointment.
  • Embodiment fifty-four is the composition of embodiment fifty-three, wherein the composition is a gel.
  • Embodiment fifty-five is the composition of any one of embodiments fifty-one to fifty-four, wherein the solvent comprises water, alcohol, or both.
  • Embodiment fifty-six is the composition of any one of embodiments fifty-one to fifty-five, further comprising one or more additional ingredients selected from one or more pH adjusters, preservatives, thickening agents, fragrances, color ingredients, emulsifiers, chelating agents, film formers, and conditioning agents.
  • Embodiment fifty-seven is a method of applying the composition of any one of embodiments fifty-one to fifty-six to skin or hair comprising applying the composition to skin or hair followed by rinsing the composition from the skin or hair within 10 minutes after application.
  • Embodiment fifty-eight is the method of embodiment fifty-seven, wherein said composition removes dirt, sebum, grease, and/or oil from the skin or hair.
  • compositions of the present invention are formulated as a topical skin composition.
  • the composition can have a dermatologically acceptable vehicle or carrier for the compounds, compositions and extracts.
  • the composition can further include a moisturizing agent or a humectant, a surfactant, a silicone containing compounds, a UV agent, an oil, and/or other ingredients identified in this specification or those known in the art.
  • the composition can be a lotion, cream, gel, serum, emulsion (e.g., oil-in- water, water-in-oil, silicone-in-water, water-in-silicone, water-in-oil-in-water, oil-in-water-in-oil, oil-in-water-in-silicone, etc.), solutions (e.g., aqueous or hydro-alcoholic solutions), anhydrous bases (e.g., lipstick or a powder), ointments, milk, paste, aerosol, solid forms, eye jellies, etc.
  • the composition can be in powdered form (e.g., dried, lyophilized, particulate, etc.).
  • compositions can be formulated for topical skin application at least 1 , 2, 3, 4, 5, 6, 7, or more times a day during use.
  • compositions can be storage stable or color stable, or both.
  • the viscosity of the composition can be selected to achieve a desired result, e.g., depending on the type of composition desired, the viscosity of such composition can be from about 1 cps to well over 1 million cps or any range or integer derivable therein (e.g., 2 cps, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 2000, 3000, 4000, 5000, 6000, 7000, 8000, 9000, 10000, 20000, 30000, 40000, 50000, 60000, 70000, 80000, 90000, 100000, 200000, 300000, 400000, 500000, 600000, 700000, 800000, 100000, 200000, 300000,
  • compositions of the present invention can also be modified to have a desired oxygen radical absorbance capacity (ORAC) value.
  • ORAC oxygen radical absorbance capacity
  • the compositions of the present invention or the component or extracts thereof identified throughout this specification can be modified to have an ORAC value per mg of at least about 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 , 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 95, 100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 2000, 3000, 4000, 5000, 6000, 7000, 8000, 9000, 10000, 15000, 20000, 30000, 50000, 100000 or more or any range derivable therein.
  • compositions in non-limiting aspects can have a pH of about 6 to about 9.
  • the pH can be 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, 13, or 14.
  • the compositions can include a triglyceride. Non-limiting examples include small, medium, and large chain triglycerides. In certain aspects, the triglyceride is a medium chain triglyceride (e.g., caprylic capric triglyceride).
  • the compositions can also include preservatives. Non-limiting examples of preservatives include methylparaben, propylparaben, or a mixture of methylparaben and propylparaben.
  • compositions of the present invention can have UVA and UVB absorption properties.
  • the compositions can have an sun protection factor (SPF) of 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, 13, 14, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, or more, or any integer or derivative therein.
  • SPF sun protection factor
  • the compositions can be sunscreen lotions, sprays, or creams.
  • compositions of the present invention can also include any one of, any combination of, or all of the following additional ingredients: water, a chelating agent, a moisturizing agent, a preservative, a thickening agent, a silicone containing compound, an essential oil, a structuring agent, a vitamin, a pharmaceutical ingredient, or an antioxidant, or any combination of such ingredients or mixtures of such ingredients.
  • the composition can include at least two, three, four, five, six, seven, eight, nine, ten, or all of these additional ingredients identified in the previous sentence.
  • Non-limiting examples of these additional ingredients are identified throughout this specification and are incorporated into this section by reference.
  • the amounts of such ingredients can range from 0.0001% to 99.9% by weight or volume of the composition, or any integer or range in between as disclosed in other sections of this specification, which are incorporated into this paragraph by reference.
  • Kits that include the compositions of the present invention are also contemplated.
  • the composition is comprised in a container.
  • the container can be a bottle, dispenser, or package.
  • the container can dispense a pre-determined amount of the composition.
  • the compositions is dispensed in a spray, mist, dollop, or liquid.
  • the container can include indicia on its surface. The indicia can be a word, an abbreviation, a picture, or a symbol.
  • compositions disclosed throughout this specification can be used as a leave-on or rinse-off composition.
  • a leave-on composition can be one that is topically applied to skin and remains on the skin for a period of time (e.g., at least 5, 6, 7, 8, 9, 10, 20, or 30 minutes, or at least 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 , 22, 23 or 24 hours, or overnight or throughout the day).
  • a rinse-off composition can be a product that is intended to be applied to the skin and then removed or rinsed from the skin (e.g. , with water) within a period of time such as less than 5, 4, 3, 2, or 1 minute.
  • An example of a rinse of composition can be a skin cleanser, shampoo, conditioner, or soap.
  • An example of a leave -on composition can be a skin moisturizer, sunscreen, mask, overnight cream, concealer, or a day cream.
  • compositions of the present invention can be pharmaceutically or cosmetically elegant or can have pleasant tactile properties.
  • “Pharmaceutically elegant,” “cosmetically elegant,” and/or “pleasant tactile properties” describes a composition that has particular tactile properties which feel pleasant on the skin ⁇ e.g., compositions that are not too watery or greasy, compositions that have a silky texture, compositions that are non-tacky or sticky, etc.).
  • Pharmaceutically or cosmetically elegant can also relate to the creaminess or lubricity properties of the composition or to the moisture retaining properties of the composition.
  • a product comprising a composition of the present invention.
  • the product can be a cosmetic product.
  • the cosmetic product can be those described in other sections of this specification or those known to a person of skill in the art.
  • Non-limiting examples of products include a moisturizer, a cream, a lotion, a skin softener, a gel, a wash, a foundation, a concealer, a night cream, a lipstick, a cleanser, a toner, a sunscreen, a mask, an anti-aging product, a deodorant, an antiperspirant, a perfume, a cologne, EDP, etc.
  • Topical application means to apply or spread a composition onto the surface of lips or keratinous tissue.
  • Topical skin composition includes compositions suitable for topical application on lips or keratinous tissue. Such compositions are typically dermatologically-acceptable in that they do not have undue toxicity, incompatibility, instability, allergic response, and the like, when applied to lips or skin. Topical skin care compositions of the present invention can have a selected viscosity to avoid significant dripping or pooling after application to skin.
  • Keratinous tissue includes keratin-containing layers disposed as the outermost protective covering of mammals and includes, but is not limited to, lips, skin, hair and nails.
  • substantially and its variations are defined as being largely but not necessarily wholly what is specified as understood by one of ordinary skill in the art, and in one non-limiting embodiment substantially refers to ranges within 10%, within 5%, within 1%, or within 0.5%.
  • the terms “inhibiting” or “reducing” or any variation of these terms includes any measurable decrease or complete inhibition to achieve a desired result.
  • the terms “promote” or “increase” or any variation of these terms includes any measurable increase or production of a protein or molecule (e.g., matrix proteins such as fibronectin, laminin, collagen, or elastin or molecules such as hyaluronic acid) to achieve a desired result.
  • compositions and methods for their use can "comprise,” “consist essentially of,” or “consist of any of the ingredients or steps disclosed throughout the specification.
  • a basic and novel characteristic of the compositions and methods disclosed in this specification includes the compositions' abilities provide a benefit to the users skin or hair, such as moisturization, cleansing, or departing of a fragrance to the skin or hair.
  • a particular composition of the present invention is designed to cleanse skin or hair.
  • the composition relies on a unique combination of any one of, any combination of, or all of cocamidopropyl betaine; phenoxyethanol; sodium chloride; caprylyl glycol; citric acid; hexylene glycol; ethylhexylglycerin; hydroxypropyl cyclodextrin.
  • the composition may further contain a fragrance.
  • the composition above is designed to work as a body wash to cleanse skin or hair while providing moisturization to the skin or hair. Two examples of such a composition are provided in Example 1 in Tables 1 and 2.
  • compositions above are designed to work as a body wash.
  • This composition includes a unique combination of any one of, any combination of, or all of tea-lauryl sulfate; PEG- 120 methyl glucose dioleate; PEG- 18 glyceryl oleate/cocoate; PEG- 12 dimethicone; PPG-30 cetyl ether; and methylparaben.
  • An example of such a composition is provided in Example 1, Table 1.
  • the composition above is designed to work as a shower gel.
  • This composition includes a unique combination of any one of, any combination of, or all of cocamidopropyl betaine; phenoxyethanol; sodium chloride; caprylyl glycol; citric acid; hexylene glycol; ethylhexylglycerin; hydroxypropyl cyclodextrin; sodium laureth sulfate; propanediol; PPG-2 hydroxyethyl coco/isostearamide; acrylates copolymer; glycerin; triethanolamine; and disodium EDTA.
  • the composition further includes Opuntia tuna fruit extract. An example of such a composition is provided in Example 1, Table 2.
  • composition of the present invention is designed to work as a composition that is designed to moisturize skin or hair.
  • the composition includes a unique combination of any one of, any combination of, or all of caprylic/capric triglyceride; hydrogenated polydecene; butylene glycol; propylene glycol stearate; PPG-26 oleate; phenoxyethanol; sorbitan stearate; sorbitan laurate; dimethicone; caprylyl glycol; chlorphenesin; xanthan gum; carbomer; and disodium EDTA.
  • the composition above may further contain a fragrance.
  • An example of such a composition is provided in Example 1, Table 3.
  • composition of the present invention is designed to work as a fragrance, perfume, cologne, deodorant, EDP, etc.
  • the composition includes a unique combination of any one of, any combination of, or all of denatured alcohol; water; glycerin; and fragrance.
  • An example of such a composition is provided in Example 1, Table 4.
  • composition of the present invention is designed to work as a fragrance, perfume, cologne, deodorant, EDP, etc.
  • the composition includes a unique combination of any one of, any combination of, or all of denatured alcohol; water; fragrance; propylene glycol; ethylhexylglycerin; and octenidine HC1.
  • An example of such a composition is provided in Example 1, Table 5.
  • composition of the present invention is designed to work as a composition that is designed to conceal unwanted color or blemishes of or on skin.
  • the composition includes a unique combination of any one of, any combination of, or all of PEG-9 polydimethylsiloxyethyl dimethicone; quaternium-90 bentonite; and tocopherol.
  • the composition above may further contain water.
  • the composition above may further contain titanium dioxide; dimethicone; cyclopentasiloxane; hydrogenated polydecene; propanediol; hydrogenated polycyclopentadiene; methyl trimethicone; iron oxides; methyl methacrylate crosspolymer; and isododecane.
  • the composition above may further contain glycerin; acrylates/dimethicone copolymer; bismuth oxychloride; PEG-9 dimethicone; cyclohexasiloxane; magnesium sulfate; iron oxides; phenoxyethanol; hexylene glycol; disodium stearoyl glutamate; caprylyl glycol; chlorphenesin; dipotassium glycyrrhizate; disodium EDTA; and hydroxypropyl cyclodextrin.
  • glycerin acrylates/dimethicone copolymer
  • bismuth oxychloride PEG-9 dimethicone
  • cyclohexasiloxane cyclohexasiloxane
  • magnesium sulfate iron oxides
  • phenoxyethanol hexylene glycol
  • disodium stearoyl glutamate hexylene glycol
  • caprylyl glycol
  • compositions can be applied to the skin or hair and remain on the skin or hair for a period of time (e.g., at least 1 , 2, 3, 4, 5, 10, 20, 30, or 60 minutes or more). After which, the composition, if needed, can be rinsed from the skin or peeled from the skin.
  • a period of time e.g., at least 1 , 2, 3, 4, 5, 10, 20, 30, or 60 minutes or more.
  • compositions of the present invention can include any amount of the ingredients discussed in this specification.
  • the compositions can also include any number of combinations of additional ingredients described throughout this specification (e.g., pigments, or additional cosmetic or pharmaceutical ingredients).
  • concentrations of the any ingredient within the compositions can vary.
  • the compositions can comprise, consisting essentially of, or consist of, in their final form, for example, at least about 0.0001°/ ⁇ , 0.0002%, 0 0003%
  • compositions of the present invention can be incorporated into all types of vehicles.
  • vehicles include emulsions (e.g., water-in-oil, water-in-oil-in- water, oil-in-water, silicone-in-water, water-in-silicone, oil-in-water-in-oil, oil-in-water-in-silicone emulsions), creams, lotions, solutions (both aqueous and hydro-alcoholic), anhydrous bases (such as lipsticks and powders), gels, masks, peels, and ointments.
  • emulsions e.g., water-in-oil, water-in-oil-in- water, oil-in-water, silicone-in-water, water-in-silicone, oil-in-water-in-oil, oil-in-water-in-silicone emulsions
  • creams lotions, solutions (both aqueous and hydro-alcoholic), anhydrous bases (such as lipsticks and powders),
  • compositions can also include additional ingredients such as cosmetic ingredients and pharmaceutical active ingredients.
  • additional ingredients such as cosmetic ingredients and pharmaceutical active ingredients.
  • additional ingredients are described in the following subsections. 1. Cosmetic Ingredients
  • fragrance agents artificial and natural; e.g. , gluconic acid, phenoxyethanol, and triethanolamine
  • dyes and color ingredients e.g., MICA, Blue 1, Blue 1 Lake, Red 40, titanium dioxide, D&C blue no. 4, D&C green no. 5, D&C orange no. 4, D&C red no. 17, D&C red no. 33, D&C violet no. 2, D&C yellow no. 10, and D&C yellow no.
  • flavoring agents / aroma agents e.g., Stevia rebaudiana (sweetleaf) extract, and menthol
  • adsorbents e.g., adsorbents, lubricants, solvents, moisturizers (including, e.g., emollients, humectants, film formers (e.g., polyquaternium-7), occlusive agents, and agents that affect the natural moisturization mechanisms of the skin), water-repellants, UV absorbers (physical and chemical absorbers such as para-aminobenzoic acid (“PABA”) and corresponding PABA derivatives, titanium dioxide, zinc oxide, etc.), essential oils, vitamins (e.g., A, B, C, D, E, and K), trace metals (e.g., zinc, calcium and selenium), anti-irritants (e.g., steroids and non-steroidal anti-inflammatories), botanical extracts (e.g., aloe vera, chamomile, cucumber
  • UV absorption agents that can be used in combination with the compositions of the present invention include chemical and physical sunblocks.
  • chemical sunblocks that can be used include para-aminobenzoic acid (PABA), PABA esters (glyceryl PABA, amyldimethyl PABA and octyldimethyl PABA), butyl PABA, ethyl PABA, ethyl dihydroxypropyl PABA, benzophenones (oxybenzone, sulisobenzone, benzophenone, and benzophenone- 1 through 12), cinnamates (octyl methoxycinnamate, isoamyl p-methoxycinnamate, octylmethoxy cinnamate, cinoxate, diisopropyl methyl cinnamate, DEA-methoxycinnamate, ethyl diisopropylcinnamate, glyceryl oc
  • PABA para-
  • Non-limiting examples of moisturizing agents that can be used with the compositions of the present invention include amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG- 15 butanediol, polyglyceryl sorbitol, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • acetylated lanolin examples include acetylated lanolin, acetylated lanolin alcohol, alanine, algae extract, aloe barbadensis, aloe-barbadensis extract, aloe barbadensis gel, althea officinalis extract, apricot (prunus armeniaca) kernel oil, arginine, arginine aspartate, arnica montana extract, aspartic acid, avocado (persea gratissima) oil, barrier sphingolipids, butyl alcohol, beeswax, behenyl alcohol, beta-sitosterol, birch (betula alba) bark extract, borage (borago officinalis) extract, butcherbroom (ruscus aculeatus) extract, butylene glycol, calendula officinalis extract, calendula officinalis oil, candelilla (euphorbia cerifera) wax, canola oil, cap
  • Non-limiting examples of antioxidants that can be used with the compositions of the present invention include acetyl cysteine, ascorbic acid polypeptide, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl palmitate, ascorbyl stearate, BHA, BHT, t-butyl hydroquinone, cysteine, cysteine HCI, diamylhydroquinone, di-t- butylhydroquinone, dicetyl thiodipropionate, dioleyl tocopheryl methylsilanol, disodium ascorbyl sulfate, distearyl thiodipropionate, ditridecyl thiodipropionate, dodecyl gallate, erythorbic acid, esters of ascorbic acid, ethyl ferulate, ferulic acid, gallic acid esters, hydroquinone, isooc
  • compositions of the present invention can include a structuring agent.
  • Structuring agent in certain aspects, assist in providing rheological characteristics to the composition to contribute to the composition's stability.
  • structuring agents can also function as an emulsifier or surfactant.
  • Non- limiting examples of structuring agents include stearic acid, palmitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmitic acid, the polyethylene glycol ether of stearyl alcohol having an average of about 1 to about 21 ethylene oxide units, the polyethylene glycol ether of cetyl alcohol having an average of about 1 to about 5 ethylene oxide units, and mixtures thereof.
  • Emulsifiers include stearic acid, palmitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmitic acid, the polyethylene glycol ether of stearyl alcohol having an average of about 1 to about 21 ethylene oxide units, the polyethylene glycol
  • the compositions do not include an emulsifier.
  • the compositions can include one or more emulsifiers.
  • Emulsifiers can reduce the interfacial tension between phases and improve the formulation and stability of an emulsion.
  • the emulsifiers can be nonionic, cationic, anionic, and zwitterionic emulsifiers (See McCutcheon's (1986); U.S. Pat. Nos. 5,011,681; 4,421,769; 3,755,560).
  • Non-limiting examples include esters of glycerin, esters of propylene glycol, fatty acid esters of polyethylene glycol, fatty acid esters of polypropylene glycol, esters of sorbitol, esters of sorbitan anhydrides, carboxylic acid copolymers, esters and ethers of glucose, ethoxylated ethers, ethoxylated alcohols, alkyl phosphates, polyoxyethylene fatty ether phosphates, fatty acid amides, acyl lactylates, soaps, TEA stearate, DEA oleth-3 phosphate, polyethylene glycol 20 sorbitan monolaurate (polysorbate 20), polyethylene glycol 5 soya sterol, steareth-2, steareth-20, steareth-21, ceteareth-20, cetearyl glucoside, cetearyl alcohol, C12-13 pareth-3, PPG-2 methyl glucose ether distearate, P
  • silicone containing compounds include any member of a family of polymeric products whose molecular backbone is made up of alternating silicon and oxygen atoms with side groups attached to the silicon atoms.
  • silicones can be synthesized into a wide variety of materials. They can vary in consistency from liquid to gel to solids.
  • the silicone containing compounds that can be used in the context of the present invention include those described in this specification or those known to a person of ordinary skill in the art.
  • Non-limiting examples include silicone oils (e.g. , volatile and nonvolatile oils), gels, and solids.
  • the silicon containing compounds includes a silicone oils such as a polyorganosiloxane.
  • Non-limiting examples of polyorganosiloxanes include dimethicone, cyclomethicone, polysilicone-11, phenyl trimethicone, trimethylsilylamodimethicone, stearoxytrimethylsilane, or mixtures of these and other organosiloxane materials in any given ratio in order to achieve the desired consistency and application characteristics depending upon the intended application (e.g., to a particular area such as the skin, hair, or eyes).
  • a "volatile silicone oil” includes a silicone oil have a low heat of vaporization, i.e. normally less than about 50 cal per gram of silicone oil.
  • Non- limiting examples of volatile silicone oils include: cyclomethicones such as Dow Corning 344 Fluid, Dow Corning 345 Fluid, Dow Corning 244 Fluid, and Dow Corning 245 Fluid, Volatile Silicon 7207 (Union Carbide Corp., Danbury, Conn.); low viscosity dimethicones, i.e. dimethicones having a viscosity of about 50 est or less ⁇ e.g., dimethicones such as Dow Corning 200-0.5 est Fluid).
  • the Dow Corning Fluids are available from Dow Corning Corporation, Midland, Michigan.
  • Cyclomethicone and dimethicone are described in the Third Edition of the CTFA Cosmetic Ingredient Dictionary (incorporated by reference) as cyclic dimethyl polysiloxane compounds and a mixture of fully methylated linear siloxane polymers end-blocked with trimethylsiloxy units, respectively.
  • Other non-limiting volatile silicone oils that can be used in the context of the present invention include those available from General Electric Co., Silicone Products Div., Waterford, N.Y. and SWS Silicones Div. of Stauffer Chemical Co., Adrian, Michigan. g. Essential Oils
  • Essential oils include oils derived from herbs, flowers, trees, and other plants.
  • oils are typically present as tiny droplets between the plant's cells, and can be extracted by several method known to those of skill in the art (e.g., steam distilled, enfleurage (i.e., extraction by using fat), maceration, solvent extraction, or mechanical pressing). When these types of oils are exposed to air they tend to evaporate (i.e., a volatile oil). As a result, many essential oils are colorless, but with age they can oxidize and become darker. Essential oils are insoluble in water and are soluble in alcohol, ether, fixed oils (vegetal), and other organic solvents. Typical physical characteristics found in essential oils include boiling points that vary from about 160° to 240° C and densities ranging from about 0.759 to about 1.096.
  • Essential oils typically are named by the plant from which the oil is found.
  • rose oil or peppermint oil are derived from rose or peppermint plants, respectively.
  • essential oils that can be used in the context of the present invention include sesame oil, macadamia nut oil, tea tree oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, coriander oil, thyme oil, pimento berries oil, rose oil, anise oil, balsam oil, bergamot oil, rosewood oil, cedar oil, chamomile oil, sage oil, clary sage oil, clove oil, cypress oil, eucalyptus oil, fennel oil, sea fennel oil, frankincense oil, geranium oil, ginger oil, grapefruit oil, jasmine oil, juniper oil, lavender oil, lemon oil, lemongrass oil, lime oil, mandarin oil, marjoram oil, myrrh oil, neroli oil, orange oil, patchouli oil, pepper oil, black pepper oil, petitgrain oil, pine
  • Thickening agents include substances which that can increase the viscosity of a composition.
  • Thickeners includes those that can increase the viscosity of a composition without substantially modifying the efficacy of the active ingredient within the composition.
  • Thickeners can also increase the stability of the compositions of the present invention.
  • thickeners include hydrogenated polyisobutene, sodium chloride, trihydroxystearin, ammonium acryloyldimethyltaurate/vp copolymer, or a mixture of them.
  • Non-limiting examples of additional thickening agents that can be used in the context of the present invention include carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, and gums.
  • carboxylic acid polymers include crosslinked compounds containing one or more monomers derived from acrylic acid, substituted acrylic acids, and salts and esters of these acrylic acids and the substituted acrylic acids, wherein the crosslinking agent contains two or more carbon-carbon double bonds and is derived from a polyhydric alcohol (see U.S. Pat. Nos. 5,087,445; 4,509,949; 2,798,053; CTFA International Cosmetic Ingredient Dictionary, Fourth edition, 1991 , pp. 12 and 80).
  • carboxylic acid polymers examples include carbomers, which are homopolymers of acrylic acid crosslinked with allyl ethers of sucrose or pentaerytritol (e.g., CarbopolTM 900 series from B. F. Goodrich).
  • Non-limiting examples of crosslinked polyacrylate polymers include cationic and nonionic polymers. Examples are described in U.S. Pat. Nos. 5, 100,660 ; 4,849,484; 4,835,206; 4,628,078; 4,599,379).
  • Non-limiting examples of polyacrylamide polymers include polyacrylamide, isoparaffin and laureth-7, multi-block copolymers of acrylamides and substituted acrylamides with acrylic acids and substituted acrylic acids.
  • Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof.
  • alkyl substituted cellulose where the hydroxy groups of the cellulose polymer is hydroxyalkylated (preferably hydroxy ethylated or hydroxypropylated) to form a hydroxyalkylated cellulose which is then further modified with a C IO -C30 straight chain or branched chain alkyl group through an ether linkage.
  • these polymers are ethers of C 10-C30 straight or branched chain alcohols with hydroxyalkylcelluloses.
  • Other useful polysaccharides include scleroglucans comprising a linear chain of (1-3) linked glucose units with a (1-6) linked glucose every three unit.
  • Non-limiting examples of gums that can be used with the present invention include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.
  • Preservatives Preservatives
  • Non-limiting examples of preservatives that can be used in the context of the present invention include quaternary ammonium preservatives such as polyquaternium-1 and benzalkonium halides (e.g., benzalkonium chloride ("BAC") and benzalkonium bromide), parabens (e.g., methylparabens and propylparabens), phenoxyethanol, benzyl alcohol, chlorobutanol, phenol, sorbic acid, thimerosal, benzoic acid, iodopropynyl butylcarbamate, methylisothiazolinone, methylchloroisothiazolinone, or combinations thereof.
  • quaternary ammonium preservatives such as polyquaternium-1 and benzalkonium halides (e.g., benzalkonium chloride (“BAC”) and benzalkonium bromide), parabens (e.g., methylparabens and propy
  • Pharmaceutical active agents are also contemplated as being useful with the compositions of the present invention.
  • Non-limiting examples of pharmaceutical active agents include anti-acne agents, agents used to treat rosacea, analgesics, anesthetics, anorectals, antihistamines, anti-inflammatory agents including non-steroidal antiinflammatory drugs, antibiotics, antifungals, antivirals, antimicrobials, anti-cancer actives, scabicides, pediculicides, antineoplastics, antiperspirants, antipruritics, antipsoriatic agents, antiseborrheic agents, biologically active proteins and peptides, burn treatment agents, cauterizing agents, depigmenting agents, depilatories, diaper rash treatment agents, enzymes, hair growth stimulants, hair growth retardants including DFMO and its salts and analogs, hemostatics, kerotolytics, canker sore treatment agents, cold sore treatment agents, dental and periodontal treatment agents, photosensitizing actives,
  • Kits are also contemplated as being used in certain aspects of the present invention.
  • compositions of the present invention can be included in a kit.
  • a kit can include a container.
  • Containers can include a bottle, a metal tube, a laminate tube, a plastic tube, a dispenser, a pressurized container, a barrier container, a package, a compartment, a lipstick container, a compact container, cosmetic pans that can hold cosmetic compositions, or other types of containers such as injection or blow-molded plastic containers into which the dispersions or compositions or desired bottles, dispensers, or packages are retained.
  • the kit and/or container can include indicia on its surface.
  • the indicia for example, can be a word, a phrase, an abbreviation, a picture, or a symbol.
  • the containers can dispense a pre-determined amount of the composition.
  • the container can be squeezed ⁇ e.g., metal, laminate, or plastic tube) to dispense a desired amount of the composition.
  • the composition can be dispensed as a spray, an aerosol, a liquid, a fluid, or a semi-solid.
  • the containers can have spray, pump, or squeeze mechanisms.
  • a kit can also include instructions for employing the kit components as well the use of any other compositions included in the container. Instructions can include an explanation of how to apply, use, and maintain the compositions.
  • Formulations having the ingredients from Example 1 were prepared as topical skin or hair compositions.
  • the formulation in Table 1 was prepared as a body wash.
  • the formulation in Table 2 was prepared as a shower gel.
  • the formulation in Table 3 was prepared as a body lotion.
  • the formulation in Table 4 was prepared as a fragrance mist.
  • the formulation in Table 5 was prepared as a Eau de perfume (EDP).
  • the formulation in Table 6 was prepared as a concealer.
  • *Formulation can be prepared by mixing the ingredients in a beaker under heat 70-75°C until homogenous. Subsequently, the formulation can be cooled to standing room temperature (20-25°C). Further, and if desired, additional ingredients can be added, for example, to modify the rheological properties of the composition. **Excipients can be added, for example, to modify the rheological properties of the composition.
  • the amount of water can be varied so long as the amount of water in the composition is at least 60% w/w, and preferably between 60 to 85% w/w.
  • *Formulation can be prepared by mixing the ingredients in a beaker under heat 70-75°C until homogenous. Subsequently, the formulation can be cooled to standing room temperature (20-25°C). Further, and if desired, additional ingredients can be added, for example, to modify the rheological properties of the composition. **Excipients can be added, for example, to modify the rheological properties of the composition.
  • the amount of water can be varied so long as the amount of water in the composition is at least 60% w/w, and preferably between 60 to 85% w/w.
  • *Formulation can be prepared by mixing the ingredients in a beaker under heat 70-75°C until homogenous. Subsequently, the formulation can be cooled to standing room temperature (20-25°C). Further, and if desired, additional ingredients can be added, for example, to modify the rheological properties of the composition. **Excipients can be added, for example, to modify the rheological properties of the composition.
  • the amount of water can be varied so long as the amount of water in the composition is at least 60% w/w, and preferably between 60 to 85% w/w.
  • *Formulation can be prepared by mixing the ingredients in a beaker until homogenous. Further, and if desired, additional ingredients can be added, for example, to modify the rheological properties of the composition.
  • **Excipients can be added, for example, to modify the rheological properties of the composition.
  • the amount of water can be varied so long as the amount of water in the composition is at least 10% w/w, and preferably between 15 to 30% w/w.
  • *Formulation can be prepared by mixing the ingredients in a beaker until homogenous. Further, and if desired, additional ingredients can be added, for example, to modify the rheological properties of the composition.
  • **Excipients can be added, for example, to modify the rheological properties of the composition.
  • the amount of water can be varied so long as the amount of water in the composition is at least 3% w/w, and preferably between 5 to 20 % w/w.
  • *Formulation can be prepared by mixing the ingredients in a beaker under heat 70-75°C until homogenous. Subsequently, the formulation can be cooled to standing room temperature (20-25°C). Further, and if desired, additional ingredients can be added, for example, to modify the rheological properties of the composition. **Excipients can be added, for example, to modify the rheological properties of the composition. Alternatively, the amount of water can be varied so long as the amount of water in the composition is at least 10% w/w, and preferably between 20 to 40% w/w. TABLE 7*
  • *Formulation can be prepared by mixing the ingredients in a beaker under heat 70-75°C until homogenous. Subsequently, the formulation can be cooled to standing room temperature (20-25°C). Further, and if desired, additional ingredients can be added, for example, to modify the rheological properties of the composition. **Excipients can be added, for example, to modify the rheological properties of the composition.
  • the amount of water can be varied so long as the amount of water in the composition is at least 10% w/w, and preferably between 20 to 40% w/w.
  • Assays that can be used to determine the efficacy of any one of the ingredients or any combination of ingredients or compositions having said combination of ingredients disclosed throughout the specification and claims can be determined by methods known to those of ordinary skill in the art. The following are non-limiting assays that can be used in the context of the present invention. It should be recognized that other testing procedures can be used, including, for example, objective and subjective procedures.
  • B16 Pigmentation Assay Melanogenesis is the process by which melanocytes produce melanin, a naturally produced pigment that imparts color to skin, hair, and eyes. Inhibiting melanogenesis is beneficial to prevent skin darkening and lighten dark spots associated with aging.
  • This bioassay utilizes B16-F1 melanocytes (ATCC), an immortalized mouse melanoma cell line, to analyze the effect of compounds on melanogenesis. The endpoint of this assay is a spectrophotometric measurement of melanin production and cellular viability.
  • B16-F1 melanocytes can be cultivated in standard DMEM growth medium with 10% fetal bovine serum (Mediatech) at 37°C in 10% C0 2 and then treated with any one of the active ingredients, combination of ingredients, or compositions having said combinations disclosed in the specification for 6 days. Following incubation, melanin secretion was measured by absorbance at 405 nm and cellular viability was quantified.
  • Collagen Stimulation Assay Collagen is an extracellular matrix protein critical for skin structure. Increased synthesis of collagen helps improve skin firmness and elasticity.
  • This bioassay can be used to examine the effect of any one of the active ingredients, combination of ingredients, or compositions having said combinations disclosed in the specification on the production of procollagen peptide (a precursor to collagen) by human epidermal fibroblasts.
  • the endpoint of this assay is a spectrophotometric measurement that reflects the presence of procollagen peptide and cellular viability.
  • the assay employs the quantitative sandwich enzyme immunoassay technique whereby a monoclonal antibody specific for procollagen peptide has been pre-coated onto a microplate.
  • Standards and samples can be pipetted into the wells and any procollagen peptide present is bound by the immobilized antibody. After washing away any unbound substances, an enzyme-linked polyclonal antibody specific for procollagen peptide can be added to the wells. Following a wash to remove any unbound antibody-enzyme reagent, a substrate solution can be added to the wells and color develops in proportion to the amount of procollagen peptide bound in the initial step using a microplate reader for detection at 450nm. The color development can be stopped and the intensity of the color can be measured.
  • Subconfluent normal human adult epidermal fibroblasts (Cascade Biologies) cultivated in standard DMEM growth medium with 10% fetal bovine serum (Mediatech) at 37°C in 10% C0 2 , can be treated with each of the combination of ingredients or compositions having said combinations disclosed in the specification for 3 days. Following incubation, cell culture medium can be collected and the amount of procollagen peptide secretion quantified using a sandwich enzyme linked immuno-sorbant assay (ELISA) from Takara (#MK101).
  • ELISA sandwich enzyme linked immuno-sorbant assay
  • TNF-a Tumor Necrosis Factor Alpha
  • TNF-a TNF superfamily
  • This bioassay can be used to analyze the effect of any one of the active ingredients, combination of ingredients, or compositions having said combinations disclosed in the specification on the production of TNF-a by human epidermal keratinocytes.
  • the endpoint of this assay can be a spectrophotometric measurement that reflects the presence of TNF-a and cellular viability.
  • the assay employs the quantitative sandwich enzyme immunoassay technique whereby a monoclonal antibody specific for TNF-a has been pre-coated onto a microplate.
  • Standards and samples can be pipetted into the wells and any TNF-a present is bound by the immobilized antibody. After washing away any unbound substances, an enzyme-linked polyclonal antibody specific for TNF-a can be added to the wells. Following a wash to remove any unbound antibody-enzyme reagent, a substrate solution can be added to the wells and color develops in proportion to the amount of TNF-a bound in the initial step using a microplate reader for detection at 450nm. The color development can be stopped and the intensity of the color can be measured.
  • Subconfluent normal human adult keratinocytes (Cascade Biologies) cultivated in EpiLife standard growth medium (Cascade Biologies) at 37°C in 5% C0 2 , can be treated with phorbol 12-myristate 13-acetate (PMA, lOng/ml, Sigma Chemical, #P1585-1MG) and any one of the active ingredients, combination of ingredients, or compositions having said combinations disclosed in the specification for 6 hours.
  • PMA has been shown to cause a dramatic increase in TNF-a secretion which peaks at 6 hours after treatment.
  • cell culture medium can be collected and the amount of TNF-a secretion quantified using a sandwich enzyme linked immuno-sorbant assay (ELISA) from R&D Systems (#DTA00C).
  • ELISA sandwich enzyme linked immuno-sorbant assay
  • Antioxidant (AO) assay An in vitro bioassay that measures the total antioxidant capacity of any one of the ingredients, combination of ingredients, or compositions having said combinations disclosed in the specification. The assay relies on the ability of antioxidants in the sample to inhibit the oxidation of ABTS ® (2,2'-azino-di-[3- ethylbenzthiazoline sulphonate]) to ABTS ® + by metmyoglobin.
  • the antioxidant system of living organisms includes enzymes such as superoxide dismutase, catalase, and glutathione peroxidase; macromolecules such as albumin, ceruloplasmin, and ferritin; and an array of small molecules, including ascorbic acid, a-tocopherol, ⁇ -carotene, reduced glutathione, uric acid, and bilirubin.
  • enzymes such as superoxide dismutase, catalase, and glutathione peroxidase
  • macromolecules such as albumin, ceruloplasmin, and ferritin
  • small molecules including ascorbic acid, a-tocopherol, ⁇ -carotene, reduced glutathione, uric acid, and bilirubin.
  • the sum of endogenous and food-derived antioxidants represents the total antioxidant activity of the extracellular fluid. Cooperation of all the different antioxidants provides greater protection against attack by reactive oxygen or nitrogen radicals, than any single compound alone.
  • the overall antioxidant capacity may give more relevant biological information compared to that obtained by the measurement of individual components, as it considers the cumulative effect of all antioxidants present in plasma and body fluids.
  • the capacity of the antioxidants in the sample to prevent ABTS oxidation is compared with that of Trolox, a water-soluble tocopherol analogue, and is quantified as molar Trolox equivalents.
  • Anti-Oxidant capacity kit # 709001 from Cayman Chemical (Ann Arbor, Michigan USA) can be used as an in vitro bioassay to measure the total anti-oxidant capacity of each of any one of the active ingredients, combination of ingredients, or compositions having said combinations disclosed in the specification. The protocol can be followed according to manufacturer recommendations.
  • the assay relied on antioxidants in the sample to inhibit the oxidation of ABTS® (2,2'-azino-di-[3- ethylbenzthiazoline sulphonate]) to ABTS®-+ by metmyoglobin.
  • the capacity of the antioxidants in the sample to prevent ABTS oxidation can be compared with that Trolox, a water-soluble tocopherol analogue, and was quantified as a molar Trolox equivalent.
  • ORAC Assay Oxygen Radical Absorption (or Absorbance) Capacity
  • ORAC ORAC of any one of the active ingredients, combination of ingredients, or compositions having said combinations disclosed in the specification can also be assayed by measuring the antioxidant activity of such ingredients or compositions.
  • This assay can quantify the degree and length of time it takes to inhibit the action of an oxidizing agent such as oxygen radicals that are known to cause damage cells ⁇ e.g., skin cells).
  • the ORAC value of any one of the active ingredients, combination of ingredients, or compositions having said combinations disclosed in the specification can be determined by methods known to those of ordinary skill in the art (see U.S. Publication Nos. 2004/0109905 and 2005/0163880; Cao et al. (1993)), all of which are incorporated by reference).
  • the assay described in Cao et al. (1993) measures the ability of antioxidant compounds in test materials to inhibit the decline of B-phycoerythrm (B-PE) fluorescence that is induced by a peroxyl radical generator, AAPH.
  • B-PE B-phycoeryth
  • Mushroom tyrosinase activity assay In mammalian cells, tyrosinase catalyzes two steps in the multi-step biosynthesis of melanin pigments from tyrosine (and from the polymerization of dopachrome). Tyrosinase is localized in melanocytes and produces melanin (aromatic quinone compounds) that imparts color to skin, hair, and eyes. Purified mushroom tyrosinase (Sigma) can be incubated with its substrate L-Dopa (Fisher) in the presence or absence of each of the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification.
  • L-Dopa France
  • Pigment formation can be evaluated by colorimetric plate reading at 490nm.
  • the percent inhibition of mushroom tyrosinase activity can be calculated compared to non-treated controls to determine the ability of test ingredients or combinations thereof to inhibit the activity of purified enzyme.
  • Test extract inhibition was compared with that of kojic acid (Sigma).
  • MMP3 Matrix Metalloproteinase Enzyme Activity
  • MMP9 An in vitro matrix metalloprotease (MMP) inhibition assay.
  • MMPs are extracellular proteases that play a role in many normal and disease states by virtue of their broad substrate specificity.
  • MMP3 substrates include collagens, fibronectins, and laminin; while MMP9 substrates include collagen VII, fibronectins and laminin.
  • this assay is designed to measure protease activity of MMPs using a thiopeptide as a chromogenic substrate (Ac-PLG-[2-mercapto-4-methyl-pentanoyl]-LG-OC2H5)5,6.
  • the MMP cleavage site peptide bond is replaced by a thioester bond in the thiopeptide.
  • COX is a bifunctional enzyme exhibiting both cyclooxygenase and peroxidase activities.
  • the cyclooxygenase activity converts arachidonic acid to a hydroperoxy endoperoxide (Prostaglandin G2; PGG2) and the peroxidase component reduces the endoperoxide (Prostaglandin H2; PGH2) to the corresponding alcohol, the precursor of prostaglandins, thromboxanes, and prostacyclins.
  • This COX Inhibitor screening assay measures the peroxidase component of cyclooxygenases.
  • the peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized N,N,N',N'-tetramethyl-p- phenylenediamine (TMPD).
  • This inhibitor screening assay includes both COX-1 and COX-2 enzymes in order to screen isozyme-specific inhibitors.
  • the Colormetric COX (ovine) Inhibitor screening assay (#760111, Cayman Chemical) can be used to analyze the effects of each of the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification on the activity of purified cyclooxygnase enzyme (COX-1 or COX-2).
  • purified enzyme, heme and test extracts can be mixed in assay buffer and incubated with shaking for 15 min at room temperature. Following incubation, arachidonic acid and colorimetric substrate can be added to initiate the reaction. Color progression can be evaluated by colorimetric plate reading at 590nm. The percent inhibition of COX-1 or COX-2 activity can be calculated compared to non-treated controls to determine the ability of test extracts to inhibit the activity of purified enzyme.
  • Lipoxygenase (LO) Assay An in vitro lipoxygenase (LO) inhibition assay.
  • LOs are non-heme iron-containing dioxygenases that catalyze the addition of molecular oxygen to fatty acids. Linoleate and arachidonate are the main substrates for LOs in plants and animals. Arachadonic acid may then be converted to hydroxyeicosotrienenoic (HETE) acid derivatives, that are subsequently converted to leukotirenes, potent inflammatory mediators.
  • HETE hydroxyeicosotrienenoic
  • the Colorimetric LO Inhibitor screening kit (#760700, Cayman Chemical) can be used to determine the ability of each of the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification to inhibit enzyme activity.
  • Purified 15- lipoxygenase and test ingredients can be mixed in assay buffer and incubated with shaking for 10 min at room temperature. Following incubation, arachidonic acid can be added to initiate the reaction and mixtures incubated for an additional 10 min at room temperature.
  • Colorimetric substrate can be added to terminate catalysis and color progression was evaluated by fluorescence plate reading at 490nm. The percent inhibition of lipoxyganse activity can be calculated compared to non-treated controls to determine the ability of each of the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification to inhibit the activity of purified enzyme.
  • Probes (Eugene, Oregon USA) can be used as an in vitro enzyme inhibition assay for measuring inhibition of elastase activity for each of the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification.
  • the EnzChek kit contains soluble bovine neck ligament elastin that can be labeled with dye such that the conjugate's fluorescence can be quenched.
  • the non- fluorescent substrate can be digested by elastase or other proteases to yield highly fluorescent fragments. The resulting increase in fluorescence can be monitored with a fluorescence microplate reader. Digestion products from the elastin substrate have absorption maxima at -505 nm and fluorescence emission maxima at -515 nm.
  • the peptide, chloromethyl ketone can be used as a selective, collective inhibitor of elastase when utilizing the EnzChek Elastase Assay Kit for screening for elastase inhibitors.
  • Oil Control Assay An assay to measure reduction of sebum secretion from sebaceous glands and/or reduction of sebum production from sebaceous glands can be assayed by using standard techniques known to those having ordinary skill in the art.
  • the forehead can be used.
  • Each of the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification can be applied to one portion of the forehead once or twice daily for a set period of days (e.g., 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, 13, 14, or more days), while another portion of the forehead is not treated with the composition.
  • sebum secretion can be assayed by application of fine blotting paper to the treated and untreated forehead skin. This is done by first removing any sebum from the treated and untreated areas with moist and dry cloths. Blotting paper can then be applied to the treated and untreated areas of the forehead, and an elastic band can be placed around the forehead to gently press the blotting paper onto the skin. After 2 hours the blotting papers can be removed, allowed to dry and then transilluminated. Darker blotting paper correlates with more sebum secretion (or lighter blotting paper correlates with reduced sebum secretion.
  • Erythema Assay An assay to measure the reduction of skin redness can be evaluated using a Minolta Chromometer. Skin erythema may be induced by applying a 0.2% solution of sodium dodecyl sulfate on the forearm of a subject. The area is protected by an occlusive patch for 24hrs. After 24 hrs, the patch is removed and the irritation-induced redness can be assessed using the a* values of the Minolta Chroma Meter. The a* value measures changes in skin color in the red region. Immediately after reading, the area is treated with the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification. Repeat measurements can be taken at regular intervals to determine the formula's ability to reduce redness and irritation.
  • Skin Moisture/Hydration Assay Skin moisture/hydration benefits can be measured by using impedance measurements with the Nova Dermal Phase Meter.
  • the impedance meter measures changes in skin moisture content.
  • the outer layer of the skin has distinct electrical properties. When skin is dry it conducts electricity very poorly. As it becomes more hydrated increasing conductivity results. Consequently, changes in skin impedance (related to conductivity) can be used to assess changes in skin hydration.
  • the unit can be calibrated according to instrument instructions for each testing day. A notation of temperature and relative humidity can also be made. Subjects can be evaluated as follows: prior to measurement they can equilibrate in a room with defined humidity (e.g., 30-50%) and temperature (e.g., 68-72°C).
  • Skin Clarity and Reduction in Freckles and Age Spots Assay Skin clarity and the reduction in freckles and age spots can be evaluated using a Minolta Chromometer. Changes in skin color can be assessed to determine irritation potential due to product treatment using the a* values of the Minolta Chroma Meter. The a* value measures changes in skin color in the red region. This is used to determine whether each of the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification is inducing irritation. The measurements can be made on each side of the face and averaged, as left and right facial values. Skin clarity can also be measured using the Minolta Meter.
  • the measurement is a combination of the a*, b, and L values of the Minolta Meter and is related to skin brightness, and correlates well with skin smoothness and hydration. Skin reading is taken as above.
  • skin clarity can be described as L/C where C is chroma and is defined as (a ⁇ + b ⁇ )l/2.
  • Clinical Grading of Skin Tone Assay Clinical grading of skin tone can be performed via a ten point analog numerical scale: (10) even skin of uniform, pinkish brown color.
  • Clinical Grading of Skin Smoothness Assay Clinical grading of skin smoothness can be analyzed via a ten point analog numerical scale: (10) smooth, skin is moist and glistening, no resistance upon dragging finger across surface; (7) somewhat smooth, slight resistance; (4) rough, visibly altered, friction upon rubbing; and (1) rough, flaky, uneven surface. Evaluations were made independently by two clinicians and averaged.
  • SFLs superficial facial lines
  • Skin Firmness Assay with a Hargens Ballistometer Skin firmness can be measured using a Hargens ballistometer, a device that evaluates the elasticity and firmness of the skin by dropping a small body onto the skin and recording its first two rebound peaks.
  • the ballistometry is a small lightweight probe with a relatively blunt tip (4 square mm- contact area) was used. The probe penetrates slightly into the skin and results in measurements that are dependent upon the properties of the outer layers of the skin, including the stratum corneum and outer epidermis and some of the dermal layers.
  • Skin softness/suppleness can be evaluated using the Gas Bearing Electrodynamometer, an instrument that measures the stress/strain properties of the skin.
  • the viscoelastic properties of skin correlate with skin moisturization. Measurements can be obtained on the predetermined site on the cheek area by attaching the probe to the skin surface with double- stick tape. A force of approximately 3.5 gm can be applied parallel to the skin surface and the skin displacement is accurately measured. Skin suppleness can then be calculated and is expressed as DSR (Dynamic Spring Rate in gm/mm).
  • DSR Dynamic Spring Rate in gm/mm
  • Appearance of Lines and Wrinkles Assay with Replicas The appearance of lines and wrinkles on the skin can be evaluated using replicas, which is the impression of the skin's surface. Silicone rubber like material can be used. The replica can be analyzed by image analysis. Changes in the visibility of lines and wrinkles can be objectively quantified via the taking of silicon replicas form the subjects' face and analyzing the replicas image using a computer image analysis system. Replicas can be taken from the eye area and the neck area, and photographed with a digital camera using a low angle incidence lighting. The digital images can be analyzed with an image processing program and are of the replicas covered by wrinkles or fine lines was determined.
  • the surface contour of the skin can be measured by using the profilometer/Stylus method. This includes either shining a light or dragging a stylus across the replica surface.
  • the vertical displacement of the stylus can be fed into a computer via a distance transducer, and after scanning a fixed length of replica a cross-sectional analysis of skin profile can be generated as a two-dimensional curve. This scan can be repeated any number of times along a fix axis to generate a simulated 3-D picture of the skin.
  • Ten random sections of the replicas using the stylus technique can be obtained and combined to generate average values.
  • the values of interest include Ra which is the arithmetic mean of all roughness (height) values computed by integrating the profile height relative to the mean profile height.
  • MELANODERM Assay the efficacy of each of the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification compositions can be evaluated by using a skin analog, such as, for example, MELANODERMTM Melanocytes, one of the cells in the skin analog, stain positively when exposed to L-dihydroxyphenyl alanine (L- DOPA), a precursor of melanin.
  • the skin analog, MELANODERMTM ⁇ can 3 ⁇ 4 e treated with a variety of bases containing each of the active ingredients, any one of the combination of ingredients, or compositions having said combinations disclosed in the specification or with the base alone as a control.
  • an untreated sample of the skin analog can be used as a control.
  • compositions and/or methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents which are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.
  • CTFA Cosmetic Ingredient Dictionary and Handbook, 12 th Edition, 2008
  • CTFA Cosmetic Ingredient Dictionary and Handbook, 12 th Edition, 2008
  • CTFA Cosmetic Ingredient Dictionary and Handbook, 4 th Edition, 1991

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Abstract

La présente invention concerne d'une manière générale des procédés et des compositions utiles pour hydrater, nettoyer, calmer, traiter, masquer, et/ou parfumer la peau ou les cheveux.
PCT/US2015/063995 2014-12-05 2015-12-04 Compositions cosmétiques WO2016090247A1 (fr)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1025392B1 (nl) * 2018-01-11 2019-03-29 Laboratoires Pi Care Bvba Octenidinehydrochloride bevattende emulsies
US10786442B2 (en) * 2018-08-08 2020-09-29 Wicky Suyanto Topical composition for reducing age spots and wrinkles
WO2023237747A1 (fr) 2022-06-10 2023-12-14 Unilever Ip Holdings B.V. Utilisations de compositions déodorantes pour réduire les mauvaises odeurs sur les vêtements
WO2024128980A1 (fr) * 2022-12-16 2024-06-20 Rock & Herb Pte Ltd Composition topique

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US20090082472A1 (en) * 2007-09-25 2009-03-26 Peters Marlin W Hand sanitizer and method of preparation
WO2010124280A2 (fr) * 2009-04-24 2010-10-28 New Century Pharmaceuticals, Inc. Onguent topique à base de sérum-albumine humaine pour le traitement de l'acné, du psoriasis, de la toxicité induite par egfr, le vieillissement prématuré de la peau et autres affections cutanées
US20130202543A1 (en) * 2010-06-14 2013-08-08 Symrise Ag Use of polyols for enhancing the cooling effect of a cooling substance and cooling mixtures having an enhanced cooling effect
US20130345316A1 (en) * 2012-06-21 2013-12-26 L'oreal Water-releasing cosmetic composition
US20140080924A1 (en) * 2012-09-17 2014-03-20 Richard T. Rigg Self-emulsifying and stabilizing gel for stabilizing cosmetic compositions
US20140322151A1 (en) * 2011-11-22 2014-10-30 Clariant Finance (Bvi) Limited Use Of Isosorbide Caprylates/Caprates In Deodorants And Antiperspirants

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090082472A1 (en) * 2007-09-25 2009-03-26 Peters Marlin W Hand sanitizer and method of preparation
WO2010124280A2 (fr) * 2009-04-24 2010-10-28 New Century Pharmaceuticals, Inc. Onguent topique à base de sérum-albumine humaine pour le traitement de l'acné, du psoriasis, de la toxicité induite par egfr, le vieillissement prématuré de la peau et autres affections cutanées
US20130202543A1 (en) * 2010-06-14 2013-08-08 Symrise Ag Use of polyols for enhancing the cooling effect of a cooling substance and cooling mixtures having an enhanced cooling effect
US20140322151A1 (en) * 2011-11-22 2014-10-30 Clariant Finance (Bvi) Limited Use Of Isosorbide Caprylates/Caprates In Deodorants And Antiperspirants
US20130345316A1 (en) * 2012-06-21 2013-12-26 L'oreal Water-releasing cosmetic composition
US20140080924A1 (en) * 2012-09-17 2014-03-20 Richard T. Rigg Self-emulsifying and stabilizing gel for stabilizing cosmetic compositions

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1025392B1 (nl) * 2018-01-11 2019-03-29 Laboratoires Pi Care Bvba Octenidinehydrochloride bevattende emulsies
US10786442B2 (en) * 2018-08-08 2020-09-29 Wicky Suyanto Topical composition for reducing age spots and wrinkles
WO2023237747A1 (fr) 2022-06-10 2023-12-14 Unilever Ip Holdings B.V. Utilisations de compositions déodorantes pour réduire les mauvaises odeurs sur les vêtements
WO2024128980A1 (fr) * 2022-12-16 2024-06-20 Rock & Herb Pte Ltd Composition topique

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