WO2016088137A3 - A novel process for the synthesis of boron enriched magnetic nanoparticles - Google Patents

A novel process for the synthesis of boron enriched magnetic nanoparticles Download PDF

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Publication number
WO2016088137A3
WO2016088137A3 PCT/IN2015/050180 IN2015050180W WO2016088137A3 WO 2016088137 A3 WO2016088137 A3 WO 2016088137A3 IN 2015050180 W IN2015050180 W IN 2015050180W WO 2016088137 A3 WO2016088137 A3 WO 2016088137A3
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic nanoparticles
boron
carborane
boron enriched
tagged
Prior art date
Application number
PCT/IN2015/050180
Other languages
French (fr)
Other versions
WO2016088137A2 (en
Inventor
Siddappa PATIL
Shivaputra Patil
Rangappa KERI
Geetha BALAKRISHNA
Original Assignee
Jain University, A Deemed Varsity Under Section 3 Of The Universities Grants Commission Act
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jain University, A Deemed Varsity Under Section 3 Of The Universities Grants Commission Act filed Critical Jain University, A Deemed Varsity Under Section 3 Of The Universities Grants Commission Act
Publication of WO2016088137A2 publication Critical patent/WO2016088137A2/en
Publication of WO2016088137A3 publication Critical patent/WO2016088137A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00—Compounds of iron
    • C01G49/02—Oxides; Hydroxides
    • C01G49/08—Ferroso-ferric oxide [Fe3O4]
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/42—Magnetic properties
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/22—Compounds of iron
    • C09C1/24—Oxides of iron

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The preparation method of the boron enriched magnetic nanoparticles includes steps of: (a) reacting hydroxyl substituted magnetic nanoparticles with 3-chloropropyltriethoxysilane and 3-aminopropyltriethoxysilane to form silyl amine and silyl chloride tagged magnetic nanoparticles; (b) reacting silyl amine tagged magnetic nanoparticles with o-carborane aldehyde to form carborane-appended magnetic nanoparticles; and (c) reacting silyl chloride tagged magnetic nanoparticles with 1-methyl-o-carborene in presence of n-butyllithium to form carborane-appended magnetic nanoparticles. The boron enriched magnetic nanoparticles are nontoxic and shows the magnetic property at room temperature. Hopefully, these boron enriched magnetic nanoparticles would deliver sufficient amount of boron within tumor cells with minimal toxicity and to perform biological evaluation.
PCT/IN2015/050180 2014-12-01 2015-11-30 A novel process for the synthesis of boron enriched magnetic nanoparticles WO2016088137A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN6012CH2014 2014-12-01
IN6012/CHE/2014 2014-12-01

Publications (2)

Publication Number Publication Date
WO2016088137A2 WO2016088137A2 (en) 2016-06-09
WO2016088137A3 true WO2016088137A3 (en) 2016-07-21

Family

ID=56092624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/050180 WO2016088137A2 (en) 2014-12-01 2015-11-30 A novel process for the synthesis of boron enriched magnetic nanoparticles

Country Status (1)

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WO (1) WO2016088137A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113788926B (en) * 2021-09-06 2023-05-05 内蒙合成化工研究所 Preparation method of carborane hybridized siloxane-polyurethane

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130210047A1 (en) * 2011-12-28 2013-08-15 The Hong Kong University Of Science And Technology Silica nanoparticles with aggregation induced emission characteristics as fluorescent bioprobe for intracellular imaging and protein carrier

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130210047A1 (en) * 2011-12-28 2013-08-15 The Hong Kong University Of Science And Technology Silica nanoparticles with aggregation induced emission characteristics as fluorescent bioprobe for intracellular imaging and protein carrier

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DAVID C. KENNEDY ET AL.: "SERS detection and boron delivery to cancer cells using carborane labelled nanoparticles", CHEMICAL COMMUNICATIONS, 15 October 2009 (2009-10-15), pages 6750 - 6752 *
SARITA KANGO ET AL.: "Surface modification of inorganic nanoparticles for development of organic-inorganic nanocomposites", JOURNEL:PROGRESS IN POLYMER SCIENCE, vol. 38, August 2013 (2013-08-01), pages 1232 - 1261, XP028575736, DOI: doi:10.1016/j.progpolymsci.2013.02.003 *

Also Published As

Publication number Publication date
WO2016088137A2 (en) 2016-06-09

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