WO2016088117A3 - Method for connecting scaffold structures for tissue engineering applications, implants and transplants in surgery by means of layer-by-layer methods - Google Patents

Method for connecting scaffold structures for tissue engineering applications, implants and transplants in surgery by means of layer-by-layer methods Download PDF

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Publication number
WO2016088117A3
WO2016088117A3 PCT/IB2016/000309 IB2016000309W WO2016088117A3 WO 2016088117 A3 WO2016088117 A3 WO 2016088117A3 IB 2016000309 W IB2016000309 W IB 2016000309W WO 2016088117 A3 WO2016088117 A3 WO 2016088117A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
layer
structures
surgery
tissue engineering
Prior art date
Application number
PCT/IB2016/000309
Other languages
German (de)
French (fr)
Other versions
WO2016088117A8 (en
WO2016088117A2 (en
Inventor
Thomas Groth
Deepak GUDURU
George Altankov
Marcy Zenobi-Wong
Christopher MILAN
Emma CAVALLI
Matti KESTI
Original Assignee
Martin-Luther-Universität Halle-Wittenberg
Eidgenössische Technische Hochschule Zürich
Institut De Bioenerginyeria De Catalunya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martin-Luther-Universität Halle-Wittenberg, Eidgenössische Technische Hochschule Zürich, Institut De Bioenerginyeria De Catalunya filed Critical Martin-Luther-Universität Halle-Wittenberg
Publication of WO2016088117A2 publication Critical patent/WO2016088117A2/en
Publication of WO2016088117A8 publication Critical patent/WO2016088117A8/en
Publication of WO2016088117A3 publication Critical patent/WO2016088117A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A61L15/585—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

1. Method for connecting scaffold structures for tissue engineering applications, implants and transplants in surgery by means of layer-by-layer methods. 2.1 In tissue engineering applications, the ideal tissue adhesive should secure the relevant construct in the wound bed and facilitate, and if possible, promote the integration of the implant or transplant into the surrounding healthy tissue. In doing this, the tissue adhesive must not hinder the natural healing processes. 2.2 The solution according to the invention allows the targeted production of modular tissue constructs by the connection of porous membranes, woven fibres, pressed or sponge-type structures, particles or hydrogels with the aid of layer-by-layer (LbL) methods. Said method according to the invention of combining porous scaffold structures, membranes, structures consisting of woven fibres or pressed structures, particles and hydrogels, in a modular manner, to form complex tissue constructs, and of transferring these into tissue defects, is based on the coating of said shaped bodies with polyelectrolyte multilayers (PEM) which allow the adherence or bonding of neighbouring shaped bodies by chemical or biochemical processes. 3. The invention relates to the use of tissue adhesives in surgery, tissue engineering and regenerative medicine.
PCT/IB2016/000309 2014-12-05 2016-02-03 Method for connecting scaffold structures for tissue engineering applications, implants and transplants in surgery by means of layer-by-layer methods WO2016088117A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102014017950.8 2014-12-05
DE102014017950.8A DE102014017950A1 (en) 2014-12-05 2014-12-05 Method for joining framework structures for tissue engineering applications, implants and grafts in surgery by means of layer-by-layer method

Publications (3)

Publication Number Publication Date
WO2016088117A2 WO2016088117A2 (en) 2016-06-09
WO2016088117A8 WO2016088117A8 (en) 2016-07-21
WO2016088117A3 true WO2016088117A3 (en) 2016-09-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2016/000309 WO2016088117A2 (en) 2014-12-05 2016-02-03 Method for connecting scaffold structures for tissue engineering applications, implants and transplants in surgery by means of layer-by-layer methods

Country Status (2)

Country Link
DE (1) DE102014017950A1 (en)
WO (1) WO2016088117A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005052035A1 (en) * 2003-11-28 2005-06-09 Universite Louis Pasteur Method for preparing crosslinked polyelectrolyte multilayer films
WO2015000933A2 (en) * 2013-07-02 2015-01-08 Eth Zurich Microtissues

Family Cites Families (6)

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JP2003500172A (en) * 1999-06-01 2003-01-07 ブリストル−マイヤーズ スクイブ カンパニー Fibrin polymer structure
FR2901143B1 (en) * 2006-05-16 2008-10-03 Centre Nat Rech Scient "METHOD OF CONSTRUCTING FUNCTIONAL LIVING MATERIALS, MATERIALS OBTAINED AND APPLICATIONS"
US8426179B2 (en) 2007-08-30 2013-04-23 Northwestern University Synthetic peptide and peptide conjugates and related tissue coupling methods via transglutaminase enzyme
US8986380B2 (en) * 2010-06-09 2015-03-24 Trustees Of Tufts College Multilayered silk scaffolds for meniscus tissue engineering
EP2678048B1 (en) 2011-02-22 2018-11-21 Institut National de la Sante et de la Recherche Medicale (INSERM) Nano-reservoirs technology for use in bone and/or cartilage regeneration
CN102660202B (en) * 2012-05-14 2013-11-06 吉林大学 Method for preparing adhesive coating and adhesive film based on layer-by-layer assembly technology

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005052035A1 (en) * 2003-11-28 2005-06-09 Universite Louis Pasteur Method for preparing crosslinked polyelectrolyte multilayer films
WO2015000933A2 (en) * 2013-07-02 2015-01-08 Eth Zurich Microtissues

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DAISUKE MATSUKUMA ET AL: "Adhesion of Two Physically Contacting Planar Substrates Coated with Layer-by-Layer Assembled Films", LANGMUIR, vol. 25, no. 17, 1 September 2009 (2009-09-01), US, pages 9824 - 9830, XP055285172, ISSN: 0743-7463, DOI: 10.1021/la900924w *
MINGYAN ZHAO ET AL: "Improved Stability and Cell Response by Intrinsic Cross-Linking of Multilayers from Collagen I and Oxidized Glycosaminoglycans", BIOMACROMOLECULES, vol. 15, no. 11, 10 November 2014 (2014-11-10), US, pages 4272 - 4280, XP055286059, ISSN: 1525-7797, DOI: 10.1021/bm501286f *
RONG HUANG ET AL: "Biomimetic LBL structured nanofibrous matrices assembled by chitosan/collagen for promoting wound healing", BIOMATERIALS., vol. 53, 9 March 2015 (2015-03-09), GB, pages 58 - 75, XP055285906, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2015.02.076 *
XIN SHANGJING ET AL: "Cytotoxicity and antibacterial ability of scaffolds immobilized by polysaccharide/layered silicate composites", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS, LTD. BARKING, GB, vol. 92, no. 2, 23 November 2012 (2012-11-23), pages 1880 - 1886, XP028972878, ISSN: 0144-8617, DOI: 10.1016/J.CARBPOL.2012.11.040 *
ZHOU BIN ET AL: "Chitosan/phosvitin antibacterial films fabricated via layer-by-layer deposition", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 64, 17 December 2013 (2013-12-17), pages 402 - 408, XP028608435, ISSN: 0141-8130, DOI: 10.1016/J.IJBIOMAC.2013.12.016 *

Also Published As

Publication number Publication date
WO2016088117A8 (en) 2016-07-21
WO2016088117A2 (en) 2016-06-09
DE102014017950A1 (en) 2016-06-09

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