WO2016071770A3 - Biological markers for identifying ibrutinib resistance in patients having mantle cell lymphoma and methods of using the same - Google Patents

Biological markers for identifying ibrutinib resistance in patients having mantle cell lymphoma and methods of using the same Download PDF

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Publication number
WO2016071770A3
WO2016071770A3 PCT/IB2015/002303 IB2015002303W WO2016071770A3 WO 2016071770 A3 WO2016071770 A3 WO 2016071770A3 IB 2015002303 W IB2015002303 W IB 2015002303W WO 2016071770 A3 WO2016071770 A3 WO 2016071770A3
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WO
WIPO (PCT)
Prior art keywords
methods
cell lymphoma
mantle cell
patients
identifying
Prior art date
Application number
PCT/IB2015/002303
Other languages
French (fr)
Other versions
WO2016071770A2 (en
Inventor
Sriram Balasubramanian
Michael Schaffer
Aleksandra RIZO
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of WO2016071770A2 publication Critical patent/WO2016071770A2/en
Publication of WO2016071770A3 publication Critical patent/WO2016071770A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Disclosed herein are methods of predicting a likelihood of responsiveness to treatment with ibrutinib in a patient having mantle cell lymphoma and methods of treating a patient having mantle cell lymphoma.
PCT/IB2015/002303 2014-11-05 2015-11-05 Biological markers for identifying ibrutinib resistance in patients having mantle cell lymphoma and methods of using the same WO2016071770A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462075544P 2014-11-05 2014-11-05
US62/075,544 2014-11-05

Publications (2)

Publication Number Publication Date
WO2016071770A2 WO2016071770A2 (en) 2016-05-12
WO2016071770A3 true WO2016071770A3 (en) 2016-08-11

Family

ID=55221449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/002303 WO2016071770A2 (en) 2014-11-05 2015-11-05 Biological markers for identifying ibrutinib resistance in patients having mantle cell lymphoma and methods of using the same

Country Status (1)

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WO (1) WO2016071770A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10045990B2 (en) 2015-03-04 2018-08-14 Arizona Board Of Regents On Behalf Of Arizona State University ERBB4 inhibitors and methods of use thereof
AU2018258263A1 (en) * 2017-04-24 2019-10-24 Genentech, Inc. ErbB2/Her2 mutations in the transmembrane or juxtamembrane domain

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013059738A2 (en) * 2011-10-19 2013-04-25 Pharmacyclics, Inc. Use of inhibitors of bruton's tyrosine kinase (btk)
WO2016019341A1 (en) * 2014-08-01 2016-02-04 Pharmacyclics Llc Biomarkers for predicting response of dlbcl to treatment with a btk inhibitor
WO2016022853A1 (en) * 2014-08-08 2016-02-11 Pharmacyclics Llc Bruton's tyrosine kinase inhibitor combinations and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013059738A2 (en) * 2011-10-19 2013-04-25 Pharmacyclics, Inc. Use of inhibitors of bruton's tyrosine kinase (btk)
WO2016019341A1 (en) * 2014-08-01 2016-02-04 Pharmacyclics Llc Biomarkers for predicting response of dlbcl to treatment with a btk inhibitor
WO2016022853A1 (en) * 2014-08-08 2016-02-11 Pharmacyclics Llc Bruton's tyrosine kinase inhibitor combinations and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AILEEN NOVERO ET AL: "Ibrutinib for B cell malignancies", EXPERIMENTAL HEMATOLOGY & ONCOLOGY, BIOMED CENTRAL LTD, LONDON, UK, vol. 3, no. 1, 28 January 2014 (2014-01-28), pages 4, XP021176524, ISSN: 2162-3619, DOI: 10.1186/2162-3619-3-4 *
AMIN AALIPOUR ET AL: "Bruton tyrosine kinase inhibitors: a promising novel targeted treatment for B cell lymphomas", BRITISH JOURNAL OF HAEMATOLOGY, vol. 163, no. 4, 24 September 2013 (2013-09-24), GB, pages 436 - 443, XP055153751, ISSN: 0007-1048, DOI: 10.1111/bjh.12573 *
ANDREW M. INTLEKOFER ET AL: "Precision therapy for lymphoma-current state and future directions", NATURE REVIEWS CLINICAL ONCOLOGY, vol. 11, no. 10, 1 January 2014 (2014-01-01), NY, US, pages 585 - 596, XP055263742, ISSN: 1759-4774, DOI: 10.1038/nrclinonc.2014.137 *
BALASUBRAMANIAN SRIRAM ET AL: "78: Mutational Analysis of Patients with Primary Resistance to Single-Agent Ibrutinib in Relapsed or Refractory Mantle Cell Lymphoma (MCL)", vol. 124, no. 21, 1 December 2014 (2014-12-01), pages Abstr.78, XP008179755, ISSN: 0006-4971, Retrieved from the Internet <URL:http://www.bloodjournal.org/content/124/21/78> *

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Publication number Publication date
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