WO2016062832A3 - Vaccine development against the poultry red mite dermanyssus gallinae - Google Patents

Vaccine development against the poultry red mite dermanyssus gallinae Download PDF

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Publication number
WO2016062832A3
WO2016062832A3 PCT/EP2015/074542 EP2015074542W WO2016062832A3 WO 2016062832 A3 WO2016062832 A3 WO 2016062832A3 EP 2015074542 W EP2015074542 W EP 2015074542W WO 2016062832 A3 WO2016062832 A3 WO 2016062832A3
Authority
WO
WIPO (PCT)
Prior art keywords
prm
mite
antibodies
poultry
dermanyssus gallinae
Prior art date
Application number
PCT/EP2015/074542
Other languages
French (fr)
Other versions
WO2016062832A2 (en
Inventor
Sebastian Ulbert
Gustavo Rodrigues Makert dos Santos
Original Assignee
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. filed Critical Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
Priority to EP15784675.9A priority Critical patent/EP3209324A2/en
Publication of WO2016062832A2 publication Critical patent/WO2016062832A2/en
Publication of WO2016062832A3 publication Critical patent/WO2016062832A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0003—Invertebrate antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/11—Immunoglobulins specific features characterized by their source of isolation or production isolated from eggs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The Poultry Red Mite (PRM) Dermanyssus gallinae causes high economic losses and is among the most devastating parasites in poultry farming world-wide. Different chemical, physical and biological strategies try to control the expansion of PRM. However, a solution to this problem still has highest priority. We present here an innovative method for the development of an immunological control strategy, based on the identification of mite protein antigens which elicit antibodies with anti-mite activity in the immunized chicken. Hens were immunized with different PRM protein extracts and IgY-antibodies were extracted from the eggs. A PRM in vitro feeding assay which used chicken blood spiked with these IgY enabled the detection of antibodies which caused PRM mortality. A novel combination of 2D-gel analysis and comparative analysis of antibody binding patterns followed by proteomic approaches led to the identification of candidate antigens responsible for the generation of such protective antibodies. These results show the high potential of this strategy for the development of a vaccine against the poultry mite Dermanyssus gallinae.
PCT/EP2015/074542 2014-10-23 2015-10-22 Vaccine development against the poultry red mite dermanyssus gallinae WO2016062832A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15784675.9A EP3209324A2 (en) 2014-10-23 2015-10-22 Vaccine development against the poultry red mite dermanyssus gallinae

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14189993 2014-10-23
EP14189993.0 2014-10-23

Publications (2)

Publication Number Publication Date
WO2016062832A2 WO2016062832A2 (en) 2016-04-28
WO2016062832A3 true WO2016062832A3 (en) 2016-06-16

Family

ID=51868003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2015/074542 WO2016062832A2 (en) 2014-10-23 2015-10-22 Vaccine development against the poultry red mite dermanyssus gallinae

Country Status (2)

Country Link
EP (1) EP3209324A2 (en)
WO (1) WO2016062832A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108191975A (en) * 2018-01-19 2018-06-22 广州益琪琳生物科技有限公司 Mite allergen special yolk immune globulin antibody and its antiallergy preparation
CN111683208A (en) * 2020-06-09 2020-09-18 深圳拔越软件有限公司 Intelligent configuration method and device for television wall

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARKLE S ET AL: "Immunological control of the poultry red mite", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, US, vol. 1149, 1 December 2008 (2008-12-01), pages 36 - 40, XP002692546, ISSN: 1749-6632, DOI: 10.1196/ANNALS.1428.057 *
BARTLEY KATHRYN ET AL: "Assessment of cathepsin D and L-like proteinases of poultry red mite, Dermanyssus gallinae (De Geer), as potential vaccine antigens", PARASITOLOGY, ENGLAND, vol. 139, no. 6, 1 May 2012 (2012-05-01), pages 755 - 765, XP009167278, DOI: 10.1017/S0031182011002356 *
DATABASE UniProt [online] 11 July 2012 (2012-07-11), "RecName: Full=Putative uncharacterized protein LOC100996504;", XP002737141, retrieved from EBI accession no. UNIPROT:I3L1I5 Database accession no. I3L1I5 *
JANE GRIMWOOD ET AL: "The DNA sequence and biology of human chromosome 19", NATURE, vol. 428, no. 6982, 1 April 2004 (2004-04-01), pages 529 - 535, XP055175894, ISSN: 0028-0836, DOI: 10.1038/nature02399 *

Also Published As

Publication number Publication date
WO2016062832A2 (en) 2016-04-28
EP3209324A2 (en) 2017-08-30

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