WO2016059647A3 - Triaminotriazine picolinonitrile derivatives as potent reverse transcriptase inhibitor of hiv-1 - Google Patents

Triaminotriazine picolinonitrile derivatives as potent reverse transcriptase inhibitor of hiv-1 Download PDF

Info

Publication number
WO2016059647A3
WO2016059647A3 PCT/IN2015/000386 IN2015000386W WO2016059647A3 WO 2016059647 A3 WO2016059647 A3 WO 2016059647A3 IN 2015000386 W IN2015000386 W IN 2015000386W WO 2016059647 A3 WO2016059647 A3 WO 2016059647A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
triaminotriazine
picolinonitrile
derivatives
reverse transcriptase
Prior art date
Application number
PCT/IN2015/000386
Other languages
French (fr)
Other versions
WO2016059647A2 (en
Inventor
Dhananjay Vithalrao MANE
Sandip Namdev GAVADE
Smita Shrikant KULKARNI
Ramesh Shivram PARANJAPE
Original Assignee
SHRI CHHATRAPTI SHIVAJI COLLEGE Maharashtra, India)
National Aids Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHRI CHHATRAPTI SHIVAJI COLLEGE Maharashtra, India), National Aids Research Institute filed Critical SHRI CHHATRAPTI SHIVAJI COLLEGE Maharashtra, India)
Publication of WO2016059647A2 publication Critical patent/WO2016059647A2/en
Publication of WO2016059647A3 publication Critical patent/WO2016059647A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention discloses triamino triazine picolinonitriles of formula- I useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis, or in the treatment or prevention of human immunodeficiency virus (HIV) infections. The invention further discloses process for preparation of compounds of formula-I and pharmaceutical composition thereof.
PCT/IN2015/000386 2014-10-13 2015-10-13 Triaminotriazine picolinonitrile derivatives as potent reverse transcriptase inhibitor of hiv-1 WO2016059647A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3238/MUM/2014 2014-10-13
IN3238MU2014 2014-10-13

Publications (2)

Publication Number Publication Date
WO2016059647A2 WO2016059647A2 (en) 2016-04-21
WO2016059647A3 true WO2016059647A3 (en) 2016-08-11

Family

ID=55747507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000386 WO2016059647A2 (en) 2014-10-13 2015-10-13 Triaminotriazine picolinonitrile derivatives as potent reverse transcriptase inhibitor of hiv-1

Country Status (1)

Country Link
WO (1) WO2016059647A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0834507B1 (en) * 1996-10-01 2004-05-19 Janssen Pharmaceutica N.V. Substituted diamino-1,3,5-triazine derivatives
WO2009042435A1 (en) * 2007-09-21 2009-04-02 Array Biopharma Inc. Pyridin-2 -yl-amino-i, 2, 4 -thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
EP1479397B1 (en) * 2002-02-05 2011-06-08 Astellas Pharma Inc. 2,4,6-triamino-1,3,5-triazine derivative

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0834507B1 (en) * 1996-10-01 2004-05-19 Janssen Pharmaceutica N.V. Substituted diamino-1,3,5-triazine derivatives
EP1479397B1 (en) * 2002-02-05 2011-06-08 Astellas Pharma Inc. 2,4,6-triamino-1,3,5-triazine derivative
WO2009042435A1 (en) * 2007-09-21 2009-04-02 Array Biopharma Inc. Pyridin-2 -yl-amino-i, 2, 4 -thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
US8212045B2 (en) * 2007-09-21 2012-07-03 Array Biopharma, Inc. Pyridin-2-yl-amino-1, 2, 4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus

Also Published As

Publication number Publication date
WO2016059647A2 (en) 2016-04-21

Similar Documents

Publication Publication Date Title
JOP20210109A1 (en) Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
WO2016109689A3 (en) Derivatives and methods of treating hepatitis b infections
MX2017010506A (en) A new quinoline derivative for use in the treatment and prevention of viral infections.
PH12019502201A1 (en) Substituted indoline derivatives as dengue viral replication inhibitors
PH12018502077A1 (en) Substituted indoline derivatives as dengue viral replication inhibitors
PH12015501156A1 (en) Pharmaceutical compositions
TR201905009T4 (en) Polycyclic-carbamoylpyridone compounds and their pharmaceutical uses.
PH12017500571A1 (en) Mono-or di-substituted indole derivatives as dengue viral replication inhibitors
MX2018011788A (en) Substituted indoline derivatives as dengue viral replication inhibitors.
MY169159A (en) Piperidino-pyrimidine derivatives for the treatment of viral infections
EP3757105A3 (en) Polycyclic pyridone derivative having integrase inhibitory activity
PH12017501272A1 (en) Indole derivatives as dengue viral replication inhibitors
PH12015500724B1 (en) 1, 2, 4-triazine derivatives for the treatment of viral infections
MX2017003928A (en) Long acting pharmaceutical compositions.
MX2018006773A (en) Pharmaceutical compositions containing doravirine, tenofovir disoproxil fumarate and lamivudine.
IN2014MU00916A (en)
WO2015198263A3 (en) Novel betulinic proline substituted derivatives as hiv inhibitors
MX2018011095A (en) Carbapenem compounds.
TW201613939A (en) Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication
WO2016059647A3 (en) Triaminotriazine picolinonitrile derivatives as potent reverse transcriptase inhibitor of hiv-1
MY185672A (en) Mono-or di-substituted indole derivatives as dengue viral replication inhibitors
EA033921B9 (en) Sialic acid derivatives and use thereof in treating influenza viral infections
WO2015134854A3 (en) Small molecule vif dimerization antagonists as anti-hiv agents and for use as hiv/aids therapeutics
WO2015084763A3 (en) Process for making reverse transcriptase inhibitors

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15850425

Country of ref document: EP

Kind code of ref document: A2