WO2016054053A3 - Hiv-1 antibodies and uses thereof (adcc and bispecific abs) - Google Patents
Hiv-1 antibodies and uses thereof (adcc and bispecific abs) Download PDFInfo
- Publication number
- WO2016054053A3 WO2016054053A3 PCT/US2015/052963 US2015052963W WO2016054053A3 WO 2016054053 A3 WO2016054053 A3 WO 2016054053A3 US 2015052963 W US2015052963 W US 2015052963W WO 2016054053 A3 WO2016054053 A3 WO 2016054053A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hiv
- antibodies
- adcc
- fragments
- bispecific abs
- Prior art date
Links
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 3
- 230000008685 targeting Effects 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- AIDS & HIV (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention relates, in general, to HIV-1 antibodies including antibodies which bind to the surface of HIV-1 virus infected cells and/or mediate antibody-dependent cellular cytoxicity (ADCC)-, and, in particular, to ADCC-mediating antibodies (and fragments thereof) suitable for use, for example, in reducing the risk of HIV-1 infection in a subject. The invention is directed to bispecific antibody molecules which comprise an arm targeting HIV-1 and a second arm targeting an effector cell. The invention further relates to compositions comprising such antibodies or antibody fragments, and their therapeutic use.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462056864P | 2014-09-29 | 2014-09-29 | |
US62/056,864 | 2014-09-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016054053A2 WO2016054053A2 (en) | 2016-04-07 |
WO2016054053A3 true WO2016054053A3 (en) | 2016-05-19 |
Family
ID=55631354
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2015/052916 WO2016054023A1 (en) | 2014-09-29 | 2015-09-29 | Hiv-1 antibodies and uses thereof (adcc and bispecific abs) |
PCT/US2015/052963 WO2016054053A2 (en) | 2014-09-29 | 2015-09-29 | Hiv-1 antibodies and uses thereof (adcc and bispecific abs) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2015/052916 WO2016054023A1 (en) | 2014-09-29 | 2015-09-29 | Hiv-1 antibodies and uses thereof (adcc and bispecific abs) |
Country Status (1)
Country | Link |
---|---|
WO (2) | WO2016054023A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111819196B (en) * | 2017-12-21 | 2022-10-28 | 纽约市哥伦比亚大学理事会 | Bispecific HIV-1 neutralizing antibodies |
BR112020016485A2 (en) * | 2018-02-15 | 2020-12-15 | Macrogenics, Inc. | BINDING MOLECULE, PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING A DISEASE |
CN117597364A (en) * | 2021-05-12 | 2024-02-23 | 百进生物科技公司 | anti-CCR 8 antibodies, antigen-binding fragments thereof, reagents and compositions, and methods of making and using the same |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060286112A1 (en) * | 2005-05-16 | 2006-12-21 | Sirid-Aimee Kellermann | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
US20070065444A1 (en) * | 2005-09-07 | 2007-03-22 | Amgen Fremont Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 |
US20090169562A1 (en) * | 2006-06-06 | 2009-07-02 | Mark Throsby | Human Binding Molecules Having Killing Activity Against Enterococci and Uses Thereof |
US20110044994A1 (en) * | 2009-03-17 | 2011-02-24 | Po-Ying Chan-Hui | Human immunodeficiency virus (hiv)-neutralizing antibodies |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2926830B1 (en) * | 2010-08-31 | 2017-08-02 | Theraclone Sciences, Inc. | Human immunodeficiency virus (hiv)-neutralizing antibodies |
US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
-
2015
- 2015-09-29 WO PCT/US2015/052916 patent/WO2016054023A1/en active Application Filing
- 2015-09-29 WO PCT/US2015/052963 patent/WO2016054053A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060286112A1 (en) * | 2005-05-16 | 2006-12-21 | Sirid-Aimee Kellermann | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
US20070065444A1 (en) * | 2005-09-07 | 2007-03-22 | Amgen Fremont Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 |
US20090169562A1 (en) * | 2006-06-06 | 2009-07-02 | Mark Throsby | Human Binding Molecules Having Killing Activity Against Enterococci and Uses Thereof |
US20110044994A1 (en) * | 2009-03-17 | 2011-02-24 | Po-Ying Chan-Hui | Human immunodeficiency virus (hiv)-neutralizing antibodies |
Non-Patent Citations (5)
Title |
---|
DATABASE GenBank [o] 10 January 2000 (2000-01-10), "Homo sapiens clone 810 immunoglobulin lambda light chain variable region mRNA, partial cds", Database accession no. AF194566 * |
DATABASE GenBank [o] 15 October 2014 (2014-10-15), "Homo sapiens clone DH333 immunoglobulin light chain variable region mRNA, partial cds", Database accession no. KM067760 * |
DATABASE GenBank [o] 7 June 2007 (2007-06-07), "Homo sapiens clone CBc3bmMK-d4 immunoglobulin mu heavy chain mRNA, partial cds", Database accession no. AY670753 * |
DATABASE GenBank [o] 9 August 2015 (2015-08-09), "Homo sapiens clone L002643_H007034_DH195 immunoglobulin light chain variable region mRNA, partial cds", Database accession no. KT304591 * |
DATABASE GenBank [o] 9 August 2015 (2015-08-09), "Homo sapiens clone TrH007034_DH195 immunoglobulin heavy chain variable region mRNA, partial cds", Database accession no. KT304359 * |
Also Published As
Publication number | Publication date |
---|---|
WO2016054023A1 (en) | 2016-04-07 |
WO2016054053A2 (en) | 2016-04-07 |
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