Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/08—Anti-ageing preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0208—Tissues; Wipes; Patches
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
  • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/41—Particular ingredients further characterized by their size
  • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Definitions

• the invention relates to a method for the application of a cosmetic composition containing at least one active substance on the skin.
• the invention also relates to a means for carrying out this method of the application of the cosmetic composition.
• polyglycols, polyesters and/or from the group consisting of substances with a keratolytic effect, such as salicylic acid, lactic acid, glycolic acid, mandelic acid, azelaic acid or ellagic acid, and also vitamins, amino acids, antioxidants, coenzymes, substances with a soothing effect (e.g. plant extracts, such as aloe vera or chamomile, panthenol, etc.), substances based on the principle of mechanical pore cleansing (e.g. zeolite, kaolin, titanium dioxide, zinc oxide, etc.) and/or from the group consisting of active substances which are found in natural oils and essential oils (e.g.
• substances with a keratolytic effect such as salicylic acid, lactic acid, glycolic acid, mandelic acid, azelaic acid or ellagic acid
• vitamins, amino acids, antioxidants, coenzymes substances with a soothing effect
• substances with a soothing effect e.g. plant extracts, such
• argan oil, almond oil, macadamia oil, tea tree oil, etc.), etc. including substances exhibiting antimicrobial properties or other known active substances stimulating skin regeneration.
• the aim of using these compositions is especially skin rehydration, which contributes to at least partial reducing or eliminating wrinkles and/or to accelerating/improving the healing process of wounds/scars or other undesirable skin defects.
• These cosmetic compositions are applied on the skin surface at the site of desired action, e.g. in the form of a (hydro)gel or a cream (ointment), or they are applied by injection as a filler.
• the cosmetic composition applied freely on the skin is exposed to the risk of accidental removal, whereby a certain aesthetic disadvantage, especially in case of prolonged application, is also its visibility.
• the goal of the invention is to eliminate the drawbacks of the current methods for the application of cosmetic compositions by proposing a method for the application of cosmetic compositions on the skin in the form of a (hydro)gel or a cream (ointment), whereby this method would protect the site of aplication as well as the applied composition from external influences.
• the aim of the invention is also to provide a means for the application of the cosmetic composition by the method according to the invention.
• the goal of the invention is achieved by a method for the application of a cosmetic composition in the form of a (hydro)gel or a cream containing at least one active substance, in which the cosmetic composition is applied on the skin at the site of desired action, whereupon it is at least partially overlaid by a barrier layer, which contains polymeric nanofibers made of or containing as one of its components at least one biocompatible polymer and/or its copolymer and/or at least one biopolymer and/or its derivative, and/or before being applied on the skin, the cosmetic composition is applied on the surface of the barrier layer, which is then put on the skin by its surface with applied cosmetic composition, by which means the cosmetic composition and the site of desired action of the active substance/substances close against external influences, but remain accessible to atmospheric oxygen.
• the barrier layer contains at least one active substance which is identical with the active substance of the cosmetic composition and/or at least one active substance which strengthens and/or enhances and/or complements the effect of the active substance/substances of the cosmetic composition, and/or at least one antimicrobial substance.
• this layer is after being overlaid or after the application of the cosmetic composition, or before the application of the cosmetic composition at least partially overlaid by an auxiliary layer, which contains polymeric nanofibers made of or containing as one of its components at least one biocompatible polymer and/or its copolymer and/or at least one biopolymer and/or its derivative.
• auxiliary layer may in case of need contain at least one active substance identical with that contained in the cosmetic composition and/or at least one active substance which strengthens and/or enhances and/or complements the effect of the active substance/substances of the cosmetic composition and/or at least one antimicrobial substance.
• a suitable biocompatible polymer for the preparation of the barrier layer or, if necessary, the auxiliary layer is particularly a biocompatible polymer selected from the group consisting of polycaprolactone (PCL), polylactic acid (PLA), copolymer of lactic acid and glycolic acid (PLGA), polyglutamic acid (PGA), polyvinyl alcohol (PVA), polyethylene oxide (PEO), their copolymers, derivatives or their mixtures.
• PCL polycaprolactone
• PLA polylactic acid
• PLGA copolymer of lactic acid and glycolic acid
• PGA polyglutamic acid
• PVA polyvinyl alcohol
• PEO polyethylene oxide
• a suitable biocompatible polymer for the preparation of the barrier layer or, if necessary, the auxiliary layer is especially biopolymer selected from the group consisting of polysaccharides (hyaluronic acid, chitosan, pectin, copolymers of glucuronic acid and its derivatives), alginates, peptides and their hydrolysates (collagen, elastin, silk fibroin, zein), cellulose, their copolymers, derivatives or their mixtures.
• polysaccharides hyaluronic acid, chitosan, pectin, copolymers of glucuronic acid and its derivatives
• alginates alginates
• peptides and their hydrolysates collagen, elastin, silk fibroin, zein
• cellulose their copolymers, derivatives or their mixtures.
• the barrier and/or the auxiliary layer may further contain nanofibers made of synthetic polymer and/or nanofibers containing synthetic polymer as one of its components which provides suitable mechanical properties to this layer.
• the suitable synthetic polymer is especially synthetic polymer selected from the group consisting of polyamide (PA), polyvinylidene (di)fluoride (PVDF), polyurethane (PUR), their copolymers and mixtures.
• the barrier layer and/or the auxiliary layer is overlaid by a cover layer of material in the form of a (hydro)gel or a cream, which contains a lipid (oil) component, which penetrates into the interfibrous spaces of the barrier layer and/or the auxiliary layer or into its nanofibres and increases its transparency.
• the barrier layer and/or the auxiliary layer is overlaid by a cover layer containing a pigment.
• the cover layer in any of the embodiments may contain at least one active substance which is identical with the active substanceof the cosmetic composition and/or at least one active substance which strengthens and/or enhances and/or complements the effect of the active substance/substances of the cosmetic composition, and/or at least one antimicrobial substance.
• the cover layer is formed directly by the cosmetic composition.
• At least one active substance which strengthens and/or enhances and/or complements the effect of the active substance/substances of the cosmetic composition, present in the barrier layer and/or in the auxiliary layer and/or in the cover layer is preferably an active substance selected from the group consisting of antioxidants, vitamins, proteins, coenzymes, amino acids, peptides and their hydrolysates, synthetic polymers, salicylic acid, lactic acid, glycolic acid, mandelic acid, azelaic acid, ellagic acid, plant extracts, zeolites, kaolin, titanium dioxide, zinc oxide, natural oils, natural essential oils.
• the barrier layer and/or the auxiliary layer is moistened before the application, whereby during subsequent drying shrinkage occurs, causing contraction of the skin, which may contribute to the penetration of the active substance/substances of the cosmetic composition into the skin.
• the aim of the invention is achieved by a means for the application of the cosmetic composition containing at least one active substance, in which the cosmetic composition is arranged on a barrier layer which contains polymeric nanofibers made of or containing as one of its components at least one biocompatible polymer and/or its copolymer and/or its derivative and/or at least one biopolymer and/or copolymer and/or its derivative.
• an auxiliary layer made of or containing as one of its components at least one biocompatible polymer and/or its copolymer and/or its derivative and/or at least one biopolymer and/or its copolymer and/or its derivative, or the cover layer.
• the barrier layer and/or the auxiliary layer and/or the cover layer preferably contains at least one active substance which is identical with the active substance of the cosmetic composition and/or at least one active substance which strengthens and/or enhances and/or complements the effect of active substance/substances of the cosmetic composition, and/or at least one antimicrobial substance.
• this means is at least from one side overlaid by a protective layer based on a polymer in the form of a foam, a film, a foil, a woven and non-woven fabric or their combinations.
• the aim of the invention is further achieved by a method for the application of a cosmetic composition containing hyaluronic acid on the skin with a wrinkle/wrinkles, whose principle consists in that after this cosmetic composition is applied on the skin, it is at least partially overlaid by a barrier layer which contains polymeric nanofibers made of or containing as one of its components at least one biocompatible polymer and/or its copolymer and/or at least one biopolymer and/or its derivative and/or at least one synthetic polymer and/or its derivate and/or its copolymer, and which is pressed to the skin, following the shape of its surface, and/or before being applied to the skin, the cosmetic composition is applied on the surface of the barrier layer, which is afterwards pressed to the skin with its surface covered with the applied cosmetic composition, following the shape of its surface.
• the cosmetic composition and the site of desired action of its active substance/substances are closed against external influences, but remain accessible to atmospheric oxygen, whereby the barrier layer subsequently shrinks due to the contact with hyaluronic acid contained in the cosmetic composition, which pulls out the skin in the wrinkle area to the level of the surrounding skin.
• the barrier layer subsequently shrinks due to the contact with hyaluronic acid contained in the cosmetic composition, which pulls out the skin in the wrinkle area to the level of the surrounding skin.
• small and medium wrinkles are mechanically smoothed out and the depth and size of the larger ones is reduced, whereby this effect of the barrier layer is complemented and fixed by the penetration of hyaluronic acid and, simultaneously, by adding moisture from the cosmetic composition into the skin and the hypodermis.
• a suitable barrier layer for this application is a layer of nanofibers having a basis weight in the range from 3 to 15 g/m 2 , preferably from 6 to 13 g/m 2 .
• the shrinkage of the barrier layer can be increased by addition of a suitable salt in an amount from 0.05 to 5 % (w/w) of dry weight of polymeric nanofibres.
• suitable salts include, for example, monovalent salts of Li + (e.g. LiCI), Na + , K + , divalent salts of Mg 2+ , Ca 2+ , Zn 2+ , Cu 2+ , ammonium salts (NH4) + of organic and inorganic acids, etc., or a mixture of at least two of them.
• the visual characteristics of the barrier layer of nanofibers e.g. by addition of any tenside, or a mixture of at least two tensides, the tenside/tensides enhancing the transparency as well as wettability of the barrier layer.
• the amount of the tenside, or a mixture of tensides is by one or two orders lower than the amount of the salt, i.e. it is in an interval of 0.0005 to 0.5 % of dry weight of the polymeric nanofibers.
• Fig. 1 schematically represents the principle of one variant of the method of the application of a cosmetic composition on the skin according to the invention
• Fig. 2 schematically represents the principle of the second variant of the application of a cosmetic composition on the skin according to the invention
• Fig. 3 schematically represents the application of a cosmetic composition according to the invention in the variant aimed at smoothing wrinkles
• Fig. 4 illustrates the principle of the application of this variant.
• Fig. 5a shows a photograph of the skin before the application of the cosmetic composition using the method according to the invention
• Fig. 5b shows a photograph of this skin 24 hours after the application of the cosmetic composition by the method according to the invention
• Fig. 5a shows a photograph of the skin before the application of the cosmetic composition using the method according to the invention
• Fig. 5b shows a photograph of this skin 24 hours after the application of the cosmetic composition by the method according to the invention
• FIG. 5c shows a photograph of this skin 48 hours after the application of the cosmetic composition according to the invention.
• Fig. 6a there is a digital image of the skin relief before the application of the cosmetic composition by the method according to the invention
• Fig. 6b shows a digital image of the skin relief 24 hours after the application of the cosmetic composition by the method according to the invention
• Fig. 6c shows a digital image of the skin relief 48 hours after the application of the cosmetic composition by the method according to the invention.
• an active substance selected from the group of substances with hydratation effects e.g. polysaccharides, such as hyaluronic acid, salts of hyaluronic acid, chitosan and its derivatives, derivatives of glucuronic acid (e.g.
• argan oil, almond oil, macadamia oil, tea tree oil, etc.), and other known active substances, including substances exhibiting antimicrobial properties or other known active substances stimulating skin regeneration, etc., or another known cosmetically active substance, or a mixture of at least two of them, on the skin according to the invention consists in that to the skin 1 at the site 2 of desired action of the active substance/substances (e.g.
• any known cosmetic composition 3 is applied in a usual manner in the form of a (hydro)gel or a cream (ointment) containing this/these active substance/substances, which is after that at least partially overlaid by a barrier layer 4.
• the barrier layer 4 is then in case of need at least partially overlaid by the cover layer 5 (see Fig. 1 and Fig. 2).
• the cosmetic composition 3 is applied in the form of a continuous or discontinuous layer (e.g. pointwise).
• the barrier layer 4 contains polymeric nanofibers, or it is formed by at least one layer of polymeric nanofibers. Due to the small interfibrous spaces (having a size in the order of tens to hundreds of nanometers) it prevents penetration of undesired biological impurities (e.g. microorganisms) and mechanical impurities (e.g. dust particles, etc.) from the external environment to the site 2 of desired action or to the cosmetic composition 3, by which means this site 2 with the applied cosmetic composition 3, including, as the case may be, also its surroundings, closes against external influences.
• undesired biological impurities e.g. microorganisms
• mechanical impurities e.g. dust particles, etc.
• the site 2 of desired action helps to create a suitable microclimate for the action of the active substance/substances of the cosmetic composition 3, and promotes the healing process (if the site 2 of desired action is, e.g., a cut or a wound, a scar or acne, etc.), and, optionally, it also keeps the skin 1 pores open.
• Suitable materials of the nanofibers of the barrier layer 4 include especially biocompatible polymers, such as polycaprolactone (PCL), polylactic acid (PLA), copolymer of lactic acid and glycolic acid (PLGA), polygfutamic acid (PGA), polyvinyl alcohol (PVA), polyethylene oxide (PEO) etc., their copolymers, derivatives or mixtures (whereby these at least two biocompatible polymers, or at least one biocompatible polymer and at least one copolymer/derivative, or two copoiymers/derivatives simultaneously included in the individual nanofibers, or constitute at least two types of nanofibers, each type being made of a different biocompatible (co)polymer), and particularly biopolymers, such as polysaccharides (e.g.
• hyaluronic acid chitosan, pectin, copolymers of glucuronic acid and their derivatives, alginates, etc.
• polypeptides and their hydrolysates collagen, elastin, silk fibroin
• zein zein
• cellulose and other known biopolymers including their derivatives or mixtures containing at least one biopolymer and/or at least one derivative (provided that these at least two biopolymers, or at least one biopolymer and at least one derivative, or two derivatives are simultaneously included in the individual nanofibers, or constitute at least two types of nanofibers, each type being made of a different biopolymer and/or derivative or mixture), at least one of which is biocompatible.
• nanofibers or parts of the nanofibers made of the synthetic polymer/polymers provide the required mechanical properties to the resulting barrier layer 4, and the nanofibers or parts of the nanofibers from the biocompatible polymer/polymers reduce the danger of allergic reaction or other unwanted effects caused by the presence of a synthetic material.
• Examples of synthetic polymer which can be used include polyamide (PA), polyvinylidene (di)fluoride (PVDF) and polyurethanes (PUR), their copolymers and mixtures (containing at least two synthetic polymers or at least one synthetic polymer and at least one copolymer, or at least two copolymers).
• PA polyamide
• PVDF polyvinylidene
• PUR polyurethanes
• the barrier layer 4 is at least partially composed of a hydrophobic polymer (containing nanofibers made of a hydrophobic polymer or from mixtures of at least one hydrophobic polymer with at least one non-hydrophobic polymer), which prevents water from penetrating from the external environment to the site of 2 of desired action with the applied cosmetic composition 3, due to which this site 2 is closed against the external influences even more thoroughly, but it remains accessible to atmospheric oxygen from the external environment.
• a hydrophobic polymer containing nanofibers made of a hydrophobic polymer or from mixtures of at least one hydrophobic polymer with at least one non-hydrophobic polymer
• the basis weight of the barrier layer 4 is 1 to 30 g/m 2 , preferably 10 to 30 g/m 2 , although, if necessary, or, e.g., in the case of the presence of at least one active substance, may be even higher.
• the barrier layer 4 may be prepared by any of the known methods for producing a layer of polymeric nanofibers based on any chemical and/or physical principle, the most suitable of them being electrostatic spinning using a spinning electrode of an elongated shape - for example in the shape of a cylinder (see, e.g., EP 1673493) or a string (see, e.g., EP 2059630 or EP 2173930), or any method thereof modified according to WO 2014079400, since these methods currently ensure achieving the highest homogeneity of the layer of polymeric nanofibers being formed in all directions, and, moreover, these methods are the only ones that enable industrial-scale preparation of this layer.
• the barrier layer 4 may contain at least one active substance, which may be incorporated in the material of its nanofibers in the form of (nano)particles and/or may be arranged on the surface of the nanofibers and/or on the surface of the barrier layer 4 in the form of (nano)particles and/or impregnation and/or a film and/or it may be chemically covalently and/or non- covalently bound directly to the polymer of the nanofibers and/or in the case of polymeric active substances, at least some nanofibers of the barrier layer 4 may be made at least partially directly from it.
• a suitable active substance is, e.g., an active substance which strengthens and/or enhances and/or complements the effect of the active substance/substances of the cosmetic composition and/or acts in another positive manner on the site 2 of desired action - e.g. renews the natural biochemistry of the skin, cleans or disinfects the skin , causes opening of the sebaceous channels and expanding pores, soothes the skin 1, etc.
• active substances include, e.g. antioxidants, vitamins, proteins, coenzymes, amino acids, polypeptides and their hydrolysates (e.g. collagen, elastin, gelatin), synthetic polymers (e.g.
• polyglycols, polyesters), and/or substances with a keratolytic effect namely especially salicylic acid, lactic acid, glycolic acid, mandelic acid, azelaic acid, ellagic acid, and/or substances with a soothing effect (e.g. plant extracts, such as aloe vera or chamomile, panthenol, etc.) and/or substances based on mechanical pore cleansing (e.g. zeolite, kaolin, titanium dioxide, zinc oxide, etc.) and/or an active substance which is found in natural oils and essential oils (e.g.
• the barrier layer 4 may contain at least one active substance, which protects the site 2 of desired action of the cosmetic composition 3 e.g. from microorganisms from the external environment, etc. - e.g. an antimicrobial substance, including antibiotics, silver and/or its compounds and/or compounds of iodine, copper, etc.
• auxiliary layer 41 which contains polymeric nanofibers or is composed of a layer of polymeric nanofibers (see Fig. 2).
• the auxiliary layer 41 may be the same as the barrier layer 4, or it can differ from it by a material and/or diameter of nanofibers and/or size of the interfibrous spaces and/or basis weight and/or thickness and/or content of the active substance/substances and/or type of the active substance/substances and/or by another parameter or aspect.
• the auxiliary layer 41 contains at least one active substance which protects the site 2 of desired action of the cosmetic composition 3 from penetration of microorganisms, whereby in that case the barrier layer 4 may only contain an active substance/substances which strengthens/strengthen and/or enhances/enhance and/or complements/complement the effect of the active substance/substances of the cosmetic composition and/or acts/act in another positive manner on the site 2 of desired action.
• the auxiliary layer 41 has larger interfibrous spaces than the barrier layer 4, and so the barrier layer 4 mechanically blocks possible biological impurities and the auxiliary layer 41 simultaneously acts on them by its active substance/substances, which liquidates/liquidate or at least weakens/weaken them. Beside this active substance/these active substances or instead of it/them, the auxiliary layer 4J_ may contain at least one antimicrobial substance.
• the application of the barrier layer 4 and, possibly, also the auxiliary layer 41 on the user ' s skin 1 with sufficient resistance is ensured by the adhesive properties of the cosmetic composition 3. Nevertheless, the barrier layer 4, or the auxiliary layer 41 if it overlaps the barrier layer 4, may be provided with an adhesive means arranged along at least a part of its circumference.
• the barrier layer 4 and/or the auxiliary layer 41 may contain beside polymeric nanofibers also other components, e.g. microfibers or another/other linear and/or planar formation/formations (e.g. a substrate, preferably permeable, on which the nanofibers of this layer 4, 41 were deposited during their preparation), which provides/provide the required mechanical properties to this layer 4, 41 and/or facilitates/facilitate handling it/them, etc.
• polymeric nanofibers also other components, e.g. microfibers or another/other linear and/or planar formation/formations (e.g. a substrate, preferably permeable, on which the nanofibers of this layer 4, 41 were deposited during their preparation), which provides/provide the required mechanical properties to this layer 4, 41 and/or facilitates/facilitate handling it/them, etc.
• a cover layer 5 in the form of a (hydro)gel or a cream is applied on the external surface of the barrier layer 4, or the auxiliary layer 41, whereby the composition of the (hydro)gel or cream makes the barrier layer 4 and, possibly, also the auxiliary layer 41 transparent or more transparent, which is either based on the principle of filling the interfibrous spaces and a corresponding change in the index of light refraction on the surface of the layer/layers 4, 41 ⁇ and/or its/their material, or one of the components penetrates directly into the structure of the nanofibers of the barrier layer 4 and/or the auxiliary layer 41, changing their colour into transparent or more transparent - either temporarily or permanently.
• the cover layer 5 In the case of temporary transparency the cover layer 5 must be applied repeatedly depending on the requirements of transparency duration. As a signal for its repeated application it is possible to use lightening (or whitening) of the barrier layer 4 or the auxiliary layer 41, which occurs as a result of reduced content of water in it.
• the cover layer 5 contains a proportion of a lipid (oil) component and water, which is determined by the material and/or parameters of the barrier layer 4 and/or the auxiliary layer 41 , whereby its lipid (oil) component penetrates into the interfibrous spaces of the barrier layer 4_and/or the auxiliary layer 4J. and/or into their nanofibers.
• the cover layer 5 is composed of a layer made of a nontransparent materia! and masking the barrier layer 4 and, possibly, the auxiliary layer 41, is based on the principle of make-up, whereby this layer is overlaid and possibly its interfibrous spaces are also at least partially filled by a material (e.g. in the form of emulsion) containing a pigment or other components, which are capable of masking the barrier layer 4 and, possibly, also the auxiliary layer 41 according to the type and colour of the user ' s skin.
• a material e.g. in the form of emulsion
• the cover layer 5 may contain at least one active substance/substances identical with the active substance of the cosmetic composition 3, or it can be even formed directly by this cosmetic composition (preferably, e.g., by hyaluronic acid and/or its salt/salts), or it can contain at least one active substance which strengthens and/or enhances and/or complements the effect of the active substance/substances of the cosmetic composition 3 and/or acts in another positive manner on the site 2 of desired action, whereby the barrier layer 4 and, possibly, also the auxiliary layer 41 due to its/their structure and interfibrous spaces enables/enable the penetration of this active substance/these active substances to the site 2 of desired action.
• the cover layer 5 may contain at least one antimicrobial substance, which protects the site 2 of desired action of the active substance/substances of the cosmetic composition 3, for example from microorganisms from the external environment.
• the entire structure or, in other words, all the applied layers are simply removed from the skin i by peeling off. The entire procedure is repeated as needed.
• the barrier layer 4 and/or the auxiliary layer 41 is applied on the applied cosmetic composition 3 moistened (or possibly during the application it is sufficiently moistened by moisture content in the cosmetic composition 3), whereby during subsequent drying it shrinks and causes slight contraction of the skin at the site 2 of desired action, which is desirable when using some active substances, and this/these active substance/substances therefore penetrate into the structure of the skin 1 more easily and more deeply.
• the barrier layer 4, possibly in combination with the auxiliary layer 41_, is preferably stored and applied arranged on a suitable carrier, based, e.g., on polymer, particularly polyolefins or polyesters or polyurethanes, or their combination in the form of a foam, a film, a foil, a woven or non-woven textile and their combinations.
• this carrier is either removed or, in case of need, remains on it, whereby it may create or help to create a cover layer 5.
• the cosmetic composition 3 is applied on the surface of the cover layer 4, and is applied together with it, when the cover layer 4 is applied on the skin ⁇ with its surface with the applied cosmetic composition 3.
• a suitable active substance of the cosmetic composition 3 is especially hyaluronic acid. It is a biocompatible linear polysaccharide polymer, naturally occurring in high concentrations in intercellular matrix and in the form of a sodium salt, or, more specifically, hyaluronan or sodium hyaluronate, is part of connective, epithelial and neural tissues. Since it has the ability to bind an enormous quantity of water and prevent collagen deposition at the site of injured tissue, it enables the so-called scarless healing and a very good hydration of the skin ⁇ .
• a means for the application of the cosmetic composition 3 according to the invention contains a barrier layer 4 containing or composed of nanofibers made of biocompatible polymer and/or biopolymer (possibly with the addition of synthetic polymer or synthetic polymer nanofibers), on one surface of which is applied the cosmetic composition containing at least one active substance.
• auxiliary layer 41 containing or composed of nanofibers of biocompatible polymer and/or biopolymer (possibly with the addition of synthetic polymer or synthetic polymer nanofibers), or the cover layer 5, or the cover layer 5 covers the surface of auxiliary layer 41.
• the barrier layer 4 and/or the auxiliary layer 41 and/or the cover layer 5 may contain at least one active substance which strengthens and/or enhances and/or complements the effect of the active substance/substances of the cosmetic composition 3 and/or acts in another positive manner on the na site 2 of desired action - e.g. renews the natural biochemistry of the skin, cleans or disinfects the skin 1, causes opening the sebaceous channels, expanding pores, soothes the skin i, etc.
• Such an active substance is particularly salicylic acid, lactic acid, glycolic acid, mandelic acid, azelaic acid, ellagic acid, vitamins, amino acids, antioxidants, coenzymes, substances with a soothing effect (e.g. plant extracts, such as aloe vera or chamomile, panthenol etc.) and/or a substance based on mechanical pore cleansing (e.g. zeolites, kaolin, titanium dioxide, zinc oxide, etc.) and/or an active substance which is found in natural oils and essential oils (e.g. argan oil, almond oil, macadamia oil, tea tree oil, etc.) and/or any other known active substance, or a mixture at least two of them.
• a soothing effect e.g. plant extracts, such as aloe vera or chamomile, panthenol etc.
• mechanical pore cleansing e.g. zeolites, kaolin, titanium dioxide, zinc oxide, etc.
• the barrier layer 4 and/or the auxilliary layer 41 and/or the cover layer 5 may contain at least one active substance which protects the site 2 of desired action of the cosmetic composition 3, for example, from microorganisms from the external environment, etc. - e.g. an antimicrobial substance, including antibiotics, silver and/or its compounds and/or compounds of iodine, copper, etc.
• the means is at least on one side covered with a protective layer based on polymer, particularly polyolefin or polyester or polyurethane, or their combinations, in the form of a foam, a film, a foil, a woven or non-woven textile and their combinations, which protects it from mechanical damage and/or contamination, and also facilitates handling it.
• a protective layer based on polymer, particularly polyolefin or polyester or polyurethane, or their combinations, in the form of a foam, a film, a foil, a woven or non-woven textile and their combinations, which protects it from mechanical damage and/or contamination, and also facilitates handling it.
• the above-described materials and methods for the application of the cosmetic composition are intended especially for long-term cosmetic application, e.g. all day long or even longer, during which the main factor of desired action is the cosmetic composition 3, or, more specifically, the active substance/substances contained in it.
• the cosmetic composition 3 or, more specifically, the active substance/substances contained in it.
• the barrier layer 4 is applied only for a very limited period of minutes or a maximum of tens of minutes, it is not necessary for its nanofibers to be made of biocompatible polymer.
• a suitable polymer is, for example, polyvinylidene fluoride (PVDF) or polyurethane (PUR).
• the barrier layer 4 may be formed by or contain nanofibers made of any of the above-mentioned biocompatible polymers (and/or their derivatives and/or copolymers) and/or biopolymers (and/or their derivatives), which when in contact with hyaluronic acid shrinks (which in principle applies to each of the above-mentioned materials), or this type of synthetic polymer/such synthetic polymers.
• An example of suitable synthetic polymers are, for example, polyamides, proteins and polypeptides (e.g.
• gelatin collagen, albumin, keratin, casein, silk protein, etc.), including glycoproteins, lipoproteins and enzymes; polysaccharides (e.g. chitin, chitosan, carrageenans, alginates, pectins, guar gum, starch, xanthan, polygalacturonic acid, hyaluronic acid, cellulose, cyclodextrins, dextrans), including their derivatives; polystyrenes; poly(alkyl methacrylates); polyalkylimides; polyanhydride esters; polycaprolacone; polyacrylic acid; polycarbonates; polyvinyl acetate; polyvinyl carbazole; polyvinyl chloride; polyvinyl pyrrolidone; polyvinyl butyral; polyiactic acid; polyglycolic acid; polylactic-co-glycolic acid; polybutylene terephthalate; polyaniline; poly (2-hydroxyethyl me
• a suitable material of the barrier layer 4 is - among others - e.g. a layer of polyurethane nanofibers, which at a basis weight below 6 g/m 2 has shrinkage approximately 30 % and tensile strength approximately 2 N, while at a basis weight from 6 to 12 g/m 2 the shrinkage achieved is approximately 25 % and tensile strength is more than 5 N - see the following table.
• a layer of polyurethane nanofibers which at a basis weight below 6 g/m 2 has shrinkage approximately 30 % and tensile strength approximately 2 N, while at a basis weight from 6 to 12 g/m 2 the shrinkage achieved is approximately 25 % and tensile strength is more than 5 N - see the following table.
• polyvinylidene fluoride the mechanical properties with similar basis weights are very similar.
• barrier layer 4 ⁇ it is possible to combine polyurethane and polyvinylidene fluoride, or any of them with another biocompatible polymer which has been mentioned above (and/or its derivative and/or copolymer) and/or biopolymer (and/or its derivative) and/or synthetic polymer.
• nanofibers of size 50 x 25 mm was used, the distance between clamping points of this sample was 30 mm, the speed of stretching the sample was 20 mm/min, the load of the sample was 100 N.
• the shrinkage of the barrier layer 4 of nanofibers may be increased by addition of a suitable salt in an amount ranging from 0.05 to 5 % (w/w) of dry weight of polymeric nanofibers.
• a suitable salt include, for example, monovalent salts of Li + (e.g. LiCl), Na + , K + , divalent salts of Mg 2+ , Ca + , Zn 2+ , Cu 2+ , ammonium salts (NH4) + of organic and inorganic acids, etc., or a mixture of at least two of them.
• Li + e.g. LiCl
• Na + , K + divalent salts of Mg 2+ , Ca + , Zn 2+ , Cu 2+
• ammonium salts (NH4) + of organic and inorganic acids, etc. or a mixture of at least two of them.
• the content of LiCl below 1 % w/w increases shrinkage by up to 29 %.
• Salt/salts is/are added to a solution of polymer, being entrained into individual fibers during spinning.
• the amount of the tenside, or the mixture of tensides is by one or up to two orders lower than the amount of salt/salts, that is in the interval 0.0005 - 0.5 % (w/w) of dry weight of polymeric nanofibers.
• the cosmetic composition 3 is applied either directly on the skin ⁇ (usually of the face and neck), whereupon it is at least partially overlaid by the barrier layer 4, and/or before being applied to the skin 1 , the cosmetic composition 3 is applied to one surface of the barrier layer 4, which is subsequently put with this surface on the skin 1.
• the barrier layer 4 is pressed to the skin so that it will follow the shape of the surface as perfectly as possible, including the individual wrinkles 8.
• hyaluronic acid ensures sufficient adhesion between the skin i and the barrier layer 4.
• another cosmetic composition 3 or another layer of the same cosmetic composition is afterwards applied to the free space of the barrier layer 4.
• Fig. 3 shows a cross sectional view of of the skin lacking molecules of hyaluronic acid 6 and with collapsed bonds between the cells 7, causing creation of wrinkles 8, with the applied layer of the cosmetic composition 3 and the barrier layer 4.
• the barrier layer 4 not only closes the space of the application of the cosmetic composition 3 against the external environment, but at the same time it helps to smooth out small and medium wrinkles 8, and to reduce the depth and size of the large ones 8, when it shrinks in contact with hyaluronic acid, thus pulling out the skin in the area of the wrinkle 8 to the level of the surrounding skin i - see Fig. 4.
• Fig. 4 schematically represents the action of the barrier layer 4 during its shrinking, when the surface of the skin 1_ is pulled out, and hyaluronic acid 6 and water is supplemented into its structure.
• a suitable barrier layer 4 for this application is a layer of nanofibers made of any of the above-mentioned biocompatible polymers (and their derivatives and/or copolymers) and/or biopolymers (and their derivatives) and/or polyvinylidene fluoride and/or polyurethane having a basis weight from 3 to 15 g/m 2 , preferably from 6 to 13 g/m 2 .
• the larger the basis weight of the barrier layer 4 the larger the force which it is able to develop during its shrinking and thus also the effect achieved. Therefore, by changing this parameter the barrier layer 4 can be adapted to specific application.
• the barrier layer 4 or the layer of the cosmetic composition 3, which covers the barrier layer 4 can be overlaid by the auxiliary layer 41 or the cover layer 5, as described above.
• Figures 5a to 5c are photographs of a part of the skin before application and 24 and 48 hours after the application of the cosmetic composition 3 containing 1 % low molecular hyaluronic acid and 1 % high molecular of hyaluronic acid, when using the barrier layer 4 composed of a layer of polyurethane nanofibers with a basis weight of 1 g/m 2 .
• Fig. 6a to 6c there are digital images of the skin relief of this part of the skin I before application and 24 and 48 hours after the application of the cosmetic composition by the method according to the invention. From these photographs removal of small and medium wrinkles 8 is apparent, as well as a substantial reduction of the depth and size of the larger wrinkles 24 hours (Fig. 5b, 6b) or 48 hours (Fig. 5c, 6c) after the application of the cosmetic composition 3.

Landscapes

• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Dermatology (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Gerontology & Geriatric Medicine (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• Cosmetics (AREA)

Priority Applications (1)

Applications Claiming Priority (2)

Publications (1)

Family

ID=54608208

Family Applications (1)

Country Status (3)

Cited By (3)

Citations (11)

• 2014
  • 2014-09-30 CZ CZ2014-674A patent/CZ2014674A3/cs unknown
• 2015
  • 2015-09-30 EP EP15797579.8A patent/EP3206757A1/en not_active Withdrawn
  • 2015-09-30 WO PCT/CZ2015/000111 patent/WO2016050227A1/en active Application Filing

Patent Citations (11)

Also Published As

Similar Documents

Legal Events