WO2016022387A3 - A mouse model for multiple sclerosis - Google Patents

A mouse model for multiple sclerosis Download PDF

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Publication number
WO2016022387A3
WO2016022387A3 PCT/US2015/042885 US2015042885W WO2016022387A3 WO 2016022387 A3 WO2016022387 A3 WO 2016022387A3 US 2015042885 W US2015042885 W US 2015042885W WO 2016022387 A3 WO2016022387 A3 WO 2016022387A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
multiple sclerosis
cns
mouse model
disclosed
Prior art date
Application number
PCT/US2015/042885
Other languages
French (fr)
Other versions
WO2016022387A2 (en
Inventor
Saud A. Sadiq
Massimiliano CRISTOFANILLI
Original Assignee
Tisch Multiple Sclerosis Research Center Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tisch Multiple Sclerosis Research Center Of New York filed Critical Tisch Multiple Sclerosis Research Center Of New York
Publication of WO2016022387A2 publication Critical patent/WO2016022387A2/en
Publication of WO2016022387A3 publication Critical patent/WO2016022387A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/10—Animals modified by protein administration, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are methods to induce multiple sclerosis-like lesions in the CNS of an animal by intracerebral administration of acellular CSF from a subject with MS into the CNS of the animal. The methods produce animals with demyelinated CNS lesions suitable for study of MS. The disclosed methods can be used to determine the efficacy of treatment for MS. Further disclosed are animals produced by these methods.
PCT/US2015/042885 2014-08-07 2015-07-30 A mouse model for multiple sclerosis WO2016022387A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462034507P 2014-08-07 2014-08-07
US62/034,507 2014-08-07

Publications (2)

Publication Number Publication Date
WO2016022387A2 WO2016022387A2 (en) 2016-02-11
WO2016022387A3 true WO2016022387A3 (en) 2016-09-01

Family

ID=55264744

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/042885 WO2016022387A2 (en) 2014-08-07 2015-07-30 A mouse model for multiple sclerosis

Country Status (1)

Country Link
WO (1) WO2016022387A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115474581B (en) * 2022-09-16 2023-05-26 华中科技大学同济医学院附属协和医院 Construction method, kit and application of spinal subacute joint variable disease model

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033466A1 (en) * 1996-03-14 1997-09-18 Bio Merieux Non-genetically modified mammal as a model for multiple sclerosis
WO2013049362A2 (en) * 2011-09-27 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Method of treating multiple sclerosis by intrathecal depletion of b cells and biomarkers to select patients with progressive multiple sclerosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033466A1 (en) * 1996-03-14 1997-09-18 Bio Merieux Non-genetically modified mammal as a model for multiple sclerosis
WO2013049362A2 (en) * 2011-09-27 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Method of treating multiple sclerosis by intrathecal depletion of b cells and biomarkers to select patients with progressive multiple sclerosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOLD ET AL.: "Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research", BRAIN, vol. 129, 2006, pages 1953 - 1971 *
SAEKI ET AL.: "Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients", PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 6157 - 6161 *

Also Published As

Publication number Publication date
WO2016022387A2 (en) 2016-02-11

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