WO2016014799A9 - Epidermal growth factor and blockade of immune checkpoints in cancer immunotherapy - Google Patents

Epidermal growth factor and blockade of immune checkpoints in cancer immunotherapy Download PDF

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Publication number
WO2016014799A9
WO2016014799A9 PCT/US2015/041738 US2015041738W WO2016014799A9 WO 2016014799 A9 WO2016014799 A9 WO 2016014799A9 US 2015041738 W US2015041738 W US 2015041738W WO 2016014799 A9 WO2016014799 A9 WO 2016014799A9
Authority
WO
WIPO (PCT)
Prior art keywords
growth factor
epidermal growth
egf
blockade
cancer immunotherapy
Prior art date
Application number
PCT/US2015/041738
Other languages
French (fr)
Other versions
WO2016014799A1 (en
Inventor
George Weiner
Mohammed Milhem
Amani MAKKOUK
Zuhair K. BALLAS
Lyse NORIAN
Original Assignee
University Of Iowa Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Iowa Research Foundation filed Critical University Of Iowa Research Foundation
Publication of WO2016014799A1 publication Critical patent/WO2016014799A1/en
Publication of WO2016014799A9 publication Critical patent/WO2016014799A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/485—Epidermal growth factor [EGF] (urogastrone)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Disclosed are methods, compositions, kits, and systems for diagnosing and/or treating a patient via immunotherapy. The diagnostic methods including detecting epidermal growth factor (EGF) and administering to the patient a therapeutic antibody that binds to a cell surface receptor of a regulatory T cell (Treg) based on the detected EGF. The treatment methods include administering EGF or an agonist of the EGF receptor and administering the therapeutic antibody that binds to a cell surface receptor of a Treg.
PCT/US2015/041738 2014-07-23 2015-07-23 Epidermal growth factor and blockade of immune checkpoints in cancer immunotherapy WO2016014799A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462028109P 2014-07-23 2014-07-23
US62/028,109 2014-07-23

Publications (2)

Publication Number Publication Date
WO2016014799A1 WO2016014799A1 (en) 2016-01-28
WO2016014799A9 true WO2016014799A9 (en) 2016-02-25

Family

ID=55163761

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/041738 WO2016014799A1 (en) 2014-07-23 2015-07-23 Epidermal growth factor and blockade of immune checkpoints in cancer immunotherapy

Country Status (1)

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WO (1) WO2016014799A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX370449B (en) 2013-12-12 2019-12-13 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof.
MX383464B (en) 2015-07-13 2025-03-14 Cytomx Therapeutics Inc ANTI-PD-1 ANTIBODIES, ACTIVATABLE ANTI-PD-1 ANTIBODIES, AND METHODS OF USING THE SAME.
JP6843868B2 (en) 2015-09-29 2021-03-17 セルジーン コーポレイション PD-1 binding protein and its usage
EP3515943A4 (en) 2016-09-19 2020-05-06 Celgene Corporation Methods of treating vitiligo using pd-1 binding proteins
CA3036701A1 (en) 2016-09-19 2018-03-22 Celgene Corporation Methods of treating immune disorders using pd-1 binding proteins
AU2018250312C1 (en) 2017-04-07 2024-08-22 Tambo, Inc. Bioorthogonal compositions

Also Published As

Publication number Publication date
WO2016014799A1 (en) 2016-01-28

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