WO2016006996A1 - Therapeutic kinesiology tape comprising non-steroidal anti-inflammatory drugs (nsaids) - Google Patents
Therapeutic kinesiology tape comprising non-steroidal anti-inflammatory drugs (nsaids) Download PDFInfo
- Publication number
- WO2016006996A1 WO2016006996A1 PCT/MY2014/000216 MY2014000216W WO2016006996A1 WO 2016006996 A1 WO2016006996 A1 WO 2016006996A1 MY 2014000216 W MY2014000216 W MY 2014000216W WO 2016006996 A1 WO2016006996 A1 WO 2016006996A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- therapeutic tape
- therapeutic
- ketoprofen
- tape
- sodium
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 34
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 title claims abstract description 30
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229960000991 ketoprofen Drugs 0.000 claims abstract description 26
- 239000012790 adhesive layer Substances 0.000 claims abstract description 18
- 239000004744 fabric Substances 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 6
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 4
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 4
- 229960001193 diclofenac sodium Drugs 0.000 claims description 4
- 229960001680 ibuprofen Drugs 0.000 claims description 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 4
- 229960002009 naproxen Drugs 0.000 claims description 4
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims description 4
- WVYADZUPLLSGPU-UHFFFAOYSA-N salsalate Chemical compound OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O WVYADZUPLLSGPU-UHFFFAOYSA-N 0.000 claims description 4
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims description 4
- 239000004925 Acrylic resin Substances 0.000 claims description 3
- 229920000178 Acrylic resin Polymers 0.000 claims description 3
- -1 carpofen Chemical compound 0.000 claims description 3
- VZUGVMQFWFVFBX-UHFFFAOYSA-N 2-(4-cyclohexyl-1-naphthyl)propanoic acid Chemical compound C12=CC=CC=C2C(C(C(O)=O)C)=CC=C1C1CCCCC1 VZUGVMQFWFVFBX-UHFFFAOYSA-N 0.000 claims description 2
- PYSICVOJSJMFKP-UHFFFAOYSA-N 3,5-dibromo-2-chloropyridine Chemical compound ClC1=NC=C(Br)C=C1Br PYSICVOJSJMFKP-UHFFFAOYSA-N 0.000 claims description 2
- PJJGZPJJTHBVMX-UHFFFAOYSA-N 5,7-Dihydroxyisoflavone Chemical compound C=1C(O)=CC(O)=C(C2=O)C=1OC=C2C1=CC=CC=C1 PJJGZPJJTHBVMX-UHFFFAOYSA-N 0.000 claims description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 2
- UDKCHVLMFQVBAA-UHFFFAOYSA-M Choline salicylate Chemical compound C[N+](C)(C)CCO.OC1=CC=CC=C1C([O-])=O UDKCHVLMFQVBAA-UHFFFAOYSA-M 0.000 claims description 2
- MQHWFIOJQSCFNM-UHFFFAOYSA-L Magnesium salicylate Chemical class [Mg+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O MQHWFIOJQSCFNM-UHFFFAOYSA-L 0.000 claims description 2
- SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 claims description 2
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 claims description 2
- BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 claims description 2
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 2
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims description 2
- 229960000590 celecoxib Drugs 0.000 claims description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 2
- 229960001231 choline Drugs 0.000 claims description 2
- 229960002688 choline salicylate Drugs 0.000 claims description 2
- KXZOIWWTXOCYKR-UHFFFAOYSA-M diclofenac potassium Chemical compound [K+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KXZOIWWTXOCYKR-UHFFFAOYSA-M 0.000 claims description 2
- 229960004515 diclofenac potassium Drugs 0.000 claims description 2
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 claims description 2
- 229960000616 diflunisal Drugs 0.000 claims description 2
- 229960005293 etodolac Drugs 0.000 claims description 2
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 claims description 2
- 229960005341 fenoprofen calcium Drugs 0.000 claims description 2
- VHUXSAWXWSTUOD-UHFFFAOYSA-L fenoprofen calcium (anhydrous) Chemical compound [Ca+2].[O-]C(=O)C(C)C1=CC=CC(OC=2C=CC=CC=2)=C1.[O-]C(=O)C(C)C1=CC=CC(OC=2C=CC=CC=2)=C1 VHUXSAWXWSTUOD-UHFFFAOYSA-L 0.000 claims description 2
- FULAPETWGIGNMT-UHFFFAOYSA-N firocoxib Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C=1C(C)(C)OC(=O)C=1OCC1CC1 FULAPETWGIGNMT-UHFFFAOYSA-N 0.000 claims description 2
- 229960002524 firocoxib Drugs 0.000 claims description 2
- 229960002390 flurbiprofen Drugs 0.000 claims description 2
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims description 2
- MSYBLBLAMDYKKZ-UHFFFAOYSA-N hydron;pyridine-3-carbonyl chloride;chloride Chemical compound Cl.ClC(=O)C1=CC=CN=C1 MSYBLBLAMDYKKZ-UHFFFAOYSA-N 0.000 claims description 2
- 229960000905 indomethacin Drugs 0.000 claims description 2
- 229960004752 ketorolac Drugs 0.000 claims description 2
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 claims description 2
- UAWXGRJVZSAUSZ-UHFFFAOYSA-N licofelone Chemical compound OC(=O)CC=1N2CC(C)(C)CC2=C(C=2C=CC=CC=2)C=1C1=CC=C(Cl)C=C1 UAWXGRJVZSAUSZ-UHFFFAOYSA-N 0.000 claims description 2
- 229950003488 licofelone Drugs 0.000 claims description 2
- 229960002202 lornoxicam Drugs 0.000 claims description 2
- OXROWJKCGCOJDO-JLHYYAGUSA-N lornoxicam Chemical compound O=C1C=2SC(Cl)=CC=2S(=O)(=O)N(C)\C1=C(\O)NC1=CC=CC=N1 OXROWJKCGCOJDO-JLHYYAGUSA-N 0.000 claims description 2
- 229960002373 loxoprofen Drugs 0.000 claims description 2
- KHPKQFYUPIUARC-UHFFFAOYSA-N lumiracoxib Chemical compound OC(=O)CC1=CC(C)=CC=C1NC1=C(F)C=CC=C1Cl KHPKQFYUPIUARC-UHFFFAOYSA-N 0.000 claims description 2
- 229960000994 lumiracoxib Drugs 0.000 claims description 2
- 229940013798 meclofenamate Drugs 0.000 claims description 2
- 229960003464 mefenamic acid Drugs 0.000 claims description 2
- 229960001929 meloxicam Drugs 0.000 claims description 2
- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 claims description 2
- 229960005249 misoprostol Drugs 0.000 claims description 2
- 229960004270 nabumetone Drugs 0.000 claims description 2
- 229960003940 naproxen sodium Drugs 0.000 claims description 2
- CDBRNDSHEYLDJV-FVGYRXGTSA-M naproxen sodium Chemical compound [Na+].C1=C([C@H](C)C([O-])=O)C=CC2=CC(OC)=CC=C21 CDBRNDSHEYLDJV-FVGYRXGTSA-M 0.000 claims description 2
- 229960000965 nimesulide Drugs 0.000 claims description 2
- HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 claims description 2
- 229960002739 oxaprozin Drugs 0.000 claims description 2
- OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 claims description 2
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960004662 parecoxib Drugs 0.000 claims description 2
- 229960002702 piroxicam Drugs 0.000 claims description 2
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims description 2
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 claims description 2
- 229960000371 rofecoxib Drugs 0.000 claims description 2
- 229960000953 salsalate Drugs 0.000 claims description 2
- 229960004025 sodium salicylate Drugs 0.000 claims description 2
- 229960000894 sulindac Drugs 0.000 claims description 2
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 claims description 2
- 229960002871 tenoxicam Drugs 0.000 claims description 2
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 claims description 2
- 229960002044 tolmetin sodium Drugs 0.000 claims description 2
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims description 2
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- YMBXTVYHTMGZDW-UHFFFAOYSA-N loxoprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1CC1C(=O)CCC1 YMBXTVYHTMGZDW-UHFFFAOYSA-N 0.000 claims 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
- A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0273—Adhesive bandages for winding around limb, trunk or head, e.g. cohesive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Definitions
- THERAPEUTIC KINESIOLOGY TAPE COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)
- the present invention relates to a dermal therapeutic tape, and more particularly, the present invention relates to an elastic therapeutic tape containing nonsteroidal anti-inflammatory drugs (NSAIDs).
- NSAIDs nonsteroidal anti-inflammatory drugs
- Non-steroidal anti-inflammatory drugs are often relied on for the treatment of acute or chronic symptoms of inflammation and for relieving pain and soreness from exercise.
- the NSAIDs are often used in the form of transdermal patches which deliver the drugs into the body through the skin.
- European Patent No. EP 0664119 B1 disclosed a percutaneous administration tape whereby the ketoprofen drug is provided in the adhesive layer.
- United States Patent Application No. US 20050152958 A1 disclosed a ketoprofen patch for the topical application of ketoprofen.
- the base cloth of the conventional medicinal patches only acts as a platform for providing the NSAID without additional benefits.
- the conventional patches are normally not waterproof and have to be peeled off when taking shower, and are therefore only suitable for use in one day.
- the use of elastic therapeutic tape such as a kinesiology tape for applying to the body has been well defined as the elastic tape is known to have many beneficial effects to the muscles.
- the kinesiology tape provides support and stability to muscles and joints while increasing circulation.
- the kinesiology tape is also known for aiding in restoration of normal fluids perfusion, activation of analgesic system, activation of lymph flow, and adjustment of muscle tension.
- the kinesiology tape is stretchable such that it allows free movement of the body without restriction to the flow of bodily fluids.
- the kinesiology tape is often used without any medication incorporated therein to achieve the above mentioned benefits.
- the present invention relates to a dermal therapeutic tape comprising a stretchable base cloth formed from the material of a kinesiology tape, and an adhesive layer provided on one side of the base cloth, wherein the adhesive layer comprises NSAIDs.
- the NSAIDs is ketoprofen provided at an amount of 0.2 to 0.5 mg/cm 2 of the therapeutic tape.
- the present invention relates to dermal therapeutic tape comprising stretchable base cloth formed from the material of a kinesiology tape, and an adhesive layer provided on one side of the base cloth, wherein the adhesive layer comprises non-steroidal anti-inflammatory drugs (NSAIDs).
- NSAIDs non-steroidal anti-inflammatory drugs
- the preferred NSAID for incorporating into the adhesive layer is ketoprofen.
- the stretchable base cloth is made from any materials which display certain degree of flexibility, including but not limited to woven fabric, and polymeric material such as polyethylene.
- the base cloth is stretchable up to 130 - 140% of the original length, so that the application of the tape allows non-restrictive motion where the tape is applied.
- the flexibility of the therapeutic tape is also essential in increasing blood flow and circulation and alleviating pain due to muscle and joint injuries.
- the stretchable base cloth formed from kinesiology tape comprises an elastic warp thread and a non-elastic weft thread, wherein the elastic warp threads are twisted together with other fibrous threads.
- the adhesive layer is provided on one side of the base cloth for adhering tape to the skin of the user.
- the adhesive is a pressure-sensitive acrylic resin such that the adhesive is activated and the bonds are formed once it is applied to the skin without external agent such as a solvent, water, or heat. The degree of bonding is dependent on the amount of pressure which is applied to the therapuetic tape.
- the monomer of the acrylic resin which can be used include, acrylic acid, 2-ethylhexyl acrylate, butyl acrylate, ethyl acrylate, methyl acrylate, ethyl acrylate, n-propyl acrylate, butyl acrylate, pentyl acrylate, dimethylaminoethyl diacrylate, 1 ,6-hexanediol diacrylate, diethylene glycol diacrylate, diethylene glycol triacrylate, trimethylol propane triacrylate, methyl methacrylate, butyl methacrylate, pentyl methacrylate, ethylene glycol dimethacrylate, 1 ,3-butylene glycol amide, trimethylamine acrylamide, trimethylamine methacrylamide, methacrylic acid, and acrylonitrile.
- the adhesive layer is disposed in a specific pattern of multiple parallel wave-shaped strips on the base cloth, so that the tape, when adhered to the skin, is non-restrictive and allows a full range of motion.
- the adhesive layer further comprises hardener and diluent.
- the hardener used can be ethylcellulose and methacrylic acid copolymers.
- the diluents can be any pharmaceutically acceptable inert carrier.
- the non-steroidal anti-inflammatory drugs (NSAIDs) are provided in the adhesive layer so that the active substance is available for transdermal dissipation into the body when the adhesive layer is in contact with the skin.
- the NSAIDS which can be used include but not limited to aspirin, choline, magnesium salicylates, choline salicylate, celecoxib, diclofenac potassium, diclofenac sodium, diclofenac sodium with misoprostol, diflunisal, etodolac, fenoprofen calcium, flurbiprofen, firocoxib, ibuprofen, indomethacin, ketoprofen, ketorolac, licofelone, lornoxicam, loxoprofen, lumiracoxib, meclofenamate sodium, meclofenamate acid, mefenamic acid, meloxicam, nabumetone, naproxen, naproxen sodium, nimesulide, oxaprozin, parecoxib, piroxicam, rofecoxib, salsalate, sodium salicylate, sulindac, tenoxicam, tolmetin sodium, and valde
- the NSAIDs used are derivative of propionic acid including ibuprofen, naproxen, carpofen, vedaprofen, and ketoprofen.
- the most preferred NSAIDs according to the present invention is ketoprofen.
- Ketoprofen is superior to other NSAIDs with regards to its effectiveness to reduce acute pain and soreness from exercise. Ketoprofen also aids active sportspersons to recover from injuries and tiredness from intense physical activities.
- the ketoprofen incorporated into the adhesive layer can be provided in the form of salt, ester, or preferably free acid.
- the ketoprofen can be provided in R and S enantiomers, a combination or a racemate thereof.
- the ketoprofen is provided at an amount of 0.2 to 0.5 mg/cm 2 of the therapeutic tape.
- the rolled tape of the size 5 cm X 5 meter will be provided a total of 600 mg of ketoprofen, whereas the tape with the size 10 cm X 5 m will be a total of 1200 mg of ketoprofen.
- 3840 mg of ketoprofen will be used for the therapeutic tape of the size 5 cm X 32 m
- 7680 mg of ketoprofen will be used for the therapeutic tape of the size 10 cm X 32 m.
- 30 - 60 mg of ketoprofen is disposed in the adhesive layer of the pre-cut therapeutic tape with the size of 5 cm width and 26 cm length.
- the therapeutic tape of 10 cm width and 26 cm length 60 mg of therapeutic tape is preferable to be used.
- the amount of the ketoprofen used in relation to the size of the ketoprofen is specifically catered to provide an effective dosage without exceeding the maximum limit of 300 mg in one day.
- the therapeutic tape can be provided in any predetermined sizes.
- the preferred width of the kinesiology tape is 5 cm to 10 cm.
- the therapeutic can also be provided in rolled tape, whereby the desired length of the tape cut from the rolled tape before applying to the body.
- the size of the rolled tape includes but not limited to 5 cm X 5 m, 10 cm X 5 m, 5 cm X 32 m, and 10 cm X 32 m.
- the therapeutic tape can also be provided in pre-cut tapes.
- the preferred sizes of the precut tape are 5cm X 26 cm and 10 cm X 26 cm.
- the therapeutic tape incorporated with ketoprofen is suitable for use in hospital for treating patients with muscles injuries, as well as for individual use for relieving muscle pain and soreness from sports.
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
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Abstract
The present invention relates to a therapeutic tape comprising stretchable base cloth formed from the material of a kinesiology tape; an adhesive layer provided on one side of the base cloth; and a composition of non-steroidal anti- inflammatory drugs (NSAIDs) disposed in the adhesive layer. In a preferred embodiment, the non-steroidal anti-inflammatory drug is ketoprofen.
Description
THERAPEUTIC KINESIOLOGY TAPE COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)
Technical field of the invention The present invention relates to a dermal therapeutic tape, and more particularly, the present invention relates to an elastic therapeutic tape containing nonsteroidal anti-inflammatory drugs (NSAIDs).
Background of the invention
Non-steroidal anti-inflammatory drugs (NSAIDs) are often relied on for the treatment of acute or chronic symptoms of inflammation and for relieving pain and soreness from exercise. The NSAIDs are often used in the form of transdermal patches which deliver the drugs into the body through the skin.
European Patent No. EP 0664119 B1 disclosed a percutaneous administration tape whereby the ketoprofen drug is provided in the adhesive layer. United States Patent Application No. US 20050152958 A1 disclosed a ketoprofen patch for the topical application of ketoprofen. However, the base cloth of the conventional medicinal patches only acts as a platform for providing the NSAID without additional benefits. Further, the conventional patches are normally not waterproof and have to be peeled off when taking shower, and are therefore only suitable for use in one day. The use of elastic therapeutic tape such as a kinesiology tape for applying to the body has been well defined as the elastic tape is known to have many beneficial effects to the muscles. The kinesiology tape provides support and stability to muscles and joints while increasing circulation. The kinesiology tape is also known for aiding in restoration of normal fluids perfusion, activation of analgesic system, activation of lymph flow, and adjustment of muscle tension. The kinesiology tape is stretchable such that it allows free movement of the body without restriction to the flow of bodily fluids. The kinesiology tape is often used
without any medication incorporated therein to achieve the above mentioned benefits.
It is therefore desirable to provide a therapeutic tape which allows the topical application of NSAIDs and simultaneously confers the benefits of the kinesiology taping.
Summary of the invention It is an objective of the present invention to provide a tape for reducing pain and soreness from physical exercise.
It is also an objective of the present invention to provide a therapeutic tape having the beneficial effects of kinesiology taping and NSAIDs.
It is a further objective of the present invention to provide a therapeutic tape which accelerates the recovery from muscles and joints injuries.
The present invention relates to a dermal therapeutic tape comprising a stretchable base cloth formed from the material of a kinesiology tape, and an adhesive layer provided on one side of the base cloth, wherein the adhesive layer comprises NSAIDs.
In one aspect of the present invention, the NSAIDs is ketoprofen provided at an amount of 0.2 to 0.5 mg/cm2 of the therapeutic tape.
Detailed description of the preferred embodiments
The present invention will now be described in more detail, in which preferred embodiments of the invention are described herein. This invention may, however, be embodied in many different forms and should not be construed as being limited to the embodiments set forth herein; rather, these embodiments
are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
The present invention relates to dermal therapeutic tape comprising stretchable base cloth formed from the material of a kinesiology tape, and an adhesive layer provided on one side of the base cloth, wherein the adhesive layer comprises non-steroidal anti-inflammatory drugs (NSAIDs). The preferred NSAID for incorporating into the adhesive layer is ketoprofen. In a preferred embodiment, the stretchable base cloth is made from any materials which display certain degree of flexibility, including but not limited to woven fabric, and polymeric material such as polyethylene. In a more preferred embodiment, the base cloth is stretchable up to 130 - 140% of the original length, so that the application of the tape allows non-restrictive motion where the tape is applied. The flexibility of the therapeutic tape is also essential in increasing blood flow and circulation and alleviating pain due to muscle and joint injuries. In a preferred embodiment, the stretchable base cloth formed from kinesiology tape comprises an elastic warp thread and a non-elastic weft thread, wherein the elastic warp threads are twisted together with other fibrous threads.
The adhesive layer is provided on one side of the base cloth for adhering tape to the skin of the user. In a preferred embodiment, the adhesive is a pressure- sensitive acrylic resin such that the adhesive is activated and the bonds are formed once it is applied to the skin without external agent such as a solvent, water, or heat. The degree of bonding is dependent on the amount of pressure which is applied to the therapuetic tape. The monomer of the acrylic resin which can be used include, acrylic acid, 2-ethylhexyl acrylate, butyl acrylate, ethyl acrylate, methyl acrylate, ethyl acrylate, n-propyl acrylate, butyl acrylate, pentyl acrylate, dimethylaminoethyl diacrylate, 1 ,6-hexanediol diacrylate, diethylene glycol diacrylate, diethylene glycol triacrylate, trimethylol propane triacrylate, methyl methacrylate, butyl methacrylate, pentyl methacrylate, ethylene glycol dimethacrylate, 1 ,3-butylene glycol amide, trimethylamine acrylamide, trimethylamine methacrylamide, methacrylic acid, and acrylonitrile. In a
preferred embodiment, the adhesive layer is disposed in a specific pattern of multiple parallel wave-shaped strips on the base cloth, so that the tape, when adhered to the skin, is non-restrictive and allows a full range of motion. In a preferred embodiment of the present invention, the adhesive layer further comprises hardener and diluent. By way of non-limiting example, the hardener used can be ethylcellulose and methacrylic acid copolymers. The diluents can be any pharmaceutically acceptable inert carrier. In a preferred embodiment, the non-steroidal anti-inflammatory drugs (NSAIDs) are provided in the adhesive layer so that the active substance is available for transdermal dissipation into the body when the adhesive layer is in contact with the skin. The NSAIDS which can be used include but not limited to aspirin, choline, magnesium salicylates, choline salicylate, celecoxib, diclofenac potassium, diclofenac sodium, diclofenac sodium with misoprostol, diflunisal, etodolac, fenoprofen calcium, flurbiprofen, firocoxib, ibuprofen, indomethacin, ketoprofen, ketorolac, licofelone, lornoxicam, loxoprofen, lumiracoxib, meclofenamate sodium, meclofenamate acid, mefenamic acid, meloxicam, nabumetone, naproxen, naproxen sodium, nimesulide, oxaprozin, parecoxib, piroxicam, rofecoxib, salsalate, sodium salicylate, sulindac, tenoxicam, tolmetin sodium, and valdecoxib.
In a preferred embodiment, the NSAIDs used are derivative of propionic acid including ibuprofen, naproxen, carpofen, vedaprofen, and ketoprofen. The most preferred NSAIDs according to the present invention is ketoprofen. Ketoprofen is superior to other NSAIDs with regards to its effectiveness to reduce acute pain and soreness from exercise. Ketoprofen also aids active sportspersons to recover from injuries and tiredness from intense physical activities. The ketoprofen incorporated into the adhesive layer can be provided in the form of salt, ester, or preferably free acid. In addition, the ketoprofen can be provided in R and S enantiomers, a combination or a racemate thereof.
In a preferred embodiment, the ketoprofen is provided at an amount of 0.2 to 0.5 mg/cm2 of the therapeutic tape. For example, the rolled tape of the size 5 cm X 5 meter will be provided a total of 600 mg of ketoprofen, whereas the tape with the size 10 cm X 5 m will be a total of 1200 mg of ketoprofen. Further, 3840 mg of ketoprofen will be used for the therapeutic tape of the size 5 cm X 32 m, and 7680 mg of ketoprofen will be used for the therapeutic tape of the size 10 cm X 32 m. In yet another example, 30 - 60 mg of ketoprofen is disposed in the adhesive layer of the pre-cut therapeutic tape with the size of 5 cm width and 26 cm length. For the therapeutic tape of 10 cm width and 26 cm length, 60 mg of therapeutic tape is preferable to be used. The amount of the ketoprofen used in relation to the size of the ketoprofen is specifically catered to provide an effective dosage without exceeding the maximum limit of 300 mg in one day.
The therapeutic tape can be provided in any predetermined sizes. The preferred width of the kinesiology tape, however, is 5 cm to 10 cm. The therapeutic can also be provided in rolled tape, whereby the desired length of the tape cut from the rolled tape before applying to the body. The size of the rolled tape includes but not limited to 5 cm X 5 m, 10 cm X 5 m, 5 cm X 32 m, and 10 cm X 32 m. In an alternative embodiment, the therapeutic tape can also be provided in pre-cut tapes. The preferred sizes of the precut tape are 5cm X 26 cm and 10 cm X 26 cm.
The therapeutic tape incorporated with ketoprofen is suitable for use in hospital for treating patients with muscles injuries, as well as for individual use for relieving muscle pain and soreness from sports.
Although the present invention has been described in a specific embodiment as in the above description, it is understood that the above description does not limit the invention to the above given details. It will be apparent to those skilled in the art that various changes and modification may be made therein without departing from the principle of the invention or from the scope of the appended claims.
Claims
1 . A therapeutic tape comprising
a stretchable base cloth formed from the material of a kinesiology tape; an adhesive layer provided on one side of the base cloth; and
a composition of non-steroidal anti-inflammatory drugs (NSAIDs) disposed within the adhesive layer.
2. A therapeutic tape according to claim 1 , wherein the composition of nonsteroidal anti-inflammatory drugs is any one or combination of aspirin, choline, magnesium salicylates, choline salicylate, celecoxib, diclofenac potassium, diclofenac sodium, diclofenac sodium with misoprostol, diflunisal, etodolac, fenoprofen calcium, flurbiprofen, firocoxib, ibuprofen, indomethacin, ketoprofen, ketorolac, licofelone, lornoxicam, loxoprofen, lumiracoxib, meclofenamate sodium, meclofenamate acid, mefenamic acid, meloxicam, nabumetone, naproxen, naproxen sodium, nimesulide, oxaprozin, parecoxib, piroxicam, rofecoxib, salsalate, sodium salicylate, sulindac, tenoxicam, tolmetin sodium, valdecoxib, ibuprofen, naproxen, carpofen, vedaprofen, and ketoprofen.
3. A therapeutic tape according to claim 1 , wherein the non-steroidal antiinflammatory drugs is ketoprofen.
4. A therapeutic tape according to claim 3, wherein the ketoprofen is provided at an amount of 0.2 to 0.5 mg/cm2 of the therapeutic tape.
5. A therapeutic tape according to claim 1 , wherein the adhesive layer comprises acrylic resin.
6. A therapeutic tape according to claim 1 , wherein the stretchable base cloth is formed from an elastic warp thread and a non-elastic weft thread.
7. A therapeutic tape according to claim 1 , wherein the therapeutic tape is provided with predetermined sizes of 5 cm X 5 m, 10 cm X 5 m, 5 cm X 32 m, and 10 cm X 32 m.
8. A therapeutic tape according to claim 1 , wherein the therapeutic tape is provided in pre-cut strip with predetermined size of 5cm X 26cm to 10cm X 26cm.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI2014701869 | 2014-07-08 | ||
| MYPI2014701869 | 2014-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2016006996A1 true WO2016006996A1 (en) | 2016-01-14 |
Family
ID=55064537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/MY2014/000216 WO2016006996A1 (en) | 2014-07-08 | 2014-08-05 | Therapeutic kinesiology tape comprising non-steroidal anti-inflammatory drugs (nsaids) |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2016006996A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019194871A1 (en) * | 2018-04-05 | 2019-10-10 | Erbst Steven Robert | Therapeutic elastic bandage for modulating the endocannabinoid system |
| ES2835399A1 (en) * | 2019-12-20 | 2021-06-22 | Univ Jaen | Procedure for obtaining a textile material carrying molecules of pharmacological interest and material thus obtained (Machine-translation by Google Translate, not legally binding) |
| WO2022125624A1 (en) * | 2020-12-09 | 2022-06-16 | Vizuri Health Sciences Consumer Healthcare, Inc. | Highly elastic patches and masks for delivery of therapeutic agents |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130060209A1 (en) * | 2011-05-12 | 2013-03-07 | Parker Campbell Tyler | Athletic Tape |
| AU2012257803A1 (en) * | 2011-05-17 | 2013-12-19 | Gazi Altinok | Kinesiologic tape |
| WO2014028396A2 (en) * | 2012-08-13 | 2014-02-20 | Hicken Matthew | Therapeutic elastic tape |
-
2014
- 2014-08-05 WO PCT/MY2014/000216 patent/WO2016006996A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130060209A1 (en) * | 2011-05-12 | 2013-03-07 | Parker Campbell Tyler | Athletic Tape |
| AU2012257803A1 (en) * | 2011-05-17 | 2013-12-19 | Gazi Altinok | Kinesiologic tape |
| WO2014028396A2 (en) * | 2012-08-13 | 2014-02-20 | Hicken Matthew | Therapeutic elastic tape |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019194871A1 (en) * | 2018-04-05 | 2019-10-10 | Erbst Steven Robert | Therapeutic elastic bandage for modulating the endocannabinoid system |
| US20210015680A1 (en) * | 2018-04-05 | 2021-01-21 | Steven Robert ERBST | Therapeutic elastic bandage for modulating the endocannabinoid system |
| ES2835399A1 (en) * | 2019-12-20 | 2021-06-22 | Univ Jaen | Procedure for obtaining a textile material carrying molecules of pharmacological interest and material thus obtained (Machine-translation by Google Translate, not legally binding) |
| WO2022125624A1 (en) * | 2020-12-09 | 2022-06-16 | Vizuri Health Sciences Consumer Healthcare, Inc. | Highly elastic patches and masks for delivery of therapeutic agents |
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