WO2016004911A8 - A cocrystal of ivabradine hydrochloride and (r)-mandelic acid and its pharmaceutical composition - Google Patents

A cocrystal of ivabradine hydrochloride and (r)-mandelic acid and its pharmaceutical composition Download PDF

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Publication number
WO2016004911A8
WO2016004911A8 PCT/CZ2015/000076 CZ2015000076W WO2016004911A8 WO 2016004911 A8 WO2016004911 A8 WO 2016004911A8 CZ 2015000076 W CZ2015000076 W CZ 2015000076W WO 2016004911 A8 WO2016004911 A8 WO 2016004911A8
Authority
WO
WIPO (PCT)
Prior art keywords
cocrystal
pharmaceutical composition
mandelic acid
ivabradine hydrochloride
relates
Prior art date
Application number
PCT/CZ2015/000076
Other languages
French (fr)
Other versions
WO2016004911A1 (en
Inventor
Ondrej Dammer
Veronika SLADKOVA
Eliska SKOREPOVA
Gregor Sedmak
Original Assignee
Zentiva, K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, K.S. filed Critical Zentiva, K.S.
Publication of WO2016004911A1 publication Critical patent/WO2016004911A1/en
Publication of WO2016004911A8 publication Critical patent/WO2016004911A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Abstract

The present invention relates to a new solid form of ivabradine hydrochloride and (R)-mandelic acid of formula (II) hi the molar ratio of 1:1. The method of preparing the above mentioned cocrystal consists in mixing or grinding the individual components in the presence of a solvent The present invention also relates to a polymorphically stable pharmaceutical composition and a granulate, which contains the cocrystal and a pharmaceutically acceptable excipient.
PCT/CZ2015/000076 2014-07-10 2015-07-10 A cocrystal of ivabradine hydrochloride and (r)-mandelic acid and its pharmaceutical composition WO2016004911A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZPV2014-478 2014-07-10
CZ2014-478A CZ305436B6 (en) 2014-07-10 2014-07-10 Solid form of ivabradine hydrochloride and (R)-mandelic acid and pharmaceutical composition thereof

Publications (2)

Publication Number Publication Date
WO2016004911A1 WO2016004911A1 (en) 2016-01-14
WO2016004911A8 true WO2016004911A8 (en) 2016-05-19

Family

ID=53765011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2015/000076 WO2016004911A1 (en) 2014-07-10 2015-07-10 A cocrystal of ivabradine hydrochloride and (r)-mandelic acid and its pharmaceutical composition

Country Status (2)

Country Link
CZ (1) CZ305436B6 (en)
WO (1) WO2016004911A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3887374A2 (en) * 2018-11-27 2021-10-06 Teva Pharmaceuticals International GmbH Solid state forms of lumateperone salts and processes for preparation of lumateperone and salts thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (en) 1991-09-27 1993-11-12 Adir Cie NOVELS (BENZOCYCLOALKYL) ALKYLAMINES, THEIR PREPARATION PROCESS, AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2868777B1 (en) 2004-04-13 2006-05-26 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
FR2882553B1 (en) 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE BETA FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2882556B1 (en) 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE GAMMA D FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2882555B1 (en) 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE GAMMA FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2882554B1 (en) 2005-02-28 2007-05-04 Servier Lab IVABRADINE HYDROCHLORIDE BETA D-CRYSTALLINE FORM, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2891827B1 (en) 2005-10-11 2007-12-28 Servier Lab CRYSTALLINE DELTAD FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2891826B1 (en) 2005-10-11 2007-12-28 Servier Lab CRYSTALLINE FORM 6 OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
ATE544754T1 (en) 2006-11-30 2012-02-15 Cadila Healthcare Ltd METHOD FOR PRODUCING IVABRADINE HYDROCHLORIDE
EP2471780B1 (en) * 2007-05-30 2014-11-26 Ind-Swift Laboratories Limited Crystalline Ivabradine Oxalate Salts and Polymorphs Thereof
CN101774969B (en) 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 Ivabradine sulfate and method for preparing type I crystal thereof
EA201290772A1 (en) 2010-02-12 2013-02-28 КРКА, д.д., НОВО МЕСТО NEW FORMS OF IVABRADIN HYDROCHLORIDE
WO2011104723A2 (en) * 2010-02-23 2011-09-01 Ind-Swift Laboratories Limited Acid addition salts of ivabradine and preparation thereof
US20130116239A1 (en) * 2010-06-14 2013-05-09 ratiopharm GnbH Ivabradine-containing pharmaceutical composition with modified release
EP2726462B1 (en) * 2011-08-02 2017-03-22 Sandoz AG Acetone solvate of ivabradine hydrochloride
EP2589594A1 (en) 2011-11-04 2013-05-08 Urquima S.A. Ivabradine hydrochloride Form IV
CZ305096B6 (en) * 2013-10-02 2015-04-29 Zentiva, K.S. Ivabradine hydrochloride and (S)-mandelic acid solid form and pharmaceutical composition thereof

Also Published As

Publication number Publication date
CZ2014478A3 (en) 2015-09-16
WO2016004911A1 (en) 2016-01-14
CZ305436B6 (en) 2015-09-16

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