WO2015193888A8 - Surface treatment by water-soluble polymers and lipids/liposomes - Google Patents

Surface treatment by water-soluble polymers and lipids/liposomes Download PDF

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Publication number
WO2015193888A8
WO2015193888A8 PCT/IL2015/050606 IL2015050606W WO2015193888A8 WO 2015193888 A8 WO2015193888 A8 WO 2015193888A8 IL 2015050606 W IL2015050606 W IL 2015050606W WO 2015193888 A8 WO2015193888 A8 WO 2015193888A8
Authority
WO
WIPO (PCT)
Prior art keywords
water
liposomes
soluble polymer
lipids
surface treatment
Prior art date
Application number
PCT/IL2015/050606
Other languages
French (fr)
Other versions
WO2015193888A1 (en
Inventor
Jacob Klein
Ronit Goldberg
Jasmine SEROR
Lin WEIFENG
Reut MASHIACH
Original Assignee
Yeda Research And Development Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.
Priority to CN201580043754.8A priority Critical patent/CN107073031B/en
Priority to US15/319,005 priority patent/US10940111B2/en
Priority to CA2950535A priority patent/CA2950535C/en
Priority to ES15808959T priority patent/ES2894829T3/en
Priority to EP15808959.9A priority patent/EP3154550B1/en
Publication of WO2015193888A1 publication Critical patent/WO2015193888A1/en
Publication of WO2015193888A8 publication Critical patent/WO2015193888A8/en
Priority to IL249573A priority patent/IL249573B/en
Priority to US17/190,537 priority patent/US11633358B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed

Abstract

A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water- soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
PCT/IL2015/050606 2014-06-15 2015-06-15 Surface treatment by water-soluble polymers and lipids/liposomes WO2015193888A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201580043754.8A CN107073031B (en) 2014-06-15 2015-06-15 Surface treatment with water-soluble polymers and lipids/liposomes
US15/319,005 US10940111B2 (en) 2014-06-15 2015-06-15 Surface treatment by water-soluble polymers and lipids/liposomes
CA2950535A CA2950535C (en) 2014-06-15 2015-06-15 Surface treatment by water-soluble polymers and lipids/liposomes
ES15808959T ES2894829T3 (en) 2014-06-15 2015-06-15 Surface treatment using water-soluble polymers and lipids/liposomes
EP15808959.9A EP3154550B1 (en) 2014-06-15 2015-06-15 Surface treatment by water-soluble polymers and lipids/liposomes
IL249573A IL249573B (en) 2014-06-15 2016-12-14 Surface treatment by water-soluble polymers and lipids/liposomes
US17/190,537 US11633358B2 (en) 2014-06-15 2021-03-03 Surface treatment by water-soluble polymers and lipids/liposomes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462012379P 2014-06-15 2014-06-15
US62/012,379 2014-06-15

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US15/319,005 A-371-Of-International US10940111B2 (en) 2014-06-15 2015-06-15 Surface treatment by water-soluble polymers and lipids/liposomes
US17/190,537 Continuation US11633358B2 (en) 2014-06-15 2021-03-03 Surface treatment by water-soluble polymers and lipids/liposomes

Publications (2)

Publication Number Publication Date
WO2015193888A1 WO2015193888A1 (en) 2015-12-23
WO2015193888A8 true WO2015193888A8 (en) 2016-01-28

Family

ID=54934950

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/IL2015/050605 WO2015193887A1 (en) 2014-06-15 2015-06-15 Surface treatment of contact lens and treatment of ocular discomfort by water soluble polymers and lipids/liposomes
PCT/IL2015/050606 WO2015193888A1 (en) 2014-06-15 2015-06-15 Surface treatment by water-soluble polymers and lipids/liposomes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/IL2015/050605 WO2015193887A1 (en) 2014-06-15 2015-06-15 Surface treatment of contact lens and treatment of ocular discomfort by water soluble polymers and lipids/liposomes

Country Status (7)

Country Link
US (4) US11883533B2 (en)
EP (2) EP3154413B1 (en)
CN (1) CN107073031B (en)
CA (2) CA2950535C (en)
ES (2) ES2894829T3 (en)
IL (1) IL249573B (en)
WO (2) WO2015193887A1 (en)

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* Cited by examiner, † Cited by third party
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WO2015193887A1 (en) 2014-06-15 2015-12-23 Yeda Research And Development Co. Ltd. Surface treatment of contact lens and treatment of ocular discomfort by water soluble polymers and lipids/liposomes
IL243285A0 (en) 2015-12-22 2016-04-21 Yeda Res & Dev Lipid analogs and liposomes comprising same
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EP3530265A1 (en) * 2018-02-27 2019-08-28 LipoCoat B.V. Universal method for the preparation of lipid-based coatings
EP3530266A1 (en) * 2018-02-27 2019-08-28 LipoCoat B.V. A lipid-based coating composition, and an object having a lipid-based coating
WO2020006471A1 (en) * 2018-06-29 2020-01-02 The Regents Of The University Of Colorado, A Body Corporate Therapeutic hydrogels and contact lens for corneal melting
CN111307646B (en) * 2020-02-27 2022-02-01 西南石油大学 Method for measuring adsorption capacity of polymer treating agent in brine drilling fluid on clay surface
EP4191324A1 (en) * 2020-08-03 2023-06-07 Seed Co., Ltd. Contact lens solution and utilization thereof
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CN115322644B (en) * 2021-05-11 2023-06-02 中国科学院宁波材料技术与工程研究所 Modified alkynyl polymer coating constructed in situ at interface and preparation method and application thereof
WO2023031928A1 (en) * 2021-08-31 2023-03-09 Liposphere Ltd. Sterile liposome-containing compositions and articles
GB2622890A (en) * 2022-09-27 2024-04-03 Coopervision Int Ltd Sustained fatty acid release from contact lens

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Also Published As

Publication number Publication date
EP3154550A4 (en) 2018-05-16
WO2015193888A1 (en) 2015-12-23
EP3154413B1 (en) 2021-08-25
EP3154550B1 (en) 2021-08-04
WO2015193887A8 (en) 2016-02-04
ES2897733T3 (en) 2022-03-02
US11883533B2 (en) 2024-01-30
IL249573B (en) 2022-02-01
EP3154413A4 (en) 2018-03-07
ES2894829T3 (en) 2022-02-16
CN107073031A (en) 2017-08-18
CA3187647A1 (en) 2015-12-23
US20170128365A1 (en) 2017-05-11
EP3154413A1 (en) 2017-04-19
US20170119811A1 (en) 2017-05-04
CA2950535A1 (en) 2015-12-23
EP3154550A1 (en) 2017-04-19
CN107073031B (en) 2021-08-24
US11633358B2 (en) 2023-04-25
US20210186876A1 (en) 2021-06-24
US10940111B2 (en) 2021-03-09
US20210378960A1 (en) 2021-12-09
WO2015193887A1 (en) 2015-12-23
CA2950535C (en) 2023-03-28
IL249573A0 (en) 2017-02-28

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