WO2015189571A1 - Agent antimicrobien pour trempage du trayon - Google Patents

Agent antimicrobien pour trempage du trayon Download PDF

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Publication number
WO2015189571A1
WO2015189571A1 PCT/GB2015/051617 GB2015051617W WO2015189571A1 WO 2015189571 A1 WO2015189571 A1 WO 2015189571A1 GB 2015051617 W GB2015051617 W GB 2015051617W WO 2015189571 A1 WO2015189571 A1 WO 2015189571A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
antimicrobial
quaternary ammonium
water
antimicrobials
Prior art date
Application number
PCT/GB2015/051617
Other languages
English (en)
Inventor
Keith John Harris
Original Assignee
Fantex Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fantex Limited filed Critical Fantex Limited
Publication of WO2015189571A1 publication Critical patent/WO2015189571A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Definitions

  • This invention relates to a water-soluble antimicrobial composition for use as a teat dip for cattle, was well as to a liquid antimicrobial comprising the water- soluble antimicrobial composition. This invention also relates to the use of the liquid antimicrobial composition.
  • teat dips substances called "teat dips" in the farming of animals such as cows, goats and sheep for their milk. These substances are generally liquids which may be applied to the animal's teats either pre- or post-milking.
  • teat dips kill bacteria on the teat, as well as helping seal the teat end to prevent entry of bacteria into the udder between milkings. This can reduce the spread of bacteria (for example, into the milk that is being produced).
  • teat dips include formaldehyde, which is a substance known to be toxic to humans. This invention therefore seeks to provide an alternative teat dip composition which has reduced toxicity and improved functionality.
  • This invention relates to a water-soluble antimicrobial composition for use as a teat dip for cattle, the composition comprising at least two antimicrobials.
  • the water-soluble antimicrobial composition is preferably in the form of a powder.
  • antimicrobial is used to refer to a substance that can kill microorganisms or inhibit their growth. Examples of antimicrobials include germicides, antibiotics, antibacterials, antivirals and antifungals. It is preferred that the antimicrobial provides up to a log 4 reduction in the number of cells of the microorganism in question. For example, a reduction in the number of cells from 10 8 to 10 4 would be a log 4 reduction (ie killing of 99.9% of the cells in question).
  • At least one of the antimicrobials is a quaternary ammonium compound.
  • the quaternary ammonium compound is preferably a quaternary ammonium alkyl compound. More preferably, the quaternary ammonium alkyl compound is benzalkonium chloride or didecyldimethylammonium chloride.
  • the composition comprises two quaternary ammonium compounds.
  • the composition comprises two quaternary ammonium alkyl compounds. More preferably, the composition comprises benzalkonium chloride and didecyldimethylammonium chloride.
  • the composition additionally comprises a third antimicrobial.
  • the third antimicrobial is preferably 2-bromo-2-nitropropane-l,3- diol.
  • compositions of the invention include polyhexanides, preferably polyhexamethylene biguanide, and/or chlorophenols, preferably 4-chloro-3,5-dimethylphenol, 2 -chloro-3 -methyl-phenol, 2,4-dichloro-3,5-dimethylphenol, 2,4-dichloro-5-methylphenol, 4-chloro-3- methylphenol and/or 2,4,6-trichlorophenol.
  • polyhexanides preferably polyhexamethylene biguanide
  • chlorophenols preferably 4-chloro-3,5-dimethylphenol, 2 -chloro-3 -methyl-phenol, 2,4-dichloro-3,5-dimethylphenol, 2,4-dichloro-5-methylphenol, 4-chloro-3- methylphenol and/or 2,4,6-trichlorophenol.
  • a particular preferred composition comprises benzalkonium chloride, didecyldimethylammonium chloride and 2-bromo-2-nitropropane-l,3-diol.
  • This invention also relates to a liquid antimicrobial composition comprising:
  • the liquid antimicrobial composition additionally comprises a surfactant, more preferably a cationic surfactant.
  • the cationic surfactant is preferably cocamidopropyl betaine.
  • Cationic surfactants are preferred in compositions comprising cationic antimicrobials such as quaternary ammonium compounds. This is because anionic surfactants tend to deactivate cationic antimicrobials.
  • the weight ratio of (a), optionally including the cationic surfactant, to (b), is 1:4 to 1:8. More preferably, the weight ratio of (a), optionally including the cationic surfactant, to (b), is about 1:6.
  • Such compositions can be supplied as a "concentrate" for the end user (ie a farmer) to dilute with water.
  • the weight ratio of (a), optionally including the cationic surfactant, to (b), is 1:15 to 1:25. More preferably, the weight ratio of (a), optionally including the cationic surfactant, to (b), is about 1:20.
  • Such compositions are suitable for use as a teat dip without further dilution.
  • This invention also relates to a method of preparing a water-soluble antimicrobial composition as described above, comprising the step of mixing at least two antimicrobials.
  • the mixing step comprises mixing three antimicrobials. It is preferred that the antimicrobials are powders.
  • This invention also relates to a method of applying the liquid antimicrobial composition as described above to the teat of a cow, goat or sheep.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition antimicrobienne soluble dans l'eau destiné à être utilisé comme liquide de trempage des trayons pour les bovins, la composition comprenant au moins deux agents antimicrobiens. L'invention concerne également une composition antimicrobienne liquide comprenant les étapes consistant à : (a) la composition antimicrobienne, soluble dans l'eau et (b) de l'eau. En outre, l'invention concerne un procédé de préparation de la composition antimicrobienne soluble dans l'eau comprenant l'étape consistant à mélanger au moins deux agents antimicrobiens.
PCT/GB2015/051617 2014-06-12 2015-06-03 Agent antimicrobien pour trempage du trayon WO2015189571A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1410526.6A GB201410526D0 (en) 2014-06-12 2014-06-12 Antimicrobial for teat dip
GB1410526.6 2014-06-12

Publications (1)

Publication Number Publication Date
WO2015189571A1 true WO2015189571A1 (fr) 2015-12-17

Family

ID=51266518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2015/051617 WO2015189571A1 (fr) 2014-06-12 2015-06-03 Agent antimicrobien pour trempage du trayon

Country Status (2)

Country Link
GB (1) GB201410526D0 (fr)
WO (1) WO2015189571A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049830A (en) * 1974-11-13 1977-09-20 Milmark Research, Inc. Bovine teat dip
GB1554615A (en) * 1977-04-07 1979-10-24 Wilson E S Quaternary ammonium ammonium compound teat dips
CA1135192A (fr) * 1979-09-05 1982-11-09 Edward S. Wilson Compose utilise pour soigner la mastite chez les vaches
EP0282211A2 (fr) * 1987-03-13 1988-09-14 Betz Europe, Inc. Compositions antibactériennes et leur application
WO2002069954A1 (fr) * 2001-03-02 2002-09-12 Mcj, Inc. Composition and et methodes de traitement et de prevention de la mammite bovine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049830A (en) * 1974-11-13 1977-09-20 Milmark Research, Inc. Bovine teat dip
GB1554615A (en) * 1977-04-07 1979-10-24 Wilson E S Quaternary ammonium ammonium compound teat dips
CA1135192A (fr) * 1979-09-05 1982-11-09 Edward S. Wilson Compose utilise pour soigner la mastite chez les vaches
EP0282211A2 (fr) * 1987-03-13 1988-09-14 Betz Europe, Inc. Compositions antibactériennes et leur application
WO2002069954A1 (fr) * 2001-03-02 2002-09-12 Mcj, Inc. Composition and et methodes de traitement et de prevention de la mammite bovine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PHILPOT W N ET AL: "HYGIENE IN THE PREVENTION OF UDDER INFECTIONS. IV. EVALUATION OF TEAT DIPS WITH EXCISED COWS' TEATS", JOURNAL OF DAIRY SCIENCE, AMERICAN DAIRY SCIENCE ASSOCIATION, US, vol. 61, no. 7, 1 July 1978 (1978-07-01), pages 950 - 955, XP001109155, ISSN: 0022-0302, DOI: 10.3168/JDS.S0022-0302(78)83672-8 *

Also Published As

Publication number Publication date
GB201410526D0 (en) 2014-07-30

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