WO2015189158A1 - Dispositif conique résorbable pour la reconstruction tissulaire en cas de sténose du bassinet rénal et/ou de sténose de la jonction pyélo-urétérale - Google Patents

Dispositif conique résorbable pour la reconstruction tissulaire en cas de sténose du bassinet rénal et/ou de sténose de la jonction pyélo-urétérale Download PDF

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Publication number
WO2015189158A1
WO2015189158A1 PCT/EP2015/062738 EP2015062738W WO2015189158A1 WO 2015189158 A1 WO2015189158 A1 WO 2015189158A1 EP 2015062738 W EP2015062738 W EP 2015062738W WO 2015189158 A1 WO2015189158 A1 WO 2015189158A1
Authority
WO
WIPO (PCT)
Prior art keywords
fabric
pga
renal pelvis
stenosis
reinforcing rings
Prior art date
Application number
PCT/EP2015/062738
Other languages
English (en)
Inventor
Antonio Sambusseti
Gianni Cancarini
Original Assignee
Antonio Sambusseti
Gianni Cancarini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antonio Sambusseti, Gianni Cancarini filed Critical Antonio Sambusseti
Publication of WO2015189158A1 publication Critical patent/WO2015189158A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/009—Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/048—Ureters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable

Definitions

  • the present invention relates to an absorbable conical device, preferably in PGA fabric, suitable for replacing the tissues of the renal pelvis and/or of the ureteropelvic junction in the case of stenosis, neoplasms or other types of diseases that obstruct the flow of urine.
  • the upper part of the ureter the one in direct contact with the kidney, takes the name of renal pelvis and represents the anatomical entity which holds the urine produced by the kidney, conveying it into the ureter.
  • the renal pelvis has a shape roughly comparable to a funnel crushed in anteroposterior direction whose base turned upwards and outwards is divided into various recesses (calyces) which are housed in the kidney while its narrowed end or apex is turned downwards, continuing into the ureter.
  • the point of connection between said renal pelvis and said ureter is defined as ureteropelvic junction. It happens at times that said pelvis and/or said ureteropelvic junction are affected by stenosis, neoplasms or other types of diseases, which obstruct the flow of urine and that these phenomena can only be cured by means of a surgical operation so as to restore the flow of urine.
  • the ureteropelvic junction has very often a narrowing which determines an obstacle to the normal flow of urine which goes to accumulate in the renal pelvis, causing the dilation thereof.
  • This dilation causes a compression of the kidney with damage which can even lead to the functional loss of the same.
  • a surgical operation of pyeloplasty has therefore to be provided in order to remodel the ureteropelvic junction by removal of the stenotic segment and subsequent reconstructive plastic surgery so as to re-create a passage for the urine of adequate cross- section.
  • This remodelling which takes place by removing part of the tissue and performing successive sutures, to give thereto the shape and the dimension required, may be unsuitable in the case wherein the tissues to be sutured are weakened or thin for congenital or pathological reasons.
  • the object of the present invention is that of overcoming, at least in part, the disadvantages of the prior art by providing a biocompatible patch for the replacement of tissues due to stenosis, neoplasms or other types of diseases of renal pelvises and/or ureteropelvic junctions.
  • An object of the present invention relates to an absorbable conical device, preferably in PGA fabric, suitable for replacing tissues due to stenosis or other types of diseases of the renal pelvis and/or stenosis of the ureteropelvic junction.
  • Said device internally hollow, has a conical or truncated cone shape, with substantially circular cross-section, whose larger base, turned upwards when in use, is convex similarly to an ice cream cone, with a central hole in said convex base; the smaller base, which represents the narrowed end, is instead turned downwards when in use and also has a central hole.
  • the configuration of said device is therefore similar to that of the natural renal pelvis including the ureteropelvic junction.
  • the present conical device is made from a patch of bioabsorbable fabric, preferably in PGA, and is coupled to one or more flexible reinforcing rings, preferably three, made in a thermoformed polymeric material, also biocompatible and resorbable yet of greater rigidity compared to the fabric. More particularly the fabric of the present device is made using an ultra-lightweight monofilament or yarn deriving from PGA fibres (polyglycolic acid or polyglycolide), preferably homopolymer: said PGA is a highly biocompatible and resorbable polymer, as well as resistant to urine.
  • the fabric of the device of the present invention can be made by weaving in various ways a monofilament or yarn in PGA, creating a knit fabric, a woven fabric or a nonwoven fabric.
  • a knit fabric is preferred, more preferably a warp knit, in that provided with a rougher surface with respect to other fabrications and able to take on a net configuration (mesh) whose meshes (holes) are very small.
  • Said fabric is moreover preferably texturised. It has in fact been found that texturing, as well as making the fabric rougher on the surface, also confers a greater rigidity and impermeability to urine with respect to the non-texturised fabric. In fact it can be presumed that the texturing goes to cover the micro holes which exist between the meshes of the fabric.
  • Texturing of the fabric can be earned out in various ways: through the use of rough surface monofilament obtained according to the methods known in the art or by a heat- setting treatment of the fabric to obtain raised parts in the fibres, adding greater volume to the filament. This latter method of texturing is preferred.
  • the fabric before being transformed into the device, has a generally rectangular profile in plan view and with dimensions, including thickness, not binding for the purpose of the present invention.
  • the thickness of the aforesaid fabric is however fairly reduced so as to ensure the elasticity and the flexibility necessary for the transformation of the fabric into the device in accordance with the present invention.
  • said thickness can vary between 0.1 mm and 2 cm.
  • said thickness is approximately 0.3-0.6 mm, more preferably approximately 0.4-0.53 mm, even more preferably 0.45 mm.
  • the reinforcing rings are substantially more rigid than the fabric yet at the same time provided with a certain elasticity such as to be able to be lightly compressed radially.
  • Said reinforcing rings are obtained by injection of a copolymer of lactic acid and glycolic acid, denoted as PGA/PLA (poly(lactic-co-glycolic) acid) and thermoforming.
  • PGA/PLA poly(lactic-co-glycolic) acid
  • the lactic acid is a chiral molecule
  • polymer such as PDLA, PLLA, PDLLA, where D and L represent the two stereoisomers.
  • the PLLA has a crystallinity of 37%, a glass transition temperature between 50 and 80°C and a melting temperature of 173-178°C, while the polymer deriving from the polymerisation of a racemic mixture, PDLLA, is amorphous.
  • the reinforcing rings Once the reinforcing rings have been obtained through thermoforming, they are then attached to the fabric in PGA, placing them towards the interior of the cone and stitching them with suture stitches of resorbable yam, for example absorbable MONOTIME ®.
  • the thickness of the aforesaid reinforcing rings can vary between 0.1 and 5 mm, preferably between 0.5 and 1 mm. In a preferred embodiment said thickness is approximately 0.8 mm.
  • the device of the present invention is not to be removed subsequently, after its implanting, since resorbable substantially with the same rate equal to that of growth of the new tissue.
  • the inner and outer surfaces of said device are without sowing of cultured cells and in this condition the conical device is implanted in the patient, without any previous coating of the conical device with cultured tissue cells and any surface treatment to encourage the engraftment of the growing tissues.
  • Said conical device being in fabric, can be cut in situ during the surgical operation so that it can be shaped as far as a possible to the removed zone which it replaces, therefore allowing a tissue reconstruction with shape almost equal to the original and natural one.
  • said device can replace almost completely the part of pelvis which is external to the kidney; or if the zone of pelvis removed is small the device can be cut at the most appropriate height in order to be able to replace the zone of pelvis removed.
  • the abovementioned device has been found to be suitable to act as scaffold after the insertion inside the patient, growing thereon only autologous cells generated by the process of tissue reconstruction of the patient which takes place only after its insertion.
  • Figure 1 is a partially sectioned front view of a kidney
  • Figure 2 is a front view of the conical device in accordance with the invention.
  • Figures 3 a and 3b are perspective views of the elements which compose the device of the invention before their assembly.
  • a conical device denoted overall by reference numeral 100, suitable to be used as an implant for the tissue reconstruction of the renal pelvis and/or of the ureteropelvic junction in the case of stenosis, neoplasms or other types of diseases that obstruct the flow of urine.
  • Said implant 100 is formed by a fabric 1, formed from a patch in PGA with rectangular or square profile (Fig. 3b), which, during assembly, is coupled to a plurality of reinforcing rings 2, with different diameter one from the other, which constitute the frame thereof.
  • This frame acts as load-bearing structure for the fabric 1 allowing it to be shaped as a cone and to maintain this shape even under the weight of the growing new tissue of the renal pelvis and/or of the ureteropelvic junction, thus obtaining a self-supporting conical device 100.
  • the reinforcing rings 2 which are placed on the inner surface 3 of the fabric 1 are attached integrally thereto by means of resorbable sutures, avoiding the use of adhesive materials which could give rise to undesirable reactions.
  • the PGA/PLA copolymer of the reinforcing rings 2 of the frame can be formed, for example, by 30% of PGA and by 70% of PLA.
  • PLA/PGA copolymer poly(lactic-co-glycolic) acid
  • PLA/PGA copolymer poly(L-lactic-co-glycolic)
  • L-lactic acid is 82-88% by moles while the glycolic acid is 18-12% by moles.
  • This copolymer is commercially known by the name Resomer® LG 855S.
  • the fabric 1 in PGA is preferably a warp knit.
  • its weave is such that the interstitial space is smaller than 200 microns, preferably around 160 microns, corresponding to an average area of the holes equal to about 0.02 mm 2 . This guarantees impermeability to urine, avoiding leaks.
  • said fabric 1 is made with yarns having dimensions of approximately 50-200 deniers, monofilament or multifilament, preferably multifilament.
  • the warp knit manufacture does not allow a woven or a nonwoven or a felt-like material to be obtained.
  • This warp knitting process is carried out on a machine for warp knitting with a density of
  • the inner 3 and outer surfaces of the fabric 1 appear very rough since, preferably, they are subjected to texturing, in addition to the warp knit fabrication, in order to increase further the non-adherence to the fibrotic capsule.
  • Outer surface is understood to be the surface intended to come into contact with the internal tissues of the patient while inner surface 3 refers to the one turned towards the interior of the cone 100 which will be intended to come into contact with the urine.
  • the fabric 2 is texturised and made with a 75 denier/30 filaments (parallel one to the other) yarn, where 75 denier is the dimension of the yarn corresponding to 75 g/10000 yards of yarn (10000 yards-9000 metres) and 30 is the number of smaller threads which form each yarn.
  • the aforementioned fabric 1 and the aforementioned reinforcing rings 2 are found to be neutral when in contact with the growing new tissue of the renal pelvis and/or of the ureteropelvic junction: this entails a rapid population of the implanted device 100 by the cells of the surrounding growing tissue.
  • the process is as follows. First of all a surgical operation is carried out to remove the area of a pelvis 200 (Fig. 1) affected by the stenosis or other types of diseases, for example by cutting it in two distinct points along the same number of cutting planes C and D (Fig. 1). After which, during the operation, the conical device 100, made previously, is cut to size, for example along a plane A (Fig. 2) or along two planes so as to shape said conical device 100 to the stenotic area removed, comprised between the two planes C and D.
  • a suture yarn in resorbable material is preferably used, with dimensions of approximately 4/0.
  • the motivation of this choice lies in the need for the conical device and sutures to be resorbed in the same timespan.
  • the suture yarn is then inserted in a curved cylindrical needle, three-quarter round, including Bassini ones.
  • suture yams in bioabsorbable polymers which can be used for the case in question, at the discretion of the surgeon.
  • the holes of the suture stitches in the cell tissue do not constitute a risk of leaks of liquid, in that in a few hours the tissue is reconstructed.
  • the holes of the suture stitches are in any case, preferably, sealed and closed with a cc (a drop) of surgical glue, such as for example Glubran 2TM, normally available commercially.
  • the device 100 is prepared in a controlled environment i.e. with controlled contamination, in a white room. After processing said device 100 is enclosed by a sheet of Tyvek to avoid contaminations and sent to a cycle of sterilisation with gamma rays. At this point the device 100 is ready to be used in an operation.
  • the present conical device 100 does not need to be coated with cultured cells in order to be able to be implanted in the patient, since it is found that it is suitable for acting as scaffold after its insertion, allowing therefore growing thereon of only autologous cells, generated by the process of tissue reconstruction of the patient, without the need for any surface treatment to encourage the engraftment of the growing tissues.

Abstract

L'invention concerne un dispositif conique résorbable autoportant (100) en textile (1), de préférence en PGA, destiné à être utilisé en tant qu'implant pour la reconstitution tissulaire du bassinet rénal et/ou de la jonction pyélo-urétérale après sténose, néoplasme ou autre type de maladie qui obstrue l'écoulement de l'urine. Le dispositif (100) comprend une base convexe plus grande dotée d'un orifice central et une base plus petite également pourvue d'un orifice central, ledit dispositif conique (100) comportant en outre un ou plusieurs anneaux de renfort (2) ayant des diamètres différents, en matériau polymère thermoformé résorbable et fixés d'un seul tenant audit textile (1). Le dispositif peut être façonné in situ pendant l'intervention chirurgicale, pour adopter la forme de la zone excisée du bassinet rénal et/ou de la jonction pyélo-urététrale, au moyen de découpes selon un ou deux plans d'incision, de manière à ce que la reconstruction tissulaire prenne la forme naturelle d'origine. Le dispositif (100) peut être implanté sans application en surface de cellules tissulaires cultivées et/ou autre traitement de surface favorisant la prise des greffons des tissus du bassinet rénal et/ou de la jonction pyélo-urétérale.
PCT/EP2015/062738 2014-06-12 2015-06-08 Dispositif conique résorbable pour la reconstruction tissulaire en cas de sténose du bassinet rénal et/ou de sténose de la jonction pyélo-urétérale WO2015189158A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2014A001069 2014-06-12
ITMI20141069 2014-06-12

Publications (1)

Publication Number Publication Date
WO2015189158A1 true WO2015189158A1 (fr) 2015-12-17

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Application Number Title Priority Date Filing Date
PCT/EP2015/062738 WO2015189158A1 (fr) 2014-06-12 2015-06-08 Dispositif conique résorbable pour la reconstruction tissulaire en cas de sténose du bassinet rénal et/ou de sténose de la jonction pyélo-urétérale

Country Status (1)

Country Link
WO (1) WO2015189158A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201800006816A1 (it) * 2018-06-29 2019-12-29 Patch universale riassorbibile in tessuto di pga per realizzare, in associazione a specifici conformatori, dispositivi protesici per uso veterinario

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001091668A1 (fr) * 2000-05-26 2001-12-06 Scimed Life Systems, Inc. Endoprothese ureterale
US20020055786A1 (en) * 1994-08-16 2002-05-09 Anthony Atala Reconstruction of urological structures with polymeric matrices
WO2006083991A2 (fr) * 2005-02-04 2006-08-10 Poly-Med, Inc. Stent endo-urethral absorbable composite renforce par des fibres
WO2007002260A2 (fr) * 2005-06-21 2007-01-04 Cook Incorporated Greffe implantable servant a fermer une fistule
WO2011140137A2 (fr) * 2010-05-03 2011-11-10 Tengion, Inc. Produits de recombinaison à base de cellules musculaires lisses
WO2012154806A1 (fr) * 2011-05-12 2012-11-15 Boston Scientific Scimed, Inc. Dispositif d'anastomose prépositionné et procédés d'utilisation associés
WO2013135543A1 (fr) * 2012-03-12 2013-09-19 Antonio Sambusseti Coiffe absorbable améliorée pour agrandissement de la vessie chez des patients présentant une faible compliance ou pour le remplacement d'une vaste partie de la vessie après une schistosomiase

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055786A1 (en) * 1994-08-16 2002-05-09 Anthony Atala Reconstruction of urological structures with polymeric matrices
WO2001091668A1 (fr) * 2000-05-26 2001-12-06 Scimed Life Systems, Inc. Endoprothese ureterale
WO2006083991A2 (fr) * 2005-02-04 2006-08-10 Poly-Med, Inc. Stent endo-urethral absorbable composite renforce par des fibres
WO2007002260A2 (fr) * 2005-06-21 2007-01-04 Cook Incorporated Greffe implantable servant a fermer une fistule
WO2011140137A2 (fr) * 2010-05-03 2011-11-10 Tengion, Inc. Produits de recombinaison à base de cellules musculaires lisses
WO2012154806A1 (fr) * 2011-05-12 2012-11-15 Boston Scientific Scimed, Inc. Dispositif d'anastomose prépositionné et procédés d'utilisation associés
WO2013135543A1 (fr) * 2012-03-12 2013-09-19 Antonio Sambusseti Coiffe absorbable améliorée pour agrandissement de la vessie chez des patients présentant une faible compliance ou pour le remplacement d'une vaste partie de la vessie après une schistosomiase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201800006816A1 (it) * 2018-06-29 2019-12-29 Patch universale riassorbibile in tessuto di pga per realizzare, in associazione a specifici conformatori, dispositivi protesici per uso veterinario

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